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164 articles for “drug release”
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Microsphere-Based Drug Delivery: A Critical Review of Innovations and Applications
Abstract: Microspheres have emerged as a revolutionary approach in pharmaceutical sciences, offering controlled and targeted drug delivery with improved bioavailability, stability, and patient compliance. These spherical carriers, ranging from nanometers to micrometers in size, can encapsulate both hydrophilic and hydrophobic drugs, enabling sustained and site-specific release. The development of microspheres has been significantly driven by the need to enhance drug efficacy while minimizing systemic side effects. This review provides a comprehensive …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 52–59 Read article
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Design and Evaluation of Thermo-Responsive Poly(N-isopropylacrylamide)-Based Polymeric Nanoparticles for Temperature-Triggered Intratumoral Release of Doxorubicin in Solid Tumors
Abstract: Thermo-responsive polymeric systems have emerged as promising platforms for targeted intratumoral drug delivery in cancer therapy. This study aimed to develop and evaluate poly(N-isopropylacrylamide) (PNIPAM)-based polymeric nanoparticles as intelligent carriers for temperature-responsive delivery of doxorubicin (DOX) to solid tumors. Nanoparticles were synthesized via free radical polymerization using N-isopropylacrylamide as a thermoresponsive monomer and N,N′-methylenebisacrylamide as a crosslinker, forming a stable network with a tunable lower critical solution temperature (LCST).The optimized …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 159–168 Read article
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An Effective & Novel Approach as Gastro-retentive Drug Delivery Systems
Abstract: Researcher’s curiosity about gastro-retentive drug delivery system increased so high in recent years because of its excellent drug releasing properties to the target site. The delivery system's residence time in the stomach can be extended with the usage of gastro-retentive drug delivery system by using a number of natural and synthetic polymers such as guar gum, hydoxy propyl methyl cellulose which can be used to improve the bioavailability of a …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 47–54 Read article
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Pharmaceutical Bead Formulations: A Comprehensive Overview into Advanced Drug Delivery
Abstract: Pharmaceutical beads are a unique and flexible drug delivery vehicle that provides numerous possibilities to control the release of drugs, protect them, and increase their therapeutic performance. These beads make it possible to design several types of therapeutic regimens by incorporating active pharmaceutical ingredients in a polymeric or lipid matrix. This review discusses the bead technology in drug delivery from its inception to its present application, focusing on the most …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 78–100 Read article
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A Review on Nanosponges Drug Delivery System
Abstract: The main issue that the researchers are dealing with is targeted medication delivery to locations. Crosslinking polymers produce nanosponges, which are three-dimensional drug delivery systems at the nanoscale. They have the benefit of having a large capacity to carry different-sized medications. There are numerous sizes and shapes for nanosponges. Compared to alternative delivery methods, nanosponges are preferable because they may offer a regulated medication release pattern with targeted Medication administration. …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 68–76 Read article
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Exploring Biomedical Innovations in the Formulation and Assessment of Medicated Hard Candy Lozenges Containing Metoclopramide Hydrochloride
Abstract: The objective of this study was to formulate and evaluate metoclopramide hydrochloride medicated lozenges for antiemetic action through buccal absorption by incorporating a polymer. All formulations were developed and assessed for in-vitro drug release, physical appearance, weight variation, thickness, hardness, moisture content, mouth-dissolving time, and drug content. The prepared lozenges exhibited uniformity in weight and thickness. The hardness of all formulations ranged between 7.3–15.50 kg/cm², falling within standard limits. The …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 2, 2024 · pp. 50–62 Read article
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Comprehensive Review on Pulsatile Drug Delivery System: Hybrid Approaches
Abstract: Pulsatile drug delivery systems (PDDS) represent a groundbreaking approach in pharmaceutical technology, allowing for controlled, targeted, and programmable drug release that aligns with circadian rhythms or caters to time-sensitive therapeutic requirements. Although traditional pulsatile systems have shown considerable clinical promise, their effectiveness is frequently compromised by physiological variations such as gastrointestinal transit times, changes in pH, and enzymatic activity. To tackle these obstacles, hybrid PDDS have been developed by combining …
Published in Trends in Drug Delivery · Vol. 13, Issue 1, 2026 · pp. 18–31 Read article
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Influence of Polymeric Carriers on the pH-Modifying Properties of Intracanal Medicaments in Root Canal Treatment
Abstract: Calcium hydroxide (CH) preparations and medicated gutta-percha are widely used intracanal medicaments in root canal treatment. These materials often incorporate polymeric carriers to deliver the CH payload and influence its therapeutic effect. This in-vitro study investigates the impact of different polymeric carriers on the pH-modifying properties of intracanal medicaments within the root canal system. The research focuses on two key aspects: (1) the ability of the polymers to control the …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 967–974 Read article
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Polymeric Ion-Exchange Complexes of Carbomer for Taste Masking and Enhanced Drug Bioavailability: A Physicochemical and In Vivo Study
Abstract: Famotidine (FAM) was recognized as a crystalline powder that varies in color from white to pale yellow and possesses an extremely bitter flavor. This study aimed to conceal the unpleasant flavor of FAM through employing unconventional ion-exchange resins sourced from Carbomer polymer Evaluation (Carbopol 974P). We used FTIR, DSC, and XRD to look at the drug-resin combination in its hard form to learn more about its physical and chemical properties. …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 727–740 Read article
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Biodegradable and Natural Fiber-Reinforced Polymer Composites for Sustainable Biomedical Applications
Abstract: Liposomal drug delivery has evolved into a viable approach in modern pharmacology thanks to its enhanced bioavailability, reduced systemic toxicity, and targeted drug release. Conventional liposomes have limited stability, medicine leakage, and short circulation times among other problems. Overcoming these limits, the inclusion of nano-polymers into liposomal formulations has transformed medication delivery. Thorough research has been done on the potential of nano-polymers including chitosan, hyaluronic acid, polyethylene glycol (PEG), and …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 420–432 Read article
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Biomedical Approach to Developing and Characterizing Chitosan Nanoparticles Encapsulating Urapidil for Hypertension Management
Abstract: The aim of this study was to create Chitosan Nanoparticles loaded with Urapidil to achieve controlled drug release, enhance solubility, and reduce dosing frequency to improve patient adherence to therapy for hypertension. Urapidil was formulated into nanoparticles via the ionic-gelation method using Chitosan as a polymer, Sodium tripolyphosphate as a cross-linking agent, and filled into hard gelatin capsules after lyophilization. Pre-formulation studies, including melting point analysis and determination of the …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 1, 2024 · pp. 43–51 Read article
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“DEVELOPMENT AND CHARACTERIZATION OF PHYTOSOMES FOR THE TREATMENT OF ANTI-CANCER ACTIVITY BY USING THE Spirulina (Arthospira Plantesis) EXTRACT”
Abstract: This study aims to investigate and evaluate spirulina's anticancer properties.The current research is centred on obtaining a Spirulina-containing drug. The goal is to design and create Phytosomes, characterizing them based on relevant and crucial parameters. The process of solvent evaporation was utilized in the creation of Phytosomes. Various parameters such as zeta potential, particle size, infra-red spectral analysis, % drug content, encapsulation efficiency, and % drug release (% DR) were …
Published in International Journal of Antibiotics · Vol. 1, Issue 1, 2024 · pp. 10–22 Read article
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Development and Fabrication of Biohydrogel for Targeted Delivery of Delafloxacin for Bacterial Skin Infections
Abstract: The escalating challenge of bacterial resistance necessitates innovative drug delivery systems to enhance the efficacy of antibiotics. This study focuses on the development and optimization of a biohydrogel formulation for the targeted delivery of Delafloxacin, aiming to improve its therapeutic outcomes against resistant bacterial strains. Utilizing a 3² factorial design, biohydrogel formulations incorporating Poly(N-isopropylacrylamide) (PNIPAM) and Genipin were synthesized. The optimization process was guided by Design Expert software, focusing on …
Published in Research & Reviews: A Journal of Drug Design & Discovery Read article
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Formulation and development of Lamivudine Nanoemulsion by using Emulsifying Polymers and It’s Evaluation
Abstract: Nanoemulsion is a novel approach to medicine delivery that helps to increase the bioavailability of drugs that aren’t particularly soluble in water. In this research work, nanoemulsion of Lamivudine was formulated by using polymers such as SPAN 80, TWEEN 80 and Whey protein concentrate with the help of Ultrasonication technology. The formulation was optimized. It was evaluated by assessing pH, viscosity, turbidity, in vitro franz diffusion study, particle size distribution, …
Published in Journal of Polymer & Composites · Vol. 12, Issue 6, 2024 · pp. 22–35 Read article
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Polymeric Materials in Drug Delivery: Applications in Topical Formulations
Abstract: Polymeric materials play a crucial role in modern drug delivery systems, particularly in topical formulations. These materials enhance drug stability, control release rates, and improve bioavailability, making them essential components in pharmaceutical advancements. Polymers such as chitosan, hydrogels, and emulsifying agents are widely utilized in immediate-release topical formulations, where they contribute to improving therapeutic efficacy by ensuring uniform drug distribution, increased solubility, and enhanced skin penetration. The integration of polymer-based …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 34–41 Read article
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Ocular Films as a Drug Delivery System Against Fungal Infections: Current Insights and Future Directions
Abstract: Fungal infections of the eye, including keratitis, endophthalmitis, and blepharitis, represent a challenging class of ocular diseases due to their potential for vision loss and the limited efficacy of existing treatments. These infections are caused by a range of pathogenic fungi, such as Aspergillus, Candida, and Fusarium species, and often require long-term therapeutic intervention. Conventional topical antifungal therapies, such as eye drops and ointments, suffer from poor ocular bioavailability due …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 101–109 Read article
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Biopolymer-Based Nanocomposites for Oral Drug Delivery
Abstract: Because they are biocompatible, biodegradable, and can hold a lot of different healing agents, biopolymer-based nanocomposites are looking like a good way to give drugs orally. These materials are made up of natural polymers mixed with nanoparticles. They have many benefits for drug delivery systems, such as making drugs more soluble, controlling when they are released, and making enclosed drugs more stable. Drug release rates may be altered by mixing …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 400–412 Read article
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Liposomes as Therapeutic Vehicles: Advancing Targeted Drug Delivery in Healthcare
Abstract: Liposomes represent an innovative approach to targeted drug delivery. These tiny, lipid-based vesicles can encapsulate medications, allowing them to travel directly to diseased cells while minimizing impact on healthy tissues. By using liposomes, medications can improve their effectiveness while reducing side effects, leading to better overall treatment results.. Their structure enables a controlled release of the drug, which can be particularly beneficial for therapies requiring sustained action. This technology holds …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 3, 2024 · pp. 39–46 Read article
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Bio-Inspired Membranes in Oral Drug Delivery: A Pathway to Enhanced Permeability and Targeted Therapy
Abstract: Bio-inspired membranes in oral drug delivery represent a significant advancement in pharmaceutical technology, harnessing principles of natural biological systems to improve drug permeability, bioavailability, and targeted release. This review discusses the design, materials, and fabrication techniques used in bio-inspired membranes, with a focus on materials like chitosan, silk fibroin, and synthetic polymers that mimic biological structures. By exploring the mechanisms of drug permeation, such as mucoadhesion and selective permeability, bio-inspired …
Published in International Journal of Membranes · Vol. 1, Issue 2, 2024 · pp. 39–52 Read article
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Formulation Development and Evaluation Technique for Immediate and Modified Release Capsule
Abstract: The development and evaluation of formulations for immediate-release (IR) and modified-release (MR) capsules represent a critical aspect of pharmaceutical dosage form design, offering distinct advantages in terms of drug release profiles and therapeutic outcomes. This study focuses on the formulation strategies, techniques, and evaluation methods used to develop both IR and MR capsules. Immediate-release capsules are designed to disintegrate quickly in the gastrointestinal tract, ensuring rapid drug absorption, while modified-release …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 1, 2025 · pp. 1–9 Read article