Search
84 articles for “DNA”
-
Harnessing Bacteria for Next-Generation Data Storage Technologies – A Review
Abstract: The exponential increase in global digital information has created a pressing need for storage technologies that are more durable, compact, and sustainable than conventional electronic media. While hard drives, solid-state drives, and cloud-based systems have transformed information management, they face severe limitations related to storage density, energy consumption, maintenance costs, and long-term preservation. Researchers have, therefore, begun exploring biological systems as alternative information storage platforms. Among these, bacteria have emerged …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 2, 2026 Read article
-
A Note on Vaccine Design Using Bioinformatics Methods and Applications
Abstract: Vaccines prevent infectious diseases caused by viruses and bacteria saving millions of lives.It consists of certain agents that resemble disease causative agentsand stimulates our immune system to recognize and fight foreign antigens. Immune function or an immune response is the fundamental basis of the vaccine's mechanism. Vaccines are pharmaceutical derivatives that provide an affordable way to prevent diseases.Various bioinformatics approaches can be incorporated into vaccine design studies and development. Reverse …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 1, 2023 · pp. 1–9 Read article
-
Assessment of Decellularization Techniques for Fabrication of Tubular Submucosal Scaffolds from Small Intestine for Application in Oesophageal Tissue Engineering
Abstract: In this ground-breaking study, we sought to create superior tubular scaffolds for tissue engineering by utilizing small intestine submucosa (SIS), a remarkable biomaterial with outstanding therapeutic potential. We investigated two standard detergent-perfusion procedures, peracetic acid under perfusion and classic peracetic acid-agitation, to decellularize tubular SIS, with the goal of generating scaffolds with consistent and reliable properties for oesophageal tissue engineering. To assess biocompatibility, we employed metabolic research, microscopy, mechanical tests, …
Published in Journal of Polymer & Composites · Vol. 11, Issue 3, 2023 · pp. 30–38 Read article
-
Role of Epigenetic Mechanisms in Lung Fibrosis: Therapeutic Opportunities and Challenges
Abstract: Lung fibrosis poses a serious risk to one's health since it might result in respiratory failure due to an abnormal accumulation of fibrotic tissue in the lungs. Epigenetic mechanisms, such as histone changes, DNA methylation, and non-coding RNAs, closely control gene expression patterns and cellular processes associated with lung fibrosis. Anomalies in DNA methylation patterns connected to changes in gene expression profiles and disturbances in fibrotic signalling pathways are potential …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 2, 2024 · pp. 9–20 Read article
-
Identifying Origin of Replication (ORI) sites in genomic sequence using Python-based programming and Motif analysis in Bioinformatics
Abstract: ORI sites serve a critical function in DNA replication serving as the beginning point of the process. Identifying the spots appropriately means a lot and is important for the biologists working in the lab. Detecting the ORI is not only vital for the detection of replication sites but is also important in numerous biological processes. In this study, we offer a unique approach employing Python-based motif analysis to discover the …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 11, Issue 3, 2024 · pp. 22–33 Read article
-
Epigenetic Modifications in Health, Disease, and Precision Therapeutics (From Genome to Epigenome)
Abstract: Introduction: Epigenetic alterations play a crucial role in regulating gene expression in both normal physiological and disease states. These reversible modifications—such as DNA methylation, histone acetylation, phosphorylation, ubiquitination, and chromatin remodelling—are increasingly implicated in complex diseases including cancer and neurodegenerative disorders. Despite advances in standard therapeutic approaches, patient responses remain variable, largely due to genetic heterogeneity and epigenetic dysregulation. This highlights the need for incorporating epigenetic understanding into personalized medicine. …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 15, Issue 1, 2026 Read article
-
REVIEW OF PHARMACOEPIGENETICS: BRIDGING EPIGENETICS AND PERSONALIZED MEDICINE
Abstract: Pharmacoepigenetics is an emerging field that explores how alterations in gene expression, independent of DNA sequence changes, influence individual responses to drugs. Unlike pharmacogenetics, which focuses primarily on genetic variation, pharmacoepigenetics integrates genetic, environmental, and lifestyle factors to explain interindividual differences in drug efficacy, toxicity, and resistance. Key epigenetic mechanisms including DNA methylation, histone modifications, non-coding RNAs, and RNA methylation play critical roles in regulating drug metabolism and therapeutic outcomes. …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
-
Molecular Docking and Pharmacokinetic Profiling of the Phytocompounds of Jatropha curcas as Antagonist for Salmonella typhi
Abstract: Background: Typhoid is an infection caused by the Gram-negative bacterium, Salmonella enterica serovar typhi. The study assessed the potential use of Jatropha curcas as a typhoid fever therapy alternative to traditional medications. The ability to uncover novel drug indications for currently available medications using in silico methods has increased thanks to the wealth of pharmacological and biological knowledge that is available. Objective: In this study, we assessed the potential inhibitory …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 1, 2023 · pp. 67–81 Read article
-
Recombinant Insulin
Abstract: Recombinant insulin, a revolutionary product of biotechnology, has transformed the landscape of diabetes treatment. Developed through genetic engineering techniques, recombinant insulin offers a safer, more consistent alternative to traditional animal-derived insulin. Its production involves the insertion of the human insulin gene into host organisms such as Escherichia coli or Saccharomyces cerevisiae, which serve as efficient factories for insulin synthesis. Recombinant insulin is used to treat diabetic patients who are allergic …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 39–43 Read article
-
Comparative Efficacy of Hybrid Capture 2 and Real-Time PCR in Detecting High-Risk HPV Genotypes for Cervical Cancer Screening
Abstract: Human papillomavirus (HPV) infection is a leading cause of cervical cancer, making early detection critical for effective prevention and treatment. Among the diagnostic methods available, Hybrid Capture 2 (HC2) and Real-Time Polymerase Chain Reaction (PCR) are widely used for detecting high-risk HPV genotypes, particularly HPV 16 and 18, which account for the majority of cervical cancer cases. This review aims to compare the efficacy of HC2 and Real-Time PCR in …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 2, 2024 · pp. 13–17 Read article
-
Examining the Role of Synthetic Biology in Cellular Restoration Mechanisms
Abstract: Synthetic biology has emerged as a transformative field with the potential to revolutionize cellular repair mechanisms, offering innovative solutions to repair damaged DNA, stabilize proteins, regenerate tissues, and treat a wide range of diseases. By combining principles from genetic engineering, biotechnology, and computational biology, synthetic biology enables the design of cellular systems capable of performing functions that repair cellular damage and restore normal cellular processes. This article explores the application …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 2, 2024 · pp. 19–29 Read article
-
An Integrating Multimodal Technologies and Ethical Frameworks in Addressing Challenges in Modern Wildlife Monitoring
Abstract: Wildlife monitoring plays a crucial role in understanding and conserving biodiversity, but traditional methods often have limitations in scope, accuracy, and ethical impact. Advances in multimodal technologies such as drones, acoustic sensors, environmental DNA (eDNA), and camera traps offer new avenues for gathering rich, non-invasive data. However, the integration of these technologies comes with a range of challenges, particularly in terms of ethical concerns related to animal welfare, data management, …
Published in Journal of Aerospace Engineering & Technology · Vol. 15, Issue 1, 2025 · pp. 1–7 Read article
-
Single-Cell Genomics and its Impact on Understanding Cellular Heterogeneity
Abstract: Single-cell genomics has transformed how we study the differences between individual cells, helping scientists uncover the detailed variety within tissues that traditional methods could not reveal. Traditional methods, such as RNA sequencing, average gene expression across many cells, thereby missing subtle yet important cellular variations. Single-cell technologies, such as single-cell RNA sequencing (scRNA-seq), DNA sequencing, and epigenomics, allow researchers to study individual cells in extraordinary detail like never before. This …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 1, 2025 · pp. 1–5 Read article
-
A Comprehensive Review of Forensic Medicine: Its Evolution, Scope, Applications, and Future Directions
Abstract: Forensic medicine, a key junction of medical and law, has evolved substantially throughout the centuries, responding to scientific and technological advances. Forensic medicine, derived from the Latin term forensis, meaning “before the forum,” has evolved significantly over the centuries from rudimentary methods of determining the cause of death to a sophisticated and highly specialized medical discipline. Today, it encompasses a wide range of fields, including clinical forensic medicine, forensic pathology, …
Published in Research and Reviews: A Journal of Health Professions · Vol. 15, Issue 3, 2025 · pp. 18–28 Read article
-
Digital Frontiers in Life Sciences: The Transformative Role of Computing in Modern Biology
Abstract: The integration of computers in the biological sciences has revolutionized research and experimentation, facilitating advancements in areas such as genomics, bioinformatics, systems biology, and ecological modeling. The ability to process vast amounts of biological data efficiently has transformed how scientists study complex biological systems and phenomena. Computational tools enable the analysis of DNA sequences, protein structures, metabolic pathways, and ecological dynamics, which were previously beyond the reach of traditional laboratory …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 4, Issue 1, 2026 Read article
-
A Technical Survey on Nanotechnology in Nanorobots
Abstract: Nanotechnology, the manipulation of matter at the atomic and molecular scale, has given rise to a revolutionary frontier: nanorobots – microscopic machines capable of interacting with biological systems and environments with unprecedented precision. This study explores the design, functionality, and application of nanorobots in medicine, environmental remediation, and materials science. By integrating principles from materials engineering, biotechnology, and robotics, nanorobots are engineered to perform tasks such as targeted drug delivery, …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 16, Issue 1, 2026 · pp. 14–21 Read article
-
Smart Drug Delivery Using Nanorobots
Abstract: In recent years, the field of micro/nanorobot research has gained popularity. Because it can be used in targeted medication distribution, surgical procedures, disease detection, etc., it has enormous promise in medical therapy. Different from conventional medication delivery, which depends on blood flow to drug delivery to difficult-to-reach locations is made possible by the planned micro/nanorobots' ability to move independently. Micro/nanorobots were powered by either endogenous power (chemical reaction energy) or …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 Read article
-
Multidirectional Autonomous UV Sanitation Robot
Abstract: In the healthcare environment, the spread of infectious diseases through respiratory particles poses a significant challenge to maintaining clean and safe surroundings. With shortages in surface disinfectants, the traditional manual cleaning methods have been put under scrutiny, as they often prove inadequate and leave residual contamination. Moreover, the constant operation of healthcare facilities, coupled with staff turnover, increases the risk of virus transmission among healthcare workers. To address these concerns, …
Published in International Journal of Mechanical Dynamics and Systems Analysis · Vol. 1, Issue 1, 2023 · pp. 1–10 Read article
-
Breakthroughs in Biotechnology for the Regulation of Infectious Diseases
Abstract: Infectious diseases have a heavy impact on both public health and the world’s economies. In most diseases, antibiotic resistance has become widespread over time. A variety of diseases comprising pneumonia, tuberculosis, and gonorrhea go through the same evolutionary processes, which include the formation of drug-resistant pathogens in response to selection pressure from medications and their potential extinction when drug use is ceased. Since the occurrence of drug resistance in serious …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 1, 2025 · pp. 1–25 Read article
-
CRISPR-Cas9: Revolutionizing the Genetic Frontier
Abstract: The rapid development of CRISPR/CRISPR-associated enzyme (Cas) technology has enabled truly customised treatment of human genetic disorders, paving the way for recent developments in the field of gene therapy. Because CRISPR/Cas can accurately target and edit individual genes within a genome, it has established itself as a formidable tool for genetic manipulation. CRISPR/Cas9 technology allows for precise editing of specific DNA sequences in an organism's genome. This method uses three …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 2, 2025 Read article