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40 articles for “Liver Enzymes”
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Pyrethroid Mediated Some Macromolecular and Biochemical Changes in Freshwater Teleost
Abstract: Abstract In present investigation, a freshwater fish Channa punctatus was exposed for 21 days to synthetic pyrethroid malathion at sublethal concentrations of 0.007mg L−1 and 0.093 mg L−1 that represented 10% of the 96 h LC50 of the pesticide for this fish. Tissue samples were collected at the end of the experiment and analyzed to determine oxidant/antioxidants status (catalase, LDH, DNA content, protein content, cortisol, etc.) of the fish. Enzyme …
Published in Research and Reviews: A Journal of Toxicology · Vol. 10, Issue 2, 2020 · pp. 14–21 Read article
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Mirabilis Jalapa Flower Extract as Natural Food Dye and Green Cellular Delivery of Nanoparticles
Abstract: Use of artificial colouring agents in sweets and packed food has become a common scenario now a day, which pose serious consequences in consumers especially children. Various studies around the globe reported the serious health hazards of artificial food dyes which include organ damage of liver, kidney and lungs thereby affecting metabolic enzymes, serum creatine and urea levels and brain damage resulting in neurotoxicity and even behavioural deficits in children. …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 8, Issue 2, 2023 · pp. 27–34 Read article
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Review on Histological and Functional Effect of Alcohol on Liver and Kidney
Abstract: Alcohol consumption represents the third largest risk factor for disease burden in most countries of the world. The purpose of this review is to give a comprehensive report of the existing data on the potential adverse effects of alcohol on liver and kidney toxicity. We used 82 different published materials for the compilation of this review article. The Google search engine was used for accessing published materials from databases like …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 7, Issue 2, 2018 · pp. 49–62 Read article
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The Role of Pyruvate Dehydrogenase in Non-Alcoholic Fatty Liver Disease: Therapeutic Insights and Future Directions
Abstract: Non-alcoholic fatty liver disorders (NAFLD) are defined by the accumulation of excess fat in the liver that has no other cause, such as drinking alcohol. Pyruvate dehydrogenase has been established as an alternative treatment for this disorder. NAFLD pathogenesis is complex and includes oxidative stress inflammatory processes and mitochondrial dysfunction. Impaired liver fatty acid oxidation and glucose oxidation are significant individuals in developing NAFLD, and strategies to reverse these defects …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 44–51 Read article
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Effects of Chlorpyrifos as Inducer for Oxidative Stress in Liver, Kidney and Spleen of Freshwater Fish, Pseudetroplus maculatus (Bloch, 1795)
Abstract: Chlorpyrifos is one of the most common organophosphate insecticides found abundantly in freshwater ecosystems and has been detected in agricultural and fishery products worldwide. The study focused to determine the effect of chlorpyrifos on the induction of oxidative stress in freshwater fish Pseudetroplus maculatus. Fish were exposed to sublethal concentrations (0.661 and 1.32 μg/l) of chlorpyrifos for 15 and 30 days. Activities of antioxidant enzymes and the levels of hydrogen …
Published in Research and Reviews: A Journal of Toxicology · Vol. 8, Issue 1, 2018 · pp. 20–29 Read article
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A review: Emphasis on the connection between hormones modifiable plasma lipids and metabolism of lipid in obesity
Abstract: Lipid dysfunction directly related with the obesity because increased low-density lipoprotein and triglyceride level elevated causes obesity by various mechanism. Many complications produce due to disturb metabolism of fatty acid and transferring in between various tissues. Current effort sophisticatedly established impaired fatty acid insnaring in obese persons. Additionally, overweight individuals have declined acceptance of nutritional fat through adipose tissue primary level due to this reason low-density lipoprotein level increase in …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 13, Issue 1, 2023 · pp. 1–5 Read article
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Hepatoprotective Role of Exogenous Melatonin and Insulin Plant (Costus IgneousNak.) Extract against the Streptozotocin Induced Diabetes in Rats
Abstract: The aim of the present study was to compare hepatoprotective efficacy of exogenous melatonin and insulin plant extract against streptozotocin induced hepatic complications. To induce diabetes adult female rat were administrated with STZ (15mg/kg) for consecutive six days. The confirmation of diabetic model was analyzed by blood glucose test. Following confirmation diabetic rat model were treated with exogenous MEL intraperitoneally and plant extract was administered orally. Administration of MEL and …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 1, 2018 · pp. 25–36 Read article
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The Therapeutic Repertoire of Turmeric
Abstract: ABSTRACTTurmeric has been used in the treatment of arthritis, and other inflammatory conditions, for ages. Its healing constituent, curcumin, has been found to curb the incendiary activity of the COX-2 and lipooxygenase, the two enzymes involved in elevating and sustaining inflammation. It is also suggested that curcumin has a protective effect on the liver, thanks to its anti-tumour resolve, aside from its ability to easing inflammation and combating infections. This …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 5, Issue 2, 2018 · pp. 1–9 Read article
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Protective Effects of Phyllanthus amarus and Sida acuta Extracts Against DoxorubicinInduced Toxicity in Chick Embryo Models
Abstract: Chemotherapy remains a cornerstone of cancer treatment, yet severe side effects, including cardiotoxicity often limit its clinical application. Doxorubicin, a widely used anticancer drug, is particularly associated with dose-dependent toxicities that impact the heart, liver, and kidneys. In search of complementary approaches to mitigate these adverse effects, this study evaluates the protective potential of hydro-alcoholic extracts from Phyllanthus amarus and Sida acuta, two medicinal plants with known antioxidant and anti-inflammatory …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 2, 2025 Read article
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Occupational Hepatocellular carcinoma : A review
Abstract: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths. The relationship between occupation and liver cancer has not been extensively studied however. Approximately 80% of HCC patients have had an established history of chronic liver disease and infection with hepatitis B virus (HBV) and hepatitis C virus (HCV). Nonalcoholic steatohepatitis (NASH), obesity, diabetes and smoking also increase the risk of HCC development significantly. Currently, only vinyl chloride monomer …
Published in Research and Reviews: A Journal of Medicine · Vol. 1, Issue 1, 2011 · pp. 98–106 Read article
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Role of Endogenous and Exogenous Glutathione in the Detoxification of Free Radicals
Abstract: The aging process and disease progression are the result of cellular damage by free radicals. Our first lines of defense against free radical damage are the antioxidants. They are critical for keeping optimal health and wellbeing. The need for antioxidants becomes more critical with increased exposure to free radicals. Pollution, drugs, cigarette smoke, illness, stress, and even exercise can increase free radical exposure. The accumulation of free radicals produced from …
Published in Research and Reviews: A Journal of Toxicology · Vol. 7, Issue 1, 2017 · pp. 1–14 Read article
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Protective Role of Sulforaphane against Multiorgan Toxicity in Rats: An In-vivo and In-vitro Review Study
Abstract: Sulforaphane [1-isothiocyanate-(4R) -(methylsulfinyl) butane] is a natural dietary isothiocyanate produced by the enzymatic accomplishment of the myrosinase on glucopharanin, a 4-methylsulfinylbutyl glucosinolate contained in cruciferous vegetables such as broccoli, brussel sprouts, and cabbage. Exploring of this compound against various oxidative degenerative diseases such as hepatic, nephro and cardiac diseases is growing because of its anticarcinogenic and cytoprotective properties. In several invivo and invitro experimental paradigms proved SFN and its compounds …
Published in Research and Reviews: A Journal of Toxicology · Vol. 8, Issue 1, 2018 · pp. 1–8 Read article
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Protein Deficiency and Poisoning
Abstract: Proteins are the building blocks of enzymes, hormones and many other important compounds. So it is important to maintain its balance in the body. Excess or deficiency of protein may lead to certain diseases which are harmful for the human system. Diseases such as edema, fatty liver, increase in severity of infection, greater appetite, more risk for bone fracture, skin hair and nail problem, less muscle mass, nausea, headache, mood …
Published in Research and Reviews: A Journal of Medicine · Vol. 13, Issue 1, 2023 · pp. 9–14 Read article
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Recombinant Lactobacillus helveticus PJ4-Down Regulates TLR4 Mediated Inflammatory Responses in Sucrose Induced Diabetic Rats: A Novel Therapeutic Approach
Abstract: High sucrose diet (HSD) is known to induce type 2 diabetes. Recombinant Lactobacillus helveticus PJ4 was constructed to express the InuJ gene under the xylose promoter resulting in the secretion of inulosucrase enzyme in gastrointestinal tract which polymerizes the fructose moiety of sucrose to inulin type fructans. L. helveticus (pSLP-InuJ-Vhb) transformant (LHI) was intragastrically administered to rats fed with HSD diet. The composition of fecal microbiota and short-chain fatty acids …
Published in Research and Reviews : A Journal of Immunology · Vol. 7, Issue 2, 2017 · pp. 44–65 Read article
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Deciphering the Roles of Estrogen Receptors and 27-Hydroxycholesterol in BC Progression
Abstract: Breast cancer (BC) ranks among the top causes of cancer-related deaths in women worldwide. Many risk factors of BC are linked to estrogen. Experiments of Beatson in 1896 show the role of steroid hormones as major determinant in BC. Action of steroid hormones is mediated by their receptors including Estrogen receptors (ERs). ERs are part of a subfamily of ligand-regulated transcription factors. Their primary role is to translate hormone signals …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 2, 2024 · pp. 18–26 Read article
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Hematobiochemical Alteration in Naturally Infected Cattle with Fasciola under Tropical Region
Abstract: Fascioliasis is among one of the emerging and re-emerging disease which has zoonotic importance and spread by feco-oral route. The migrating fluke causes extensive liver damage results in economic burden to the animal farmer. In present investigation 20 cattle were used to evaluate the hemato-biochemical alteration in naturally acquired fasciola infection and without other diseases. Decreased Hemoglobin, Packed cell volume (PCV), Red blood cells (RBC) count whereas; an elevated level …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 4, Issue 1, 2015 · pp. 20–23 Read article
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Harnessing the Healing Potential of Khamira Abresham Hakim Arshad Wala in the Management of Different Health Conditions
Abstract: Khamira Abresham Hakim Arshad Wala (KAHAW) is a potent Unani remedy that plays a vital role in fortifying the body's vital organs and efficiently reducing free radicals by enhancing levels of antioxidant enzymes. The term 'Khamira' originated from the Unani system of medicine and was first introduced by the esteemed Hakeem during the Mughal period. This preparation involves incorporating herbal drugs into a base (Qiwam) containing sugar or honey, resulting …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 11, Issue 1, 2024 · pp. 7–13 Read article
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The role of Ethylacetate fractions of Parkinsonia aculeata and Newbouldia laevis against Carbon Tetrachloride Toxicity in Rats
Abstract: This research work studied the preventive effect of ethylacetate fractions of Parkinsonia aculeata and Newbouldia laevis using carbontetrachloride (CCl 4 ) model to induce toxication in rats. Increased (p<0.05) serum concentrations of enzymes and non-enzymes biochemicalparameters such as lactate dehydrogenase, gamma glutamyl transferase, alkaline phosphatase, alanine and aspartate transaminases andtotal bilirubin, were seen in group of rats administered only carbon tetrachloride. However, groups that received 100 to 200mg/kg of thetwo …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 9, Issue 2, 2022 · pp. 39–50 Read article
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Pathogenesis, Immune Response and Vaccine Development in Amoebiasis
Abstract: Worldwide, approximately fifty million cases of invasive E histolytica disease occur each year and resulting in more than 100,000 deaths. It is the second leading cause of mortality due to a protozoan parasitic infection after malaria. Entamoeba histolytica infection is associated with considerable morbidity and mortality in the form of intestinal and extra-intestinal amoebiasis especially in developing countries. Recent molecular studies have conclusively proved that there are morphologically similar species …
Published in Research and Reviews : A Journal of Immunology · Vol. 5, Issue 3, 2015 · pp. 30–35 Read article
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Arsenic Induced Oxidative Stress and Its Possible Reversal by Chelation Therapy
Abstract: Arsenic (As) is a metalloid listed in group Va of the periodic chart. It exists in nature in the oxidation states +V (arsenate), +III (arsenite), 0 (arsenic) and −III (arsine). In the aqueous environment inorganic arsenic appears commonly in the oxidation states +V and +III as arsenous acid (As (III)), arsenic acid (As (V)), and their salts. Chronic and acute exposures of arsenic leads to cancer, cardiovascular disease (hypertension and …
Published in Research and Reviews: A Journal of Toxicology · Vol. 2, Issue 2, 2012 · pp. 16–37 Read article