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42 articles for “load profile”
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Comprehensive Evaluation of Quercetin from Bauhinia purpurea for Its Anti-Acne and Anti-Inflammatory Potential, Including Advances in Quercetin-Loaded Nanogel Formulation
Abstract: Acne vulgaris is among the most prevalent chronic inflammatory dermatoses in clinical dermatology, afflicting a substantial proportion of the global adolescent and adult population. Conventional pharmacotherapies — including topical retinoids, benzoyl peroxide, and systemic antibiotics — remain the therapeutic mainstay; however, their long-term utility is progressively undermined by adverse cutaneous reactions, systemic toxicity, and the rising prevalence of antibiotic-resistant Cutibacterium acnes strains. These limitations have intensified scientific interest in plant-derived …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 2, 2026 Read article
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Bio-Inspired FGPCs for Biomedical and Structural Applications
Abstract: Bio-inspired functionally graded polymer composites (FGPCs) represent a new class of smart materials that use gradient material distributions to enhance mechanical and biological properties, mimicking natural systems like bones, shells, and plant stems. FGPCs exhibit smooth gradient distributions across interfaces, which improves biocompatibility and reduces the risk of failure under complex loading and environmental conditions. In this study, bio-inspired FGPCs were designed, fabricated, and validated using a combined experimental and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 456–481 Read article
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Reliability-Based Prediction of Bearing Capacity of Shallow Foundation Along Ajaokuta-Kaduna-Kano Pipeline Track
Abstract: This paper investigates the geotechnical properties and reliability-based bearing capacity predictions for shallow foundations along the proposed Ajaokuta-Kaduna-Kano (A-K-K) pipeline track in Nigeria. The variability of subsoil properties along this route poses significant challenges to ensuring foundation stability and safety, necessitating an in-depth study. A total of twenty boreholes were strategically drilled at key locations to a maximum depth of 30 meters, providing comprehensive subsurface profiles. Soil samples collected from …
Published in Journal of Geotechnical Engineering · Vol. 12, Issue 1, 2025 · pp. 9–17 Read article
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Prediction of Depth-Induced Stress Distribution and Maintenance Cost Implications for Submerged Structural Components
Abstract: This study investigates the influence of water depth on stress distribution and structural integrity of submerged mechanical components . Structural models fabricated from mild steel, stainless steel, carbon steel, and copper alloy were examined under hydrostatic loading corresponding to water depths between 30 cm and 150 cm. Results indicate that normal and shear stresses increased proportionally with depth due to intensified hydrostatic pressure. Mild steel exhibited the highest stress concentrations, …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 3, Issue 2, 2025 · pp. 29–35 Read article
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Experimental Investigation of Aluminum Alloy 8010 by Friction Stir Welding
Abstract: A solid state welding method called friction stir welding (FSW) is used to fuse metals and alloys that are challenging to fuse using traditional fusion welding. The effects of tool pin and shoulder diameter on joining the aluminum alloy Al 8010 were examined in this study. The basis material for combining single butt-welded joints is a plate with a thickness of 6 mm. The welding was carried out on the …
Published in Journal of Materials & Metallurgical Engineering · Vol. 14, Issue 3, 2024 · pp. 14–19 Read article
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Microneedles: An Innovative Drug Delivery System
Abstract: Microneedles represent a groundbreaking innovation in drug delivery systems, offering a transformative alternative to conventional hypodermic needles and transdermal patches. This advanced technology combines the precision and efficacy of needle-based delivery with the convenience and pain-free nature of patches, creating a minimally invasive platform that addresses many limitations of traditional drug administration. Microneedles are designed to penetrate the stratum corneum – the skin’s outermost layer – without reaching pain-sensitive nerves …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 60–67 Read article
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Development and Assessment of Levetiracetam Microspheres Utilizing Synthetic and Natural Polymers: A Biomedical Engineering Perspective
Abstract: In the present study, comparative study of Levetiracetam loaded microspheres using Ethyl cellulose as synthetic and Sodium alginate as natural polymers was done. Solvent evaporation and ionic gelation technique has been successfully employed to produce Levetiracetam loaded ethyl cellulose and sodium alginate microspheres with optimal drug encapsulation that sustained the drug release over a period of time. Based on the pre-formulation studies E1 to E4 and S1 to S4 batches …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 1, 2024 · pp. 1–18 Read article
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AI-Driven Inverse Design of Functionally Graded Bio-Nanocomposites for Sustainable High-Barrier Packaging
Abstract: Multilayer plastic packaging realizes high barrier performance through laminated heterogeneous structures, but the heterogeneous structure has severe end-of-life challenges caused by the interfacial incompatibility of materials and the poor recyclability. This study proposes the inverse design of functionally graded PLA-nanoclay composite films by reinforcement learning as a monolithic alternative to traditional multilayer systems. Twin-screw extrusion is designed as a continuous control Markov decision process, and proximal policy optimization (PPO) is …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1547–1564 Read article
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Mechanical Characteristic Analysis of Five-Layer Carbon-Carbon Composite Material
Abstract: The current study investigates the fabrication and mechanical strength of five-layer carbon-carbon composite. The strong five-layer carbon-carbon composite material with high strength and modulus is made of a raw material called precursors. The polyacrylonitrile (PAN) method is used in the fabrication of carbon fiber. The characteristics of the resulting carbon material depend on the composition and structure of the precursor. A sheet of 50 x 40 cm five-layer carbon-carbon composite …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 405–417 Read article
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SiRNA-Based Multivalent Vaccines: A Systematic Review of Potential Risks, Benefits, and Future Applications
Abstract: Background: Small interfering RNA (SiRNA) technology represents a promising innovation in vaccine development, especially for multivalent vaccines that can target multiple pathogens or antigenic variants simultaneously. siRNA-based vaccines offer a unique mechanism to induce specific immune responses, presenting an adaptable and potentially powerful tool for tackling infectious diseases and cancer. Methods: This systematic review synthesizes recent studies on siRNA multivalent vaccines, focusing on their immunogenicity, safety, and effectiveness. We reviewed …
Published in International Journal of Vaccines · Vol. 2, Issue 1, 2025 · pp. 43–49 Read article
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Biopolymer-Based 3D Composite Scaffolds for Bone Tissue Engineering: Photothermal-Responsive Systems with Controlled Pt (IV) Prodrug Release
Abstract: Biopolymer-based composite scaffolds have attracted significant attention as multifunctional platforms at the intersection of polymer science, regenerative medicine, and cancer nanotherapy. In this study, a dual-functional scaffold was developed for simultaneous osteosarcoma treatment and bone regeneration using poly (L-lactic acid) (PLLA) reinforced with bioactive glass (BG) and integrated with a glutathione-responsive platinum (IV) prodrug system (PDA@Pt). To improve interfacial adhesion, photothermal conversion efficiency, and tumor-specific activation, the Pt (IV) prodrug …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 351–361 Read article
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Microsphere and Nanoparticle Drug Delivery Systems: Role of Polymers in Pharmacology
Abstract: Microsphere and nanoscale drug delivery methods have changed the field of pharmacology by making treatment agents more bioavailable, more targeted, and easier to manage. These delivery systems, which are mostly made up of polymers, look like a good way to get around the problems that traditional drug formulations have, like not dissolving well, clearing quickly, and spreading in different places. Plastics are very important in the creation of these improved …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 420–432 Read article
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Damage Evolution and Delamination Resistance in Polymer Matrix Functionally Graded Laminates
Abstract: Functionally graded laminates (FGLs) in polymer-matrix systems represent a promising pathway to enhance damage tolerance and delay delamination in advanced structural composites. In this study, we explore the mechanisms of damage initiation, propagation, and delamination resistance in polymer matrix functionally graded laminates (PM-FGLs) through a combined experimental–computational approach. Laminates with linear, exponential, and bio-inspired gradation profiles were fabricated using vacuum-assisted resin transfer molding (VARTM) and additive manufacturing techniques. Comprehensive mechanical …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 321–337 Read article
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Design and Performance Evaluation of PLA-based Umbrella Wheels for Stair-Climbing Robotic Applications
Abstract: Staircase climbing robots require a complex design capable of navigating various stair configurations. A crucial component of such robots is the wheel mechanism. This paper focuses on the umbrella wheel mechanism and its application in staircase climbing robots. In this study, a PLA–based umbrella wheel structure is developed and fabricated using fused deposition modeling (FDM) for application in stair-climbing robots. The umbrella wheel geometry enables transformation from a circular rolling …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 808–824 Read article
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Ocular Films as a Drug Delivery System Against Fungal Infections: Current Insights and Future Directions
Abstract: Fungal infections of the eye, including keratitis, endophthalmitis, and blepharitis, represent a challenging class of ocular diseases due to their potential for vision loss and the limited efficacy of existing treatments. These infections are caused by a range of pathogenic fungi, such as Aspergillus, Candida, and Fusarium species, and often require long-term therapeutic intervention. Conventional topical antifungal therapies, such as eye drops and ointments, suffer from poor ocular bioavailability due …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 101–109 Read article
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Thermo-Fluid Characterization of Corrugated U-Tube Shell-and-Tube Heat Exchanger with Polymer Composite Tube Wall: A Combined CFD and Experimental Investigation
Abstract: Shell-and-tube heat exchangers built with metallic tubes work well thermally, but corrosion problems, extra weight, and the inability to adjust the wall’s thermal properties through material choice remain genuine engineering headaches, particularly for corrosive or weight-critical applications. Over the past few years there has been a fair amount of interest in replacing metal tubes with polymer composite alternatives, since blending thermally conductive fillers — graphite nanoplatelets, boron nitride platelets and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 Read article
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Cubic B-splines for Isogeometric Analysis of Laminated Composite Plates Subjected to Hygroscopic Loading Using Classical Laminated Plate Theory
Abstract: Composite laminates are inevitably used in several engineering structures due to their high strength and stiffness to weight ratio. The laminates are subjected to change in moisture content and the flexural behavior leads to change in the strength. Presence of moisutre may induce residual stresses and strains. Isogeometric analysis is a well-proven method to perform analysis of laminated composite plates. The main focus of this study is to apply isogeometric …
Published in Journal of Polymer & Composites Read article
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Web-Based Placement Management System: A Digital Approach to Campus Hiring
Abstract: Web-based management system for placement is a complete digital platform focused on optimizing and automating the activities of campus recruitment. Placement activities are generally manual in nature and require a lot of work, which brings about inefficiencies and time lags involving students, recruiters, and placement coordinators. Such challenges are faced by the above-mentioned system that provides a single point of convergence for all students and employers, as well as coordinators, …
Published in Journal of Advanced Database Management & Systems · Vol. 12, Issue 2, 2025 · pp. 18–29 Read article
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Comprehensive Introduction: Epoxy and Polyurethane Floor Coatings—A Critical Evaluation for Modern Industrial Applications
Abstract: Industrial flooring systems are essential for ensuring operational durability, safety, and longevity in demanding environments. Epoxy and polyurethane (PU) coatings represent two predominant technologies, each offering distinct mechanical, chemical, and aesthetic profiles tailored to specific performance requirements. Epoxy systems, formed through the crosslinking of bisphenol-A-based resins with amine hardeners, excel in high-strength, chemically aggressive settings due to their superior hardness, adhesion, and chemical inertness. In contrast, PU coatings, synthesized from …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 13, Issue 1, 2026 · pp. 14–23 Read article
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Analysis of Friction Stir Welding Utilizing ANSYS: A Study Based on Simulation
Abstract: Friction Stir Welding (FSW) represents a sophisticated solid-state welding methodology that has attracted considerable scholarly attention due to its efficacy in amalgamating high-strength, lightweight substrates including aluminium, magnesium, and titanium alloys. FSW enables the fabrication of defect free products with a substantial amount of mechanical and wear properties. The process is highly sensitive to various parameters that significantly influence the quality and strength of the final product. Studies have shown …
Published in International Journal of Mechanical Dynamics and Systems Analysis · Vol. 3, Issue 2, 2025 · pp. 62–77 Read article