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421 articles for “Uses Pharmacological”
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Strategies in the Delivery of Nonsteroidal Antiinflammatory Drugs
Abstract: Non-steroidal anti-inflammatory drugs [NSAIDs]. are widely used for the management of pain, inflammation, and fever. However, their effectiveness is often limited by gastrointestinal side effects such as ulceration and bleeding, as well as systemic complications including renal toxicity and cardiovascular risks. To address these challenges, various strategies have been developed to improve the delivery of NSAIDs, aiming to enhance their therapeutic efficacy while minimizing adverse effects. This abstract provides an …
Published in Trends in Drug Delivery · Vol. 11, Issue 1, 2024 · pp. 44–61 Read article
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Phyto-chemical Screening, In Vitro Anti-arthritic Study, Formulation and Evaluation of Ethanolic Extract of Helicteres Isora Fruits
Abstract: The present investigation was aimed at exploring the anti-arthritic activity of ethanolic extract of Helicteres isora fruits, using Bovine serum albumin (BSA) and Egg albumin denaturation method. The extract was subjected to preliminary phyto-chemical screening in order to find out the major phyto-constituents present in it. Various concentrations of the extract (100, 250, and 1000 μg/ml) were prepared and the percentage inhibition of protein denaturation was determined. Diclofenac sodium (100, …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 10, Issue 1, 2020 · pp. 34–40 Read article
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Sexual Dysfunction Among Male Schizophrenics: A Comparison Between Psychotropic Medicines Treated and Treatment Naïve Patients
Abstract: Introduction: The prevalence of sexual dysfunction (SD) is higher in persons with mental disorders, particularly those treated with psychotropic medication. There are very few studies, especially in the Indian population, addressing the frequency of SD due to psychotropic medications. SD in schizophrenia may be a consequence of many factors; the condition itself, its socioeconomic impact and its treatment. Method: This cross-sectional study was conducted in the psychiatric unit of a …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 8, Issue 2, 2018 · pp. 24–30 Read article
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Evaluating the Impact of the Valsalva Maneuver on Pain Relief During Intravenous Cannulation in Patients at Selected Hospitals in Tirupati, Andhra Pradesh
Abstract: Pain can be defined as an unpleasant tactile sensation, arousing sensory experience, and an emotional response that is linked to any type of tissue, cell, or skin damage. Pain is a very common and a primary reason for which people seek health care. Among all the non-pharmacological methods for pain relieving, the Valsalva maneuver is one of the methods which is found effective in reducing the level of pain a …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 3, 2024 · pp. 1–8 Read article
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‘Betazen’ Herbal Formulation, Ameliorates Experimentally Induced Metabolic Disturbances in Insulin Resistant Rats
Abstract: The present study was designed to evaluate anti-diabetic activity of ayurvedic formulation ‘Betazen’ in experimentally induced insulin resistant rats. Wistar rats were being rendered insulin resistant by administration of dexamethasone (2 μg/day s.c), along with high fat-high sugar (HFHS) diet (i.e. vanaspati ghee and fructose enriched) for 42 days. Animals with fasting blood glucose levels (BGL) of more than 150 mg/dl were selected, divided into different groups and administered 2.7 …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 6, Issue 2, 2016 · pp. 13–23 Read article
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Bioenhancer to Boost Herbal Drug Efficacy
Abstract: Bioenhancers are natural substances that significantly improve the absorption, bioavailability, and therapeutic efficacy of drugs when co-administered, without showing notable pharmacological activity of their own. In herbal medicine, the concept of bioenhancement has received growing attention as many phytoconstituents exhibit low oral bioavailability due to poor solubility, limited permeability, and extensive first-pass metabolism. The traditional Ayurvedic system first introduced this concept through the discovery of Piperine, the active alkaloid from …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 2, 2026 · pp. 01–13 Read article
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Phytochemical Profile & Therapeutic Potential of Clematis Terniflora: A Comprehensive Review
Abstract: Clematis terniflora is a plant comes under the family Ranunculaceae, which is folk medicinal plant which is found widely in China, according to the Chinese medical system, Clematis terniflora is a widely distributed folk remedy that is used to cure rheumatoid arthritis, asthma, syphilis, gout, malaria, dysentery and used as analgesic, antitumor, anti-inflammatory, diuretic, antibacterial, antioxidants and anti-inflammatory etc. It is distributed around the world like China, Japan, Korea, Mongolia, …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 11, Issue 2, 2024 · pp. 16–24 Read article
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Protagonist of Aspirin in Primary Treatment of Cardiovascular Disease: An Overview
Abstract: AbstractAspirin (ASA) is the most used medication on the globe. The benefits of aspirin therapy for the secondary prevention of cardiovascular disease clearly outweigh the risks of bleeding, and low- dose aspirin is uniformly recommended in this condition. While the clinical use of aspirin in secondary cardiovascular disease (CVD) prevention remains undisputed, its role in primary prevention is controversial. Recently, three trials of primary prevention reported neutral net benefit results …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 9, Issue 2, 2020 · pp. 12–30 Read article
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Ludiflash—A Novel Excipient for Patient Friendly Dosage Form
Abstract: Consumers want a pleasant-tasting and fast-acting tablet that can be taken anywhere, anytime without the need of water. They want such a tablet that completely disintegrates within moments, with no bitterness or chalky aftertaste. FDTs fast disintegrating tablets are the dosage form which will disintegrate in mouth within seconds without need of water. This type of property in dosage form can be attained by addition of different varieties of excipients. …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 7, Issue 2, 2017 · pp. 5–7 Read article
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Aquatic Ecosystems: A Review on Prospecting of Anticancer Molecules from Fungi & Other Microbes
Abstract: Marine biota; namely, actinomycetes, bacteria, fungi, microalgae, green algae, oceanic weeds, mangroves, and other extremophiles constitute about 90% of the oceanic biomass. The organisms are taxonomically diverse, biologically productive/active, and biochemically unique. These unique biochemiques may act as a great source for the discovery of new bioactive molecules, including anticancer drugs. The marines produce medicinally potent biochemicals; namely, sulfated saccharides, polyphenols, and, sterols. Only a few of these alkaloids have …
Published in International Journal of Fungi · Vol. 1, Issue 2, 2024 · pp. 1–22 Read article
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Green Synthesis of Copper Nanoparticle for the Treatment of Neurodegenerative Disease
Abstract: The study of ecologically friendly CuNP synthesis is a growing area with potential applications in biomedical research and environmental remediation, as well as sustainable nanotechnology. Generally, reducing, and stabilizing agents such as microbes, plant extracts, or other natural sources are used. The green synthesis methodology guarantees the production of nanoparticles with desired characteristics for biomedical applications while simultaneously mitigating the environmental effect that comes with conventional chemical processes. CuNPs possess …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 1, 2024 · pp. 13–24 Read article
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A REVIEW: P-GLYCOPROTEIN AND ITS ROLE IN CANCER
Abstract: Abstract The review is done on how P-glycoprotein recognizes various substrates and plays a key role in cancer. Chemotherapy is used for cancer treatment but multidrug resistance of cancerous cell is the major obstacle in therapy and also an important aspect which causes failure in the treatment by effluxion of a xenobiotic on the plasma membrane. In humans, P-glycoprotein is important transmembrane transporter. It is located on the apical surface …
Published in Trends in Drug Delivery · Vol. 7, Issue 2, 2020 · pp. 26–34 Read article
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Synthesis and Characterization of Polymer-Based Benzamide Derivatives with Potential Biomedical Applications
Abstract: The present study explores the synthesis and characterization of polymer-supported benzamide derivatives, focusing on their potential biomedical applications. The use of polymer-supported synthesis offers several advantages, including improved reaction efficiency, ease of purification, and reusability of the support material, making it an environmentally friendly and cost-effective approach. The synthesis involved a stepwise reaction sequence, with polymeric supports facilitating controlled functionalization and ensuring high product purity. These materials have been widely …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 Read article
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Adverse Drug Reaction Associated with Vitamins: An Analysis of Spontaneous Reports from Pharmacovigilance Programme of India Database
Abstract: The objective of this study was to describe adverse events with the use vitamins and to identify risk factors. A retrospective study was carried out from the spontaneous adverse drug reaction (ADR) reports for the period April 2011 to March 2013 by National Coordination Centre, Pharmacovigilance Programme of India (PvPI). 29 reports of vitamins were received by NCC-PvPI, which comprised approximately 0.064% of the total 45,297 reports received at NCC-PvPI. …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 5, Issue 3, 2015 · pp. 12–18 Read article
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Extemporaneous Prescription Compounding
Abstract: It is obvious that large-scale manufacturers have very limited opportunity to customize dosage strength and dosage forms for a customer segment that is not substantially big enough due to economies of scale concept of business. Registered and skilled pharmacists, in practicing their art of compounding fills in this gap to meet individualized needs. Compounding has always been a basic part of pharmacy practice; the drugs, dosage forms, and equipment or …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 8, Issue 3, 2018 · pp. 20–30 Read article
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Anti-Ulcer Activity of Ethanolic Extract of Sesamum indicum Seed on Indomethacin-Induced Ulcer Model and Its Antioxidant Property in Gastro-Protection
Abstract: The present study was intended to investigate and evaluate the antiulcer activity of the ethanol seed extract of Sesamum indicum Linn. using Indomethacin Induced Ulcer in Albino rats and to determine its link between oxidant or antioxidant parameter. The extract of Seamum indicum Linn. was tested on indomethacin induced gastric ulcer in Albino rats. The antiulcer activity of high dose (400 mg/kg) and low dose (200 mg/kg) of ethanolic extract …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 5, Issue 2, 2015 · pp. 18–25 Read article
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Impact of Amiloride-Hydrochlorthiazide Diuretic Against the Pathway of Uric Acid – VLDL and Peroxynitrite in Essential Hypertension
Abstract: Thiazides induce metabolic derangement in terms of hyperlipidemia, glucose intolerance, hyperuricemia and electrolytes imbalance. Co-amiloride-hydrochlorthiazide therapy favorably corrects the hypokalemia that is induced by thiazides alone. This study was aimed to identify the interactions between serum uric acid, very-low-density-lipoprotein (VLDL) and peroxynitrite in essential hypertensive patients using amiloride-hydrochlorthiazide as antihypertensive therapy. A total number of fifty patients (12 males and 38 females) with a history of hypertension were admitted in …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 5, Issue 3, 2015 · pp. 6–11 Read article
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Advancements in Method Development and Validation for Levocetirizine: A Comprehensive Review
Abstract: This review article delves into the intricate realm of concurrent estimation of multiple compounds, with a specific emphasis on Levocetirizine and its related substances. It looks into how to improve analytical process specificity by using reverse phase high-performance liquid chromatography (RP-HPLC) in conjunction with UV detection. The study meticulously explores the intricacies of method development and validation, offering invaluable insights into the realms of precision and accuracy within pharmaceutical analysis. …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 1, 2024 · pp. 15–27 Read article
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A General Review of Mucuna Pruriens W.S.R to its effect on Parkinson’s Disease.
Abstract: Mucuna Pruriens is a very famous drug prescribed in classical ayurvedic science in various disorder of Nervous System including Kampavata .In Clinical Practice ,Physician used Levadopa as a Dopamine replacement agent in controlling bradykinetic symptoms apparent in Parkinson disease so used successfully in treatment of Parkinson disease.Kapikacchu(Mucuna Pruriens) is having Balya, Brimhanaha, Vrishya, and Vatahara properties and is a natural source of L-dopa. So, keeping in views of the degenerative …
Published in Research & Reviews : Journal of Herbal Science · Vol. 13, Issue 1, 2024 · pp. 1–6 Read article
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Evaluation of the Effects of Vitamin D Supplementation on Glycemic Control and Lipid Profile in Normoglycemic and STZ-Induced Type-2 Diabetic Rats
Abstract: The term diabetes mellitus describes a metabolic disorder of multiple aetiologies and is characterized by chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. The current approaches for treatment of diabetes are mostly dependent on insulin and other oral standard drugs, which have their own drawbacks. Thus, micronutrients supplementation is gaining momentum as the quest for management of diabetes …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 6, Issue 2, 2016 · pp. 24–34 Read article