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1363 articles for “Pre-clinical”
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Pharma Tech: Leveraging Software for Drug Development & Clinical Research
Abstract: The pharmaceutical sector is progressively adopting software solutions to enhance the drug development process and optimize clinical research results. Drug development is a time-consuming, expensive, and intricate process that traditionally requires extensive laboratory research, preclinical testing, and several stages of clinical trials. Software tools are revolutionizing these stages by improving efficiency, minimizing errors, and speeding up timelines. During preclinical testing, predictive software tools are used to model toxicological effects and …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 1, 2025 · pp. 11–19 Read article
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Case Study: A Patient with Uncontrolled Type 2 Diabetes and Carbuncle in Thigh Whose Diabetes is Managed by Ayurvedic Intervention
Abstract: Background: Diabetes mellitus is a global pandemic with substantial public health implications. It is a well-known multifactorial metabolic condition defined by unusually high blood glucose levels caused by a shortage of insulin, either absolute or relative. Type-2 diabetes is the most common type of diabetes, accounting for 90% of all diabetics. Carbuncle is a rare skin and soft tissue infection that primarily affects uncontrolled diabetics. Presentation of the Case: A …
Published in Research & Reviews : Journal of Herbal Science · Vol. 10, Issue 3, 2021 · pp. 8–13 Read article
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Horizons in Neuralgia Care: Addressing Unmet Needs and Future Prospects
Abstract: Neuralgia refers to intense, sharp, and often chronic pain resulting from damage or irritation to nerves. It is typically characterized by sudden, shooting pain along the course of a nerve, significantly impairing daily functioning and impacting both physical and emotional well-being. Given its intensity and chronic nature, neuralgia presents a complex challenge in clinical management, emphasizing the importance of timely diagnosis and effective intervention to improve patient outcomes. This comprehensive …
Published in International Journal of Brain Sciences · Vol. 2, Issue 2, 2025 · pp. 1–8 Read article
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Anatomical Study of Asthi vaha srotas & Clinical Study of Asthi Kshaya w.s.r to “Osteoporosis”
Abstract: AbstractAyurveda is a life science. The researchers of Ayurveda could rule out the presence of srotas spreading throughout the human body. These srotas are governed by vayu which is using all the srotas of the body to carry out all the activity of human body, without which the human society will not exist. Several synonymous words have been described by the Ayurvedacharyas for srotas. The aim of the study was …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 5, Issue 1, 2018 · pp. 15–20 Read article
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Shadows of Uncertainty: When Pneumonia Isn’t Pneumonia
Abstract: Pneumonia is a common medical condition encountered in hospitalized patients and remains a cause of morbidity worldwide. Identifying and initiating appropriate treatment in febrile patients who present with respiratory symptoms and radiographic infiltrates, reduce hospital stay, minimize complications, and lower healthcare costs. However, the assumption that every pulmonary infiltrate or opacity seen on a radiological imaging represents an infectious process such as pneumonia can lead to misdiagnosis, unnecessary investigations, prolonged …
Published in International Journal of Pathogens · Vol. 3, Issue 1, 2026 · pp. 24–29 Read article
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Clinical Study of Role of Rasayana as a Pre adjuvant and Post Treatment of Chemotherapy in the Management of Carcinoma
Abstract: Integrative oncology is a novel form of medical theory which views cancer not merely as an accumulation of genetically transformed immature cells, but sum total of feelings, images, actions evoked by cancer. Not only by those afflicted with the disease, but also by their loved ones. This has been very well understood by Ayurveda. The important tool to manage the adverse reaction is Rasayana. Rasayana through their nutrient value improves …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 11, Issue 1, 2022 · pp. 5–13 Read article
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Atypical Psychiatric Presentations of Autoimmune Encephalitis: A Case Series and Proposed Clinical Approach to Diagnosis
Abstract: Background: knowledge and detection of seronegative autoimmune encephalitis (AE) is growing rapidly, but typical psychiatric presentations risk misdiagnosis or delay in diagnosis with worse prognostic outcomes. Paraclinical markers are useful when positive, and integral to the current diagnostic framework yet have limited sensitivities leaving an unknown percentage of patients without diagnosis or treatment. Cases not meeting diagnostic criteria pose a particular clinical challenge regarding diagnosis and treatment decision making and …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 12, Issue 2, 2022 · pp. 26–37 Read article
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Enhancing Nursing Education Through AI-Driven Adaptive Learning Systems
Abstract: The integration of Artificial Intelligence (AI) in nursing education offers significant potential to enhance learning experiences by personalizing education, improving knowledge retention, and developing clinical competencies. This study evaluates the effectiveness of AI-driven adaptive learning systems compared to traditional lecture-based teaching methods in nursing education. A mixed-methods approach was used, with 200 nursing students participating in a quasi-experimental design. The intervention group (100 students) used AI-powered adaptive learning platforms for …
Published in Journal of Nursing Science & Practice · Vol. 15, Issue 2, 2025 · pp. 29–34 Read article
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Current Perspectives of Prader -Willi Syndrome: A Multisystem Approach
Abstract: Prader-Willi syndrome (PWS) is a genetic disorder with multisystem involvement, caused by the lack of expression of genes on the paternally inherited chromosome 15q11.2-q13 region from paternal 15q11-q13 deletions (about 60%) or maternal uniparental disomy 15 or both. It is a complex and contiguous gene disorder which affects the multiple systems with many clinical presentations especially hypothalamic insufficiency. The clinical features are characterized by short stature position, developmental delay, cognitive …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 2, 2024 · pp. 42–48 Read article
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Orbital Cellular Angiofibroma: One of the Rarest Tumor in Pandora’s Box
Abstract: Orbital cellular angiofibroma is one of the rarest benign mesenchymal tumors and only two cases have been reported. It typically originates from the lower reproductive tract and does not show a gender or race preference. Total surgical resection is the suggested modality of treatment. Diagnosing tumors in rare anatomical locations can pose considerable challenges, especially when they share common histopathological characteristics with more common tumors. In such cases, achieving an …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 12, Issue 2, 2023 · pp. 22–27 Read article
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Infant Examination India's Case of Sickle Cell Disease
Abstract: From the present work, it is evident that sickle cell disease causes a huge impact on health care status in many countries. The review also examines the historical background of the complications of the disease and drug development since the last few decades from the present work, it is evident that the sickle cell disease causes a huge impact on health care status in many countries. The review also examines …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 12, Issue 2, 2022 · pp. 17–26 Read article
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Simulation-Based Training in Nursing Education: An Academic Perspective
Abstract: Simulation-based education has become an important component of contemporary nursing education, providing students with opportunities to develop clinical competence, critical thinking, decision-making, and patient safety skills in a controlled learning environment. By recreating realistic clinical situations, simulation allows nursing students to apply theoretical knowledge, practice clinical procedures, and respond to patient care challenges without exposing actual patients to unnecessary risks. Different simulation approaches, including high- and low-fidelity manikins, standardized patients, …
Published in Journal of Nursing Science & Practice · Vol. 16, Issue 2, 2026 · pp. 42–47 Read article
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A Hybrid Machine Learning Approach for Cardiovascular Disease Prediction
Abstract: Heart disease ranks among the top causes of death globally. Accurately predicting cardiovascular conditions has become a key challenge in the realm of clinical data analysis. It has been shown that machine learning is an effective means of assisting with predicting and decision-making based on the large volume of data produced by the medical industry. In this study, we describe a unique approach that increases the prediction accuracy of heart-related …
Published in Journal of Artificial Intelligence Research & Advances · Vol. 12, Issue 1, 2025 · pp. 69–75 Read article
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Working Profession and Posture as Risk Factors in A Sample Population of Lower Limb Varicose Veins- An Observational Study
Abstract: AbstractPrimary varicose veins are a typical manifestation of chronic venous insufficiency. The aetiology of varicose veins is still incompletely understood despite the fact that it is a very common disease affecting all ages from teenagers to elderly people. The prevalence of varicose veins varies substantially in different parts of the world. The present study was designed to investigate the various risks factors and clinical manifestations of the occurrence of lower …
Published in Research and Reviews : Journal of Surgery · Vol. 6, Issue 3, 2017 · pp. 17–21 Read article
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Unveiling the Synergy: Sciatica, Arthritis, and Their Integrated Approach to Wellness
Abstract: This comprehensive review delves into the intricate connection between sciatica and arthritis, unraveling the etymological roots of “sciatica” from its ancient Greek and Latin origins. Tracing the historical aspects of sciatica back to the teachings of Hippocrates, the fifth-century BC Hellenic physician, sets the stage for a contemporary exploration of the interplay between these conditions. The sciatic nerve, including nerve roots spanning from L4 to S3, stands out as the …
Published in International Journal of Vaccines · Vol. 1, Issue 2, 2024 · pp. 22–31 Read article
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A Comprehensive Review on Monkeypox Infection
Abstract: Monkeypox represents a zoonotic viral affliction instigated by the monkeypox virus, which is classified within the Poxviridae family and is distinct from the virus that causes chickenpox. Initially recognized in 1958, this infection has recently attracted international scrutiny due to its escalating incidence beyond traditional endemic territories. This review delivers an exhaustive examination of monkeypox, encompassing its epidemiology, viral morphology, modes of transmission, pathogenesis, clinical presentations, and therapeutic interventions. The …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 1, 2025 · pp. 23–32 Read article
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A Survey on Cases of Urinary Tract Infection among Outdoor Patients Attending a Homoeopathic Hospital, Kolkata
Abstract: Urinary tract infection is one of the most common infections encountered by attending physicians in different hospitals in India. The disease affects all age group and both the genders but females are more common victims. The prevalence of the disease increases with the presence of obstructive uropathy and some other medical conditions. This study was taken up to analyze the basic presentations of the patients suffering from urinary tract infection …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 6, Issue 1, 2019 · pp. 14–18 Read article
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Biosensors: Emerging Diagnostic Tool for Detection of Urinary Tract Infection
Abstract: AbstractUrinary tract infection (UTI) is listed among the most common bacterial infections worldwide. It is a complex disease and poses a significant repeated and persistent healthcare issuesa significant repeated and persistent healthcare issue. Antibiotics are the only first line of medication prescribed for the treatment of UTI, which are dependent on standard conventional culture-based laboratory diagnosis. These lab-based practices lead to a typical delay of two to three days which …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 10, Issue 1, 2020 · pp. 1–4 Read article
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Clinical Evaluation of Lekhaniya Effect of Vacha (Acorus calamus) and Musta (Cyperus rotundus) in Medoroga w.s.r. to Obesity: A Comparative Study
Abstract: Present clinical study was designed to assess the lekhaniya effect of Vacha and Musta in reducing sign and symptoms of Medoroga. Lekhaniya effect can be correlates with antiobesity drug action. Total 40 patient of Medoroga were registered in the OPD of Pakwasa, (Shri Ayurved Mahavidyalaya, Nagpur). Total patients were divided equally into 2 groups: A and B. Study was done by using randomized single blind method. The trial drugs were …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 3, Issue 1, 2016 · pp. 1–8 Read article
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Plant Bioactive Metabolites and Their Role in the Prevention and Control of Dental Diseases and Infections.
Abstract: The oral diseases, including dental caries and periodontitis, affect masses worldwide, and have historically been managed with synthetic antimicrobials that cause deleterious side effects, leading to mounting bacterial resistance. Consequently, contemporary dentistry is rapidly shifting toward phytomedicine using plant bioactive molecules, such as polyphenols, terpenes, anthraquinones (berberin, eugenol, curcumin, catechins, allicin, and azadirachtin. These compounds offer potent antimicrobial, anti-inflammatory, and tissue-regenerative properties that are crucial for preventing and curing dental …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 1, 2026 · pp. 47–66 Read article