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Research & Reviews: A Journal of Drug Design & Discovery

The role of Ethylacetate fractions of Parkinsonia aculeata and Newbouldia laevis against Carbon Tetrachloride Toxicity in Rats

  1. S.W. Hassan
  2. A. H. Umar
  3. R.A. Umar
  4. M. I. Abdullahi

Abstract

This research work studied the preventive effect of ethylacetate fractions of Parkinsonia aculeata and Newbouldia laevis using carbontetrachloride (CCl 4 ) model to induce toxication in rats. Increased (p<0.05) serum concentrations of enzymes and non-enzymes biochemicalparameters such as lactate dehydrogenase, gamma glutamyl transferase, alkaline phosphatase, alanine and aspartate transaminases andtotal bilirubin, were seen in group of rats administered only carbon tetrachloride. However, groups that received 100 to 200mg/kg of thetwo ethylacetate fractions of the plants showed a reverse order of the parameters. Vitamins C and D, catalase, glutathione andsuperoxide dismutase were found to decrease (P<0.05) but increases (P<0.05) in the levels of lipid peroxides were seen in rats thatreceived only carbon tetrachloride. Different doses of the combined ethylacetate fractions and silymarin showed a significant increase ofthe antioxidants but a decrease of lipid peroxides was observed. The histopathology study of the liver sections of CCl 4 -intoxicateduntreated rats showed massive fatty changes and necrosis, these changes were reversed in the combined extract treated groups.
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