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837 articles for “Clinical”
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Blood Cell Saver Machine
Abstract: Intraoperative Cell Salvage (ICS) is a crucial technique in modern surgical practice aimed at minimizing the need for allogeneic blood transfusions. By collecting, filtering, washing, and re-infusing a patient’s own blood lost during surgery, ICS provides a safer and cost-effective alternative to donor transfusion, reducing the risk of transfusion-related infections and immunologic reactions. Initially conceptualized in the early 19th century, ICS technology evolved significantly with the introduction of the Cell …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 15, Issue 2, 2025 · pp. 51–59 Read article
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Advances in Multiclass Oral Cancer Detection Using Spectroscopic and AI Techniques
Abstract: Oral cancer, primarily OSCC, is still a major health issue worldwide, especially in low-HDI countries. Early diagnosis is essential since survival rates for early detection are much higher than for late-stage detection. However, traditional methods like visual inspection and biopsy are time-consuming, invasive, and rely on the clinician's skill, which is a limitation in accessibility and efficiency. Oral cancer detection has just been revolutionized by recent advances in spectroscopic techniques, …
Published in Research and Reviews: A Journal of Dentistry · Vol. 16, Issue 3, 2025 · pp. 39–48 Read article
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Crispr Cas – Revolutionizing Modern Therapies and Beyond
Abstract: CRISPR-Cas technology has emerged as a transformative tool in modern molecular biology, revolutionizing both fundamental research and clinical applications. This RNA-guided gene-editing system enables precise and efficient genomic modifications, offering unprecedented potential for addressing genetic disorders, infectious diseases, and oncological conditions through innovative therapeutic interventions. The inherent specificity and programmability of CRISPR-Cas systems have facilitated breakthroughs in diverse fields, including precision medicine, regenerative therapies, and immuno-oncology. Beyond its therapeutic applications, …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 1, 2025 · pp. 25–38 Read article
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AI-based Drug Discovery-Revolutionizing Pharmaceutical Research
Abstract: The traditional drug discovery process is often costly, time-consuming, and prone to high failure rates. The advent of Artificial Intelligence (AI) has revolutionized this field by significantly enhancing efficiency, reducing costs, and improving success rates. AI-driven approaches, including machine learning (ML), deep learning (DL), and natural language processing (NLP), have transformed key areas such as drug target identification, molecular screening, lead optimization, and clinical trial design. AI models can analyze …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 30–44 Read article
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Optimizing Anesthesia for Major Surgery: The Role of Sequential Combined Spinal-Epidural Technique
Abstract: The Combined Spinal Epidural (CSE) approach has been widely employed over the last decade because it achieves rapid onset and substantial blockage while also allowing for the modification or prolongation of the block. Background: Sequential spinal-epidural anesthesia (SSEA) combines the rapid onset and dense blockade of spinal anesthesia with the prolonged duration and adjustable analgesia of epidural anesthesia. This technique is particularly beneficial in major surgeries requiring prolonged operative time …
Published in Research and Reviews : Journal of Surgery · Vol. 14, Issue 2, 2025 · pp. 12–18 Read article
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A prospective investigation into seroma monitoring and skin flap anchoring following Mastectomy
Abstract: Breast cancer remains a significant global health challenge, often necessitating life-saving mastectomy surgeries. However, post-mastectomy complications—such as seroma formation and skin flap necrosis—can still impact a patient’s recovery and overall quality of life. This prospective study examines the effectiveness of seroma monitoring and skin flap anchoring following mastectomy in reducing these problems. Few prospective studies addressing these particular concerns were found in a thorough literature assessment. To fill this void, …
Published in Research and Reviews : Journal of Surgery · Vol. 14, Issue 2, 2025 Read article
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Hiv/aids pandemic and national security
Abstract: The Acquired Immune Deficiency Syndrome (AIDS) is disease caused by the Human Immunodeficiency Virus (HIV), whose clinical manifestation results in the failure of the Immune system to function normally to protect the individual from being attacked or threatened by diseases. The world's attention was drawn to the first observed case in 1981 and a second in 1982 in two different socio-cultural and economic settings and the world then fails to …
Published in Research and Reviews : A Journal of Immunology · Vol. 15, Issue 2, 2025 · pp. 53–66 Read article
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Advanced Polymer Composites for Dental Applications: A Study on Twin Wire Tucker Mechanism
Abstract: This study explores the development of advanced polymer composites for dental applications, particularly focusing on the twin wire tucker mechanism. The study investigates the polymer chemistry underlying the mechanical properties of polymer-based dental instruments, emphasizing the stability, flexibility, and ergonomic benefits of polymer composites in orthodontic applications. The incorporation of reinforced polymers into dental instruments aims to enhance performance, durability, and patient comfort. By integrating high-strength polymers with superior biocompatibility, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 1–6 Read article
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Graphene-Polymer Nanocomposites for Drug Delivery Applications
Abstract: Graphene-polymer nanocomposites (GPNCs) have gained significant attention in drug delivery due to their exceptional physicochemical properties, including high surface area, mechanical strength, tunable functionality, and biocompatibility. These nanocomposites integrate graphene derivatives, such as graphene oxide (GO) and reduced graphene oxide (rGO), with biocompatible polymers to enhance drug loading efficiency, stability, and controlled release. Various natural (chitosan, alginate) and synthetic (PLGA, PEG, PCL) polymers are used to functionalize graphene, enabling targeted …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 362–374 Read article
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Tiny Titans: The Promise of E-Nanorobots in the Fight Against Cancer
Abstract: Cancer, a disease characterized by uncontrolled cell growth, continues to be a leading cause of mortality worldwide. Despite advances in surgery, radiation, and chemotherapy, significant challenges remain in achieving targeted and effective treatments without harmful side effects. But what if we could deploy microscopic robots, engineered at the nanoscale, to precisely target and destroy cancerous cells while leaving healthy tissue untouched. The fascinating possibilities of e-nanorobots are driving extensive research …
Published in Journal of Advancements in Robotics · Vol. 12, Issue 2, 2025 · pp. 11–21 Read article
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Role of Artificial Intelligence in Health Care Decision Making: Balancing Innovation and Caution
Abstract: Healthcare is undergoing a transformation powered by artificial intelligence, which improves monitoring, diagnosis, and treatment capabilities. Among Artificial Intelligence (AI's) shortcomings is the dearth of an emotional relationship between individuals and medical personnel. Robotic surgery procedures pose the possibility of malfunctioning machinery and mistaken assumptions. So, the present systematic review focused on exploring the boon and bane of the role of AI in predicting various abnormalities in advance to improve …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 3, 2025 · pp. 24–35 Read article
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Synthesis, Molecular Docking and Biological Evaluation of Novel Chlorobenzenesulfonamide Analogues of Ibuprofen as Anti-Bacterial, Anti-Diabetic and Anti-Alzheimer Agents
Abstract: In this work, we have synthesized novel chlorobenzensulfonamide tertiary amide based analogues of Ibuprofen (Ibu) and investigated them for their anti-bacterial, anti-diabetic and anti-Alzheimer activities. In the first step, Ibu was converted to amide derivatives by incorporating different aromatic amines. These were further converted into sulfonamide analogues (Sul-Ibu, 1-9) by treating it with p-chlorobenzensulfonyl chloride. Sul-Ibu (1-9) were screened against S. aureus, B. subtilis, S. mutans, E. coli, P. aeruginosa, …
Published in International Journal of Cheminformatics · Vol. 3, Issue 1, 2025 · pp. 41–55 Read article
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Use of Nano-Formulated Ayurvedic Medicines: A Bridge Between Tradition and Modern Science in South India
Abstract: The integration of nanotechnology with traditional Ayurvedic medicine represents an exciting and emerging area of healthcare innovation. By combining the age-old wisdom of Ayurveda with the precision and efficiency of modern nanotechnology, researchers are developing new ways to enhance the effectiveness of herbal treatments. Nanotechnology allows for the creation of tiny drug delivery systems that can improve how Ayurvedic medicines are absorbed and utilized in the body, potentially making them …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 27, Issue 3, 2025 Read article
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Virtual Reality Graded Exposure Therapy For Phobia And Ptsd
Abstract: By combining virtual reality technology with graded exposure therapy, Virtual Reality Graded Exposure Therapy (VRGET) transforms the treatment of anxiety disorders. VRGET uses controlled exposure to anxiety-inducing stimuli using immersive virtual environments, addressing the global problem of anxiety disorders. By simulating real-world scenarios, VRGET provides a structured and immersive approach that allows individuals to gradually confront their fears in a controlled, supervised, and safe environment. Technology offers adaptable scenarios tailored …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 2, 2025 Read article
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An Overview of Artificially Generated Neural Networks Inside the Brain’s Structure in an Alzheimer’s Disease Patient
Abstract: Alzheimer’s disease produces significant neuronal loss, while the precise mechanisms and timing are yet unknown. Other types of cell death, such necroptosis, parthanatosis, ferroptosis, and cuproptosis, need further investigation. Based on brain images of people with mild cognitive impairment, this study assesses artificial neural networks (ANNs) used to diagnose and predict Alzheimer’s disease (AD). This research was conducted considering growing recognition among researchers and medical professionals regarding the importance of …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 2, 2025 Read article
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Past Life Regression and Psychiatry: A Critical Analysis
Abstract: Past Life Regression (PLR) is a controversial therapeutic approach. It is done through hypnosis, which recovers memories of previous lives. Although PLR has gained some popularity in alternative medicine, it is heavily criticized in mainstream psychiatry. As the effects have not been empirically validated. This study provides a comprehensive exploration of Past Life Regression (PLR), offering insights into how it can be understood within the realm of psychiatry. It delves …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 2, 2025 Read article
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U-Net Based Approach for Automated Brain Tumor Classification
Abstract: Brain tumor detection and identification play vital roles in diagnostic procedures in the field of medicine, with the conventional analysis of MRI images requiring a lot of time and also subject to variability. The proposed study involves the use of a CNN-U-Net based approach for brain tumor detection and identification automatically. The study uses a database of 3,064 contrast-enhanced T1-weighted MRI images from 233 patients with the tumors of meningioma, …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 2, 2025 Read article
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Melanoma Skin Cancer Detection Using Deep Learning
Abstract: Cancer as one of the major diseases rank in the World is still very challenging to diagnose and treat hence need for the technological advancements. Chemotherapy, radiation, as well as surgery therapies have several drawbacks including non-selective action, damage to healthy tissues, and multi-drug resistance. Smart nano-theranostics, an advanced integration of nanotechnology with diagnostic and therapeutic modalities, offers a next-generation approach for precision oncology. Thus, the development of multifunctional nanoparticles …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 2, 2025 Read article
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Not Just Cleanliness: Exploring Common Misinterpretations of Obsessive-Compulsive Disorder
Abstract: Obsessive-Compulsive Disorder (OCD) is a complex psychiatric condition that is frequently misunderstood and misrepresented by the public, media, and even within some healthcare settings. One of the most pervasive and enduring myths surrounding obsessive-compulsive disorder (OCD) is its frequent and narrow overidentification with behaviors related solely to cleanliness, orderliness, or excessive tidiness. This misconception often overshadows the broader and more complex spectrum of symptoms experienced by individuals living with the …
Published in Research and Reviews: A Journal of Medicine · Vol. 15, Issue 2, 2025 · pp. 36–40 Read article
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Repurposing Liv-52 For Primary Sclerosing Cholangitis: A Computational Docking And Pharmacokinetic Study To Evaluate Its Bile Flow-Regulating Potential
Abstract: Primary Sclerosing Cholangitis (PSC) is a long-term liver disease where the bile ducts become inflamed and scarred over time. This scarring can block the flow of bile, leading to liver damage and, eventually, liver failure. The etiology of PSC remains largely unknown, and current treatment options are limited, highlighting the need for novel therapeutic strategies. This study aims to repurpose Liv-52, a traditional herbal formulation known for its hepatoprotective properties, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 2, 2025 Read article