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446 articles for “co-infection”
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From Concept to Clinical Practice: A Detailed Review of Total Artificial Heart Devices
Abstract: Total artificial heart (TAH) devices are mechanical systems designed to take over the role of a failing heart in patients with severe heart failure. Unlike ventricular assistance devices (VADs), which only support one side of the heart, TAHs replace both ventricles, providing a possible solution for patients who cannot receive a heart transplant. Over time, TAH technology has evolved with a focus on improving biocompatibility, reducing complications related to the …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 15, Issue 1, 2025 · pp. 1–4 Read article
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Bedaquiline: An In-Depth Exploration into Its Antitubercular Significance
Abstract: Tuberculosis is still a leading infectious disease and a major threat to public health. Although there has been a slow decrease in the incidence over years, its “hard to kill nature” is responsible of about 2 million deaths in HIV infected individuals annually. Bedaquiline, a Diaryl-Quinoline drug was fast-track approved as an orphan drug to combat drug resistance. It shows potent activity against Mycobacterium tuberculosis by interfering with the production …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 06–14 Read article
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Practical studies in Vero cell and Human amnion cells for viral and stem cell applications
Abstract: Vero cells are one of the most popular mammalian continuous cells in molecular, cellular, and microbiological research. African green monkey kidneys are used to make these.One continuous cell line is the Vero cell line. This cell line is dependent on anchorage. Vero cells can be cultured in suspension because they are anchorage independent. Thought to be non-tumorigenic cells that came from a female Chlorocebus sabaeus Numerous viruses can infect vero …
Published in International Journal of Vaccines · Vol. 2, Issue 1, 2025 · pp. 1–8 Read article
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Assessing the Impact of a Structured Educational Initiative on Awareness of Vaginitis and Its Prevention Among Adolescent Girls in Selected Higher Secondary Schools in Bengaluru
Abstract: Background and Objectives: Vaginal inflammation, referred to as vaginitis, may culminate in discharge, itching, and pain. Usually, the root cause is an infection or an altered in the balance of the microbes in the vagina. In females between the ages of two and six, poor perineal hygiene—such as wiping after bowel movements from back to front or not washing hands afterward—is an important contributory factor. Another typical sign is frequent …
Published in International Journal of Midwifery Nursing And Practices · Vol. 2, Issue 2, 2024 · pp. 10–21 Read article
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Typhoid Fever: Etiology, Clinical Manifestations, Diagnosis, and Management
Abstract: Typhoid fever is a systemic and potentially life-threatening infectious disease caused by Salmonella enterica serotype Typhi, which primarily spreads through the fecal-oral route via ingestion of contaminated food and water. It continues to be a major global public health concern, particularly in developing and low-resource countries where poor sanitation, inadequate personal hygiene, and unsafe water supplies prevail. The disease is characterized by prolonged high-grade fever, abdominal discomfort, headache, loss of …
Published in Recent Trends in Infectious Diseases · Vol. 3, Issue 1, 2026 · pp. 1–4 Read article
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Barg-e-Tulsi (Ocimum sanctum Linn.) in Unani Medicine: Bridging Classical Therapeutics with Contemporary Pharmacological Evidence
Abstract: In the Unani System of Medicine (USM), Barg-e-Tulsi (Ocimum sanctum Linn.), commonly known as Tulsi or Holy Basil, is a highly valued medicinal herb that has been extensively used for centuries in the prevention and treatment of various ailments. It occupies an important place in traditional Unani therapeutics due to its broad spectrum of medicinal properties and its effectiveness in managing respiratory, gastrointestinal, neurological, and infectious disorders. Classical Unani scholars …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 13, Issue 2, 2026 Read article
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A Novel Solution to Oral Hygiene
Abstract: This paper proposes a novel approach to oral health monitoring through the development of a smart toothbrush equipped with a camera, pH sensor, and temperature sensor. The integration of these sensors allows for real-time monitoring and early detection of potential oral health issues such as cavities, gum disease, pyorrhea and enamel erosion. The camera provides visual data for assessing plaque buildup and other visible signs of oral health problems, while …
Published in Journal of Microwave Engineering and Technologies · Vol. 11, Issue 2, 2024 · pp. 29–34 Read article
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Synthesis, Characterization, Biological evaluation, and in silico study of aniline derivatives
Abstract: In many hospitals worldwide, bacterial infections brought on by resistant strains are wreaking havoc, particularly in patients who are already impaired by age, disease, and other conditions. Due to the bacterial resistance, it is required to search for newer antibacterial drugs or molecules. In the current study, we aimed to develop aniline derivatives, followed by their anti-bacterial and in silico studies. Out of all the synthesized derivatives, compound 4d was …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 2, 2025 · pp. 25–32 Read article
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Exploring the Pathophysiology of Henoch-Schönlein Purpura (HSP): A Comprehensive Review
Abstract: Blood from tiny veins can leak into nearby tissues, causing purpura, a disorder marked by red spots or patches on the skin that may have an impact on the kidneys. Henoch-Schönlein purpura (HSP) is associated with vasculitis and inflammation of blood vessels. The range of renal conditions associated with purpura includes severe glomerulonephritis and mild proteinuria. For instance, immunological complex accumulation in the renal glomeruli of HSP patients might result …
Published in International Journal of Cell Biology and Cellular Functions Read article
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Effectiveness of a Structured Teaching Programme on Knowledge and Attitude Regarding the Causes, Transmission, and Prevention of Sexually Transmitted Infections Among Rural Women in the Field Practice Area of RHTC, Yadwad, Dharwad District
Abstract: Sexually Transmitted Infections (STIs) pose serious long-term health risks, particularly for women and newborns. Women in rural areas often face significant social consequences due to inadequate STI awareness, which can lead to unsafe sexual practices. This study aimed to assess the knowledge and attitudes of rural women aged 15 to 49 years regarding the causes, transmission, and prevention of selected STIs in the RHTC Yadwad field practice area. Additionally, the …
Published in International Journal of Women's Health Nursing And Practices · Vol. 3, Issue 2, 2025 · pp. 51–78 Read article
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Nanoparticle and Lipid-Based Vaccine Delivery Systems: A Systematic Review of Platforms, Stability, Pharmacokinetics, and Immune Modulation
Abstract: The rapid evolution of vaccine technologies over the past decade has highlighted the transformative role of nanoparticle (NP) and lipid-based delivery systems in modern immunization practices. These platforms – including polymeric nanoparticles, lipid nanoparticles (LNPs), liposomes, nanoemulsions, and solid lipid nanoparticles (SLNs) – enable enhanced antigen stability, improved cellular uptake, targeted antigen delivery, and potent immune activation. This systematic review critically examines the physicochemical foundations, manufacturing approaches, stability challenges, pharmacokinetic …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 1, 2026 · pp. 18–36 Read article
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Metagenome-Informed Engineering of Monoclonal Antibodies: Mining Microbial Immunoglobulin-Like Domains for Ultra-Stable Therapeutics
Abstract: Metagenome-informed engineering represents an emerging strategy for improving the stability and functionality of monoclonal antibodies (mAbs) by leveraging the vast diversity of microbial immunoglobulin-like (Ig-like) domains (10,24). These domains, derived from uncultured bacteria and bacteriophages, exhibit exceptional thermostability, protease resistance, and structural resilience due to adaptation to extreme environments (29,30). This review highlights advances in metagenomic mining, structural characterization, and protein engineering that enable the integration of microbial Ig-like scaffolds …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 1, 2026 Read article
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Overcoming Obstacles to an HIV-1 Cure: Advances in Genome Editing, Immune System Reprogramming, and Viral Reservoir Elimination
Abstract: Human immunodeficiency virus type-1 (HIV-1) continues to represent a major global health challenge despite the remarkable success of antiretroviral therapy (ART). Although ART effectively suppresses viral replication and prolongs survival, it cannot eradicate the virus due to the persistence of long-lived latent reservoirs. In recent years, innovative therapeutic strategies have been explored with the aim of achieving either a functional remission or complete viral elimination. Advances in genome-editing technologies, particularly …
Published in International Journal of Virus Studies · Vol. 3, Issue 2, 2026 Read article
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Analysis and Identification of Malicious Mobile Applications Using Machines Learning
Abstract: Over the past few years, malware attacks on the Android platform have surged, posing significant risks to users' financial security, personal information, and device integrity. In the first half of 2019 alone, approximately 25 million smartphones were infected, highlighting the severity of these threats. The model ranks manifest features based on their frequency in normal and malicious apps, identifying key components that distinguish benign from malicious applications. To improve detection …
Published in Journal of Microcontroller Engineering and Applications · Vol. 12, Issue 2, 2025 · pp. 17–24 Read article
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Diabetic Foot Ulcer Treated successfully with Unani Formulation (Sibr Zard, Amba Haldi, Mur Maki, and Gulnar) –A Case study
Abstract: Diabetic foot ulcer (DFU) is a distressing complication of diabetes mellitus. It is encountered in about 15% of patients living with DM. It is a major cause of morbidity and mortality. The patients with DFU are at the risk of prolonged hospitalization, infection, gangrene, amputation, and even death if effective wound care faculties are not provided. It is anticipated that approximately 50%-70% of all lower limb amputations are due to …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 11, Issue 2, 2024 · pp. 7–11 Read article
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Exploring the Relationship Between Disseminated Intravascular Coagulation and Waterhouse–Friderichsen Syndrome
Abstract: Waterhouse–Friderichsen syndrome was first identified as a distinct clinical entity by Little in 1901. He described four cases from his own observations and, after examining existing literature, identified eight additional cases that he considered previously unclassified. One case in his report may have involved purpura resulting from a different cause. The knowledge of this unusual disorder developed slowly from several significant clinical observations and case reports during the first two …
Published in Research and Reviews: A Journal of Medicine · Vol. 16, Issue 2, 2026 · pp. 45–49 Read article
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Whispers of the Microbial World: Unveiling Bacterial Dialogues through Quorum Sensing
Abstract: Quorum sensing is a special way of bacteria by which they can regulate their own gene expression as per the population density of the bacteria. It is basically a type of cell-to-cell communication pathway used by the microbes. The signal molecule which helps in this mechanism are called auto inducer(AI). As the mechanism depends by changes in the cell density, so when the cell density reaches to the threshold cell …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 14, Issue 3, 2024 · pp. 1–8 Read article
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Design and Development of a Sanitary Napkin Incinerator
Abstract: Improper disposal of menstrual waste presents serious health and environmental risks, especially in rural areas with limited access to proper sanitation and waste management systems. Without adequate facilities, used menstrual products are often discarded in open spaces, water bodies, or burned, leading to pollution, foul odors, and the spread of infections. The lack of awareness, infrastructure, and stigma surrounding menstruation further worsens the issue, making it crucial to promote safe, …
Published in Journal of Energy, Environment & Carbon Credits · Vol. 15, Issue 2, 2025 · pp. 19–31 Read article
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Screening of Mustard Varieties and Lines against Clubroot and Alternaria Leaf Spot Diseases
Abstract: The experiment was conducted to find out the resistant varieties/lines against clubroot and Alternaria leaf spot diseases of mustard at the Plant Pathology Division, RARS Jamalpur, Bangladesh during the Rabi season of 2024-2025 with sixty-two (62) varieties and lines of Mustard collected from Oilseed Research Centre (ORC) and Plant Genetic Resources Centre (PGRC), Joydebpur, Gazipur-1701, Bangladesh. To screen for clubroot and Alternaria leaf spot diseases and to evaluate yield and …
Published in Research & Reviews : Journal of Agricultural Science and Technology · Vol. 14, Issue 3, 2025 · pp. 97–106 Read article
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Role of Pharmaceutical Software in Vaccine Development and Manufacturing Process Optimization
Abstract: Vaccine development and manufacturing have become increasingly complex due to the emergence of diverse vaccine platforms, stringent regulatory expectations, and global demand for safe and effective immunization. Across the vaccine lifecycle – from antigen design and preclinical evaluation to large‑scale manufacturing and post‑marketing surveillance – pharmaceutical software now plays a central role in handling data, optimizing processes, and ensuring regulatory compliance. Software tools support in silico antigen and epitope design, …
Published in International Journal of Vaccines · Vol. 3, Issue 1, 2026 · pp. 1–8 Read article