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277 articles for “disease mechanism”
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An Empirical Study of Hyperparameter Impact on Deep Learning Models for Cardamom Leaf Disease Classification
Abstract: Recent advancements in deep learning models like convolutional neural networks and self- attention mechanisms have achieved great success in the field of plant disease classification. This study investigates the efficacy of two pre-trained models, ConvNeXT-Tiny and Swin Transformer-Tiny, for leaf disease classification in cardamom using a publicly available dataset constituting three categories of leaves, namely Healthy, Colletotrichum Blight and Phyllosticta Leaf Spot. The effectiveness of the models highly depends on …
Published in Current Trends in Information Technology · Vol. 15, Issue 3, 2025 · pp. 48–60 Read article
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Epigenetic Modifications in Health, Disease, and Precision Therapeutics (From Genome to Epigenome)
Abstract: Introduction: Epigenetic alterations play a crucial role in regulating gene expression in both normal physiological and disease states. These reversible modifications—such as DNA methylation, histone acetylation, phosphorylation, ubiquitination, and chromatin remodelling—are increasingly implicated in complex diseases including cancer and neurodegenerative disorders. Despite advances in standard therapeutic approaches, patient responses remain variable, largely due to genetic heterogeneity and epigenetic dysregulation. This highlights the need for incorporating epigenetic understanding into personalized medicine. …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 15, Issue 1, 2026 Read article
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Medicinal Potential of Cullen corylifolium in Ageing and Ageing Related Diseases
Abstract: Cullen corylifolium is a tropical medicinal plant of the Fabaceae family, generally known as Babchi/Bakuchi in various regions of Asia. Cullen corylifolium is a traditional phyto-therapeutic plant of China used to manifest various pathological conditions since ages, possesing round and dark brown seeds with a rough texture. Cullen corylifolium has been previously reported to possess various properties such as antioxidant, anti-inflammatory and can be used as a solution to treat …
Published in Research & Reviews : Journal of Herbal Science · Vol. 13, Issue 2, 2024 · pp. 21–32 Read article
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Long Non-Coding RNAs: Key Regulators of Gene Expression in Development and Disease
Abstract: Long non-coding RNAs (lncRNAs) are RNA molecules that do not make proteins but are essential for controlling how genes are turned on or off in the body. These molecules help with various biological functions, such as guiding cell growth, shaping development, and influencing the progression of diseases. Recent advancements in genomics and transcriptomics have revealed the vast and complex roles of lncRNAs, with an increasing recognition of their involvement in …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 1, 2025 · pp. 11–15 Read article
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Effects of Smoking on Respiratory System
Abstract: Smoking is whispered to exacerbate respiratory diseases by harming respiratory defense mechanisms. Specifically, smoking damages mucociliary function, which impairs clearance of inhaled substances even in smokers who have no respiratory symptoms promotes bacterial adherence to airway epithelial cells. The devastating health impact of cigarette smoking is well known, Cigarette and its components produce structural changes in the respiratory tract include peri-bronchiolar inflammation and fibrosis, augmented mucosal permeability, destruction of the …
Published in Research and Reviews: A Journal of Toxicology · Vol. 3, Issue 3, 2013 · pp. 5–8 Read article
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Bone in Periodontal Health and Diseases: A Scoping Review
Abstract: Bone resorption is a basic physiologic process and central to the understanding of many key pathologies. Alveolar bone destruction is a hallmark of periodontal disease progression and its prevention is a key clinical challenge in treatment of periodontal disease. Bone loss is mediated by the host immune and inflammatory response to the microbial challenge. As individuals are not equally susceptible to the destructive effects of periodontal infections therefore, it is …
Published in Research and Reviews: A Journal of Dentistry · Vol. 12, Issue 1, 2021 · pp. 1–12 Read article
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Research and Review: On Irsale Alaq (Medicinal Leech), Mechanism of Action and its Uses with Applied Site
Abstract: Leech therapy is based on the concept of balancing body humours. In the Unani system of medicine the majority of the disease caused by the endogenous factors by excessive Humours accumulated of morbid matters foodstuffs or the metabolic products. There are 6 evacuation methods for the balancing of humours viz bloodletting, purging, vomiting, sweating, cauterization and diuresis are described. Among those methods, bloodletting methods are a most popular and effective …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 6, Issue 1, 2019 · pp. 19–25 Read article
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Liquid Biopsy in Solid Tumor: An Ultimate Source for Molecular Landscaping, Biomarker Discovery and Clinical Management
Abstract: Presently, work in the liquid biopsy field showed a great prospect utility in the diagnosis and stratification of cancer patients and furthermore personify an adaptive method for monitoring treatment response when compared to the tissue biopsy approach. Analysis of cell free DNA (cfDNA), circulating tumor cells (CTCs) and exosomes, all conjointly referred to as “liquid biopsies,” are not only a modality to monitor treatment efficacy, disease progression, and emerging therapy …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 8, Issue 3, 2019 · pp. 25–36 Read article
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Trichoderma: beneficial fungus for sustainable agriculture
Abstract: As environmentally beneficial substitutes for chemical pesticides, Trichoderma species are being utilized in agriculture more and more. Disease suppression, increased plant growth, and increased tolerance to environmental stress are just a few advantages they provide. These fungi are used in a wide range of cropping systems and formulations around the world. Their use is growing worldwide, particularly in Asia and Europe. In contemporary crop management, items derived from Trichoderma are …
Published in International Journal of Fungi · Vol. 2, Issue 2, 2025 · pp. 25–29 Read article
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Therapeutic view of Anupadeshaja vikara in Ayurveda
Abstract: Introduction: Maintenance of the health in healthy and the cure of the diseased one is the prime goal of Ayurveda science. The dosha and dhatu are responsible for the mechanism of the body. Thus, the treatment of the diseases aims at the balancing the dosha and dhatu. The spectrum of treatment of diseases includes desha, dosha, aushadha and sadhyasadhyata of the vyadhi. The term desha encompasses deha (body) and bhumi …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 10, Issue 2, 2023 · pp. 1–5 Read article
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Crossroads of Ecology and Medicine: Evaluating Pollutant-Induced Risks to Biodiversity and Human Health
Abstract: Environmental pollution has emerged as a central challenge at the crossroads of ecology and human medicine. The rapid pace of industrialization, urbanization, and agricultural intensification has led to an unprecedented release of pollutants into the air, water, and soil—triggering cascading effects on ecosystems and human health. Pollutants such as particulate matter, heavy metals, pesticides, microplastics, endocrine-disrupting chemicals, and persistent organic pollutants not only degrade biodiversity but also exert multifaceted health …
Published in International Journal of Environmental Noise and Pollution Control · Vol. 3, Issue 1, 2025 · pp. 41–53 Read article
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Comparative Efficacy and Safety of Safinamide and Rasagiline in the Treatment of Parkinson’s Disease: A Meta-Analysis and Systematic Review
Abstract: Background: Recent studies have suggested Rasagiline and Safinamide monotherapy as potential management options for Parkinson’s disease. Parkinson’s disease, a neurological disorder characterized by tremors and movement difficulties, necessitates treatments aimed at managing clinical symptoms. Levodopa remains the primary effective treatment for Parkinson’s disease symptoms; however, its long-term use often leads to motor complications in many patients. Additional therapeutic drugs, such as dopamine agonists and monoamine oxidase B inhibitors, including Safinamide …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 74–91 Read article
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Immunological Mechanisms Underlying Autoimmune Disorders: Recent Advances and Therapeutic Implications
Abstract: A diverse range of illnesses known as autoimmune disorders are typified by dysregulated immune responses against self-antigens, which result in tissue damage and persistent inflammation. Understanding the genetic, epigenetic, and environmental variables that contribute to autoimmune pathogenesis has advanced significantly during the last ten years. Current disease models have been transformed by new understandings of immunological tolerance mechanisms such as the functions of regulatory T cells, cytokine networks, and the …
Published in Research and Reviews : A Journal of Immunology · Vol. 16, Issue 1, 2026 · pp. 21–25 Read article
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An Overview of Artificially Generated Neural Networks Inside the Brain’s Structure in an Alzheimer’s Disease Patient
Abstract: Alzheimer’s disease produces significant neuronal loss, while the precise mechanisms and timing are yet unknown. Other types of cell death, such necroptosis, parthanatosis, ferroptosis, and cuproptosis, need further investigation. Based on brain images of people with mild cognitive impairment, this study assesses artificial neural networks (ANNs) used to diagnose and predict Alzheimer’s disease (AD). This research was conducted considering growing recognition among researchers and medical professionals regarding the importance of …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 2, 2025 Read article
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Decoding Innate Immunity: Mechanisms, Components, and Clinical Implication
Abstract: Innate immunology represents the body's first line of defense against pathogens, acting as a rapid, non-specific response to a wide array of microbial invaders. This part of the immune system depends on pattern recognition receptors (PRRs) to identify pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), leading to the activation of immune cells such as macrophages, dendritic cells, and neutrophils. The innate immune system also plays a crucial role …
Published in Research and Reviews : A Journal of Immunology · Vol. 15, Issue 2, 2025 Read article
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Effectiveness of Retro Walking on Pain, Functional Limitation and Range of Motion in Patients with Knee Osteoarthritis
Abstract: Background: Osteoarthritis is a degenerative joint disorder which is progressive in nature. It is one of the major health problems that causes pain, functional limitations resulting in reduced quality of life. It involves damage to the articular cartilage and surrounding tissues causing osteophyte formation. Knee osteoarthritis is common among adults with the most common symptom being mechanical pain. As the prevalence of the disease is increasing, there is a need …
Published in Research and Reviews: A Journal of Health Professions · Vol. 13, Issue 1, 2023 · pp. 26–34 Read article
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Mucormycosis: An Emerging Challenge among COVID-19 Patients
Abstract: Mucormycosis is a rare angio-invasive opportunistic fungal infection that has become an emerging challenge among COVID-19 patients. The higher incidence of mucormycosis among COVID-19 patients has been attributed to hypoxia, pre-existing or steroid induced diabetes, diabetic ketoacidosis, increased ferritin levels, and SARS-CoV-2 or steroid mediated immunosuppression. Other contributing factors include prolonged hospitalization with or without use of mechanical ventilators.The epidemiology and etiopathogenesis of this disease are still evolving. Once infected, …
Published in Research and Reviews: A Journal of Medicine · Vol. 11, Issue 2, 2021 · pp. 34–37 Read article
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Biological Membranes: Structure, Function, and Their Roles in Disease Pathophysiology
Abstract: Biological membranes are important structures that control cellular work, signal transmission, transport, and communication. Dysfunction of membranes has been considered in the development of many diseases, such as cancer, neurodegenerative diseases, and infections, with the distortion of lipid composition, protein activity, and cellular connections involved in the pathogenesis of the disease. The damage on membrane can be caused by oxidative stress, genetic mutation, and environmental influence to disrupt cellular homeostasis. …
Published in International Journal of Membranes · Vol. 3, Issue 1, 2026 · pp. 38–46 Read article
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Perspectives on ‘Kamsaharitaki’: an Ayurvedic Formulation for COVID-19 related Multisystem Inflammatory Syndrome (MIS)
Abstract: Background and Aim: Angiotensin-converting enzyme 2 receptor (ACE2), together with Transmembrane protease serine 2 (TMPRSS2), is a protein receptor for SARS-CoV-2 virus in the host subject; expression of ACE2 and TMPRSS2 reveals the multidimensional character of COVID-19 infection. SARS-CoV-2 Prominently induces pulmonary and systemic injury with other synergistic mechanisms. Preexisting chronic inflammatory conditions markedly sustain and aggravate the severity and cytokine storm. Inflammatory responses are closely linked with COVID-19 severity …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy Read article
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Metabolic Reprogramming in Carcinogenesis: An Overview
Abstract: Metabolic reprogramming is a crucial mechanism via which cells modify their metabolic pathways to adjust to changes in the environment and maintain growth, survival, and function. This phenomenon is of utmost importance in a wide range of physiological and pathological situations, specifically in cancer, immunological responses, and stem cell biology. In cancer, metabolic reprogramming facilitates fast cell growth and survival, as demonstrated by the Warburg effect, where cancer cells prioritize …
Published in Research and Reviews: A Journal of Medicine · Vol. 14, Issue 2, 2024 · pp. 32–38 Read article