Search
314 articles for “Therapeutic Management”
-
Anticancer Potential and Other Therapeutic Activities of Curcumin & Its Derivatives
Abstract: Curcumin, a compound isolated from turmeric, is used in the management of various diseases due to its extensive medicinal properties. Curcumin, the principal polyphenol isolated from Curcuma longa (turmeric), has garnered immense scientific interest for its extensive medicinal properties, including potent anti-inflammatory, antioxidant, and anticancer activities demonstrated in preclinical models. An expanding body of research indicates broad therapeutic promise in managing diverse pathologies, from various cancers to chronic inflammatory, metabolic, …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 1, 2026 · pp. 19–28 Read article
-
Tools, Modern Drugs, and Latest Investigations for the Diagnosis and Treatment of Heart Failure: A Systematic Review of the General Causes
Abstract: Heart failure (HF) diagnosis and treatment present formidable challenges, given the absence of a definitive single test. This systematic literature review aims to comprehensively analyze the current landscape of diagnostic tools, modern drugs, and latest investigative approaches in HF management. Recognizing the complexity of HF etiology, this systematic review emphasizes the importance of advanced diagnostic methods, such as genetic testing and artificial intelligence applications. The systematic review was conducted to …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 1, 2024 · pp. 1–10 Read article
-
Emerging Digital Trends in Virology Software: Optimizing Viral Discovery, Surveillance,and Patient Management.
Abstract: Virology and antiviral therapeutics are being reshaped by rapid advances in computational tools, automation platforms, and virus-focused digital health applications. Software systems now span the entire virology value chain, from in silico viral target identification and antigen design, to AI-supported clinical trial management for vaccines and antivirals, to post-marketing pharmacovigilance and patient-facing mobile tools. This review examines current and emerging software trends relevant to virus studies, emphasizing applications in viral …
Published in International Journal of Virus Studies · Vol. 3, Issue 1, 2026 · pp. 29–38 Read article
-
INVESTIGATING PHYTOCHEMICAL INHIBITORS OF PSEUDOMONAS AERUGINOSA'S AHL SYNTHASE LASI: A PATH TOWARD NOVEL THERAPEUTIC AGENTS
Abstract: Objectives: This study intended to explore the potential of phytochemicals from Allium sativum to inhibit AHL synthase LasI, a critical protein of the Quorum Sensing (QS) pathway in Pseudomonas aeruginosa, with the ultimate objective of developing therapeutic agents for managing P. aeruginosa infections. Methods: The physicochemical properties, toxicity, aggregation ability and binding potential of phytochemicals from Allium sativum to the protein AHL synthase LasI were determined. Physicochemical properties, toxicity and …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 3, 2023 · pp. 40–54 Read article
-
Chemotherapy: Side Effect and Management
Abstract: Cytotoxic drugs are therapeutic agents intended for but not constrained to, the treatment of cancer. These drugs are kenned to be highly toxic to cells, mainly through their action on cell reproduction. Cytotoxic drugs are increasingly being utilized in a variety of health care settings, laboratories and veterinary clinics for the treatment of cancer and other medical conditions such as rheumatoid arthritis, multiple sclerosis are autoimmune disorders. Cytotoxic drugs are …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 5, Issue 3, 2016 · pp. 30–40 Read article
-
Assessing the Clinical Efficacy and Safety of Semaglutide: A Comprehensive Study
Abstract: Semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), has emerged as a versatile therapeutic agent with significant potential in managing a range of diseases. Extensive research has demonstrated its efficacy in treating obesity, type 1 and type 2 diabetes, and even neurodegenerative disorders like Parkinson’s disease. This comprehensive review examines the principal outcomes derived from clinical trials that incorporate semaglutide alongside other GLP-1 agonists, with particular emphasis on the mechanisms underlying …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 96–104 Read article
-
Managing Carpal Tunnel Syndrome: Insights into Symptoms and Relief
Abstract: Carpal tunnel syndrome (CTS) is a prevalent and concerning issue affecting the wrist and hand, arising from the compression of the median nerve within the carpal tunnel. This compression results in a spectrum of distressing symptoms, including numbness, tingling, weakness, and discomfort, particularly in the thumb, index, and middle fingers. Despite its frequent association with repetitive hand movements and prolonged use of computers or handheld devices, CTS can stem from …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 1, Issue 2, 2023 · pp. 6–12 Read article
-
Mental Health Nursing Interventions in Schizophrenia Care: Effectiveness of Nurse-Led Strategies in Managing Schizophrenia Disorder
Abstract: Schizophrenia is a chronic and severe mental disorder characterized by disturbances in thought, perception, emotion, and behavior that can significantly impair an individual’s functioning and quality of life. Mental health nurses play a pivotal role in the comprehensive management of schizophrenia through patient-centered and evidence-based interventions. This article critically examines the effectiveness of nurse-led strategies in the management of schizophrenia, with particular emphasis on pharmacological support, psychosocial interventions, psychoeducation, therapeutic …
Published in Journal of Nursing Science & Practice · Vol. 16, Issue 2, 2026 · pp. 1–8 Read article
-
A Review of Drug Design Techniques Assisted by Computers to Combat Diabetes
Abstract: Diabetes mellitus is a global health concern characterized by chronic hyperglycemia and associated complications. The creation of innovative medicines with enhanced efficacy and safety profiles continues to be a top focus, notwithstanding improvements in treatment. A useful method in drug development, computer-aided drug design (CADD) makes it easier to identify possible therapeutic candidates and optimise lead molecules. An extensive synopsis of CADD tactics used in the fight against diabetes is …
Published in Emerging Trends in Personalized Medicines · Vol. 2, Issue 1, 2025 · pp. 1–10 Read article
-
Comparative Efficacy and Safety of Safinamide and Rasagiline in the Treatment of Parkinson’s Disease: A Meta-Analysis and Systematic Review
Abstract: Background: Recent studies have suggested Rasagiline and Safinamide monotherapy as potential management options for Parkinson’s disease. Parkinson’s disease, a neurological disorder characterized by tremors and movement difficulties, necessitates treatments aimed at managing clinical symptoms. Levodopa remains the primary effective treatment for Parkinson’s disease symptoms; however, its long-term use often leads to motor complications in many patients. Additional therapeutic drugs, such as dopamine agonists and monoamine oxidase B inhibitors, including Safinamide …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 74–91 Read article
-
A Review on Applications of Artificial Intelligence (AI) in Parkinsons’s Disease Diagnosis and Treatment and Its Future Challenges
Abstract: Parkinson’s disease (PD) is a long-term, progressive neurodegenerative disorder that mainly occurs in people older than 60 years, affecting nearly 1% of this population. It is chiefly marked by the loss of dopaminergic neurons in the substantia nigra, a crucial brain region responsible for controlling motor functions. The resultant dopamine deficiency significantly disrupts motor control, manifesting in clinical symptoms such as tremors, bradykinesia, muscle rigidity, and postural instability. While PD …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 3, 2025 · pp. 1–15 Read article
-
Exploring Glucagon-like peptide-1 as a Target Protein for Diabetes Mellitus Treatment: Molecular Docking and Pharmacokinetic Analysis of Phytocompounds from Momordica charantia
Abstract: Objective: This study aimed to use molecular docking techniques to explore the potential of GLP-1 (glucagon-like peptide-1) as a target protein for the treatment of diabetes mellitus, a chronic metabolic disease marked by elevated blood glucose levels. Given its crucial role in maintaining insulin secretion and glucose homeostasis, GLP-1 may serve as a future target for diabetes therapy. Method: The study employed a multi-phase method. Initially, protein extraction was carried …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 8–20 Read article
-
In Silico Analysis and Docking Study of the Active Phytocompounds of Bacopa monnieri Against Alzheimer Disease
Abstract: Objective: Alzheimer’s is a neurodegenerative disease and is the cause of 60–70% of cases of dementia. It infected a million people worldwide. An effort was undertaken to explore the potential of natural compounds found in Bacopa monnieri, a plant renowned for its extensive medicinal properties in Indian Ayurveda, to combat the disease. This was achieved through molecular docking studies, evaluation of drug-likeness, and comprehensive ADME (absorption, distribution, metabolism, and excretion) …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 2, 2024 · pp. 1–13 Read article
-
From Clinic Formulation to Development of Acebrophylline
Abstract: Acebrophylline, a commonly utilized bronchodilator with anti-inflammatory properties, has become a key therapeutic option for managing respiratory conditions like asthma, chronic obstructive pulmonary disease (COPD), and chronic bronchitis. This review explores the journey of Acebrophylline from its clinic formulation to its development and commercialization, focusing on the key aspects of formulation strategies, pharmacological properties, and regulatory considerations. The drug’s dual mechanism of action, which involves both bronchodilation and anti-inflammatory effects, …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 1, 2025 · pp. 35–48 Read article
-
Differential Gene Expression Analysis of Human Atrial Fibroblasts Reveals Dysregulation of RNA Metabolism and Translational Machinery in Atrial Fibrillation
Abstract: Atrial fibrillation (AF) is a complex cardiac arrhythmia characterized by extensive structural remodeling and the activation of atrial fibroblasts, which drive the progression of fibrosis. To identify the underlying transcriptomic alterations, we analyzed six human atrial fibroblast RNA-Seq datasets (three control and three AF) retrieved from the Sequence Read Archive. After performing rigorous quality control and adapter trimming, we aligned the reads to the GRCh38 human reference genome using a …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 4, Issue 2, 2026 · pp. 15–25 Read article
-
Drug and Non-drug Treatment Options of Fibromyalgia
Abstract: Fibromyalgia (FM) treatment does not have a clear objective pathophysiological therapeutic goal. The management of this complex condition has thus perplexed the medical community for many years, and several national and international guidelines have aimed to address this complexity. Pain relieving pharmaceutical medications are generally connected with an assortment of unfriendly reactions, for example, constipation, urinary retention, nausea, sedation, respiratory depression, myoclonus, delirium, sexual dysfunction, and hyperalgesia. The challenge of …
Published in Research and Reviews : Journal of Computational Biology · Vol. 8, Issue 3, 2019 · pp. 15–23 Read article
-
Toxicological Examination of Dopamine's Involvement in Substance Abuse: An Overview
Abstract: Dopamine, classified as a catecholamine, is an essential organic compound that plays a crucial role in the brain's reward system and regulatory processes. It is instrumental in reinforcing pleasurable activities through repeated engagement. Acting as a neurotransmitter, dopamine is released in various brain regions, including the striatum and accumbens, and is absorbed by neurons through receptors.This review aims to comprehensively outline the mechanisms of dopamine release and its pivotal role …
Published in Research and Reviews: A Journal of Toxicology · Vol. 13, Issue 3, 2023 · pp. 22–25 Read article
-
A Comprehensive Review of Ayurvedic Pharmaceutics in Charaka Samhita W.S.R to Chikitsasthana.
Abstract: Charaka Samhita provides insightful information on the holistic approach to well-being by addressing every facet of health, from illness management to preventive measures. It is organized into eight Sthana, and is filled with information on anatomy, physiology, disease etiology, diagnosis, treatment, and health maintenance principles. The term "Charakastu Chikitsite" denotes that Charaka Samhita is the greatest treatise on Ayurvedic therapeutics. Numerous subjects related to diagnosis, treatment planning, and disease management …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 11, Issue 1, 2024 · pp. 14–25 Read article
-
The Use of Autologous Platelet-Rich Plasma in Treating Web Space Scar Contractures in Pediatric Burn Patients
Abstract: Burn injuries are prevalent among children, with scald injuries emerging as the predominant type among those under the age of five, constituting more than 65% of cases. Despite receiving appropriate initial treatment and compressive therapy, deep burns often result in contractures, with web space and hand contractures being the most frequent and functionally limiting.To address these challenges in burn management, Autologous Platelet Rich Plasma (APRP) has emerged as a significant …
Published in Research and Reviews : Journal of Surgery · Vol. 13, Issue 1, 2024 · pp. 1–5 Read article
-
Evaluation of Safety of Unani Pharmacopieal Majoon-e-Lana in Cases of Neurasthenia
Abstract: Neurasthenia, referred to as Zof-e-Asaab in the Unani system of medicine, is a functional disorder characterized by generalized weakness of the nervous system. Individuals suffering from this condition commonly experience persistent fatigue, reduced physical and mental performance, low mood, irritability, disturbed sleep, and, in some cases, elevated blood pressure. Although various conventional treatment options are available for symptom management, no specific curative therapy has been established. Furthermore, long-term use of …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 13, Issue 2, 2026 Read article