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142 articles for “Inhibitory”
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Antifungal Activity of Lactic Acid Cocci Isolated from Camel Milk
Abstract: This study examines the antifungal activity of lactic acid cocci isolated from camel milk against mold growth. After the isolation, purification, and characterization of lactic acid cocci, the screening of strains with antifungal activity was done by overlay and confrontation methods against Aspergillus fumigatus. These strains show strong activity. Antifungals were selected to study their inhibitory effect on liquid medium, evaluate their antifungal spectrum, and study the effect of their …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 12, Issue 1, 2022 · pp. 14–23 Read article
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Antibacterial, Cytotoxicity Studies of Azukia mungo (L.) Masam and Correlation with in silico Docking Studies
Abstract: Introduction and Background: Azukia genus plants rich in proteinaceous anti-nutrients like tannins (especially condensed tannins) has been shown to have anti-bacterial activity against Staphylococcus aureus and antineoplastic activity against lung and liver cancer cells. Five types of procyanidins (condensed tannins) have already been isolated from Azukia mungo and structurally elucidated. But its activity against the Methicillin resistant Staphylococcus aureus (MRSA) has not yet been shown. Hence we focus our work …
Published in Research and Reviews: A Journal of Toxicology · Vol. 7, Issue 2, 2017 · pp. 21–31 Read article
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Invitro Evaluation of a Herbal Soap Formulation as an Antifungal Agent
Abstract: During the past few decades, there is a rise in the resistance of bacterial and fungal pathogens. In this accord, lot of research is being carried out and many studies are focused on the use of plant extracts as fungicides. There is archaeological evidence that the betel leaves have been chewed since very ancient times, for its activity towards bacteria and fungi. Hydroxychavicol, a phenolic substance isolated as an aqueous …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 1, Issue 3, 2011 · pp. 1–6 Read article
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Synergistic Antimicrobial Efficacy of Tazma (Melipona Spp.) and Bee (Apis Mellifera) Honey with Garlic (Allium Sativum) Against Multidrug Resistant Pathogenic Clinical Bacteria
Abstract: Investigation on the search of alternative medicine is crucial where there is development of resistance against commercial antibiotics. The main objective of this study was to investigate antimicrobial activity of tazma and bee honey in combination with garlic against multidrug resistant pathogenic bacteria. Antimicrobial activities of test samples against standard and multidrug resistant bacteria were evaluated. Vancomycin was used as positive control. Minimum inhibitory and bactericidal concentrations of samples were …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 4, Issue 3, 2014 · pp. 10–17 Read article
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Comparative Study on Physicochemical and Microbiological Characteristics of Apis mellipodae and Melipona Species Honey and Their Antibacterial Activity against Bacterial Pathogens
Abstract: Abstract:Studies on antibacterial activity, microbiological and physicochemical characteristics of honey are essential in finding of alternative medicine to prevent infectious diseases. The objective of this study was to investigate the antibacterial activity, microbiological and physicochemical properties of Tazma honey in comparison with honey. Antimicrobial activity and minimum inhibitory and bactericidal concentration of samples were determined. Microbiological and physicochemical characteristics of honey were carried out using standard methods. Antimicrobial activity of …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 5, Issue 1, 2015 · pp. 14–23 Read article
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Nanostructured TiO2 Prepared Through Sol–Gel Method Enhances the Activity of Antibiotics against Gram Positive Bacteria
Abstract: The synthesis and bioactivity of titanium dioxide (TiO2) nanoparticles has been extensively studied. However, the antibacterial activity of TiO2 individually or in combination with different antibiotics has not been demonstrated. TiO2 was prepared by sol–gel process using precursor Titanium (IV) Chloride (TiCl4) and concentrated sulfuric acid in 4 h of calcinations at 550 °C and the enhancement effect of TiO2 nanoparticle on the antibacterial activity of different antibiotics was evaluated …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 2, Issue 1, 2012 · pp. 6–12 Read article
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Antibacterial Activity of CaSO4 Nanorods Prepared via Hydrothermal Method Compared to Bulk CaSO4
Abstract: 800x600 Normal 0 false false false EN-US X-NONE X-NONE Calcium sulphate (CaSO4) nanorods have been synthesized by low-temperature hydrothermal method using CaSO4 powder as precursor and hexadecylamine (HDA) as surfactant at 180 0C for 7 days. The powder X-ray diffraction (PXRD) patterns were studied. Scanning electron microscopy (SEM) images show nanorods have diameters of about 100nm-200nm and length of about 2-10μm. Fourier transformed infrared spectrum (FTIR) shows a strong doublet …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 3, Issue 1, 2013 · pp. 1–6 Read article
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Candida albicans: In vitro Inhibition of Morphological Transition by Analgesic Compounds
Abstract: This study aimed to investigate, in vitro, the effect of some analgesic compounds, which inhibit the activity of cyclooxygenase isoenzymes, on the morphological transition of Candida albicans from unicellular budding yeast to a filamentous form. C. albicans ATCC 10231 cultured in Sabouraud’s dextrose broth supplemented with 20% human serum for 72 h at 30 °C in the presence or absence of tramadol of HCl, ketorlac tromethamine, piroxicam and acetaminophen at …
Published in Research and Reviews: A Journal of Medicine · Vol. 3, Issue 3, 2013 · pp. 11–15 Read article
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QSAR Analysis on a Series of Triazole Based Tubulin Polymerization Inhibitors
Abstract: AbstractThe polymerization progression of microtubules is vital to their natural capacities. Polymerization flow allows microtubules to embrace spatial courses of action that can change quickly because of cell needs and, at times, to perform mechanical work. Compounds that interfere with the microtubule-tubulin equilibria in cells are helpful in the treatment of human diseases. A few triazoles mimics of combretastatin-benzothiazole (CAB) hybrids had good activity as inhibitors both of tubulin polymerization …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 4, Issue 2, 2017 · pp. 5–20 Read article
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Significance of Growth Rate, Acceptability of Fermented Milk and Release of Peptides by Lactic Cultures
Abstract: Ten lactic cultures (S. thermophilus MD2, S. thermophilus MD8, Lc. lactis 009, L. fermentum AI2, L. fermentum AI3, L. fermentum 138, L. plantarum AD29, L. rhamnosus NS4, L. rhamnosus NS6 and E. feacalis ND3) isolated from vegetables and fermented foods were evaluated for their potential to ferment milk, produce good quality curd and ability to release peptides in fermented milk. It was found that S. thermophilus MD8, S. thermophilus MD2 …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 5, Issue 1, 2016 · pp. 31–40 Read article
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Evaluation of Different Essential Oils for Antifungal Activity on Postharvest Decay of Avocado (Persea Americana Mill.) of Sikkim, India
Abstract: Commercially available essential oils of Basil oil, Clove oil, Citronella oil, Ginger oil and methanol extracted fern oil, Artemisia oil, and Stinging nettle oil were tested for growth inhibitions of two fungi isolated from infected avocado fruit from Sikkim, India which were identified as Fusarium sp. and Penicillium digitatum on the basis of colony morphology and microscopic examination. Inhibitory effect of essential oils was investigated by well diffusion method by …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 9, Issue 2, 2019 · pp. 44–51 Read article
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In vitro/In vivo Study of Anti-inflammatory Effect of Cyperus rotundus on Diabetic Complications
Abstract: The reactive oxygen species (ROS) develop oxidative stress that contributes to the cause of human diseases. Radicals which enhance inflammation are nitric oxide, hydroxyl radical, hydrogen peroxide, and superoxide. Anion mediate and amplify the inflammation process, mediate vascular permeability and platelet aggregation leading to diabetic complications due to disruption of steady state of pro-oxidants and antioxidants. Cyperus rotundus plant extract was subjected to foraging radical activity with hemolysate sample to …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 9, Issue 1, 2019 · pp. 24–32 Read article
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Investigation of Annonaceae Acetogenins for Inhibition of Dengue Viral Protease using in silico Docking Studies
Abstract: Dengue viruses (DENVs) cause severe and widespread epidemics of diseases such as dengue fever and dengue hemorrhagic fever/dengue shock syndrome. Unfortunately, there is at present neither prophylaxis nor specific treatment to cure the disease and thus it is need of the hour to develop new antiviral therapeutic agents to combat diseases caused by DENV. Non-structural protein NS3 play a major role in the processing of polyprotein and replication of the …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 9, Issue 1, 2019 · pp. 47–52 Read article
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In silico potential drug target identification against 4-aminobutyrate aminotransferase for Huntington diseases
Abstract: Huntington disease, HD is a progressive neurodegenerative disorder. Some excitatory chemicals released like glutamate which causes the cell damage and the neuron die due to over accumulation of the glutamate in Huntington diseases (HD), which is regulated by the GABA also known as gamma- amino butyric acid, it is a major inhibitory neurotransmitter of the nervous system. Here we are targeting the pyridoxal dependent enzyme which degrades the GABA neurotransmitter, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 4, Issue 3, 2017 · pp. 1–5 Read article
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Exploring Molecular Structural Requirement of Acetylcholinesterase Inhibitors Using Molecular Docking Study
Abstract: To explore the molecular structure requirement of acetyl-cholinesterase inhibitors, we used some flavonoid derivatives and calculated its binding interaction with acetylcholinesterase enzyme using 1EVE PDB. Flavonoids are one of the largest class and plant secondary metabolites known to have variety of biological activity for human wellbeing. Also reported its acetylcholinesterase inhibitory potency by various researchers. To know the properties and selection of flavonoids, we were used databases through Google Scholar, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 3, 2018 · pp. 20–34 Read article
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Antibacterial Activity of Leaf and Flower Extract of Lablab purpureus against Clinical Isolates of Staphylococcus aureus
Abstract: The present study was undertaken to determine inhibitory activity of leaf and flower extracts of Lablab purpureus against clinical isolates of Staphylococcus aureus. Agar well diffusion assay was performed to determine antibacterial activity. Among extracts, the flower extract has shown marked inhibition of S. aureus isolates. It can be concluded that the leaf and flower extracts possess inhibitory components. The bioactive components present in the plant are to be separated …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 1, Issue 2, 2014 · pp. 5–7 Read article
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2D-QSAR Studies on Unsaturated 4-Azasteroids as 5α-reductase Inhibitors
Abstract: Dihydrotestosterone (DHT) a major circulating male hormone is produced by NADPH dependent enzyme 5α-reductase (5 alpha R) and has been found to be causative agent in the development of pathological condition i.e. benign prostate hyperplasia (BPH). Thus inhibition of 5α-reductase enzyme represents a novel target in the treatment of BPH. Present study describes the relationship between the 5α-Reductase inhibitory activity for structurally related unsaturated 4-azasteroids derivatives and their physicochemical descriptors …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 4, Issue 1, 2017 · pp. 26–37 Read article
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Anti-tuberculosis Effects of the Extracts from Humulus japonicus and Humulus lupulus in in vitro and ex-vivo TB Models
Abstract: AbstractObjectives: Anti-tuberculosis effects of Humulus japonicus and Humulus lupulus were evaluated in in vitro direct killing ability and in ex-vivo indirect killing ability through human macrophages. Methods: H37Rv or XDR strain or NTM was treated with Crude extracts of Humulus japonicas and Humulus lupulus to estimate the MIC(Minimal Inhibitory Concentration) or MKC(Minimal Killing Concentration). Results: The MIC or MKC of the extracts of Humulus japonicus was 31.2 µg/ml for H37Rv …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 9, Issue 3, 2022 · pp. 40–49 Read article
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Identification of Promising Lead Compounds from Capsicum annuum Targeting BACE-1 for Alzheimer’s Disease Therapy: A Molecular Docking Study
Abstract: Background: Alzheimer's disease (AD) is a neurodegenerative disorder affecting millions of people worldwide. Beta-secretase 1 (BACE-1) is an important therapeutic target for AD treatment. Capsicum annuum (CA) is a commonly consumed plant with potential neuroprotective properties. In this study, we aimed to identify potential lead compounds from CA that can target BACE-1 for AD therapy using molecular docking. Methods: A library of 15 compounds from CA was obtained from PubChem, …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 1, 2023 · pp. 40–49 Read article
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Molecular Docking and Pharmacokinetic Profiling of the Phytocompounds of Jatropha curcas as Antagonist for Salmonella typhi
Abstract: Background: Typhoid is an infection caused by the Gram-negative bacterium, Salmonella enterica serovar typhi. The study assessed the potential use of Jatropha curcas as a typhoid fever therapy alternative to traditional medications. The ability to uncover novel drug indications for currently available medications using in silico methods has increased thanks to the wealth of pharmacological and biological knowledge that is available. Objective: In this study, we assessed the potential inhibitory …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 1, 2023 · pp. 67–81 Read article