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538 articles for “efficacy”
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Innovations in Tuberculosis Management: Advancements in Drug-Resistant TB Treatment and Rapid Diagnostics
Abstract: Tuberculosis (TB) remains one of the deadliest infectious diseases worldwide, exacerbated by the increasing prevalence of drug-resistant strains, such as multidrug-resistant (MDR-TB) and extensively drug-resistant TB (XDR-TB). Despite advancements in first-line and second-line treatments, resistance to conventional antibiotics has complicated therapeutic strategies, necessitating novel approaches. This mini review explores emerging advancements in TB treatment, including gene editing technologies, such as CRISPR, which offer potential for precise targeting of drug-resistant bacterial …
Published in International Journal of Antibiotics · Vol. 2, Issue 2, 2025 · pp. 1–7 Read article
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In-Silico Screening of Phytochemicals for Identification of Alternative Therapy for Thyroid Cancer
Abstract: Thyroid cancer remains a significant health concern globally, necessitating the exploration of novel therapeutic alternatives to improve treatment outcomes. This study targets COT kinase (Cancer Osaka Thyroid Kinase), a protein implicated in the progression of thyroid cancer, using molecular docking methods with various phytochemicals to identify potential therapeutic compounds. PyRx and Discovery Studio were employed to evaluate the interactions and binding affinities of a diverse set of natural compounds with …
Published in International Journal of Toxins and Toxics · Vol. 2, Issue 2, 2025 · pp. 31–55 Read article
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Progression of Health and Wellness: Artificial Intelligence (AI) and Deep Learning (DL) for Precision Medicines
Abstract: Deep learning and artificial intelligence in the field of precision medicine is revolutionizing healthcare to make personalized therapeutic approaches desirable based on the unique characteristics of the patient. AI technologies improve diagnostic accuracy by analyzing medical data, spotting patterns and anomalies that human experts may miss. AI-driven models are instrumental in precision medicine, where they can predict patient response to therapies to tailor treatment plans, enhancing outcomes and reducing adverse …
Published in Emerging Trends in Personalized Medicines · Vol. 2, Issue 2, 2025 · pp. 1–5 Read article
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Emerging Therapies in Respiratory Tract Infections: Current Advances and Future Perspectives
Abstract: The impact of respiratory tract infections (RTI) as a global public health problem continues to be high morbidity and mortality rates. The development of novel therapeutic approaches stemmed from the fact that conventional treatment strategies, antibiotics, antivirals, antifungals etc. have become increasingly ineffective because of rise of antimicrobial resistance (AMR). Next generation therapies, such as novel antimicrobial agents, host directed therapies and novel drug delivery systems have come on the …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 2, 2025 · pp. 17–25 Read article
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Towards a Safer Nuclear Future: Safety, Security, and Proliferation
Abstract: The worldwide spread of nuclear technology creates both possibilities and hazards, thereby requiring a thorough strategy for nuclear safety, security, and non-proliferation. This paper looks at the linked issues of stopping nuclear accidents, protecting materials from nefarious use, and controlling the proliferation of nuclear weapons. It investigates the efficacy of treaties like the Nuclear Non- Proliferation Treaty (NPT) and looks at international regulatory systems, including those run by the International …
Published in Journal of Nuclear Engineering & Technology · Vol. 15, Issue 2, 2025 · pp. 34–47 Read article
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Polymer Chemistry and Its Applications in Pharmaceutical Composite Formulations
Abstract: Polymer chemistry plays a critical role in pharmaceutical formulations, particularly in enhancing drug stability, bioavailability, and controlled release. Polymers are widely utilized in drug delivery systems. Polymers are widely used in pharmaceutical sciences for drug delivery, controlled release, and stability enhancement. This paper explores the role of polymers in the extraction and formulation of glycyrrhetinic acid from Glycyrrhiza glabra, a bioactive compound. Various polymer-based extraction and purification techniques are discussed, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 216–221 Read article
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Investigation, Fabrication and Testing of Spur Gear Using Composite Material
Abstract: Composite materials constitute one of the favorable, efficacious material zones for tomorrow’s sustainable future through identification of materials with higher strength to weight ratio. A composite material is combination of two or more different materials with varied qualities that work together to create a material that is better than the sum of its parts. Therefore, finding some alternative material for various mechanical applications to accelerate the Indian composite industry is …
Published in Journal of Experimental & Applied Mechanics · Vol. 16, Issue 2, 2025 · pp. 1–8 Read article
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Biomedical Applications in Polymer Chemistry Innovations
Abstract: In recent years, polymers and composite materials have been extensively utilized in fabricating electro-mechanical devices for medical applications, including gum massagers for edentulous patients. These devices aid in oral tissue stimulation, improving circulation and overall gum health. This paper explores the application of polymer chemistry in the fabrication of a compact electro-mechanical gum massager designed for edentulous individuals. The device employs biocompatible elastomeric polymers that offer flexibility, durability, and controlled …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 861–868 Read article
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Exploring Oroxylum indicum Phytochemicals as VEGFR-2 Inhibitors: A Molecular Docking Approach for Cancer Management
Abstract: Cancer is still a major health problem around the world and is one of the top causes of death. A protein called VEGFR-2 (vascular endothelial growth factor receptor 2) is important because it helps blood vessels grow by supporting the survival, movement, and growth of certain cells. This process is essential for tumors to grow and spread to other parts of the body. This study focused on evaluating the binding …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 48–62 Read article
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Review of Atorvastatin As A Potent Drug For Cardio-Vascular Disease(CVD)
Abstract: Cardiovascular disease (CVD), particularly atherosclerosis, remains the leading cause of death worldwide, significantly burdening public health, especially in Western societies. Metabolic syndrome and arrhythmic complications further exacerbate cardiovascular morbidity and mortality. Among restorative specialists, statins particularly atorvastatin have gotten to central in both the essential and auxiliary anticipation of coronary heart infection (CHD) due to their strong lipid-lowering properties and additional pleiotropic impacts. Atorvastatin, a selective HMG-CoA reductase inhibitor, not …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 3, 2025 · pp. 8–18 Read article
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Accelerating Unsupervised Feature Learning: Parallelized Training of Denoising Autoencoders
Abstract: Unsupervised representation learning has become a cornerstone of contemporary machine learning, enabling algorithms to extract informative features from un-labelled, high-dimensional data. This work investigates the efficacy of stacked denoising autoencoders (SDAEs) trained via parallelized stochastic gradient descent (SGD) as a scalable approach to feature extraction. By strategically leveraging multi-threaded computation, our study systematically examines the trade-offs between increased parallelism, training efficiency, and the preservation of model accuracy. Experiments on the …
Published in Journal of Image Processing & Pattern Recognition Progress · Vol. 12, Issue 3, 2025 · pp. 56–64 Read article
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Beyond Generalized Treatment: The Future is Personalized Medicine
Abstract: Personalized medicine, which is also called as precision medicine, is reestablishing the view of new healthcare by replacing the traditional "one-size-fits-all" approach with individual therapies made according to a patients unique genomic organization, environment, and lifestyle. This article talks about the scientific foundation, important applications, ethical challenges, and the significant potential of personalized medicine in enhancing the clinical outcomes. From oncogenic and genetic disorders to chronic diseases, the addition of …
Published in Emerging Trends in Personalized Medicines · Vol. 2, Issue 2, 2025 Read article
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Synthesis, Molecular Docking and Biological Evaluation of Novel Chlorobenzenesulfonamide Analogues of Ibuprofen as Anti-Bacterial, Anti-Diabetic and Anti-Alzheimer Agents
Abstract: In this work, we have synthesized novel chlorobenzensulfonamide tertiary amide based analogues of Ibuprofen (Ibu) and investigated them for their anti-bacterial, anti-diabetic and anti-Alzheimer activities. In the first step, Ibu was converted to amide derivatives by incorporating different aromatic amines. These were further converted into sulfonamide analogues (Sul-Ibu, 1-9) by treating it with p-chlorobenzensulfonyl chloride. Sul-Ibu (1-9) were screened against S. aureus, B. subtilis, S. mutans, E. coli, P. aeruginosa, …
Published in International Journal of AgroChemistry · Vol. 3, Issue 1, 2025 · pp. 35–49 Read article
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Isolation and Characterization of Glucuronide Compound from Luffa Tuberosa (Roxb.) for Potential Applications in Polymer Chemistry
Abstract: This study explores the isolation process of glucuronide compounds from Luffa tuberosa (Roxb.) using an efficient and cost-effective method. The extracted compound, Gypsogenin-3β-O-β-D-Methyl glucuronide, is characterized using spectroscopic techniques such as IR, NMR, and Mass Spectrometry. The polymeric nature of glucuronide-based compounds and their potential applications in polymer and composite materials are discussed. The findings highlight the suitability of glucuronide derivatives in biomedical, pharmaceutical, and polymeric drug delivery systems. Additionally, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 566–572 Read article
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Magnetic and Radioactive Nanoparticles for Improved Theranostics and AI Assisted Radiation Therapy
Abstract: Nanoparticles based therapeutic and theranostics technique is becoming an active area of research in nanomedicine. The sensitivity, biocompatibility, and stability of magnetic and radioactive nanoparticles determine their functionality. This research highlights the impacts of magnetic and radioactive nanoparticles on therapeutic techniques namely, cell therapy, gene therapy, and tissue regeneration. Then, it is intended to brief a principal role of these therapeutic techniques to envisage theranostics medicine and radiation therapy using …
Published in International Journal of Advance in Molecular Engineering · Vol. 3, Issue 2, 2025 · pp. 10–21 Read article
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Fungi as Environmental Guardians: Enzymatic Solutions to Pollution
Abstract: Fungi are simple and inexpensive to cultivate, like miniature factories. Their enzymes are more environmentally friendly and safer for all to use compared to the use of dangerous chemicals. This review delves into how scientists are employing these enzymes to clean up polluted soil, purify wastewater, and even convert waste into valuable products such as biofuels.For example, fungi are amazing at cleaning! They create enzymes, which act as little workers …
Published in International Journal of Fungi · Vol. 2, Issue 2, 2025 Read article
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Advancing Gene Therapy: Next-Generation Viral Vector Engineering for Precision, Safety, and Scalability
Abstract: Gene therapy has emerged as a paradigm-shifting modality for the treatment of genetic disorders, malignancies, and rare diseases through the delivery of therapeutic nucleic acids aimed at correcting or modulating dysfunctional gene expression. Among the various delivery systems, viral vectors including adeno-associated viruses (AAVs), lentiviruses, adenoviruses, retroviruses, and herpes simplex viruses have proven indispensable owing to their high transduction efficiencies and adaptability. This review offers a comprehensive assessment of viral …
Published in International Journal of Virus Studies · Vol. 2, Issue 2, 2025 · pp. 37–55 Read article
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Advances in Polymer Chemistry for Coronary Artery Disease
Abstract: Coronary artery disease (CAD) remains the leading cause of morbidity and mortality worldwide, driving ongoing innovation in therapeutic materials and device design. Polymer chemistry has emerged as a cornerstone in the development of advanced cardiovascular interventions, offering versatile platforms to improve the safety, efficacy, and functionality of implantable devices. This review explores recent advances in the synthesis and application of biodegradable and biostable polymers, focusing on their roles in drug-eluting …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 710–716 Read article
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A Survey on Ensemble Technique for Enhanced Cyberattack Detection
Abstract: It is now more difficult than ever to safeguard enterprises against cyberattacks due to their fast growth and growing sophistication. Stronger cyberattack detection systems are becoming more and more necessary as hostile strategies continue to evolve in order to safeguard information, preserve corporate trust, and protect sensitive data. An overview of contemporary detection techniques is given in this study, with a focus on integrating machine learning (ML) to increase efficacy. …
Published in Journal Of Network security · Vol. 13, Issue 3, 2025 · pp. 50–54 Read article
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Analysis of Friction Stir Welding Utilizing ANSYS: A Study Based on Simulation
Abstract: Friction Stir Welding (FSW) represents a sophisticated solid-state welding methodology that has attracted considerable scholarly attention due to its efficacy in amalgamating high-strength, lightweight substrates including aluminium, magnesium, and titanium alloys. FSW enables the fabrication of defect free products with a substantial amount of mechanical and wear properties. The process is highly sensitive to various parameters that significantly influence the quality and strength of the final product. Studies have shown …
Published in International Journal of Mechanical Dynamics and Systems Analysis · Vol. 3, Issue 2, 2025 · pp. 62–77 Read article