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33 articles for “virulence”
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Exploring Azadirachta indica’s Potential to Combat Visceral Leishmaniasis Through GP63 Inhibition
Abstract: Objectives: Millions of people worldwide suffer from the parasite disease visceral leishmaniasis. Determine the naturally occurring active ingredients in Azadirachta indica, which are employed as a disease-prevention agent and have several uses in medicine. To choose the best ligand to use as a medication, absorption, distribution, metabolism, and excretion (ADME) studies and molecular docking are employed. Methods: To obtain the GP63 protein, the Protein Data Bank (PDB) database was accessed. …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 2, 2024 · pp. 1–12 Read article
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Live Epidemiological Tracking of COVID-19 in Senegalese Participants of the Hajj
Abstract: Background: Since the COVID-19 outbreak, global efforts have focused on controlling the disease. However, intense cross border movements pose a risk for the emergence of new SARS-CoV-2 strains. A recent example is the detection of cases among the 2024 Senegalese pilgrims returning from Mecca, Saudi Arabia. Investigations of these cases have revealed genomic evolution of the virus. The lack of surveillance may lead to the emergence of high-threat strains. This …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 2, 2025 · pp. 8–16 Read article
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Host-Pathogen Coevolution: Implications for Immune Evasion and Pathogen Fitness
Abstract: The interaction between hosts and pathogens represents a continuous evolutionary struggle, shaping both microbial virulence and host immunity. Pathogens employ diverse strategies to evade immune surveillance, ranging from antigenic variation and molecular mimicry to hijacking of host immune checkpoints. Simultaneously, hosts refine innate and adaptive immune mechanisms to counteract infection and limit damage. This reciprocal adaptation, known as host–pathogen coevolution, influences pathogen persistence, transmission, and fitness, while also sculpting immune …
Published in International Journal of Pathogens · Vol. 3, Issue 1, 2026 · pp. 6–10 Read article
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The Dual Crisis: Antibiotic Resistance and the Discovery Void – A Review of Novel Therapeutic Strategies and Non-Traditional Approaches
Abstract: The global rise of antimicrobial resistance (AMR) has emerged as one of the most critical public health challenges of the 21st century, threatening to undermine decades of therapeutic success and rendering conventional antibiotic regimens increasingly ineffective. Parallel to the escalating resistance rates is a profound “discovery void,” characterised by a steep decline in the development of new antibiotic classes since the late 20th century. Together, these two interconnected crises create …
Published in International Journal of Antibiotics · Vol. 3, Issue 1, 2026 · pp. 47–65 Read article
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Artificial Intelligence in Microbiological Research: Methods, Applications and Implications
Abstract: Artificial Intelligence (AI) is revolutionising microbiological research by enabling the rapid analysis of complex biological data and improving the accuracy, efficiency, and reliability of scientific investigations. Recent advances in machine learning, deep learning, and bioinformatics have transformed AI into a powerful tool for studying microorganisms, their genetic composition, evolutionary patterns, and interactions with hosts and the environment. AI-driven computational models can process large and complex datasets far more efficiently than …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 16, Issue 2, 2026 · pp. 22–36 Read article
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Veterinary Mycology: Fungal Infections in Livestock and Companion Animals
Abstract: Fungal infections represent a significant yet often underestimated challenge in veterinary medicine, affecting both livestock and companion animals. Veterinary mycology encompasses a diverse group of pathogens, including yeasts, molds, dimorphic fungi, and dermatophytes, that can cause localized or systemic diseases with substantial health, economic, and zoonotic implications. In livestock species, such as cattle, sheep, goats, poultry, pigs, horses, and camels, fungal infections manifest as dermatophytosis, mycotic mastitis, aspergillosis, keratomycosis, and …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 14, Issue 3, 2025 · pp. 44–51 Read article
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Updated Cardiopulmonary Resuscitation Guidelines for COVID-19 Patients
Abstract: AbstractCOVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), has claimed many lives world over. Managing COVID-19 pandemic has become very challenging for the health care workers (HCW) due to the absence of definitive treatment for the disease. Around 5–6% of cases of COVID-19 become critically ill and require intensive monitoring, advanced life support, respiratory support and treatment modalities like ECMO and Plasma therapy, etc. Older people with comorbidities …
Published in Journal of Nursing Science & Practice · Vol. 10, Issue 3, 2020 · pp. 25–35 Read article
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Development of vaccine against Helicobacter pylori using Bioinformatics approaches
Abstract: Helicobacter pylori (H. pylori) are a widespread kind of bacteria which flourish in the digestive tract and have a propensity to damage the stomach lining. The microbe infects around 60% of the adults globally. H. pylori infections are responsible for most of stomach and small intestine ulcers. Using Bioinformatics approaches, we have identified certain proteins that possess the resistance, essentiality and virulence factors for this pathogen. Computational tools and servers …
Published in Research and Reviews : Journal of Computational Biology · Vol. 8, Issue 3, 2019 · pp. 34–68 Read article
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Anthrax Toxin Time-Resolved Absorption and Resonance FT-IR and Raman Biospectroscopy and Density Functional Theory (DFT) Investigation of Vibronic-Mode Coupling Structure in Vibrational Spectra Analysis
Abstract: Anthrax toxin is a three-protein exotoxin that is secreted by the bacterium's virulent strains, the anthrax causative agent Bacillus anthracis. Harry Smith first found the toxin in 1954. Anthrax toxin consists of a protein called a protective antigen (PA) binding cell protein and two enzyme parts called an edema factor (EF) and a deadly factor (LF). These three protein components act together to impart their physiological effects. Assembled complexes containing …
Published in Research and Reviews : Journal of Computational Biology · Vol. 8, Issue 2, 2019 · pp. 23–51 Read article
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Inhibition of Bacterial Communication, Relevance to Periodontics: A Review
Abstract: To survive in hostile environment, bacteria communicate and coordinate their behavior. This cell-to-cell communication and coordination in bacteria or quorum sensing (QS), regulates bacterial growth, metabolism, biofilm formation, virulence factor secretion and various other essential functions in bacterial colonies. Many diseases of human beings, including gingival and periodontal diseases are mediated and regulated by this inter species communication. This high level of interspecies interaction is integral to the development and …
Published in Research and Reviews: A Journal of Dentistry · Vol. 7, Issue 2, 2016 · pp. 18–23 Read article
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Aluminum Oxide Nanoparticle-Adjuvanted Pasteurella multocida B:2 Vaccine is Potent and Efficacious and is Able with Keyhole Limpet Hemocyanin as a Marker to Differentiate Infected from Vaccinated Animals (DIVA)
Abstract: Pasteurella multocida B:2 causes hemorrhagic septicemia (HS) in bovines in Asia. For effective implementation of HS control program in India, a safe and efficacious vaccine to provide long lasting protection and allow differentiation of infected from vaccinated animals (DIVA) has to be developed. The objectives of the present study were to develop HS-DIVA vaccine with a companion immunodiagnostic test using keyhole limpet hemocyanin (KLH) as a marker, and to improve …
Published in Research and Reviews : A Journal of Immunology · Vol. 5, Issue 2, 2015 · pp. 8–16 Read article
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Evaluation of Antibiofilm Potential of Alginate Encapsulated Selenium Nanoparticles
Abstract: Biofilm interfere in antibiotic therapy, undergo gene transformation to become highly virulent, develop quorum sensing and protect bacteria from host immunity. To combat these biofilms the encapsulation method of nanoparticles formation using PEG can be used as they are better alternative to chemical and physical methods. In the present study, the antibiofilm and antioxidant properties of the selenium nanoparticles produced by using probiotics have been evaluated. Transmission electron microscopy (TEM) …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 8, Issue 2, 2018 · pp. 16–21 Read article
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SARS-CoV-2: A Review
Abstract: The emergence of coronavirus outbreak caused by SARS-CoV-2 has claimed lakhs of human lives and continues to be a potential danger for the world. Initial cases were detected in Wuhan, China, and over the period, the virus spread to various countries. Many nations where the spread of infection was high were forced to shut offices, educational institutions, and transportation by imposing lockdown for months. SARS-CoV-2 is genetically similar to the …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 11, Issue 3, 2021 · pp. 14–25 Read article