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45 articles for “Survival Outcome”
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Precision Medicine Approaches for Cancer Therapy Recent and Advance
Abstract: Recent advances in biotechnology have made it possible to identify intricate and distinctive biological characteristics linked to carcinogenesis. Proteomic and RNA studies, immunological markers, tumor and cell-free DNA profiling, and other methods are utilized to find these traits in order to optimize anticancer treatment for specific patients. In recent years, the focus of clinical trials has shifted considerably to enhance treatment outcomes in cancer therapy. Rather than being primarily centered …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 1, 2025 · pp. 1–11 Read article
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Triple Negative Breast Cancer—Pattern of Recurrence and Survival: A Single Institute Experience
Abstract: Triple negative breast cancer (TNBC) is a distinct biological entity and recent data shows it as a heterogeneous group with at least 6 subtypes with differences in clinical outcome.This study intends to analyze the prevalence, recurrence pattern and outcome of triple negative breast cancer in our patient cohort.We reviewed the outcomes of 244 consecutive triple negative non-metastatic breast cancer patients who were treated with a radical intent from Jan 2004 …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 6, Issue 3, 2017 · pp. 5–8 Read article
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A Case Report of Advanced Periampullary Carcinoma: Palliative Chemotherapy Following Whipple’s Surgery
Abstract: This case report delves into the complex management of a 60-year-old female patient diagnosed with Stage 4 periampullary carcinoma, encompassing the pancreatic head. Presenting with difficulty in eating, diagnostic investigations, including ERCP, confirmed the diagnosis, leading to Whipple's surgery. Postoperatively, liver metastasis was identified, prompting palliative intervention through stenting and the initiation of a GEMOX chemotherapy regimen. The patient responded favorably to the initial chemotherapy cycle, leading to a planned …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 1, 2024 · pp. 1–6 Read article
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Interfacial Performance and Structural Stability of Repaired vs. Replaced Polymer-Based Composites: A 3-Year Retrospective Analysis of 'Patch-up' Restorative Engineering
Abstract: Objective: This retrospective study aimed to evaluate the clinical longevity and interfacial success of repairing aged polymer-based composites versus complete replacement, focusing on the integration between the existing polymer matrix and the new restorative material. Materials and Methods: A retrospective clinical audit was conducted on 50 cases (n = 50) of posterior restorations with localized defects. The sample was categorized into: Group A (n = 25), where defective sites were …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 180–187 Read article
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Cancer Chronicles: An Overview of its Origins, Types, Treatment, and Prevention
Abstract: Cancer is a multifaceted illness characterized by abnormal cell growth and dissemination throughout the body. Its onset usually arises from a mix of genetic mutations and environmental factors. There exist more than 100 distinct forms of cancer, each possessing unique attributes, risk elements, and therapeutic alternatives. Cancer is a pervasive health challenge that knows no boundaries of age, race, or background, continuing to rank among the foremost causes of mortality …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 2, 2024 · pp. 36–42 Read article
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Advances in Trauma Surgery: Innovations, Historical Perspectives, and Future Directions in Patient Care
Abstract: Trauma care has evolved significantly over the past few decades, with innovations in surgical techniques, medical devices, and procedural protocols enhancing the outcomes for patients experiencing life-threatening injuries. This article explores recent surgical innovations in trauma care, focusing on advancements in hemorrhage control, rapid trauma intervention, and the use of novel technologies to improve surgical precision and recovery. Key developments such as hemostatic agents, minimally invasive techniques, and the integration …
Published in Research and Reviews : Journal of Surgery · Vol. 14, Issue 3, 2025 Read article
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Changing Trends in Advanced Epithelial Ovarian Cancer - A Review
Abstract: Despite the advances in surgery and chemotherapy, the outcome of patients affected with advanced epithelial ovarian cancer continues to be poor. Now researchers are looking at ovarian cancer through newer perspectives so as to find better treatment modalities that can improve overall survival (OS). In this chapter, we have briefly reviewed the newer areas of research in epithelial ovarian cancer. We look at how better understanding of the molecular biology, …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 3, Issue 2, 2014 · pp. 1–7 Read article
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Role of PI3K/AKT/mTOR Signaling Pathways in Breast Cancer
Abstract: Abstract: Breast cancer is among the most commonly diagnosed cancers and remains a leading cause of mortality among women globally. Although early detection and interventions aimed at curtailing tumor progression have significantly improved breast cancer survival rates, there is an ongoing demand for more potent systemic therapies to effectively prevent metastasis. A central pathway frequently associated with the growth, survival, and motility of breast cancer cells is the PI3K/AKT/mTOR signaling …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 1, 2025 · pp. 23–34 Read article
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Literature Review On Nanotechnology In Dentistry
Abstract: Nanotechnology is a relatively new field in dentistry that utilizes nanomaterials, nanorobots, and nanotechnology for diagnosing, treating, and preventing dental diseases. Nanotechnology has revolutionized various fields of dentistry, offering innovative solutions that enhance patient care, improve treatment outcomes, and contribute to the overall advancement of dental science. This cutting-edge technology has found applications in several areas, including restorative dentistry, dental implants, early cancer diagnosis, dental hypersensitivity, and pain management, among …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 15, Issue 2, 2025 · pp. 19–23 Read article
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Revolutionizing Blood Cancer Treatment: Emerging Therapies and Future Perspectives
Abstract: Blood cancer inclusive of leukemia, lymphoma and multiple myeloma poses a significant threat in the world today because of its multifactorial process and its non-amenable to standard therapies. Some of such approaches are immunotherapy, gene-editing technology and targeted small molecule inhibitors that have altered the nature of treatments. CAR T cell therapy is a molecular targeted therapy for cancers and several clinical studies have reported a huge success. Also, the …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 3, Issue 2, 2025 Read article
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Mass Spectrometry–Based Phosphoproteomic Markers to Predict Kinase Inhibitor Response in Solid Tumors
Abstract: Mass spectrometry-based phosphoproteomics has emerged as a powerful tool for predicting kinase inhibitor responses in solid tumors, offering direct functional insights into signaling pathways that surpass traditional genomic profiling by capturing dynamic kinase activities and adaptive resistance mechanisms. Technological breakthroughs, including data- independent acquisition (DIA), trapped ion mobility spectrometry (timsTOF), and efficient enrichment methods like TiO2 or IMAC, now enable comprehensive profiling of over 40,000 phosphorylation sites from limited clinical …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 4, Issue 2, 2026 Read article
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Tribological Characteristics of Dental Crowns
Abstract: Dental tribology is an emerging field that focuses on improving the design and material choices for artificial dental systems. This paper looks at different dental crown materials, their clinical efficacy and the consequences of tribological wear on teeth due to interfacial movement. Ceramics are commonly utilized in fixed dental restorations because of their superior mechanical and cosmetic qualities, which include exceptional fracture resistance and clinical endurance. Ceramic crowns, often used …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 550–559 Read article
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Anticancer, Bioactive, & Therapeutic Applications of Cannabinoids
Abstract: Cannabinoids, a complex class of lipophilic compounds found in Cannabis sativa L., are attracting significant clinical interest for their multifaceted therapeutic potential, particularly within oncology. This review provides a comprehensive synthesis of contemporary knowledge detailing the distinct anti-cancer properties of phytocannabinoids (such as δ-tetrahydrocannabinol and cannabidiol), endogenous endocannabinoids, and synthetic analogues. Accumulating evidence from robust in vitro and in vivo oncological models demonstrates that these compounds aggressively suppress tumor progression …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 15, Issue 2, 2026 · pp. 17–30 Read article
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IoT-based Heart Attack Prediction System Using Machine Learning
Abstract: Heart disease, particularly heart attacks, is one of the leading causes of mortality worldwide. Timely detection and prompt intervention play a vital role in significantly improving the survival rates of individuals at risk of cardiac events. Unfortunately, most traditional healthcare systems are not equipped with mechanisms for continuous, real-time monitoring of patients' cardiovascular health. This limitation makes it extremely difficult for healthcare providers to identify warning signs early enough to …
Published in Journal of Telecommunication, Switching Systems and Networks · Vol. 12, Issue 2, 2025 · pp. 1–5 Read article
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Comparison of Several Clinical Scoring Systems in Predicting the Outcome of Variceal Bleeding
Abstract: Background: Stratification of variceal bleeding patients into high-risk and low-risk group is very important to guide them through the suitable clinical pathway and to save the medical costs. We purposed to find out the best scoring system in the prediction of rebleeding and death after variceal bleeding by comparing four clinical scoring systems(clinical Rockall score, complete Rockall score, AIMS65 score, Child-Pugh score) which seemed to be applicable and simple. Method: …
Published in Research and Reviews: A Journal of Medicine · Vol. 15, Issue 2, 2025 Read article
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CARDIOVASCULAR EVALUATION OF NEONATES WITH PERINATAL ASPHYXIA WITH SPECIAL REFERENCE TO CARDIAC TROPONIN T LEVELS ,CREATINE KINASE MB AND 2D ECHO.
Abstract: Methods:70 term babies with perinatal asphyxia were selected as cases.They were evaluatedwithin 24 hours of birth using echocardiography and cardiac enzymes i.e. Troponin T andCK-MB levels .Results:Incidence of cardiac dysfunction in neonates was reported and correlated withcardiac enzymes.Majority had moderate HIE (51.4%), a total of 23 (32.9%) had mild HIEand 11 (15.7%) had severe HIE.Echo findings were abnormal in 45 / 70 (64.3%) of neonateswith Tricuspid regurgitation being most common …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 11, Issue 3, 2022 · pp. 29–42 Read article
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Dental Implant Analysis Using the Wear and Hardness Testing Method
Abstract: We will compare the number of implants from the manufacturer using either an analytical approach or a software-based approach using Minitab software regarding structural dental implants. Several factors influence a dental implant, and new bone grows. The implant surface is one of the elements that have a major impact on the quality of osteointegration. Various techniques and resources have been employed to modify an implant's surface to encourage osseointegration along …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 Read article
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Lesser-Known Metabolites Influencing Ovarian Function, Follicular Development, and Embryo Viability in Dairy Cows
Abstract: The intricate processes of ovarian function, follicular development, and embryo viability in dairy cows are tightly regulated by a complex network of metabolites. While conventional biomarkers, such as steroid hormones, amino acids, and glucose metabolites, have been extensively studied, a growing body of evidence suggests that lesser-known metabolites play pivotal roles in bovine reproductive physiology. Dairy cattle fertility is critical for maintaining optimal milk production and herd sustainability, necessitating deeper …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 15, Issue 3, 2025 · pp. 18–29 Read article
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Immune Dysregulation and Cytokine Circuitry in Genital Endometriosis: Mechanistic Insights and Next-Generation Immunotherapeutic Strategies
Abstract: Genital endometriosis is increasingly recognized as an immune-mediated inflammatory disorder driven by complex interactions between dysregulated immune cells, cytokine hubs, and microbiome-derived modulators. This review introduces a novel “immune–cytokine circuitry” framework that unifies innate and adaptive immune abnormalities with key cytokine loops sustaining chronic inflammation, angiogenesis, neuroinflammation, and immune tolerance. Within this circuitry, macrophage polarization, dendritic cell immaturity, NK-cell anergy, Treg expansion, Th17 amplification, and B-cell–mediated autoimmunity converge to establish …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 06–16 Read article
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Lung Cancer Detection and Classification Using Deep Learning
Abstract: Lung cancer is a disease that can be effectively treated if detected early. Various technologies, such as magnetic resonance imaging, isotopes, X-rays, and computed tomography scans, are employed for diagnosis. One of the most crucial strategies in combating cancer is early detection, which greatly enhances a patient’s likelihood of survival; this is where artificial intelligence plays a significant role. The approach proposed in this study leverages historical medical data to …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 3, 2024 · pp. 11–17 Read article