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142 articles for “Inhibitory”
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In vitro Combination Studies of Antibiotics against Bacterial Pathogens
Abstract: Antibiotic-resistant microorganisms are emerging worldwide and causing serious complications. As these microorganisms are resistant to most of the contemporary antibiotics, their control is becoming as a global health concern. Therefore, there is a need for new alternative compounds or strategies that are effective against these microbial infections and in preventing or delaying their resistance. This study was carried out to test Rifampicin as an adjuvant therapeutic agent in the treatment …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 2, Issue 1, 2012 Read article
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The Use of Allelopathic Extracts of the Resedues of Ceratophyllum demersum L. and Cuscuta trifolii Bab L. as Biocides for Some Jungles Associated with the Growth of Triticuma estivum L. in the Fields of Najaf Governorate
Abstract: This study was conducted to assess the inhibitory activity of the plants Ceratophyllum demersum L.. and Cuscutatrifolii Bab L. and Cyperus rotundus L. Water and alkhol extracts on germination and growth of Medicago hispida L., Sonchus oleraceus L . Seeds of the test plants were grown in Petridishes water-alkehol extracts at concentrations of )0%, 20%, 40%, 60% and 80%(.Plant extracts showed a significant reduction of germination percentage, velocity coefficient of …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 13, Issue 1, 2023 · pp. 1–11 Read article
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Mechanistic Studies on Aziridinyl-Benzoquinones in Cultured Tumour Cells
Abstract: This study compares the anti-tumour effects of NQO1 activated drug RH1 (2, 5-diaziridinyl-3 - hydoxymethyl-6-methyl-1, 4-benzoquinone) with a lipophilic ester derivative Es5 on the isogenic cell lines MDA 468 and MDA 468 NQO1 which differs only in expression of wtNQO1. A 39- fold enhancement of growth inhibitory activity was seen in NQO1 expressing cells compared the NQO1 null cells for the Es5 compared to the 25- fold increase seen for …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 11, Issue 2, 2023 · pp. 37–45 Read article
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Molecular Docking Evaluation of Cedrus deodara Secondary Metabolites as a Potent Anti-ovarian Cancer Agent
Abstract: Objective: According to the statistics for the year 2022 it was seen that cancer total cases is 14,61,427. After breast cancer, ovarian cancer is the second most frequent cancer among women. The estrogen receptor (PDB ID: 1X7E), progesterone receptor (PDB ID: 1A28), and Phosphoinositide 3-kinases (PDB ID: 4FJY) can be considered as target protein for ovarian cancer. The plant Cedrus deodara and its phytochemicals were chosen in this study to …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 77–93 Read article
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Study The Effect of The Alcoholic and Hot Aqueous Extract of Costus specious on Some Bacterial Species
Abstract: Plant extracts are among the methods that have been used since ancient times in alternative medicine and are still developing until recently with the progress of science and modern technologies. These materials can be used in the composition of many pharmaceutical drugs. The current research aimed to evaluate the inhibitory effect of alcoholic and hot aqueous extract of the roots of Costus specious on some gram-positive and gram-negative bacteria (Enterococcus …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 3, 2024 · pp. 13–18 Read article
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The ability of Henna Leaf Extract to affect The growth of some Fungi
Abstract: The study was conducted by preparing an aqueous extract of henna leaves, which were collected from A garden in a house located in Najaf Governorate was used to test the inhibitory effects of an extract against two fungal isolates: Aspergillus niger and Candida albicans. The extract was prepared in a series of concentrations: 5, 10, 15, 20, and 25 mg/ml. The results showed an inhibitory effect of the concentrations used …
Published in OmniScience: A Multi-disciplinary Journal · Vol. 15, Issue 2, 2025 Read article
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In vitro Antibacterial Activity of Dietary Spice Trigonella foenum-graecum and Syzygium aromaticum
Abstract: Multi-drug resistant strains of bacteria are broadly distributed in hospitals and are progressively being isolated from community. The aim of the contemporary study was to govern the potential of spices Trigonella foenum-graecum (Fenugreek) and Syzygium aromaticum (Clove) as antibacterial mediators against drug resistant and virulent strains of gram negative pathogens quarantined from urinary pathway infections. Twelve bacterial isolates from urinary tract infections were studied for their ability to produce virulence …
Published in Research & Reviews : Journal of Herbal Science · Vol. 5, Issue 1, 2016 · pp. 6–11 Read article
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In-Silico Design and Study of Novel Tetrahydro-β-Carbolines as Inhibitor of HIV-1 Reverse Transcriptase
Abstract: In the present study, we have designed 50 novel tetrahydro-β-carboline derivatives as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Docking studies of designed analogs were performed by molecular modeling software AutoDock 4.2 using HIV-1 reverse transcriptase (PDB ID: 1RT2) as receptor. Lipinski rule of five parameters and toxicity parameters were derived through online servers Molinspiration and Osiris property explorer respectively. Docking parameters such as binding free energy and predicted inhibitory constant …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 3, Issue 1, 2016 · pp. 19–30 Read article
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2D QSAR Studies on Some Novel 17a-aza-D-Homo Steroids as 5α-Reductase Inhibitors
Abstract: The major circulating hormone dihydrotestosterone (DHT) is responsible for the development and progression of benign prostate hyperplasia (BPH). Dihydrotestosterone (DHT) is by produced by NADPH dependent reduction of testosterone (T) under the catalytic effect of the enzyme 5α-reductase (5 alpha R). Inhibition of 5α-reductase enzyme is the novel approach for treatment of BPH. Present work describes relationship between the 5α-reductase inhibitory activity for structurally related amides and esters of 17a-Aza-D-Homo-17-one …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 3, Issue 2, 2016 · pp. 1–14 Read article
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In Silico Pharmacological Evaluation of Certain Commercially Available Terpenoids As Αlpha-Amylase Inhibitors for The Management of Diabetes Mellitus.
Abstract: The objective of this study was to investigate the α-amylase inhibitory activity of certain commercially available terpenoids using in silico docking studies. In this perspective, terpenoids like Abietane, Artemisinin, Carvone, Cucurbitane, Ferruginol, Lupeol, Nerolidol, Retinol, Sabinene, and Zingiberene were selected. Glibenclamide, a well-known antidiabetic drug was used as the standard. In silico docking studies were carried out using AutoDock 4.2, based on the Lamarckian genetic algorithm as the working principle. …
Published in Research and Reviews : Journal of Computational Biology Read article
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Evaluation of Tectona Grandis Leaf Extract As A Green Corrosion Inhibitor for Aluminium in 1M NaOH
Abstract: A kind of tropical hardwood tree called the Tectona grandis tree that is indigenous to India. The name "teak tree" is another common name for this kind of tree. It is a member of the plant family that is referred to as Lamiaceae. The primary purpose of this research is to investigate whether or not the plant extract has a corrosion-inhibiting quality. In this study, an aqueous extract of Tectona …
Published in Journal of Polymer & Composites · Vol. 2, Issue 2, 2023 · pp. 41–50 Read article
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Exploration of 5-Hydroxybowdichione Flavonoids As Inhibitors of Dengue Virus Ns5 RNA-Dependent RNA Polymerase Using Molecular Docking Approach
Abstract: Objectives: Human lives are now seriously threatened by dengue fever, which is brought on by the dengue virus (DENV). Aedes aegypti mosquitoes, which reproduce in still water, are the primary vectors of the arboviral virus known as dengue. It is well-recognized that phytochemicals have a high potential to eliminate bacterial, viral, and fungal infections in people. Thus, it demonstrates its inhibitory effects on the dengue virus. This study identifies some …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 1, 2023 · pp. 1–16 Read article
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The Efficacy of Fig Extract on Some Candida spp.
Abstract: The study was conducted in Al-Amin Laboratory by preparing the alcoholic extract of fig leaves, which were collected from the garden of a house in Najaf Governorate / Al-Shuara’a during the month of December 2023 for the purpose of testing its inhibitory effectiveness against two isolates of the fungus Candida albicans and Candida dubliniesis taken from Al-Amin Scientific Research Laboratory, where serial concentrations of the extract were prepared (12,9,6,3) mg/ml., …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 14, Issue 2, 2024 · pp. 19–23 Read article
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A Review on Phytochemistry and Pharmacological Properties of Curcuma amada (Zingiberaceae)
Abstract: Plant has been employed in traditional medicine since ancient times. Curcuma amada Roxb. (Mango ginger), is a member of Zingiberaceae family and the Curcuma genus. It is a distinctive spice that shares a similar appearance with ginger but provides a raw mango taste. It is considered as a valuable plant in traditional medicine which plays a crucial function in both the food and pharmaceutical industries. Ayurveda and Unani medicinal traditions …
Published in Research & Reviews : Journal of Herbal Science · Vol. 13, Issue 3, 2024 · pp. 10–20 Read article
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Evaluation of Bio-Based Polymer Composites Containing Guava Leaf Extract for Antimicrobial Functionality
Abstract: This study explores the formulation of an herbal soap using guava leaf extract as a primary ingredient. Guava leaves are a rich source of biopolymers like pectin and cellulose, which may contribute to the binding properties in the soap. The antimicrobial activity of the soap was evaluated against common skin pathogens (Staphylococcus aureus, Trichoderma spp., Aspergillus spp.). The formulated soap exhibited inhibitory effects against all tested pathogens. The weight, foaming …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 875–880 Read article
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Effect of Different Incubation Times on the Effectiveness of Oyster Mushrooms Towards the Growth of Some Fungal Isolates
Abstract: The study was conducted by preparing the filtrate of the oyster mushroom Pleurotus ostreatus, where the effectiveness of the fungal filtrate prepared from growing the fungus in the liquid Potato Dextrose Broth (PDB) medium was selected for two different periods (14, 28 days) in inhibiting some types of fungi (Aspergillus Spp : Aspergillus niger ،Aspergillus flavus, Aspergillus terreus) and some types of fungi (Candida Spp: Candida albicans, Candida tropicalis, Candida …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 15, Issue 2, 2025 · pp. 1–8 Read article
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Hydroxylated Chalcone Derivatives as Future Aldose Reductase Inhibitors: Discovery through Docking Technique
Abstract: The research endeavors molecular docking assisted exploration of ALR inhibitory perspectives of some B-ring substituted hydroxyl group (A-ring) containing chalcone compounds against human aldose reductase in complex with NADP+ and the inhibitor IDD594 (PDB ID: 1US0) by utilizing the iGEMDOCK (Genetic Evolutionary Method for Molecular Docking) software. The present investigation immensely focused on the human aldose reductase inhibitory perspectives of some hydroxylated chalcone compounds. The inhibition of the enzyme by …
Published in Research and Reviews : Journal of Computational Biology · Vol. 8, Issue 1, 2019 · pp. 8–12 Read article
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In Silico Pharmacological Evaluation of Certain Commercially Available Terpenoids As Αlpha-Amylase Inhibitors for The Management of Diabetes Mellitus
Abstract: The objective of this study was to investigate the α-amylase inhibitory activity of certain commercially available terpenoids using in silico docking studies. In this perspective, terpenoids like Abietane, Artemisinin, Carvone, Cucurbitane, Ferruginol, Lupeol, Nerolidol, Retinol, Sabinene, and Zingiberene were selected. Glibenclamide, a well-known antidiabetic drug was used as the standard. In silico docking studies were carried out using AutoDock 4.2, based on the Lamarckian genetic algorithm as the working principle. …
Published in Research and Reviews : Journal of Computational Biology · Vol. 10, Issue 2, 2021 · pp. 1–9 Read article
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Molecular Docking of Compounds against Dengue Virus Serotype 2 and Prediction of ADME Properties Using Computational Approaches.
Abstract: Objective: Human lives are now seriously threatened by dengue fever, which is brought on by the dengue virus (DENV). It is well known that phytochemicals have a great deal of promise for curing human viral, bacterial, and fungal diseases. The purpose of this research was to develop drugs against the nonstructural protein (NS5) of dengue virus 2 (DENV2).Methods: Five phytochemicals from various medicinal plants were chosen for this research. The …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 1, 2023 · pp. 1–11 Read article
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Computational Examination of Curcumin Derivatives as Promising Inhibitors for BRCA1 and BRCA2 Proteins in Breast Cancer Treatment
Abstract: Objective: Breast cancer is a major problem for global health and one of the most popular and dangerous diseases. Data from the National Cancer Registry Program (NCRP) of the National Center for Disease Informatics and Research (NCDIR), an arm of the Indian Council of Medical Research (ICMR) in Bangalore, India, shows that an estimated 1,461,427 new cancer cases will occur… Conditions in India by 2022. Among these conditions, breast cancer …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 3, 2023 · pp. 68–87 Read article