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88 articles for “Clinical Implication”
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DMARDs, Biologic Agents and Novel Experimental Strategies in The Treatment of Rheumatoid Arthritis
Abstract: An inflammatory and autoimmune disease, rheumatoid arthritis (RA) causes severe pain and inflammation in affected areas of the body. According to the report, there is no known cure for RA. Therefore, reducing discomfort and halting future harm must be the goals of present therapy. For the purpose of prevention and to reduce disease activity in RA patients, significant success has been achieved with the continued development of disease-modifying antirheumatic drugs …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 1, 2024 · pp. 14–24 Read article
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Cancer Tumor Markers And Its Latest Trends
Abstract: Almost one in six deaths occurs due to abnormal cell division; these cells are termed cancer cells in general. Cancer cells collaborate to multiply and metastasize. Our aim is to awaken awareness in people to understand their bodies and motivate them for early diagnosis,as cancer is the second leading cause of death after cardiovascular disease. The human body is a marvellous creation in nature; in response to cancer, it creates …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 3, 2024 · pp. 25–38 Read article
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Relevance of Unani Medicine (Greco-Arab Medicine) in Management of Bawāsῑr (Hemorrhoids): An Updated Review
Abstract: Hemorrhoids is a prevalent anorectal disease with substantial compromise in quality of life, and various important factors are implicated in its causation. Increased abdominal pressure, excessive straining and hard stool lead to the venous engorgement of the hemorrhoidal plexus clinically characterized by per rectal bleeding, thrombosis and symptomatic prolapse of haemorrhoidal mass. In Unani System of medicine, the primary cause for the development of hemorrhoidal disease is focal retention of …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 7, Issue 2, 2020 · pp. 20–27 Read article
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Tobacco and COVID-19: Molecular Interactions and Public Health Challenges – A Review
Abstract: Tobacco use exacerbates health risks, making it a significant concern during the COVID-19 pandemic. Smoking has been implicated in the upregulation of ACE2 receptors, critical for SARS- CoV-2 entry, and contributes to immune dysregulation and oxidative stress, worsening clinical outcomes. Methods: This review synthesizes evidence on the molecular mechanisms linking tobacco and COVID-19, assesses risk factors, such as smoking status and comorbidities, and explores public health challenges in managing the …
Published in International Journal of Virus Studies · Vol. 2, Issue 1, 2025 · pp. 1–6 Read article
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Role of Carbohydrates and Herbal Plants in the Management of Diabetes Mellitus
Abstract: This extensive review explores the intricate relationship between carbohydrates and diabetes mellitus, integrating historical perspectives, biochemical foundations, and modern therapeutic approaches. The article delves into the chemistry of carbohydrates, elucidating their structural diversity and metabolic significance in relation to diabetes pathophysiology. It traces the evolution of diabetes, understanding from ancient civilizations to contemporary molecular insights, highlighting pivotal discoveries such as insulin’s identification. They critically examined various forms of diabetes, including …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 1, 2025 · pp. 34–60 Read article
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Pregnant Women Basic Components of Focused Antenatal Care and Its Associated Factors in Public Health Institutions, West Shewa, Oromia, Ethiopia
Abstract: Background: Antenatal care is one of the most effective health interventions for preventing complication of pregnancy and childbirth. The components of basic focused antenatal care are assessment of condition of mother and pregnancy, care provision and health promotion. Poor maternal health not only affects women’s survival but has serious public implications for the survival of their children as well. However, there is no enough study that tells whether those pregnant …
Published in Research and Reviews: A Journal of Medicine · Vol. 6, Issue 1, 2016 · pp. 28–37 Read article
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Potential Implication of Ayurveda in Hemiplegia: A Case Study
Abstract: Introduction: The most prevalent condition, hemiplegia, is caused by a stroke that results in a neurological deficiency affecting one or both sides of the body, affecting the face, upper and lower limbs, and trunk. Due to similarities in clinical signs and symptoms, this illness and Pakshaghata in Ayurveda can be compared. According to Acharya Charaka, it is a Vatavyadhi, meaning that the pathophysiology of the condition involves vitiated Vata Dosha. …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 13, Issue 3, 2024 · pp. 37–41 Read article
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Innovative Vaccine Technologies: Current Landscape and Future Prospects in Preventive Medicine
Abstract: This review article presents a comprehensive analysis of recent advancements and emerging trends in vaccine development, offering insights into the dynamic landscape of preventive medicine. Delving into a spectrum of infectious diseases, including influenza, HIV/AIDS, malaria, tuberculosis, respiratory syncytial virus (RSV), Group B Streptococcus (GBS), norovirus, and chikungunya, the review highlights innovative approaches and breakthroughs in vaccine technology. It explores efforts to develop universal influenza vaccines, long-awaited HIV vaccines, and …
Published in International Journal of Vaccines · Vol. 1, Issue 2, 2024 · pp. 07–15 Read article
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Current Issues in Understanding of Diabetes
Abstract: Diabetes mellitus is a significant metabolic disorder that poses a major health concern, particularly in India. India harbours the world's highest number of diabetic patients, totalling around 130 million, with an additional 40 million categorised as prediabetic. In the global context, the number of adults suffering from diabetes was roughly 150 million in 2000, but this number is projected to significantly increase by 2030. The global prevalence of prediabetes is …
Published in Research and Reviews: A Journal of Medicine · Vol. 13, Issue 2, 2023 · pp. 1–12 Read article
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Unveiling Actionable Pathogenic Genes for Precision Oncology in Brain Cancers: Glioblastoma and Astrocytoma
Abstract: Glioblastoma (GBM) and astrocytoma are aggressive primary brain tumors characterized by significant molecular heterogeneity, complicating effective treatment. This study employed targeted next-generation sequencing of 529 cancer-associated genes on matched tumor-normal pairs from GBM and astrocytoma patients. Somatic variants were identified using a rigorous bioinformatic pipeline adhering to GATK Best Practices, with variant allele frequencies (VAF) calculated to assess clonal dominance. Functional annotation and driver mutation classification were performed using Ensemble …
Published in Research and Reviews : Journal of Computational Biology · Vol. 15, Issue 2, 2026 · pp. 43–59 Read article
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AI Adoption in Medical Libraries: A Study on SDMH’s Use of Ovid Discovery AI and Its Impact on Evidence-Based Medicine
Abstract: The role of Artificial Intelligence (AI) in transforming medical libraries is increasingly significant as these libraries evolve to become intelligent, responsive hubs for knowledge dissemination. This paper explores the adoption of AI tools at Santokba Durlabhji Memorial Hospital (SDMH) Medical Library, focusing on the integration of Ovid Discovery AI, a cutting-edge tool designed to enhance literature search accuracy, summarize content, and provide context-aware recommendations. Using a mixed-methods approach, the study …
Published in Journal of Advancements in Library Sciences · Vol. 13, Issue 2, 2026 · pp. 1–9 Read article
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Nanomedicine in Combination with Artificial Intelligence (AI): Transforming Cancer Treatment
Abstract: The convergence of nanomedicine and artificial intelligence (AI) holds transformative potential for advancing cancer treatment, particularly in liver cancer. Nanomedicine enables the development of targeted drug delivery systems, enhanced imaging modalities, and precise therapeutic interventions, while AI facilitates data-driven decision-making, personalized treatment plans, and predictive analytics. This synergistic approach can significantly improve the diagnosis, treatment, and monitoring of liver cancer by optimizing the use of nanoparticle-based therapies. AI-powered algorithms can …
Published in Trends in Drug Delivery · Vol. 12, Issue 1, 2025 · pp. 27–30 Read article
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Toward Comprehensive Immunization: The Role of Combined COVID-19 and Influenza Vaccines in Public Health
Abstract: The emergence of multi-pathogen vaccines, particularly those combining protection against COVID- 19 and influenza, marks a significant advancement in immunization efforts. These combination vaccines have the potential to streamline vaccination processes, improve vaccine uptake, and reduce the burden on healthcare systems by offering a single dose that targets both viruses. COVID-19 and seasonal influenza are major public health concerns, with overlapping symptoms and seasonal patterns that justify the rationale for …
Published in International Journal of Vaccines · Vol. 2, Issue 1, 2025 · pp. 9–17 Read article
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Advanced Security Mechanisms for Protecting Mobile Devices: A Comprehensive Analysis of Threats and Counter Measures
Abstract: The digitization of clinical care has led to significant advancements in medical devices and telemetry, fundamentally transforming the healthcare landscape. These innovations have enhanced the quality of patient care by enabling more accurate diagnoses, real-time monitoring, remote consultations, and increased transparency in clinical workflows. As a result, modern medical practices have become more efficient, data-driven, and patient-centric. Devices such as infusion pumps, pacemakers, ventilators, and wearable monitors now rely heavily …
Published in Trends in Opto-electro & Optical Communication · Vol. 15, Issue 3, 2025 · pp. 24–31 Read article
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ORIGINAL RESEARCH PAPER ON PROSPECTIVE OBSERVATIONAL STUDY FOR RISK OFPOLYPHARMACY PRESCRIPTION PATTERNS AT TERTIARY CARE HOSPITAl
Abstract: Background: Polypharmacy, the concurrent use of multiple medications, has become a prevalent concern in healthcare systems worldwide. This prospective observational study aimed to assess the relative risk and incidence of polypharmacy while investigating its impact on patient outcomes and exploring strategies for minimizing its irrational use. Forms for complete case reports and informed permission were used in the data gathering procedure. The study had 68 individuals in all, including both …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 13, Issue 2, 2023 · pp. 34–45 Read article
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A Review: Homeopathic Remedies and Their Potential Neurological Implications in Depression and Asthma
Abstract: Homeopathy, based on the principle “like cures like”, has gained popularity as a complementary treatment for chronic diseases, including depression and asthma. Both health conditions have a profound impact on the quality of life of individuals and are often treated with pharmacological interventions such as antidepressants and bronchodilators. This review reviews homeopathic remedies used to treat depression and asthma, evaluating the available clinical evidence. Although some studies suggest that homeopathy …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 1, 2025 · pp. 15–20 Read article
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Cellular Mechanisms of Autophagy in Carcinogenesis: A Narrative Review
Abstract: Autophagy is a highly conserved lysosomal degradation pathway essential for cellular homeostasis, metabolic adaptation, and survival under stress. In the context of carcinogenesis, autophagy exhibits a paradoxical and stage-dependent role. During early tumor development, autophagy acts as a tumor-suppressive mechanism by limiting genomic instability, oxidative stress, and chronic inflammation. Conversely, in established malignancies, cancer cells exploit autophagy to sustain growth, survive hostile tumor microenvironments, and resist anticancer therapies. Increasing evidence …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 15, Issue 1, 2026 · pp. 23–28 Read article
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Iron Deficiency Anaemia_A Evidence-Based Literature Review
Abstract: Iron deficiency anaemia represents a medical condition characterised by a reduction in the concentration of haemoglobin in the bloodstream below a defined level, according to the World Health Organization. The condition presents itself in two forms: functional IDA and absolute IDA. The former is characterized by normal or elevated total body iron stores, but insufficient iron supply to the bone marrow. At the same time, the latter occurs when total …
Published in Research & Reviews : Journal of Herbal Science · Vol. 13, Issue 1, 2024 · pp. 17–28 Read article
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Xenopsylla cheopis and Plague: Biology, Transmission, and Control
Abstract: Xenopsylla cheopis, the oriental rat flea, remains the most important vector of Yersinia pestis in classical rodent–flea–human plague cycles. Its biology is tightly adapted to commensal rats, especially Rattus rattus and Rattus norvegicus, whose nests provide microhabitats that support all pre adult stages and favour persistent flea populations near humans. The flea’s holometabolous life cycle, including the capacity for prolonged pupal quiescence and opportunistic host-seeking by adults, underpins its ability …
Published in International Journal of Insects · Vol. 3, Issue 2, 2026 Read article
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Pharmacological Review On Enzalutamide
Abstract: A key therapeutic option in the treatment of prostate cancer, especially metastatic castration-resistant prostate cancer (mCRPC), is Enzalutamide, a second-generation anti androgen drug. Enzalutamide, discovered by Charles Sawyer and Michael Jung at the University of California, Los Angeles, was developed and Food and Drug Administration (FDA)-approved in 2012. Its therapeutic significance was further solidified with subsequent extensions in indications to encompass metastatic castration-sensitive prostate cancer and non-metastatic castration-resistant prostate cancer. …
Published in Trends in Drug Delivery · Vol. 11, Issue 2, 2024 · pp. 7–15 Read article