Research & Reviews: A Journal of Drug Design & Discovery
Volume 9, Issue 2 (2022)
Published
Table of contents
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In Silico Assessment of Drug like Properties of Some Thiadiazole and Oxadiazole Derivatives as HDAC Inhibitors
Abstract: Purpose: To investigate in silico the drug-like properties of some thiadiazole and oxadiazole derivatives as HDAC inhibitors. Methods: We used Chemdraw Ultra 11.0 to redraw all chemical structures. Furthermore, some applications, such as Bio-Loom for Windows - version 1.5, Molinspiration Property Calculator, and ACD/I-LAB, were used to forecast the drug-like properties of thiadiazole and oxadiazole derivatives, including relative molecular mass (MW), partition coefficient log P (cLog P), number of hydrogen …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 9, Issue 2, 2022 · pp. 1–13 Read article
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Green Leafy Vegetables of Chhattisgarh Containing Vitamins and Minerals
Abstract: The present studies of Chhattisgarh Plants have been utilized as a natural source of medicinal compounds in recent years. Chhattisgarh region plants and plant-derived products is commonly used to cures and relief various physical and mental illnesses.. In Chhattisgarh state, various populations of tribal rural and local populations used various types of leafy vegetables. These tribal and local populations of Chhattisgarh particularly people around the forest area depend on leafy …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 9, Issue 2, 2022 · pp. 13–19 Read article
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Pharmaceutical Standardization of Rakta Akika Bhasma and Pishti
Abstract: Background: Akika Pishti is widely used in therapeutics to treat various disease conditions like Hridaroga (Cardiac disease) Manoroga (psychic disorders) and Raktaja Vikara (bleeding disorders). Some references found in classics also emphasized the use of Akika Bhasma. However, no work has been done to date to standardise Rakta Akika Bhasma and Pishti's pharmaceuticals. Aim: The present research work is aimed to establish the pharmaceutical standardization of Rakta Akika Bhasma and …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 9, Issue 2, 2022 · pp. 20–29 Read article
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A Review on Biotechnological Aspects of Conservation and Enhancements of Indian Snakeroot (Rauwolfia serpentina)
Abstract: Indian snakeroot (Rauwolfia serpentina) is one of the most important medicinal plants found in the Indian subcontinent, used in the treatment of various types of diseases. Recently it has been considered as a critically endangered plant by the International Union of the Conservation of Nature and Natural Resources (IUCN) due to its heavy exploitation in the past. The plant has a high demand in the international market due to its …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 9, Issue 2, 2022 · pp. 30–38 Read article
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The role of Ethylacetate fractions of Parkinsonia aculeata and Newbouldia laevis against Carbon Tetrachloride Toxicity in Rats
Abstract: This research work studied the preventive effect of ethylacetate fractions of Parkinsonia aculeata and Newbouldia laevis using carbontetrachloride (CCl 4 ) model to induce toxication in rats. Increased (p<0.05) serum concentrations of enzymes and non-enzymes biochemicalparameters such as lactate dehydrogenase, gamma glutamyl transferase, alkaline phosphatase, alanine and aspartate transaminases andtotal bilirubin, were seen in group of rats administered only carbon tetrachloride. However, groups that received 100 to 200mg/kg of thetwo …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 9, Issue 2, 2022 · pp. 39–50 Read article