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412 articles for “PKA/CREB pathway”
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Therapeutic Potential of Plant-Derived Phytochemicals in Targeting Receptor Pathways Related to Non-Enzymatic Glycation: A Meta-Analysis
Abstract: Background: Non-enzymatic glycation, where reducing sugars react with proteins, lipids, and nucleic acids, contributes to various pathological conditions, such as diabetic complications and cardiovascular diseases. This process is facilitated by the receptor for advanced glycation end-products (RAGE), which is pivotal in driving inflammation and causing tissue damage. Objective: This meta-analysis evaluates the effects of plant-derived phytochemicals on RAGE expression and associated signaling pathways, assessing their therapeutic potential in glycation-related diseases. …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 1, 2025 · pp. 60–73 Read article
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Colostrum-Driven Epigenetic Programming in Dairy Cows: A Pathway to Optimal Reproductive Health
Abstract: Colostrum is a vital nutritional source for neonatal calves, providing immune support and essential growth factors. Recent research suggests that colostrum’s impact extends beyond immediate immunological protection, influencing long-term reproductive health through epigenetic modifications. In dairy heifers, early-life exposure to high-quality colostrum may program the developing reproductive system, affecting ovarian function, uterine health, and overall fertility. The components of colostrum, including hormones, growth factors, and bioactive peptides, can induce epigenetic …
Published in Emerging Trends in Metabolites · Vol. 2, Issue 1, 2025 · pp. 35–51 Read article
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Climate-Induced Infertility in Dairy Cows: Pathways, Challenges, and Solutions for Sustainable Dairy Development
Abstract: Climate change has emerged as a significant challenge to dairy production, with profound implications for reproductive performance in dairy cows. The interplay of rising temperatures, fluctuating rainfall patterns, and increased frequency of extreme weather events disrupts key physiological, nutritional, and behavioral processes essential for fertility. Heat stress alters hormonal balance, impairs oocyte and embryo quality, reduces estrus expression, and affects pregnancy outcomes. Concurrently, climate-induced nutritional deficits, immune suppression, and increased …
Published in International Journal of Climate Conditions · Vol. 2, Issue 2, 2025 Read article
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AI-Enabled Recycling of Thermoplastic Polymer Waste in Hospitals: A Circular Economy Pathway Toward Green Hospital Certification
Abstract: This review research explores the latest role of AI in improving thermoplastic waste management for hospitals in terms of segregation accuracy, operational efficiency, and circular economy outcomes. Seventy-five relevant studies were analysed, and it was reported that AI-based systems, especially CNNs, YOLO models, and sensor-fusion approaches, achieved high accuracy in the identification and sorting of medical plastics, often above 90%. Early evidence also reveals improvements in the reduction of contaminants, …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 170–182 Read article
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Microvita as a Fermi-Boson Hybrid Quantum Excitation: A Statistical Pathway Toward Unified Physics, Chemistry, and Biological Organization
Abstract: This article reformulates Microvita as a hybrid quantum excitation that interpolates continuously between fermionic and bosonic statistical behavior. A generalized operator algebra, a dynamical statistical order parameter, and a Lorentz-covariant field equation are used to frame Microvita as an effective unification scheme rather than a mere philosophical construct. The formalism predicts renormalization-group flow between infrared fermionic and ultraviolet bosonic limits, while numerical profiles suggest vacuum-energy smoothing and topological-defect suppression in …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 17, Issue 1, 2026 · pp. 115–122 Read article
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Integrative Therapeutics for Antimicrobial Resistance and Autoimmune Disease: Evidence and Pathways
Abstract: Background: Antimicrobial resistance (AMR) is accelerating globally, while autoimmune diseases and adverse drug reactions (ADRs) continue to rise. Ayurveda offers immunomodulatory, antimicrobial, and detoxification‑oriented interventions that may complement biomedical strategies. Objective: To propose a hypothesis‑driven integrative model combining Ayurvedic phytotherapy, panchakarma detoxification, and personalized dosha‑based care with evidence‑based medical management to mitigate AMR emergence, modulate autoimmunity, and reduce ADR incidence. Methods: A synthesis of mechanistic literature on Ayurvedic herbs with …
Published in Research and Reviews : A Journal of Immunology · Vol. 16, Issue 2, 2026 · pp. 25–30 Read article
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Inhibition of PI3K/Akt/mTOR Signaling Pathway by Vitis Vinifera Phytocompounds: A Promising Strategy for Supressing Colorectal Cancer Growth and Metastasis
Abstract: Objectives: Colorectal cancer was not typically identified a few decades ago. Today, with almost 900 000 fatalities each year, it is the fourth most dangerous cancer in the world. Colorectal cancer is responsible for about 10% of all cancer diagnoses annually and cancer-related deaths worldwide. It is the second most common type of cancer in women and the third most common type in men. Incidence and death are roughly 25% …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 · pp. 64–75 Read article
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The Role of Social Media Analytics in Integrated Marketing Communication and Understanding Consumer Behaviour: The Pathway to Optimal Customer Relationship Management
Abstract: This study explores the role of social media analytics in understanding consumer behavior within the context of Integrated Marketing Communication (IMC). Businesses now have access to a lot of data thanks to the spread of social media platforms, which can give them important insights into consumer preferences, attitudes, and behaviors. This study discusses the methodologies and tools used in social media analytics and how they can be leveraged to enhance …
Published in International Journal of Electronics Automation · Vol. 1, Issue 1, 2023 · pp. 22–29 Read article
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Bio-Inspired Membranes in Oral Drug Delivery: A Pathway to Enhanced Permeability and Targeted Therapy
Abstract: Bio-inspired membranes in oral drug delivery represent a significant advancement in pharmaceutical technology, harnessing principles of natural biological systems to improve drug permeability, bioavailability, and targeted release. This review discusses the design, materials, and fabrication techniques used in bio-inspired membranes, with a focus on materials like chitosan, silk fibroin, and synthetic polymers that mimic biological structures. By exploring the mechanisms of drug permeation, such as mucoadhesion and selective permeability, bio-inspired …
Published in International Journal of Membranes · Vol. 1, Issue 2, 2024 · pp. 39–52 Read article
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Environmental Horticulture: Pathways to Sustainability and Climate Resilience
Abstract: Environmental horticulture represents a multidisciplinary approach that combines plant cultivation, landscape management, and sustainable practices to address pressing global environmental challenges while promoting ecological and societal well-being. This study delves into key themes such as sustainable horticulture, urban agriculture, vertical farming, hydroponics, aquaponics, and their significant contributions to biodiversity conservation, soil and water preservation, and climate change mitigation. The integration of innovative practices like green roofs, living walls, and biophilic …
Published in International Journal of Trends in Horticulture · Vol. 1, Issue 2, 2024 · pp. 33–38 Read article
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Livestock and Rural Livelihoods: Nutritional, Economic, and Environmental Pathways to Sustainable Development
Abstract: Livestock play a pivotal role in sustaining rural livelihoods by contributing to economic stability, social empowerment, and environmental resilience. This study explores the diverse functions of livestock in rural communities, focusing on their contributions to income generation, food security, nutrient cycling, and cultural practices. Livestock provide essential goods such as milk, meat, eggs, and fiber, which not only enhance household nutrition but also generate revenue for millions of rural families. …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 14, Issue 2, 2025 · pp. 40–56 Read article
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Communication Pathways and Project Success: Analyzing Stakeholder Coordination Impacts on Construction Outcomes
Abstract: It is very critical to have effective communication and coordination among stakeholders for the successful delivery of the projects. Effective communication keeps stakeholders well-informed about project progress, promoting transparency, trust, and collaboration. Coordination ensures that responsibilities and resources are efficiently allocated, reducing the risk of misunderstandings and enhancing decision-making processes. Inadequate stakeholder engagement can lead to confusion, delays, rework, and the failure to meet key project milestones. The impact of …
Published in Journal of Construction Engineering, Technology & Management · Vol. 15, Issue 3, 2025 · pp. 104–126 Read article
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Functional Role of Feed Enzymes in Broiler Diets: A Pathway to Enhanced Nutrient Utilization, Performance, Health and Welfare
Abstract: The inclusion of feed enzymes in broiler diets has emerged as a pivotal strategy for improving nutrient utilization, enhancing growth performance, and promoting overall health and welfare in modern poultry production. Feed enzymes, such as phytase, xylanase, and protease, facilitate the breakdown of complex molecules in feed ingredients, leading to increased bioavailability of essential nutrients and improved digestion efficiency. This review explores the underlying mechanisms by which feed enzymes contribute …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 2, 2025 · pp. 9–17 Read article
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Pathways in Drug Discovery and Development: From Molecular Targets to Market Approval
Abstract: A complicated, multidisciplinary, and resource-intensive process, the discovery and development of new pharmacological drugs is essential to the advancement of contemporary medicine. Finding and optimising lead chemicals comes after a disease-relevant biological target has been identified and validated. Through preclinical research in animal models, these leads are thoroughly assessed for toxicity, pharmacokinetics, safety, and efficacy. Clinical trials, which are carried out in several stages to evaluate safety, efficacy, ideal dosage, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 1, 2026 · pp. 01–04 Read article
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Understanding Airborne Pathogens: Pathways, Risks, and Control Strategies
Abstract: Airborne transmission is the transfer of germs through the air, mostly by respiratory droplets and aerosols that come out when you cough, sneeze, talk, or breathe. These particles can stay in the air for a long time and move a long way, especially in small or poorly ventilated places. Mycobacterium tuberculosis, measles virus, varicella-zoster virus (chickenpox), influenza virus, and more recently, SARS-CoV-2 are all infections that can be spread through …
Published in International Journal of Pathogens · Vol. 2, Issue 2, 2025 Read article
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Drug Induced Immune Mediated Nephritis: Molecular Mechanism , Pathways and Clinical Implications
Abstract: Drug-induced immune-mediated nephritis (DI-IMN) has become a more widely known cause of acute kidney injury (AKI), with the potential for development to chronic kidney disease if not detected and treated promptly. T-cell hypersensitivity to pharmaceuticals, such as antibiotics, proton pump inhibitors, nonsteroidal anti-inflammatory drugs, and immunological drugs, are the major causes for it. Beyond clinical burden, DI-IMN reflectsintricate molecular interactions that sustain interstitial inflammation and tubular injury. These interactions include …
Published in International Journal of Toxins and Toxics · Vol. 3, Issue 1, 2026 · pp. 13–29 Read article
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Photochemical Detoxification of Arsenic- and Mercury-Contaminated Soils: Geochemical Mechanisms and Pathways
Abstract: This study evaluates the geochemical aspects of soil detoxification in areas contaminated with arsenic (As) and mercury (Hg), emphasizing sustainable strategies for improving soil health and ensuring safe crop production. The research provides an ecological and toxicological assessment of regional soils and classifies them base on the concentration and mobility of toxic elements. Although the current levels of As and Hg do not yet present a critical risk to agricultural …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 4, Issue 1, 2026 · pp. 06–10 Read article
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Genetic Counseling: A Pathway to Understanding and Managing Inherited Health Risks
Abstract: Genetic counseling is an essential aspect of personalized medicine that supports individuals and families in understanding the implications of inherited health conditions. With the rising prevalence of genetic disorders and advancements in genomic technologies, counseling provides critical insights into risk factors, diagnostic options, and informed decision-making. This paper explores the classification of genetic disorders, major genetic and environmental causes, and the expanding role of genetic counseling within India’s culturally diverse …
Published in International Journal of Evidence Based Nursing And Practices · Vol. 4, Issue 1, 2026 · pp. 10–14 Read article
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Analyzing The Mechanisms of Polymerization and The Related Kinetic Pathways Using Refined Analytical Methods.
Abstract: In numerous sectors, polymeric materials play a crucial role, yet effectiveness is largely determined by their molecular structure and the processing parameters utilized. This investigation presents an integrative approach aimed at delineating the connections between polymer structure, properties, and processing through sophisticated characterization methods. With the implementation of small angle X Ray Scattering (SAXS),NMR(Nuclear magnetic resonance( spectroscopy) FM(Atomic Force Microscopy) and rheological analysis, we analyze the complex interplay between molecular …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 86–94 Read article
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Fluid Dynamics of a Stressed Freshwater Lens: Integrated Flow Modeling and Pathways for Material-Centric Interventions in Khadir Island, Gujarat
Abstract: This study applies principles of fluid dynamics and porous media mechanics to analyze the behavior and sustainability of the freshwater lens in Khadir Island, an arid sedimentary island in Gujarat, India. We develop an integrated fluid flow model that couples surface hydrology with aquifer dynamics to quantify recharge fluxes, extraction stresses, and hydraulic responses. Using 11-year hydro-meteorological data (2011–2021) and sectoral demand projections, we characterize the island’s water budget through …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 12–29 Read article