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80 articles for “pharmaceutical standardization”
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Pharmacognostical and Pharmaceutical Analysis of Amavatari Rasa- A Herbo-mineral Compound
Abstract: Amavatari Rasa is a herbo-mineral formulation, composed of processed mercury, sulphar, Terminalia chebula Retz, Terminalia bellerica Roxb., Phyllanthus embilica (Embelica officinalis Gaertn), Plambagozeylenica Linn., Commiphora wightii (Arn) Bhand and Ricinuscommunis Linn. This formulation is routinely practiced in cases of Rheumatoid Arthritis, but preliminary physicochemical and pharmacognostical profiles are not available. Considering this, an attempt has been made to develop this profile. Pharmacognostical study of raw drugs was carried out. Organoleptic …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 7, Issue 2, 2016 · pp. 6–10 Read article
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Regulatory Requirement for Pharmaceutical Marketing in USA, EU and GCC: A Comparison
Abstract: The Gulf Cooperation Council (GCC) pharmaceutical are known to be a semi-regulated market when compared with European Union (EU) and Unites States of America (USA) drug regulatory market. Product registration in GCC was challenging task in comparison to EU and USA due to lack of proper harmonised guidelines and diversity in registration procedure. The six GCC member states namely Bahrain, Kuwait, Oman, Qatar, Saudi Arabia and United Arab Emirates have …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 1, Issue 3, 2014 · pp. 16–21 Read article
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Simple, Direct and Stability-Indicating UV Spectrophotometric Assay of Pioglitazone Hydrochloride in Pharmaceuticals
Abstract: Pioglitazone hydrochloride (PGH) is an antihyperglycemic agent used in the treatment of type-2 diabetes mellitus. A simple and straight forward UV-spectrophotometric method is presented for the determination of PGH in bulk drug and tablets by measuring the absorbance of drug solution in 0.1M H2SO4 at 269 nm. A plot of absorbance versus concentration obeyed Beer’s law over 2–36 µg ml-1 concentration range (r = 0.9981) with a molar absorptivity of …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 3, 2017 · pp. 7–16 Read article
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Polymer Nanocomposites As Emerging Platforms in Pharmaceutical Nanotechnology
Abstract: Nanotechnology allows the handling of materials in the 1–100 nm range, where distinct physicochemical phenomena, including quantum effects and higher surface-to-volume ratio, enable disruptive uses in pharmaceuticals and biomedicine. Significant challenges in solubility, stability and targeted biodistribution of therapeutics can be overcome by incorporating nanostructured polymers and polymer-based composites into drug delivery systems. PLGA nanoparticle and other nanocarriers, such as PLGA micelles, dendrimers, and hydrogels, have revealed promising effects on …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 268–278 Read article
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Application of Metabolomics in Pharmacognosy
Abstract: In the field of pharmacognosy, the identification, quality control, and bioactivity evaluation of medicinal plants and natural products have become significantly more effective thanks to the development of a strong tool known as metabolomics, which is the complete study of small-molecule metabolites in biological systems. Metabolomics offers more in-depth insights into phytochemical composition, plant metabolism, and the mechanisms that underlie medicinal benefits. It does this by enabling high-throughput analysis and …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 3, 2025 · pp. 01–07 Read article
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Preliminary Analytical Study of Parangipattai Rasayanam (PRM) – A Siddha Polyherbal Formulation
Abstract: Parangipattai Rasayanam is a purely herbal product used commonly for the management of Vaatha diseases (anti-inflammatory and analgesic activity), skin diseases, etc. The Parangipattai Rasayanam is an orally administrable pharmaceutical drug which is a combination of 28 ingredients namely Parangipattai (Smilax china, Linn), Kodiveli (Plumbago zeylanica), Amukaraa (Withania somnifera, Linn), Milagu (Piper nigrum, Linn), Thipili (Piper longum, Linn), Omam (Carum capticum benth and Hook), Kurosaaniomam (Hyoscyamus niger, Linn), etc. Lack …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 1, Issue 1, 2014 · pp. 38–40 Read article
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Development and Performance Evaluation of a Polyethersulfone–Graphene Oxide Ultrafiltration Membrane for Simultaneous Drug Delivery and Virus Removal: An Experimental Investigation
Abstract: The development of multifunctional ultrafiltration membranes for simultaneous controlled drug delivery and viral removal has gained considerable attention in biomedical engineering, pharmaceutical sciences, and water purification. Polyethersulfone (PES) membranes offer excellent thermal, chemical, and mechanical stability; however, their hydrophobicity can limit permeability, antifouling performance, and biocompatibility. This study proposes the fabrication of PES–graphene oxide (GO) ultrafiltration membranes using the phase inversion technique, with systematic variation of GO concentration to optimize …
Published in International Journal of Membranes · Vol. 3, Issue 2, 2026 Read article
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Review on UV – Visible Spectroscopy and HPLC
Abstract: Like Fourier-transform infrared spectroscopy, UV-visible spectroscopy is used to determine the purity of pharmaceutical compounds. Many substances have chromospheres, which absorb certain wavelengths of ultraviolet or visible light. Using the Beer–Lambert equation, the absorption of spectra obtained from these samples at given wavelengths can be directly related to the sample concentration. Normally, UV and UV-visible spectra are recorded at high and low pH, and the results of both are compared …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 13, Issue 1, 2022 · pp. 43–54 Read article
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High-Performance Liquid Chromatographic Assay of Nateglinide and its Stability Study
Abstract: Nateglinide (NTG) is a D-phenylalanine derivative used in the treatment of type-2 diabetes mellitus. An accurate, sensitive and reproducible high-performance liquid chromatographic (HPLC) method has been developed and validated for the quantification of NTG in pharmaceutical samples. The drug was eluted from Inertsil ODS 3V (150×4.6 mm; 5 µm particle size) column at 30á´¼C with a mobile phase consisting of phosphate buffer of pH 3.3 and methanol (70:30 v/v). The …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 7, Issue 3, 2016 · pp. 41–52 Read article
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Validation and Forced Degradation Studies for the Determination of Erlotinib in Bulk and Pharmaceutical Dosage Forms by RP-HPLC
Abstract: A new reverse phase-high performance liquid chromatography (RP-HPLC) have been developed and validated for the determination of Erlotinib in bulk drug and pharmaceutical dosage form. The developed method is rapid, accurate, precise, simple and economical. The separation was carried out using column Hypersil ODS C-18 (150 mm x 4.6 mm 5 μm particle size) in isocratic mode, using mobile phase composition of 0.1% orthophosphoric acid: Acetonitrile in the ratio of …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 3, Issue 2, 2016 · pp. 44–53 Read article
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Pharmaceutico-analytical Study of Navasadara Satva
Abstract: AbstractNavasadara (Ammonium Chloride; NH4Cl) is one of the rasadravyas included under sadharana rasa varga. Navasadara satvapatana is one of the potent formulations explained in the text Rasatarangini. Navasadara satva possesses the properties like deepana, kapha nissaraka, ruchya, and indicated in amlapitta, hrudaya dourbalya, murcha, puppusashotha, etc. In general, satvapatana means extraction of metallic portion from ore. But here satvapatana process is mentioned for mineral like navasadara. So present study has …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 2, Issue 2, 2013 · pp. 32–36 Read article
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Risk & Opportunities in Development of new Drugs: A New Perspective
Abstract: The procedures of drug discovery and development are briefly described in this article. Our goal is to assist researchers whose work may be pertinent to the discovery and/or development of new drugs in framing their research reports in a way that appropriately situates their findings within the drug discovery and development process and supports the efficient translation of preclinical research to humans. One overarching theme of our article is the …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 2, 2024 · pp. 19–28 Read article
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Development and Validation of a Robust RP-HPLC Method for Rufinamide Quantification in Pharmaceutical Dosage Form
Abstract: The creation and validation of a simple, precise, and targeted reverse phase high-performance liquid chromatographic (RP-HPLC) approach allowed for the quantification of rufinamide in pharmaceutical dosage forms. With a mobile phase of methanol and water (50:50, v/v), the technique used a gradient mode Symmetry Qualisil gold C18 column (4.6 x 150mm, 5 μm). For the detection method, a flow rate of 1 mL/min was employed at 220 nm. During a …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 1, 2024 · pp. 25–32 Read article
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Production, Characterization and Toxicological Evaluation of Eco-Friendly Flavolipid Biosurfactant
Abstract: At present majority of surfactants are chemically synthesized. Nevertheless, in recent years, much attention has been directed towards biosurfactants due to their broad range of functional properties, there are cheaper as they can be produced from alternative sources. They have applications in the fields, such as: oil recovery process, as an additive in food processing industry, pharmaceuticals preparations, energy saving technologies etc. As they are being microbial derivatives, it is …
Published in Research and Reviews: A Journal of Toxicology · Vol. 4, Issue 1, 2014 · pp. 16–21 Read article
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Pharmacological Management of Parkinson’s Disease: Current Therapies and Emerging Treatments
Abstract: Objective: Parkinson's disease, behind Alzheimer's, is the second most common neurodegenerative ailment and a major cause of neurological morbidity worldwide. Clinical diagnosis is made, and current management is limited to symptomatic treatments, with levodopa remaining the cornerstone of pharmaceutical therapy. In certain patient groups, deep brain stimulation of specific basal ganglia targets can provide significant clinical relief. There are currently no proven disease-modifying medicines in clinical use that can halt …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 1, 2023 · pp. 27–39 Read article
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Physico-Chemical, Phyto-Chemical and HPTLC Analysis of Root of Melia azedarach Linn
Abstract: Mahanimba, botanically known as Melia azedarach L. is an important medicinal plant of Ayurveda. Different parts of Mahanimba are widely used to treat many ailments. Its root is used in Gridhrasi (sciatica) and also used as an ingredient of many Ayurvedic formulations. Present study was carried out to evaluate physicochemical, phyto-chemical and HPTLC analysis of root of M. azedarach Linn. following standard guidelines. Results of physicochemical study revealed that, root …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 7, Issue 2, 2016 · pp. 1–5 Read article
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UV Method of Development and Validation of Olaparib
Abstract: An analytical method must be developed and validated in the discovery, development, and production of pharmaceuticals to ensure the identification, purity, potency, and performance of drug commodities. Quality control laboratories use official test protocols that emerge from the processes. A simple ultraviolet spectrophotometric approach was designed and validated using various characteristics, including linearity. Precision, reproducibility, accuracy, robustness, ruggedness, limit of detection, and limit of quantification are among the measuring criteria. …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 20–27 Read article
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Determination of Gatifloxacin in Human Urine by Liquid Chromatography-Tandem Mass Spectrometry
Abstract: Gatifloxacin (GTF) is an antibiotic of the fourth-generation fluoroquinolone family that inhibits the bacterial enzymes DNA gyrase and topoisomerase IV. A reliable, sensitive and selective isocratic reversed phase liquid chromatographic-tandem mass spectrometric (LC-MS-MS) method was developed to determine gatifloxacin (GTF) in human urine. GTF, in urine after solid-phase extraction with SPE cartridge, was analyzed on a C18 column (Symmetric 3.5 μm; 75×4.6 mm i.d) interfaced with a triple quadrupole tandem …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 6, Issue 1, 2015 · pp. 1–6 Read article
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Lamivudine And Dolutegravir Simultaneous Dosage Forms Determined and Validated Using The RP-UPLC Method
Abstract: RP-UPLC has been used to produce a straightforward, precise, and accurate approach for the simultaneous estimation of dolutegravir and lamivudine in a pharmaceutical dose form. A HSS C18 column of 2.8 x 50 mm and featuring particles with a size of 1.6 μm was used to process the chromatogram. A mixture of 70:30 Buffer Na2HPO4 and methanol made up the mobile phase, which was pushed across the column at a …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 1, 2024 · pp. 5–13 Read article
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Design, Synthesis and Pharmacological Evaluation of Pyrazoline Substituted Benzimidazole Derivatives as Antibacterial and Antifungal Agents
Abstract: Background: Benzimidazoles are important heterocyclic compounds possessing a variety of biological activities such as anticancer, antioxidant, antiinflammatory, analgesic, anti-viral, anti-bacterial, anti-fungal and hypoglycemic activities. Pyrazolines are used as antitumor, immunosuppressive, antibacterial and anti tubercular agents. Aim : The present research focused on incorporating pyrazoline nucleus into benzimidazole nucleus to form a potent antibacterial and antifungal agent. Method: The in silico design of novel pyrazoline substituted benzimidazole derivatives was done using …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 11, Issue 3, 2020 · pp. 29–41 Read article