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136 articles for “Clinical validation”
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Exploring the Dynamic Mechanical Analysis and Biocompatibility of Compression-Molded PMMA for Biomaterial Applications
Abstract: Metals such as titanium, cobalt, and magnesium are commonly used as biomaterials. However, their use can lead to tissue reactions due to the formation of foreign bodies which may cause blood cancer. Researchers have addressed this issue by substituting biomaterials with polymethyl methacrylate materials (PMMA). The PMMA material being studied is produced using the compression molding technique. This article examines the mechanical properties and biotoxicity of PMMA. These materials have …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 482–499 Read article
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Synthesis, Characterization, and Biomedical Applications of a Silver Nanoparticle-Coated Chitosan–Fucoidan–Polymer Nanocomposite Loaded with Persea americana Leaf Extract
Abstract: Consuming a natural composite of Persea americana (Avocado) leaf extract and a chitosan and fucoidan form a biodegradable biopolymer matrix–polymer nanocomposite with biomedical applications, this study explored a potential therapeutic method. GC–MS and UV spectroscopy were used to describe the aqueous leaf extract, which was verified by phytochemical screening to contain flavonoids, tannins, phenols, terpenoids, and alkaloids. The chitosan–fucoidan biodegradable polymer matrix served as a biocompatible stabilizing and encapsulating carrier …
Published in Journal of Polymer & Composites · Vol. 14, Issue 5, 2026 · pp. 130–148 Read article
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Comparison of Recording of Blood Pressure by Mercury Sphygmomanometer and Digital Sphygmometer: A Pilot Study
Abstract: Mercury sphygmomanometers are being replaced by other devices due the risk of mercury exposure to individuals as well as the environment. However, the accuracy of blood pressure (BP) recording must be ensured. The devices should be clinically validated before use. Present study was done to compare the recording of BP with mercury and digital sphygmomanometer. A descriptive comparative study design was employed. Fifty hospitalised patients were purposively selected. Patient information …
Published in Journal of Nursing Science & Practice · Vol. 5, Issue 1, 2015 · pp. 34–37 Read article
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Three-Dimensional Finite Element Modeling Study of Stress Distribution in Calcaneal Fracture
Abstract: The calcaneus is one of the biggest load-bearing tarsal bone in human body and therefore, many authors stress the importance of its biomechanical modeling and analysis in several aspects. We predicted possible fracture lines’ characteristics throughout the reconstruction of three-dimensional finite element modeling from CT slices and biomechanical analysis of stress state within talo-calcaneal complex, and its clinical validity was identified by comparing with radiographic/intraoperative findings. We reconstructed the 3-D …
Published in Research and Reviews : Journal of Surgery · Vol. 10, Issue 2, 2021 · pp. 11–34 Read article
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Smart Polymer Composite Scaffolds for Tissue Engineering with Integrated Machine Learning Feedback
Abstract: Another potential solution to improving the results of tissue engineering is smart polymer composite scaffolds, which are capable of dynamic adaptation to changing biological factors, but typical scaffolds cannot change dynamically. This paper suggests a comprehensive system to integrate biodegradable polymer composite scaffolds with sensing and machine learning-based feedback to allow the real-time monitoring and active regulation of tissue regeneration events. The system uses biocompatible materials of PLA/PCL composite of …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 Read article
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A Standards-Compliant API Framework for Integrating NAMASTE and ICD-11 TM2 Terminologies into Indian Electronic Medical Records (EMRs)
Abstract: The lack of standardized, interoperable terminology services has hindered the integration of India’s traditional medical systems into the mainstream digital health infrastructure. Although ICD-11 Traditional Medicine Module 2 (TM2) offers an internationally harmonized classification for traditional medicine diagnoses and the NAMASTE portal defines structured vocabularies for AYUSH conditions, current Electronic Medical Record (EMR) platforms in India are unable to natively consume, map, or translate these terminologies in a way that …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 15, Issue 2, 2026 · pp. 19–27 Read article
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Artificial Intelligence -Driven in Clinical Pharmacy Practice: Transforming Medication Management and Patient-Centred Care
Abstract: Artificial intelligence (AI) is transforming clinical pharmacy practice by enhancing the safety, accuracy, and efficiency of medication management while supporting evidence-based clinical decision-making. Recent advances in machine learning, deep learning, natural language processing, and predictive analytics have enabled the integration of AI into various aspects of pharmacy practice, including drug discovery, pharmacovigilance, clinical decision support, personalized medicine, medication adherence, and patient counselling. The objective of this review is to provide …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 3, 2026 Read article
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Mechanical and Morphological Characterization of Halloysite Nanotube (HNT) Reinforced Urethane Dimethacrylate (UDMA) Dental Composites
Abstract: Dental resin composites are widely used in restorative dentistry because of their excellent aesthetics, conservative cavity preparation, and satisfactory mechanical properties. However, their long-term clinical performance is limited by polymerization shrinkage, wear, microcrack formation, water absorption, and degradation in the oral environment. This study investigates the mechanical and morphological characteristics of Halloysite Nanotube (HNT)-reinforced Urethane Dimethacrylate (UDMA) dental composites to enhance the structural performance and durability of restorative materials. UDMA-based …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 Read article
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Harnessing the Bioactive Potential of Calotropis gigantea and Calotropis procera
Abstract: The medicinal plants of the Apocynaceae family Calotropis gigantea and Calotropis procera have gained more and more interest as source of bioactive molecules for biomedical applications like cancer therapy. They have various pharmacological activities, which are believed to be linked to various phytochemical constituents such as cardenolides, cardiac glycosides, flavonoids, triterpenoids, steroids, phenolic compounds, alkaloids, and proteins in their latex. The recent molecular and cellular studies show that extracts and …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 2, 2026 Read article
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Evaluation of Safety of Unani Pharmacopieal Majoon-e-Lana in Cases of Neurasthenia
Abstract: Neurasthenia, referred to as Zof-e-Asaab in the Unani system of medicine, is a functional disorder characterized by generalized weakness of the nervous system. Individuals suffering from this condition commonly experience persistent fatigue, reduced physical and mental performance, low mood, irritability, disturbed sleep, and, in some cases, elevated blood pressure. Although various conventional treatment options are available for symptom management, no specific curative therapy has been established. Furthermore, long-term use of …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 13, Issue 2, 2026 Read article
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An Analysis of Machine Learning Models for Early Cardiac Risk Stratification
Abstract: The paper shows an in-depth study of machine learning and artificial intelligence solutions to early cardiac risk stratification which has a crucial necessity because cardiovascular disease (CVD) prediction remains a significant issue that needs to be improved beyond the conventional risk score. Since CVD is the most serious disease killer in the world, claiming 17.9 million deaths every year, there is a strong need to get the most sophisticated predictive …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 13, Issue 2, 2026 Read article
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Automated Blood Cell Counting and Disease Identification Using Image Processing: Implications for Polymer Composite- Based Biomedical Diagnostic Devices
Abstract: Accurate quantification of blood cells is central to clinical decision-making and to the performance of emerging polymer composite–based diagnostic platforms. This work presents a cost-effective, image-processing pipeline for automated counting of red blood cells (including overlapping cells), white blood cells, and platelets from Leishman-stained peripheral blood smears, and articulates its relevance to polymer composite microfluidic and biosensor devices. Implemented in Python with OpenCV, the workflow performs grayscale conversion, median/Gaussian denoising, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 262–270 Read article
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Surajmukhi (Helianthus annuus L.): Medicinal Importance in Unani Literature and Modern Evidence
Abstract: Helianthus annuus L. (Sunflower), belonging to the family Asteraceae, is a well-recognized plant in both traditional and modern systems of medicine. In Unani medicine, it is described under the name “Shams-ul-Nahar,” attributed with specific Mizaj (temperament) and pharmacological actions. The plant is considered to possess a hot and moist temperament (Har Ratab), and different parts, including its seeds, oil, and leaves, have been employed in classical formulations. Sunflower seeds are …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 14, Issue 3, 2025 · pp. 68–75 Read article
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Integrative Perspectives on Lipoma: Traditional Therapeutics from Siddha, Ayurveda, and Unani with Biomedical Correlates
Abstract: Background: Lipoma is the most common benign soft tissue tumor, with an incidence of approximately 2 per 1,000 individuals annually. Modern biomedicine attributes its pathogenesis to genetic abnormalities like HMGA2 rearrangements and dysregulated adipogenesis via PPARγ pathways. Effective pharmacological therapies are lacking. Traditional Indian systems – Siddha, Ayurveda, and Unani – offer unique perspectives and non‑surgical approaches yet remain underexplored in integrative research. Objective: To critically evaluate the descriptions, pathophysiological …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 13, Issue 1, 2026 · pp. 19–33 Read article
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Pain Management Through Ayurvedic Tablets and Capsules
Abstract: Triphala Guggulu is a classical formulation widely used in Ayurveda for the management of metabolic and inflammatory disorders. It represents a synergistic combination of Triphala – composed of Emblica officinalis, Terminalia bellirica, and Terminalia chebula – along with the oleo-gum resin of Commiphora mukul. In traditional Ayurvedic practice, this formulation has been prescribed for conditions, such as arthritis, obesity, hyperlipidemia, and chronic constipation, primarily due to its reputed ability to …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 13, Issue 1, 2026 · pp. 23–28 Read article
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Prevalence and Risk Factors in a Sample Population of Hemiplegia—An Observational Study
Abstract: Falij is the paralysis of longitudinal half of the body starting either below the neck, sparing head and face or covering the entire longitudinal half of the body from head to toe. It draws analogy with hemiplegia occurring due to stroke. Unani system of medicine asserts to possess treatment for motor recovery in Falije Nisfi. Almost all ancient Unani physicians have advocated Tanqia and Ta’deel as treatment of Falij caused …
Published in Research and Reviews: A Journal of Medicine · Vol. 9, Issue 2, 2019 · pp. 25–29 Read article
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Autonomous Calibration of Medical Devices Using Synthetic Biosignals and Adaptive Learning
Abstract: The accuracy and reliability of modern biomedical diagnostic devices are critically dependent on effective calibration mechanisms capable of handling dynamic physiological and environmental variations. Conventional calibration approaches, which rely on static reference signals and manual adjustments, are inadequate in addressing challenges such as sensor drift, noise interference, motion artifacts, and long-term performance degradation. To overcome these limitations, this research proposes an innovative AI-driven adaptive biosignal simulation and calibration architecture for …
Published in Journal of Instrumentation Technology & Innovations · Vol. 16, Issue 2, 2026 Read article
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Fungal-derived Nutraceuticals & Bioactive Compounds with Physiotherapeutic and Health- promoting Properties: A Comprehensive Review
Abstract: Fungal-derived nutraceuticals represent a rapidly expanding field in biomedical research, offering a rich source of bioactive compounds with diverse therapeutic applications. This comprehensive review examines the physiotherapeutic and health-promoting properties of fungal metabolites, including polysaccharides, terpenes, proteins, peptides, alkaloids, fatty acids, vitamins, and minerals. Fungi produce over 9,000 bioactive compounds from approximately 22,500 microbial metabolites, with less than 5% of the fungal kingdom explored [1] . The major bioactive constituents …
Published in International Journal of Fungi · Vol. 2, Issue 2, 2025 Read article
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Electrochemical Biosensors for Disease Diagnostics
Abstract: Electrochemical biosensors have emerged as one of the most promising tools for disease diagnosis because they combine high sensitivity, rapid response, portability, and low cost in a single analytical platform. In recent years, growing interest in early disease detection has pushed researchers to develop biosensors that can detect clinically important biomarkers in blood, saliva, urine, sweat, and other biological fluids. These sensors work through the interaction between a biological recognition …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 28, Issue 2, 2025 · pp. 43–54 Read article
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Unani Medicine Uncovered: Core Concepts And Quality Evaluations
Abstract: Unani medicine, a traditional healing system primarily reliant on herbal remedies, finds its roots in the ancient wisdom of Greek philosopher Hippocrates (460–377 BC) and his associates. Its evolution and prominence, however, owe much to the support of Persian and Arab empires before making its way to the Indian subcontinent around the mid-14th century. Unani practitioners believe that each individual possesses a unique temperament shaped by the interplay of four …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 13, Issue 1, 2024 · pp. 10–17 Read article