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75 articles for “PolyPhen”
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Anticancer Potential and Other Therapeutic Activities of Curcumin & Its Derivatives
Abstract: Curcumin, a compound isolated from turmeric, is used in the management of various diseases due to its extensive medicinal properties. Curcumin, the principal polyphenol isolated from Curcuma longa (turmeric), has garnered immense scientific interest for its extensive medicinal properties, including potent anti-inflammatory, antioxidant, and anticancer activities demonstrated in preclinical models. An expanding body of research indicates broad therapeutic promise in managing diverse pathologies, from various cancers to chronic inflammatory, metabolic, …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 1, 2026 · pp. 19–28 Read article
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Plant Bioactive Metabolites and Their Role in the Prevention and Control of Dental Diseases and Infections.
Abstract: The oral diseases, including dental caries and periodontitis, affect masses worldwide, and have historically been managed with synthetic antimicrobials that cause deleterious side effects, leading to mounting bacterial resistance. Consequently, contemporary dentistry is rapidly shifting toward phytomedicine using plant bioactive molecules, such as polyphenols, terpenes, anthraquinones (berberin, eugenol, curcumin, catechins, allicin, and azadirachtin. These compounds offer potent antimicrobial, anti-inflammatory, and tissue-regenerative properties that are crucial for preventing and curing dental …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 1, 2026 · pp. 47–66 Read article
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A Review of Herbal Photoprotective Agents: From Traditional Knowledge to Modern Sunscreen Formulations
Abstract: Continuous exposure of skin to UV rays leads to tanning, premature aging, sunburn, pigmentation, and skin cancer. Sunscreens are widely used to protect the skin from these harmful stimuli. However, sunscreen components may interfere with other health concerns like irritation, itching, allergic reactions, and distinct environmental damage. This major concern initiated the introduction of herbal photoprotective agents, which are eco-friendly, safer for use, and rich in antioxidants (preventing free radicals). …
Published in Research & Reviews : Journal of Herbal Science · Vol. 15, Issue 1, 2026 · pp. 8–13 Read article
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Polymeric Micelles for Medicinal Plant Solubilization and Delivery of Bioactive Compounds
Abstract: This study involved the design, fabrication, and characterization of polymeric micellar nanocomposites utilizing amphiphilic block copolymers to effectively encapsulate and transport hydrophobic phytoconstituents. The selected bioactive molecule is curcumin, a polyphenol with limited water solubility. A polymeric system known as PEG-PCL was utilized to fabricate core-shell nanostructures by a solvent evaporation-induced self-assembly method. The resulting nanocomposites exhibited homogeneity and colloidal stability, characterized by a zeta potential of −18.7 ± 1.4 …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 208–219 Read article
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Phytotherapeutic Potential of Melaleuca: An Integrative Review of Phytochemistry and Antimicrobial, Antifungal, Antioxidant, and Antiviral Mechanisms
Abstract: Melaleuca alternifolia and other species of the Melaleuca genus stand out for the broad spectrum of pharmacological properties attributed to their bioactive compounds, such as monoterpenes, sesquiterpenes, flavonoids, and polyphenols. This study aimed to critically review and analyze scientific evidence produced between 2005 and 2025 regarding the antimicrobial, antifungal, antioxidant, and antiviral activities of Melaleuca, correlating its phytochemistry with molecular mechanisms of action. For this purpose, an integrative literature review …
Published in Research & Reviews : Journal of Herbal Science · Vol. 15, Issue 2, 2026 Read article
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Evaluation of the Formation, Concentration, and Mitigation of Heterocyclic Amines in Selected Nigerian Proteinaceous Delicacies
Abstract: This study characterised the kinetics and concentration profiles of six HCA congeners — 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 2-Amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx), 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ), 1-Methyl-9H-pyrido[3,4-b]indole (harman), and 9H-pyrido[3,4-b]indole (norharman) — in six Nigerian food preparations (grilling of popular delicacies — including suya, kilishi, asun, and smoked catfish (eja aro)) using validated liquid chromatography–tandem mass spectrometry (LC-MS/MS) under three cooking modalities (charcoal grilling, pan-frying, oven-roasting). The inhibitory potential of five natural marinade formulations — …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 15, Issue 2, 2026 · pp. 1–11 Read article
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EXTRACTION OF POWDER FROM SAPOTA (CHICKOO) FRUIT
Abstract: Nature has blessed us with a wonderful sweet fruit sapota which is commonly known as chickoo which has a sweet taste and which is liked by people of all ages. It is also a most popular fruit in Asia. It has Medicinal property due to chemical constituents such as polyphenol ascorbic acids, it can also be used in cosmetics. But the fruit sapota (chickoo) has very short shelf life because …
Published in Journal of Catalyst & Catalysis · Vol. 6, Issue 1, 2019 · pp. 6–9 Read article
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Synthesis and Characterization of Bamboo-Supported Nano Zerovalent Iron (NZVI-AB) for Cr(VI) Sequestration
Abstract: Remediation of chromium contaminated sites present both technological and economic challenges, as conventional methods are often too expensive and difficult to operate. In this study, bamboo supported Zero-valent iron (Fe0) nanoparticles were synthesized, characterized, and were tested for removal of Cr(VI). Fe0 nanoparticles were synthesized by the reduction of ferric chloride with avocado polyphenols and characterized by FTIR (Fourier transform infrared) spectroscopy and XRD (X-ray diffraction). Batch experiments were performed …
Published in Journal of Materials & Metallurgical Engineering · Vol. 10, Issue 3, 2020 · pp. 1–7 Read article
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The Change in Physico-chemical, Biochemical and Microbiological Parameters of White, Green, Black and Oolong Tea during Storage in Different Packaging with Different Desiccants
Abstract: Tea is commercially important cash crop. The shelf life of tea is a major concern of tea industries. Different types of tea like White, Oolong, Green and Black tea have some individually distinct quality parameters like physico-chemical, biochemical and microbial content, which are changed (deteriorated) during storage-and the trend of changes are also distinct for each type. Use of different packaging materials along with different desiccant like silica, calcium chloride …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 10, Issue 3, 2020 · pp. 38–48 Read article
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Gossypetin Inhibits ROS Generation in HeLa and HepG2 Cell Lines
Abstract: Antioxidants are known for their ability to neutralize the reactive oxygen species present within the living system. These antioxidants are mainly secondary metabolites present in plant products and are generally known as nutraceuticals or bioactive compounds. Antioxidant can be categorized into many categories based upon their structure and activities like flavonoids, anthrocyanins and carotenoids. Flavonoids are heterogeneous polyphenolic compounds having beneficiary effect on human body and are also known to …
Published in Research and Reviews: A Journal of Toxicology · Vol. 7, Issue 1, 2017 · pp. 25–31 Read article
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Molecular Mechanism of Fluoride Induced Oxidative Stress and Its Possible Reversal by Chelation Therapy
Abstract: Fluorine (Fl) a member of the halogen family is the most electronegative and reactive of all the elements of the Periodic table. Chronic and acute exposures of fluoride leads to cardiovascular disease (hypertension and atherosclerosis), neurological disorders, gastrointestinal disturbances, liver disease, renal disease, reproductive effects, other health disorders and also affects the antioxidant system in the body. Furthermore, reactive oxygen species (ROS)-mediated oxidative damage is a common malady in fluoride …
Published in Research and Reviews: A Journal of Toxicology · Vol. 3, Issue 2, 2013 · pp. 7–34 Read article
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Phytotherapeutic Potential of Melaleuca: An Integrative Review of Phytochemistry and Antimicrobial, Antifungal, Antioxidant, and Antiviral Mechanisms
Abstract: Melaleuca alternifolia and other species of the Melaleuca genus stand out for the broad spectrum of pharmacological properties attributed to their bioactive compounds, such as monoterpenes, sesquiterpenes, flavonoids, and polyphenols. This study aimed to critically review and analyze scientific evidence produced between 2005 and 2025 regarding the antimicrobial, antifungal, antioxidant, and antiviral activities of Melaleuca, correlating its phytochemistry with molecular mechanisms of action. For this purpose, an integrative literature review …
Published in Research & Reviews : Journal of Herbal Science · Vol. 15, Issue 2, 2026 · pp. 16–30 Read article
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Antimicrobial, Antioxidant Evaluation of Majestic Darjeeling Green and Black Tea during Storage
Abstract: Three months storage in ambient temperature and humidity causes the changes in biochemical (antioxidant) and antimicrobial properties of Darjeeling green and black tea. Having higher extent of total polyphenol and non-enzymatic antioxidant flavonoid content green teas are able to show higher antioxidant and antimicrobial activities against different microorganisms. Due to manufacturing procedures (greater extent of fermentation) some of the enzyme activities (including antioxidant enzyme catalase, phenylalanine ammonia lyase) are lowered …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 5, Issue 3, 2015 · pp. 24–34 Read article
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Computational Investigation of nsSNPs of PRSS1 Gene
Abstract: This research is done for the prioritizing of SNPs of a gene PRSS1 causing hereditary pancreatitis. In this analysis, the authors found out some nsSNPs as less stable, deleterious, probably damaging retain high risk score. It was also predicted that SIFT is fast SNPs server with comparison of PolyPhen2. By Doing its energy calculation and stability prediction, we can also determine the stability of mutant protein, that is ok whether …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 1, Issue 1, 2014 · pp. 15–22 Read article
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In Silico Study of Curcumin-Sugar Conjugates as Dual Inhibitors on Both COX-1 and COX-2 Enzymes for the Discovery of Anti-inflammatory Agents
Abstract: Curcumin is a polyphenolic compound well known for its anti-inflammatory properties. The aim of the study was to design some novel curcumin derivatives that are water soluble as well as good anti-inflammatory agents with fewer side effects. In silico study was performed on the proteins by using three softwares iGEMDOCK, AutoDOCK, AutoDOCKVina as dual inhibitors for both COX-1 and COX-2. The result gives us theoretical contribution for understanding the ligand-protein …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 4, Issue 1, 2017 · pp. 25–30 Read article
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Role of Plant-based Natural Products in the Treatment of Type 2 Diabetes
Abstract: Diabetes mellitus is caused by the elevation of blood sugar levels and has become a serious health concern worldwide with the number of cases steadily increasing annually. Due to the increased side effects and costs associated with the use of conventional drugs, alternative treatment methods that use natural compounds from medicinal plants have been researched. This review summarizes the recent advances and discoveries of plant based natural compounds used for …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 12, Issue 2, 2021 · pp. 1–14 Read article
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Phytochemical and Nutritional Analysis of Wild Edible Fruit of Diospyros melanoxylon Roxb. used by the Tribes of Bhiwapur Tahsil of Nagpur District, (M.S.), India
Abstract: AbstractWild edible fruits play an important role in human life and are the important constituents of the traditional diet. Due to their easy availability, these fruits are very commonly utilized by the tribal population. The study aimed to understand the utilization of wild fruit of Diospyros melanoxylon Roxb. The contemporary investigation marked to access the nutritional and phytochemical analysis of full-grown fruits of a widely known medicinal plant of Diospyros …
Published in Research & Reviews : Journal of Botany · Vol. 5, Issue 1, 2016 · pp. 19–24 Read article
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Comparison of Antioxidant and Antimicrobial Potential of Tea Samples from Seven Valleys of Darjeeling
Abstract: Darjeeling, Queen of Hills, located at the foothills of the Himalaya is famous for its muscatel flavored universally acclaimed tea. Tea plantations in Darjeeling are restricted to Darjeeling and Kurseong sub-divisions. Tea is grown at an altitude ranging from 1968 ft msl-6500 ft msl. Fresh tea leaves (two leaves and a bud) were collected from seven different valleys of Darjeeling viz. Darjeeling East, Darjeeling West, Kurseong South, Kurseong North, Mirik, …
Published in Research and Reviews : Journal of Crop science and Technology · Vol. 9, Issue 2, 2020 · pp. 4–13 Read article
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Herbs and Spices: Traditional Medicine to Deliver Therapeutic Benefits from Frozen Dairy Products
Abstract: Herbs and spices possessing various bioactive phytochemicals such as flavonoids, lignans, sulfides, polyphenols, saponins, plants sterols, curcumins have been identified. These phytochemicals have been shown to exhibit several medicinal benefits such as antioxidative, antihypertensive, anti-inflammatory, antidiabetic, and antimicrobial properties. The present review briefly discussed about Shatavari, Aloe vera, Alma, Tulsi, Ginger, and Turmeric. The frozen dairy products are a good carrier for delivery of herb’s benefits to the consumer. Fortification …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 10, Issue 3, 2021 · pp. 27–34 Read article
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Vegetables as Functional Ingredients in Cheese and Cheese-like Products
Abstract: Cheese is an excellent dietary source of high-quality protein, vitamins and minerals such as absorbable dietary calcium. However, it lacks in certain phytonutrients like antioxidants and polyphenols. The enrichment of cheese products with vegetables is an effective way to promote functionality by improving rheological and physicochemical properties of the final product.Vegetables with higher dietary fibres could be used to improve the fiber content of cheese and cheese like products. In …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 11, Issue 3, 2022 · pp. 6–14 Read article