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97 articles for “Clinical translation”
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Epigenetic Modifications in Health, Disease, and Precision Therapeutics (From Genome to Epigenome)
Abstract: Introduction: Epigenetic alterations play a crucial role in regulating gene expression in both normal physiological and disease states. These reversible modifications—such as DNA methylation, histone acetylation, phosphorylation, ubiquitination, and chromatin remodelling—are increasingly implicated in complex diseases including cancer and neurodegenerative disorders. Despite advances in standard therapeutic approaches, patient responses remain variable, largely due to genetic heterogeneity and epigenetic dysregulation. This highlights the need for incorporating epigenetic understanding into personalized medicine. …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 15, Issue 1, 2026 Read article
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Formulation Challenges in Long-acting Injectable Small Molecules: Emerging Strategies and Perspectives
Abstract: Long-acting injectable (LAI) formulations represent a transformative approach in pharmacotherapy, particularly for conditions demanding sustained drug exposure over weeks to months. Although biologics have dominated this space historically, the adaptation of LAI technology to small molecules presents a distinct and complex set of challenges rooted in physicochemical properties, manufacturing scalability, and regulatory expectations. This review systematically addresses the principal formulation barriers encountered in developing LAI small-molecule products, including aqueous solubility …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 · pp. 15–26 Read article
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STRUCTURAL–EPIGENOMIC ATLAS: CNV/SV- DRIVEN PROGNOSTIC REFINEMENT ACROSS CANCERS
Abstract: Structural genomic alterations, including copy number variations (CNVs) and structural variants (SVs), play a central role in cancer initiation and progression. These alterations extend beyond gene dosage effects and interact dynamically with epigenomic mechanisms such as DNA methylation, histone modifications, and three-dimensional chromatin organization. Recent pan-cancer studies have demonstrated that CNV burden and SV signatures reflect key oncogenic processes including chromothripsis, homologous recombination deficiency, enhancer hijacking, and extrachromosomal DNA (ecDNA) …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 4, Issue 1, 2026 · pp. 35–43 Read article
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Comparative Proteomics: From Cell Lines to Clinical Samples
Abstract: Comparative proteomics is a powerful tool for understanding the molecular differences between various biological samples. It entails identifying and measuring proteins in complex biological samples to assess their abundance, modifications, and interactions under various conditions. This approach plays a crucial role in advancing biomedical research, especially in disease understanding, biomarker discovery, and therapeutic development. While cell lines are widely used for proteomic studies due to their controlled environments and reproducibility, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 3, 2024 · pp. 30–34 Read article
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Postbiotics Unveiled: Mechanistic Insights and Therapeutic Implications in Obesity.
Abstract: The burgeoning global obesity epidemic necessitates innovative therapeutic approaches, and postbiotics, bioactive compounds arising from microbial fermentation, have emerged as promising contenders in reshaping obesity management. This comprehensive review explores the multifaceted mechanisms by which postbiotics impact obesity, from modulating gut microbiota composition to influencing metabolic pathways and enhancing energy expenditure. The exploration of postbiotics is rooted in a deeper understanding of the gut–brain axis and bidirectional communication between gut …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 1, 2026 · pp. 11–28 Read article
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Dental Pulp Stem Cells Derived from Wisdom Teeth as Multitarget Biological Modulators of Alzheimer’s and Parkinson’s Disease: Mechanistic Insight and Translational Perspective
Abstract: Alzheimer’s disease and Parkinson’s disease are chronic, progressive neurodegenerative disorders with complex pathogenic pathways such as neuroinflammation, oxidative stress, mitochondrial dysfunction, synaptic degeneration, and reduced neurotrophic signalling. Despite the large amount of research, the pharmacological treatments in use offer only symptomatic relief and cannot significantly prevent or slow down disease progression sufficiently; new pathogenetic treatment strategies are necessary. In recent years, stem cell-based approaches have gained interest as potential therapeutic …
Published in Research and Reviews: A Journal of Dentistry · Vol. 17, Issue 2, 2026 · pp. 7–28 Read article
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Understanding Leukemogenesis: Challenges and Advancements in Diagnostic Approaches
Abstract: Leukaemia development, or leukemogenesis, is a multifactorial process driven by a complex interplay of environmental, genetic, and epigenetic factors. Despite substantial advancements in technology and medicine, which have enhanced our understanding of the contributing factors, early and accurate diagnosis remains a major challenge due to the overlapping clinical features shared by the various leukaemia subtypes. This study explores the molecular and cellular mechanisms underlying leukemogenesis, while also addressing the difficulties …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 3, Issue 1, 2025 · pp. 11–22 Read article
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Clone-Specific Drug Delivery Systems: Targeted Approaches and Future Clinical Applications
Abstract: Clone-specific drug delivery systems represent a transformative frontier in personalized medicine, addressing the longstanding challenge of clonal heterogeneity within diseases such as cancer, infectious diseases, and autoimmune disorders. Traditional drug delivery platforms often fail to discriminate between pathogenic and healthy cells, leading to systemic toxicity and reduced therapeutic efficacy. In contrast, clone-specific systems aim to selectively target and eliminate disease-driving cellular clones based on unique molecular signatures, thereby improving treatment …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 21–29 Read article
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Physicochemical Transitions and Polymerization Dynamics in Multi-Generational Dentin Adhesives: A Critical Review of the Resin-Dentin Composite Interface
Abstract: Adhesive dentistry has undergone a transformative refinement over the past three decades, transitioning from technique-sensitive, multi-step etch-and-rinse protocols to streamlined universal formulations. This narrative review critically synthesizes evidence from thirty peer-reviewed investigations to evaluate the evolution of dentin bonding agents from the fourth through the eighth generations. The analysis places particular emphasis on the physicochemical dynamics of the resin-dentin interface, including interfacial bond strength metrics, marginal integrity, and microleakage behavior. …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 209–228 Read article
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Beyond Conventional Membranes: Advanced Functional Platforms for Precision Healthcare and Biomedical Applications
Abstract: Traditional membrane technologies have historically been used as passive separation barriers in filtration, purification, and biomedical applications. Recent progress in nanotechnology, biomaterials, bioengineering, and surface modification has revolutionised membranes into dynamic, intelligent, and multifunctional platforms that can sense, regulate, and engage with biological systems. These sophisticated functional membranes provide unparalleled prospects for precision medicine by facilitating targeted drug administration, bio sensing, tissue restoration, organ assistance, diagnostic uses, and individualised therapy …
Published in International Journal of Membranes · Vol. 3, Issue 2, 2026 Read article
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A Study of Clinical Education Practice of Clinical Instructors Accompanying Nursing Students of Kashmir Division, Deployed for Clinical Posting in SKIMS Soura
Abstract: Introduction: Clinical education also called clinical teaching, is one of the practical based approaches whereby the students are exposed to natural and practical settings. Clinical education refers to the process of educating and training healthcare professionals, such as medical students, nurses, or other allied health professionals, in a real-world clinical setting. This form of teaching is crucial for translating theoretical knowledge into practical skills and fostering the development of clinical …
Published in Journal of Nursing Science & Practice · Vol. 14, Issue 2, 2024 · pp. 32–38 Read article
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The Role of Natural Products in Antiviral Drug Discovery: Insights into Mechanisms and Therapeutic Potential
Abstract: Drug discovery has always relied heavily on natural sources, especially when it comes to creating antiviral medications. This review explores the therapeutic potential of various natural products, including plant extracts, marine compounds, and microbial metabolites, in the fight against viral infections. We examine the mechanisms of action by which these natural compounds exert their antiviral effects, including direct inhibition of viral replication, modulation of host immune responses, and interference with …
Published in International Journal of Virus Studies · Vol. 1, Issue 2, 2024 · pp. 36–47 Read article
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Plant-Derived Psychotropic Agents Targeting Neurotransmitter Systems: Pharmacognostic Evidence, Mechanisms, and Clinical Relevance
Abstract: Psychiatric health problems are also a large burden on global health and existing psychotropic drugs may be restricted by relative effectiveness, side effects, and inadequate long-term tolerability. Plant- based psychotropic agents have subsequently been the focus of interest in the form of complementary or alternative therapies. This review outlines the pharmacognostic, mechanisms of action and therapeutic importance of plant-based psychotropic agents against central neurotransmitter systems. The traditional medicinal practices give …
Published in International Journal of Brain Sciences · Vol. 3, Issue 1, 2026 · pp. 34–42 Read article
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Stem Cells in Dentistry A Review
Abstract: While the regeneration of a lost tissue is known to mankind for several years, it is only in the recent past that research on regenerative medicine/dentistry has gained momentum and eluded the dramatic yet scientific advancements in the field of molecular biology. The growing understanding of biological concepts in the regeneration of oral/dental tissues coupled with experiments on stem cells is likely to result in a paradigm shift in the …
Published in Research and Reviews: A Journal of Dentistry · Vol. 2, Issue 1-3, 2011 · pp. 50–59 Read article
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Plant Bioactive Metabolites and Their Role in the Prevention and Control of Dental Diseases and Infections.
Abstract: The oral diseases, including dental caries and periodontitis, affect masses worldwide, and have historically been managed with synthetic antimicrobials that cause deleterious side effects, leading to mounting bacterial resistance. Consequently, contemporary dentistry is rapidly shifting toward phytomedicine using plant bioactive molecules, such as polyphenols, terpenes, anthraquinones (berberin, eugenol, curcumin, catechins, allicin, and azadirachtin. These compounds offer potent antimicrobial, anti-inflammatory, and tissue-regenerative properties that are crucial for preventing and curing dental …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 1, 2026 · pp. 47–66 Read article
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Anticancer, Bioactive, & Therapeutic Applications of Cannabinoids
Abstract: Cannabinoids, a complex class of lipophilic compounds found in Cannabis sativa L., are attracting significant clinical interest for their multifaceted therapeutic potential, particularly within oncology. This review provides a comprehensive synthesis of contemporary knowledge detailing the distinct anti-cancer properties of phytocannabinoids (such as δ-tetrahydrocannabinol and cannabidiol), endogenous endocannabinoids, and synthetic analogues. Accumulating evidence from robust in vitro and in vivo oncological models demonstrates that these compounds aggressively suppress tumor progression …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 15, Issue 2, 2026 · pp. 17–30 Read article
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Role of Fluid Engineering in Biomedical and Healthcare Systems: A Comprehensive Review
Abstract: Fluid engineering — the study and application of fluid behavior, transport, and interaction — has become a cornerstone of modern biomedical and healthcare systems. This review synthesizes the multifaceted roles fluid engineering plays across diagnostics, therapeutics, biomedical devices, and physiological modeling. Micro-fluidics enables precise manipulation of microliter and nanoliter volumes, facilitating rapid point-of-care diagnostics, high-throughput screening, and the fabrication of uniform nano particles for targeted drug delivery. In cardiovascular medicine, …
Published in Trends in Mechanical Engineering & Technology · Vol. 16, Issue 1, 2026 · pp. 1–5 Read article
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Therapeutic Potential of Terminalia arjuna Bark in the Management of Hemorrhoids: A Comprehensive Review
Abstract: Background: Hemorrhoids appear frequently among anorectal disorders since they create vascular swelling together with pain symptoms, while leading to bleeding and mucosal tissue tending to slide out. Though effective therapy exists, traditional treatments produce various adverse effects and lead to recurrence and inconsistent patient following of medical recommendations over the long term. Plantbased therapeutic medicines have gained rising demand, which leads experts to investigate medicinal plants with established pharmacological effects. …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 2, 2025 · pp. 22–32 Read article
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Graphene-Based Electronic Skin for Wearable Health Monitoring and Human–Machine Interaction, Materials, Structures, and AI Integration
Abstract: Graphene-based electronic skin (e-skin) has emerged as a transformative technology for next-generation wearable health monitoring and advanced human–machine interaction (HMI). Owing to its outstanding electrical conductivity, mechanical flexibility, atomic-scale thickness, and biocompatibility, graphene enables the fabrication of ultrathin, conformal, and multifunctional sensors capable of mimicking the sensory functions of natural human skin. Over the past decade, research in this domain has progressed rapidly across four interconnected fronts: material synthesis and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 175–180 Read article
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Advances in Deep Learning for Medical Image Analysis in the Era of Precision Medicine
Abstract: Medical imaging is fundamental to modern healthcare but analyzing the high-dimensional data requires advanced techniques. Manual image interpretation is time-consuming, subjective and limited in detecting complex patterns and minute details. Recent breakthroughs in Deep Learning offer transformative advances for unlocking clinically relevant information from medical images. This paper provides a comprehensive 6000+ word review of the current state-of-the-art Deep Learning techniques for medical image analysis including detailed coverage of key …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 2, 2023 · pp. 10–23 Read article