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1908 articles for “evaluator” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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Evaluation and Demonstration of Integrated Fish (Cyprinus carpio)-Poultry-Forage-Vegetable production in Alicho Wuriro District, SNNPR, Ethiopia
Abstract: The study was conducted in Silte Zone Alicho Wuriro district, situated at about 187 km Southwest of Addis Ababa, and the objectives were to evaluate and demonstrate the use of poultry manure as a fish feed and pond organic fertilizer and the profitability of fish-poultry-horticulture - forage in the integrated farming system. Poultry breeds of Bovine brown which was layers, fish species (Cyprinus carpio) and different varieties of horticultural and …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 11, Issue 2, 2022 · pp. 6–14 Read article
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Synthesis and Antimicrobial Evaluation of Novel Benzimidazolyl Chalcones
Abstract: A new synthesis of benzimidazolyl chalcones derivatives of N1-[4-(1H-benzo[d]imidazol-2-yl) phenyl] derivatives were synthesized. These compounds have been characterized by detailed IR and NMR spectral analysis and have been screened for their antimicrobial activity in-vitro against bacterial Strains of Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia, Staphylococcus aureus, and Bacillus subtelis, and fungal strains of Aspergillus niger and Candida albicans were used. Most of the tested compounds exploited potent antimicrobial activity with …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 4, Issue 3, 2017 · pp. 22–29 Read article
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Formulation and Evaluation of Microballoons of Ramipril
Abstract: The present study was an attempt to develop microballoons of Ramipril to prolong gastric residence time in stomach and to control drug release in therapeutic range. Ramipril is ACE inhibitor having short half-life of 2–4 h and bioavailability 28%. Microballoon was formulated using Eudragit E100 and HPMC K4M in different ratios by emulsion solvent evaporation technique using methanol as evaporating solvent and liquid paraffin as a processing medium. Microballoons were …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 5, Issue 2, 2018 · pp. 13–30 Read article
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Evaluation for Analgesic and Antipyretic Activities of Celosia argentea
Abstract: In the present study, we have evaluated different extracts of Celosia argentea seeds for analgesic and antipyretic activities using different models of pain and rectal temperature. The analgesic activity of Celosia argentea was carried out using eddy’s hot plate method in mice. The antipyretic activity was carried out using yeast induced pyrexia in rats. The three different extracts (Ext I: Pet ether, Ext II: Ethanol, Ext III: Aqueous) of Celosia …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 8, Issue 1, 2018 · pp. 31–34 Read article
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Evaluation for Diuretic Activity of Cassia auriculata
Abstract: The present study has been designed to elucidate the pharmacological activities like analgesic, anti-inflammatory and diuretic activities of flowers of Cassia auriculata on albino mice and rats. The doses for pharmacological activities was fixed petroleum ether, methanol and aqueous extracts was 500 mg/kg b.w. respectively. Analgesic activity was carried out by Eddy’s hot plate method. In this model, nociceptive reaction toward thermal stimuli in mice is a well validated model …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 8, Issue 2, 2018 · pp. 6–9 Read article
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Formulation and Evaluation of Antibacterial, Antifungal Cream of Garlic Oil
Abstract: Plan: The main aim of our research was to develop a novel cream formulation consisting of garlic oil for the treatment of secondary skin infections. Prologue: Topical route is most suitable route for skin infections. The development of topical drug delivery systems designed to have systemic effects appears to be beneficial for a number of drugs on account of the several advantages over conventional routes of drug administration. Methodology: A …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 6, Issue 1, 2019 · pp. 10–13 Read article
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Anxiety Due to Predator Odour as a Novel Tool for Evaluating Anxiolytic Drugs
Abstract: Development of anxiolytic drugs is impaired due to the absence of a proper and reliable method. We have used the ethological aspects of animals such as intent to mate and food avoidance to research an anxiolytic drug called Aforte. Our findings have clearly shown that the ethological parameters are more reliable than the conventional pharmacological test such as elevated plus maze test, rota rod test, forced swim test. The ethological …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 9, Issue 1, 2019 · pp. 12–15 Read article
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Evaluation of Antioxidant Activity of Coumarin Isolated from Eupatorium triplinerve
Abstract: Eupatorium triplinerve (Asteraceae) is a slender herb with narrow lanceolate leaves. Extract of the plant is used as antiseptic, and in the treatment of various ulcers and haemorrhages. Ayapana is a rich source of naturally occurring coumarin chemicals. Coumarins are chemical compounds found in many plants and which usually have a sweet scent—much like newly-mown hay. Coumarin has clinical value as the precursor for several anticoagulant drugs; most notably, one …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 1, Issue 1, 2014 · pp. 18–22 Read article
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Comparative Evaluation of In Vitro Antioxidant Activity of Bark, Flowers and Fruit Extracts of Pongamia pinnata
Abstract: In Indian history, the use of herbal remedies for various diseases has proved its efficacy. Free radicals are the main cause of disease such as diabetes, hypertension, inflammation, etc. The various parts of plant Pongamia pinnata possess good antioxidant activities. The objective of the study was to determine free radical scavenging activity of various plant parts by in vitro free radical scavenging assay such as DPPH assay, ABTS radical decolorization …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 2, Issue 2, 2015 · pp. 14–21 Read article
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Synthesis, Characterization and Biological Evaluation of Some Novel Phenazine Derivatives
Abstract: Novel phenazine analogues (PZ1‑PZ6) were synthesized, characterized by the spectral analysis and screened for anti-arthritis activity by bovin serum and egg albumin protein denaturation method. The synthetic route involves the equimolar mixture of ortho-phenylenediamine and ammonium persulphate which were dissolved in 1 M HCl to give 2,3-diaminophenazine(I). Different substituted aromatic aldehydes were added to the 2,3-diaminophenazine(I) and dissolved in methanol. The reaction mixture was stirred for 1‑2 h and then …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 3, 2019 · pp. 31–37 Read article
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Synthesis, Characterization and Pharmacological Evaluation of Amide Derivates of Prednisolone
Abstract: prodrugs. These novel prodrugs were also characterized with the help of usual analytical and spectral techniques (IR spectroscopy and NMR spectroscopy). These newly synthesized ester derivates of prodrugs were screened for their spectral techniques. All the above compounds showed significant anti-inflammatory effect at 50 mg/kg p.o. and the experimental data are statistically significant at p< 0.05 level. The pharmacological activities exhibited by synthesized novel compounds have confirmed that they may …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 3, Issue 1, 2016 · pp. 1–13 Read article
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Phytochemical, Acute Toxicity and Heavy Metals Evaluation of Khaya senegalensis (Desr.) A. Juss (Meliaceae) Stem Bark
Abstract: The present work was aimed to determine the phytochemical constituents, median lethal dose (LD50) and levels of heavy metals in Khaya senegalensis stem bark obtained from Kano State, Nigeria. The preliminary phytochemical screening revealed the presence of steroids, terpenoids, alkaloids, anthraquinones, saponins, phenolic compounds and carbohydrates, while the LD50 of the aqueous stem bark extract was above 5000 mg/kg body weight using OECD and Lorke’s method. The heavy metals analysis …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 7, Issue 1, 2020 · pp. 1–7 Read article
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Clinical Evaluation of Lekhaniya Effect of Vacha (Acorus calamus) and Musta (Cyperus rotundus) in Medoroga w.s.r. to Obesity: A Comparative Study
Abstract: Present clinical study was designed to assess the lekhaniya effect of Vacha and Musta in reducing sign and symptoms of Medoroga. Lekhaniya effect can be correlates with antiobesity drug action. Total 40 patient of Medoroga were registered in the OPD of Pakwasa, (Shri Ayurved Mahavidyalaya, Nagpur). Total patients were divided equally into 2 groups: A and B. Study was done by using randomized single blind method. The trial drugs were …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 3, Issue 1, 2016 · pp. 1–8 Read article
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Formulation Development and Evaluation of Furosemide Loaded Solid Lipid Microparticles
Abstract: Furosemide is a loop diuretic because of having very low half-life, low oral bioavailability, degraded in gastric juice; it was chosen to formulate as the solid lipid microparticle (SLMs) to overcome above. In this study, an attempt was made to improve the oral bioavailability of furosemide by preparing SLMs using stearic acid (SA) and cetostearyl alcohol (CsA) as lipid polymers by hot homogenization method at different drug: polymer ratios (1:5, …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 6, Issue 2, 2019 · pp. 6–18 Read article
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Evaluation of Some of the Antibiotics in the Management of Hepatic Encephalopathy (HE): An Overview
Abstract: Hepatic encephalopathy (HE) is a common complication among patients with liver cirrhosis associated with a high mortality rate. It is marked by fluctuating neuropsychiatric and cognitive impairment, which can be severe and life threatening. Liver cirrhosis is a leading cause of morbidity and mortality worldwide but exact prevalence of cirrhosis is not known. Prevalence of HE, also known as portosystemic encephalopathy (PSE), is 24% in cirrhotic patients. The diagnosis remains …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 10, Issue 3, 2020 · pp. 22–39 Read article
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Formulation and Evaluation of Solid Lipid Nanoparticles of BCS Class II Drug
Abstract: In the present study, we explored the potential of antihypertensive drug loaded solid lipid nanoparticles (SLNs), as a new formulation in improving the oral bioavailability of drug, which otherwise reported with poor bioavailability. The problem of poor water-solubility has remained as a significant challenge in pharmaceutical industry. The reduction of drug particle to the nano-level increases the surface area and improves solubility and dissolution of drug and proportionate increase in …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 6, Issue 2, 2019 · pp. 32–54 Read article
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Formulation and Evaluation of Curcumin Loaded Transferosomal Nasal In-Situ Gel for Alzheimer’s Disease
Abstract: Objective: To develop a novel delivery of curcumin by formulating its transfersome into nasal in situ gel. Methods: Curcumin transfersomes were prepared by thin film hydration method. Optimization of the formulation was performed using Design Expert software. Formulation and characterization of optimized batch of curcumin transfersomes were performed. The nasal in situ gel was prepared by incorporating the optimized transfersome. Results: The pH, drug content, in-vitro drug release profile and …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 6, Issue 2, 2019 · pp. 19–31 Read article
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In-Vitro Evaluation of Extended Release Atorvastatin Tablets by using Natural Gums
Abstract: The present research is the formulation of extended-release tablets Atorvastatin is used as a hypoglycemic agent; it is HMG CoA Reductase inhibitor. All the formulation were prepared with using different grades of xanthan gum, guar gum, sodium alginate, then all the formulations were subjected to pre-compression and post-compression parameters such as angle of repose, bulk density, tapped density, Carr’s index, Hausner's ratio, weight variation, thickness, hardness, friability and drug content. …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 6, Issue 2, 2019 · pp. 55–62 Read article
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Design and Evaluation Cefaclor Microspheres for Bioavailability Enhancement
Abstract: This study attempted to formulate microspheres for oral administration of Cefaclor by using different polymers like Hydroxypropyl methylcellulose (HPMC) K4M, (HPMC) K15M and Ethylcellulose (EC) which increases the gastric residence time and thereby the bioavailability. Solvent evaporation method was found to be the best due to its ease of fabrication without compromising the activity of the drug. Cefaclor is a second-generation cephalosporin antibiotic used to treat certain ear, lung, skin, …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 6, Issue 3, 2019 · pp. 39–48 Read article
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DESIGN AND EVALUATION OF SANDWICH TABLET FOR SUSTAINED RELEASE DRUG DELIVERY OF DICLOFENAC SODIUM.
Abstract: The objective of this experiment was to create bilayer sandwich pills using the model medication diclofenac. A lengthy duration of action is provided by the combination of an immediate and sustained release layer, which lengthens the effect in the body. Diclofenac sodium has excellent antipyretic, analgesic and anti-inflammatory effects. A super disintegrating carboxyl agent, such as methyl cellulose, is used for the quick release layer of a bilayer sandwich tablet …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 10, Issue 2, 2023 · pp. 1–8 Read article