Search
34 articles for “toxicological assessment”
-
The Alarming Impact of Microplastics on the Reproductive System of Fish
Abstract: Environmental contaminants that are biologically active significantly affect ecosystems, animals, and human health. Plastic pollution has drawn international attention for its detrimental effect on the environment and biodiversity health. The aquatic ecology of our planet is full of microplastics. Regular, extensive use of nonbiodegradable polymers required several years for them to break down. Over the course of those years, it discharged tiny particles of 100 nm or less. Due to …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 13, Issue 2, 2024 · pp. 8–13 Read article
-
Protective Effects of Phyllanthus amarus and Sida acuta Extracts Against DoxorubicinInduced Toxicity in Chick Embryo Models
Abstract: Chemotherapy remains a cornerstone of cancer treatment, yet severe side effects, including cardiotoxicity often limit its clinical application. Doxorubicin, a widely used anticancer drug, is particularly associated with dose-dependent toxicities that impact the heart, liver, and kidneys. In search of complementary approaches to mitigate these adverse effects, this study evaluates the protective potential of hydro-alcoholic extracts from Phyllanthus amarus and Sida acuta, two medicinal plants with known antioxidant and anti-inflammatory …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 2, 2025 Read article
-
Effects of Sub Chronic Dermal Exposure of Gasoline Blended with Varying Concentration of Benzene on Hepatic Mixed Function Oxidases in Rats
Abstract: Interaction of chemicals in a mixture, their biotransformation and adverse impact, if any, on environment and workroom atmosphere needs to be evaluated to identify the nature of potential toxic effects elicited by constituent chemical(s) in a mixture. The nature of chemical interaction(s) through which an individual chemical in a mixture undergoes metabolism and/or biotransformation in the target tissue could be helpful in evaluation of its toxic potential. Gasoline is a …
Published in Research and Reviews: A Journal of Toxicology · Vol. 3, Issue 1, 2013 · pp. 1–5 Read article
-
Valeton Phytoconstituents from Curcuma Phaeocaulis as Prion Protein Mutant V210I Inhibitors: A Computational Docking and Virtual Screening Study
Abstract: Objective: Creutzfeldt-Jakob disease (CJD), a neurological disorder that is sporadic, fatal, communicable, and worsens rapidly, is caused by abnormal folding of prion proteins. Identifying and assessing the potential of phytocompounds from the Curcuma phaeocaulis Valeton plant as a new therapeutic candidate aimed at the treatment of CJD is the objective of this research article. Methods: In this experiment, we assessed outcomes following an in-silico assessment to design a new oral …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 2, 2023 · pp. 1–16 Read article
-
Metallic Impurities Present in Environmental Water Samples Were Analyzed at Trace Levels Using ICP-MS-KED
Abstract: Elemental impurities in environmental water samples must be carefully monitored since they may have unintended pharmacological and toxicological consequences. For the simultaneous determination of eight metals (Cr, Ni, Cd, Pb, Hg, As, Se, and Sb) in water by ICP-MS, an accurate and sensitive approach has been devised and validated.The method's validity is confirmed through assessment of various criteria for new techniques, including linearity and range, accuracy, precision, selectivity, limit of …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 14, Issue 1, 2023 · pp. 53–58 Read article
-
Recent Trends of Violent Asphyxial Deaths in Barpeta, Assam
Abstract: Asphyxial death is a common incident in forensic practice and determination of the manner of death whether suicidal, homicidal or accidental is of utmost significance. This study was conducted in the Department of Forensic Medicine, Fakhruddin Ali Ahmed Medical College, Barpeta, Assam, India. A total of 89 cases of violent asphyxial deaths occurred during the period of 1st January to 31st December 2016 were studied. In this study, an attempt …
Published in Research and Reviews: A Journal of Toxicology · Vol. 7, Issue 2, 2017 · pp. 1–5 Read article
-
Cardiotoxicity Associated with Tyrosine Kinase Inhibitors in Philadelphia Chromosome-Positive Leukemias: An Overview of Mechanisms, Clinical Implications, and Management Strategies
Abstract: Tyrosine kinase inhibitors have greatly enhanced the outlook for individuals diagnosed with Philadelphia chromosome-positive leukemias, including chronic myeloid leukemia and acute lymphoblastic leukemia. However, these therapeutic agents are associated with Cardiotoxicities and can manifest as left ventricular dysfunction, which may progress to heart failure, along with electrocardiographic abnormalities, dysrhythmias, hypertension, myocardial ischemia, and thromboembolic events. The unclear frequency of drug-induced cardiovascular complications, coupled with uncertainties regarding their reversibility and long-term …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 3, 2024 · pp. 18–24 Read article
-
Chalcones: Beyond Bioactive Properties - Exploring Their Potential as Polymeric Materials
Abstract: Chalcones, a class of natural compounds characterized by their unique chemical structure, have garnered significant attention in recent years for their diverse pharmacological and biological activities. This review aims to comprehensively assess and summarize the latest research spanning the last five years. By synthesizing findings from a plethora of studies, this retrospective analysis elucidates the evolving landscape of chalcone research, shedding light on their therapeutic potential and biological effects. The …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 997–1003 Read article
-
TOXICOLOGY: Present-Day Difficulties for Investigating Safety Science and Target Safety Evaluation of Major Human Hepatocytes
Abstract: Preclinical toxicology has developed into a more thorough understanding of toxicity pathways from its descriptive beginnings. Technological developments have made it possible to forecast safety occurrences, mitigate adverse effects, and create safety biomarkers. Because they are able to self-renew and specialize into different types of human body cells, stem cells are currently being employed for in vitro toxicological applications. However, as compared to primary human hepatocytes, stem cell-derived HLCs perform …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 3, 2024 · pp. 31–40 Read article
-
Evaluation of the antioxidants potential and total phenolic contents of the Albbizia siris a drug plant
Abstract: Free radicals are the major problems of the world today. They are formed endogenously as well as exogenously by different kinds of metabolic processes in the body. Some of them are highly toxic process causing considerable damage to the system and produce several kindsof disorders. Antioxidants are the substance which reduces the formation of free radicals inthe body and are responsible for degradation of free radical and reactive oxygen species …
Published in Research and Reviews: A Journal of Toxicology · Vol. 9, Issue 1, 2019 · pp. 21–25 Read article
-
Practices and Health Related Toxic Symptoms of Pesticide Use among Farm Workers
Abstract: The present study was conducted among farm workers at Amritsar, Punjab with the objectives to assess the practices related to purchase, storage and usage before and after spraying of pesticides and to assess the health related toxic symptoms of pesticide use. Data was collected from 100 farm workers selected by purposive sampling with the help of self-structured tool. The study revealed varied and inappropriate practices related to purchase, storage and …
Published in Research and Reviews: A Journal of Toxicology · Vol. 6, Issue 3, 2016 · pp. 25–29 Read article
-
Pattern of Poisoning, Management and Antidote Availability in St. Paulo’s Specialized Hospital Addis Ababa, Ethiopia
Abstract: Poisoning is the contact with a substance that results in toxicity. It can be deliberate or accidental. Antidotes are substances opposing the harmful effect of poisons and are cornerstones in the management of poisoning. Availability of antidotes highly affects the effective poisoning management. To assess the poisoning management in relation to an antidote availability. A retrospective study was used to assess the practice of poisoning management and antidote availability in …
Published in Research and Reviews: A Journal of Toxicology · Vol. 5, Issue 3, 2015 · pp. 8–12 Read article
-
Effects of Intraperitoneal Administration of ATRA on the Testis of Elastase Induced Emphysematous Rats
Abstract: Emphysema is the pathological manifestation primarily associated with lungs. However, there are evidences of extra-pulmonary manifestations related to emphysema. The inflammation developed during emphysema triggers the release of several inflammatory mediators, which affects the proximal as well as distal organs. The present study was designed to determine the effect of inflammatory spillage on testicular tissue of male Sprague dawley rats; moreover, the main focus was to assess the potential role …
Published in Research and Reviews: A Journal of Toxicology · Vol. 6, Issue 3, 2016 · pp. 1–12 Read article
-
Antibacterial, Cytotoxicity Studies of Azukia mungo (L.) Masam and Correlation with in silico Docking Studies
Abstract: Introduction and Background: Azukia genus plants rich in proteinaceous anti-nutrients like tannins (especially condensed tannins) has been shown to have anti-bacterial activity against Staphylococcus aureus and antineoplastic activity against lung and liver cancer cells. Five types of procyanidins (condensed tannins) have already been isolated from Azukia mungo and structurally elucidated. But its activity against the Methicillin resistant Staphylococcus aureus (MRSA) has not yet been shown. Hence we focus our work …
Published in Research and Reviews: A Journal of Toxicology · Vol. 7, Issue 2, 2017 · pp. 21–31 Read article