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75 articles for “meta-analysis”
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Computational Approaches to Understanding Cellular Signaling Pathways
Abstract: Cellular signaling pathways are fundamental in regulating vital processes, such as cell growth, differentiation, and apoptosis. The intricate and interconnected nature of these signaling networks requires sophisticated methods for their analysis. Computational approaches, including mathematical modeling, network analysis, and machine learning, have revolutionized the way researchers analyze and simulate cellular signaling. This article provides a comprehensive overview of computational strategies employed to model signaling pathways, with a focus on integrating …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 2, 2024 · pp. 8–13 Read article
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Advancements in Ore Beneficiation Technologies: A Review of Modern Extraction Methods
Abstract: Ore beneficiation plays an essential role in the mining industry, as it facilitates the extraction of valuable minerals from their ores while ensuring maximum efficiency and minimal environmental impact. Beneficiation technologies have evolved significantly over time, leading to improvements in metal recovery rates and reduced waste generation. These advancements have enabled the mining industry to address increasing resource demands, with a particular focus on sustainability and cost-effectiveness. In this review, …
Published in International Journal of Minerals · Vol. 2, Issue 1, 2025 · pp. 36–40 Read article
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Light-Dark Cycle Disruption in Hypothalamus Tissue of Mus Musculus Causes Change in the Expression of Gm45928 Gene
Abstract: The majority of organisms on earth display consistent 24-hour rhythms in their physiology and behavior due to circadian biology. Light and dark cycles play a key role in setting our internal body clock, which controls things like our sleep patterns, hormone levels, body temperature, and metabolism. The disruption of the light-dark cycle has significant effects on the molecular and behavioral rhythms of the circadian clock of hypothalamus. Gm45928 is a …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 1, 2025 · pp. 32–46 Read article
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Investigate an Implementation Study of TI-6AL-4V Lattice-based Scaffold Design Using Finite Element Analysis
Abstract: Implementation studies are advised to determine the effectiveness and performance of bone scaffolding in morphology, which has been demonstrated scientifically. The rehabilitation of bone defects, which is still a complex problem in orthopedic surgery, was the subject of an implementation study we provided. Biomaterial scaffolding porosity and pore size are essential in both in vivo and in vitro bone development. However, it has been linked to various drawbacks, including poor …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 1, 2023 · pp. 28–35 Read article
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The Study of Nutritional Requirements and Physiological Changes in Space Station
Abstract: This article focuses on the impact of physiological adaptations to weightlessness on nutrient and food requirements in space. These modifications entail reductions in body water and plasma volume, which affect the cardiovascular and renal systems. Spaceflight poses intricate and predominantly detrimental effects on the human body, spanning both short and long durations. Long-term weightlessness leads to significant issues like muscle atrophy, skeletal deterioration, cardiovascular function deceleration, reduced red blood cell …
Published in International Journal of Nutritions · Vol. 1, Issue 2, 2024 · pp. 7–10 Read article
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Conductive Polymers for Electro-Mechanical Systems: Structure–Property Relationships and Mechanical Behavior Under Stress
Abstract: Conductive polymers represent a unique class of functional materials that combine the electrical characteristics of metals with the mechanical flexibility of polymers. These dual properties are critical for the next generation of electro-mechanical systems, including wearable sensors, soft robotics, structural health monitoring (SHM), and biomedical actuators. However, the mechanical performance of conductive polymers under diverse stress conditions—such as elongation, cyclic loading, bending, and impact—remains a key challenge, limiting their long-term …
Published in International Journal of Electro-Mechanics and Material Behaviour · Vol. 3, Issue 1, 2025 · pp. 25–30 Read article
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Molecular Docking of Saraca asoca (Ashoka) Phytocompounds for Ovarian Cancer Therapy
Abstract: Objective: One of the top five cancers that causes death in women is ovarian cancer, with increases awareness till date the rate of survival is unpredictable. Even though there are advance treatments introduced, chemotherapy is most suggested to the ovarian cancer patients but the rate of relapses increased and the tumors get resistant towards the drugs. This present study is to evaluate the interaction of phytocompounds from Saraca asoca an …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 27–35 Read article
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Synergistic Integration of MEMS and Spintronics for Precision Data Analytics in Cheminformatics
Abstract: The transformational potential of merging spintronics and Micro-Electromechanical Systems (MEMS) technologies in cheminformatics is investigated in this work. Recent advancements in MEMS, particularly through the use of microbeam sensors and accelerometers, enhance the precision of data collection and processing, especially in biomedical applications such as drug delivery systems and chemical sensing. The synchronization of oscillations in MEMS devices leads to improved reliability and data accuracy, enabling the development of sophisticated …
Published in International Journal of Cheminformatics · Vol. 2, Issue 1, 2024 · pp. 20–26 Read article
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Multi-Target Molecular Docking of Anantmul (Hemidesmus indicus) Compounds for Tay-Sachs Disease Treatment
Abstract: This research aimed to study the effects of the plant Anantmul (Hemidesmus indicus) in the treatment of Tay-Sachs disease using molecular docking studies. Tay-Sachs disease is a neurodegenerative autosomal recessive disorder caused due to accumulation of the molecule GM2 ganglioside which is caused due to lack of enzyme Beta Hexosaminidase which breaks down GM2 Ganglioside. Anantmul (Hemidesmus indicus) is a an ayurvedic plant used in the Indian subcontinent that has …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 2, 2024 · pp. 61–69 Read article
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Antimicrobial Peptides in Fiddler Crabs: Structural Analysis and Potential Applications
Abstract: Crustaceans represent the largest and most ecologically and economically significant group of marine and aquatic arthropods. Their biomass and critical role in ecosystems highlight their importance. Among crustaceans, decapods are frequently used as model organisms in studies of immune responses due to their significant commercial value and the need to mitigate disease outbreaks in shellfish aquaculture. Antimicrobial host-defense peptides (AMPs) are pivotal in metazoan immunity, especially for invertebrates lacking adaptive …
Published in International Journal of Cheminformatics · Vol. 2, Issue 2, 2024 · pp. 26–32 Read article
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Enhancing Machinability in the Heat Treatment of Inconel 718: A Comprehensive Review
Abstract: The increasing need for materials with high strength and heat resistance, particularly in aerospace applications, creates machining issues. These materials are generally difficult to machine because to their strong wear resistance, abrasion resistance, and low heat conductivity. This produces strong cutting forces and temperatures, resulting in a limited tool life. variances in the microstructures of various materials can induce variations in machinability due to variances in chemical composition, casting, forging …
Published in International Journal of Energy and Thermal Applications · Vol. 2, Issue 1, 2024 · pp. 9–20 Read article
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Production and optimization of amylase enzyme using bacillus subtilis under solid state fermentation and its characterization
Abstract: This study employed solid state fermentation to maximize amylase production by Bacillus subtilis (OR578403). The research began by discovering and analyzing amylase-producing bacteria in soil samples followed with biochemical, molecular characterization. By using commercially available substrates like wheat bran, rice bran, and wheat rava were obtained from the local market and employed as solid substrates, which may influence amylase production and to be assessed. The identified organism was Bacillus subtilis, …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 4, Issue 1, 2026 Read article
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Importance of inflammatory marker ratio and lipid profile ratio in Acute Ischemic Stroke
Abstract: Background: Acute Ischemic Stroke is a chronic inflammatory disease that is projected to be one of the leading causes of mortality affecting millions of people globally. It is essential to study the Platelet lymphocyte ratio (PLR), Neutrophil lymphocyte ratio (NLR) ratios and C reactive protein (CRP) in impacting the inflammatory status during stroke. It is also important that altered lipid metabolism could influence the inflammatory conditions associated with AIS. Hence …
Published in International Journal of Brain Sciences · Vol. 1, Issue 1, 2024 · pp. 19–31 Read article
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Exploring Azadirachta indica’s Potential to Combat Visceral Leishmaniasis Through GP63 Inhibition
Abstract: Objectives: Millions of people worldwide suffer from the parasite disease visceral leishmaniasis. Determine the naturally occurring active ingredients in Azadirachta indica, which are employed as a disease-prevention agent and have several uses in medicine. To choose the best ligand to use as a medication, absorption, distribution, metabolism, and excretion (ADME) studies and molecular docking are employed. Methods: To obtain the GP63 protein, the Protein Data Bank (PDB) database was accessed. …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 2, 2024 · pp. 1–12 Read article
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Insilico Structural Analysis and Homology Modeling of Crustin Protein from Fiddler Crab Species
Abstract: In terms of biomass and ecological or economic importance, the crustacea are the largest, most noticeable, and possibly, the most significance group of marine or aquatic arthropods. Because of their enormous commercial value and the necessity to prevent disease outbreaks in the shellfish aquaculture industry, decapods are the experimental animals of choice for practically all biological studies involving immune responses. Antimicrobial host-defense peptides (AMPs) are major components of metazoan immunity, …
Published in International Journal of Cheminformatics · Vol. 1, Issue 1, 2023 · pp. 1–7 Read article
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Bioactive Compounds in Ethanolic Extract of Strychnos innocua Root Using Gas Chromatography and Mass Spectrometry (GC-MS)
Abstract: Medicinal plants are of great relevance with endless pharmaceutical and therapeutic properties. They are source of wide array of secondary metabolites or bioactive compounds/phytochemicals (phenols, alkaloids, flavonoids, terpenoids, tannins, steroids and saponins) which can discharge numerous biological functions (antimicrobial, antioxidant, antiviral, antifungal, anti-fibrotic, immune-modulatory, cytotoxic, antipyretic, antitumor, antihelminthic, antiprotozoal, antibacterial, and so on). The use of gas chromatography and mass spectrometry analysis in identifying the bioactive compounds in the ethanolic …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 1, 2023 · pp. 9–14 Read article
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Determination of fire Resistivity of Door and Window Materials at Portharcourt Markets in Nigeria
Abstract: The persistence of fire outbreaks in markets is a problem in Nigeria and the repetition of this problem is very frequent at Port Harcourt in Rivers State. To curtail this problem, research was made on the three major markets in Port Harcourt with the aim of determining the fire resistivity of their door and window materials, in order to generate guidelines for designing doors and windows of market buildings in …
Published in International Journal of Architectural Design and Planning · Vol. 1, Issue 1, 2023 Read article
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Optimized Web-based Online Food Ordering System: Design and Implementation
Abstract: Online food ordering systems have undergone a profound metamorphosis with the advent of digital technologies, catalyzing a pivotal shift in the operational dynamics of the gastronomic sector. This paper elucidates the conceptualization, design, and implementation of an advanced, web-based food ordering system, meticulously engineered to elevate the efficiency and sophistication of food service operations. Employing the rigorously structured Systems Analysis and Design Methodology (SSADM), this system represents a transformative departure …
Published in International Journal of Computer Science Languages · Vol. 2, Issue 2, 2024 · pp. 1–25 Read article
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A Study on Friction Stir Processing Effected on Hardness and Tensile Properties When Single Pass and Double Pass Is Considered Using Al 6061 And Steel Material
Abstract: The principle of friction stir welding was initially employed to build the emerging technology known as friction stir processing, or FSP. FSP has shown to be a successful method of developing face mixes and increasing the material's mechanical parcels. Aluminum blends are among those accoutrements over which the FSP can be performed successfully. The study comprised the careful processing of steel and Al 6061 samples using both single and double …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 2, Issue 1, 2024 · pp. 16–23 Read article
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Extrapolations of Periwinkle Secondary Metabolites as Multitarget Inhibitor of Breast Cancer Proteins
Abstract: Objective: Breast cancer is considered one of the most common and dangerous forms of cancer. It is a significant public health issue on a global scale. The study estimates that 10.0 million people will die from cancer this year, and 19.3 million people will develop the disease overall (BC). In this computation approach, nowadays emphasizes new drug discovery, the target protein epidermal growth factor receptor (EGFR) (5UGB), estrogen receptor (ER) …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 1, 2023 · pp. 36–49 Read article