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130 articles for “Cardiovascular disease”
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Effectiveness of structured teaching programme on knowledge regarding ECG and its basic interpretation among second semester BSc Nursing students in selected nursing college at Pathanamthitta district
Abstract: Cardiovascular diseases have now become the leading cause of mortality in India. Cardiovascular disease accounts for twenty five percent of all mortality. Electrocardiogram has an important role in the early detection and treatment of various cardiovascular diseases. Over the year significant advancements have been made in the field of ECG research, leading to the development of new techniques, technologies and algorithms for ECG analysis. ECG allows nurse to diagnose and …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 1, Issue 2, 2023 · pp. 09–20 Read article
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Assessing the Clinical Efficacy and Safety of Semaglutide: A Comprehensive Study
Abstract: Semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), has emerged as a versatile therapeutic agent with significant potential in managing a range of diseases. Extensive research has demonstrated its efficacy in treating obesity, type 1 and type 2 diabetes, and even neurodegenerative disorders like Parkinson’s disease. This comprehensive review examines the principal outcomes derived from clinical trials that incorporate semaglutide alongside other GLP-1 agonists, with particular emphasis on the mechanisms underlying …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 96–104 Read article
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Role of Artificial Intelligence in Health Care Decision Making: Balancing Innovation and Caution
Abstract: Healthcare is undergoing a transformation powered by artificial intelligence, which improves monitoring, diagnosis, and treatment capabilities. Among Artificial Intelligence (AI's) shortcomings is the dearth of an emotional relationship between individuals and medical personnel. Robotic surgery procedures pose the possibility of malfunctioning machinery and mistaken assumptions. So, the present systematic review focused on exploring the boon and bane of the role of AI in predicting various abnormalities in advance to improve …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 3, 2025 · pp. 24–35 Read article
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Cardiovascular Modeling with Computational and Mathematical Methods
Abstract: The cardiovascular system, a complex network responsible for delivering life-sustaining oxygen and nutrients throughout the body, is a prime target for advanced understanding and improved therapies. Due to the inherent difficulties in directly observing internal physiological processes and the complexities of interactions within the system, computational and mathematical modeling have emerged as powerful tools in cardiovascular research. This article explores the significance of these methods in unveiling the heart's secrets …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 12, Issue 2, 2025 · pp. 11–21 Read article
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Revealing the Hemodynamic Orchestra: Contrasting Analysis of Blood Flow Patterns in a Bifurcated Carotid Artery
Abstract: Understanding blood flow patterns in the carotid artery (CA) is crucial for detecting cardiovascular diseases. Computational fluid dynamics simulations compared non-Newtonian (non-Newt) and Newtonian (Newt) models under pulsatile and laminar flow. CA geometry was accurately designed using ANSYS Space Claim & Fusion360, and simulations were run in ANSYS Fluent. Discrepancies between non-Newt and Newt models were found, especially in bifurcation's distal regions prone to plaque. Pressure ranged from 27.870 Pa …
Published in Journal of Polymer & Composites · Vol. 11, Issue 13, 2023 · pp. 229–247 Read article
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The Interplay Between Hyperglycemia, Endothelial Dysfunction, and Cardiovascular Risk in the Context of COVID-19: Implications for Long-term Health
Abstract: The COVID-19 pandemic has highlighted the potential impact of hyperglycemia, especially its link to cardiovascular disease (CVD) and endothelial dysfunction. COVID-19 can cause systemic inflammation and endothelial damage, worsening complications related to hyperglycemia. Persistent inflammation and endothelial dysfunction are crucial elements in the progression of atherosclerosis and other cardiovascular diseases. The long-term health effects of COVID-19, known as “Long COVID” or post-acute sequelae of SARS-CoV-2 infection (PASC), have raised concerns …
Published in Research and Reviews: A Journal of Medicine · Vol. 14, Issue 2, 2024 · pp. 27–31 Read article
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Therapeutic Potential of Plant-Derived Phytochemicals in Targeting Receptor Pathways Related to Non-Enzymatic Glycation: A Meta-Analysis
Abstract: Background: Non-enzymatic glycation, where reducing sugars react with proteins, lipids, and nucleic acids, contributes to various pathological conditions, such as diabetic complications and cardiovascular diseases. This process is facilitated by the receptor for advanced glycation end-products (RAGE), which is pivotal in driving inflammation and causing tissue damage. Objective: This meta-analysis evaluates the effects of plant-derived phytochemicals on RAGE expression and associated signaling pathways, assessing their therapeutic potential in glycation-related diseases. …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 1, 2025 · pp. 60–73 Read article
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A Lightweight Cost-Sensitive Explainable Ensemble Framework for Early Heart Disease Risk Prediction
Abstract: Cardiovascular disease is still one of the leading causes of death, and hence, the early prediction of risk is a very important task in preventive medicine. Although recent studies have shown encouraging results in the application of machine learning algorithms to the prediction of heart disease, it has been noticed that most of the algorithms are more concerned with accuracy-driven optimization than the concerns of safety and false negatives. In …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 4, Issue 2, 2026 Read article
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A Comprehensive Review of Antioxidant Activity of Bhringraj (Eclipta alba) : An Indian Ancient Herb
Abstract: Eclipta alba, commonly known as Bhringraj, is an herb widely utilized in traditional Indian medicine (Ayurveda) for its diverse therapeutic properties, particularly in promoting hair growth, enhancing liver function, and improving overall health. Among its numerous biological activities, the plant’s antioxidant potential has garnered significant interest in modern phytochemistry. Oxidative stress, caused by an imbalance between reactive oxygen species (ROS) and the body’s antioxidant defenses, is a key contributor to …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 12, Issue 1, 2025 · pp. 12–21 Read article
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Health Hazards of Nanoparticles and Environmental Pollutants
Abstract: The exponential growth in the use of nanoparticles and the prevalence of environmental pollutants have raised significant concerns regarding their health hazards. Nanoparticles, owing to their unique physicochemical properties—such as small size, high surface areatovolume ratio, and chemical reactivity—can penetrate biological barriers, including the bloodbrain barrier, and interact at the cellular and molecular levels. This can lead to oxidative stress, inflammation, and cellular dysfunction, ultimately resulting in potential toxicity. Similarly, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 1, 2025 · pp. 1–9 Read article
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Drug Screening Using Stem Cell Technology
Abstract: Stem cell technology in drug screening has transformed the research and development sector of pharmaceuticals. Although stem cells imitate their human counterparts in terms of both safety and potential, it is a new paradigm for mimicking diseases of humans and scale measuring for toxicity. These tissues will, therefore, be more predictive of what will happen in humans during clinical situations, compared to conventional cell lines or animal models, since they …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 3, 2025 · pp. 42–51 Read article
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Cell Membranes as Therapeutic Targets: Implications in Infectious and Metabolic Disorders
Abstract: This is a review of the crucial role played by cell membranes in health and disease with respect to their contribution to infectious and metabolic diseases. Dysfunction of membranes, such as membrane transporter changes and changes in lipid content, has been associated with a variety of diseases, including diabetes, cardiovascular disease, and cancer. The present therapeutic approaches are focused on attacking membrane constituents by disrupting the entry of pathogens or …
Published in International Journal of Membranes · Vol. 3, Issue 1, 2026 · pp. 47–53 Read article
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Assessment of Finerenone Safety and Efficacy in Individuals with Type 2 Diabetes and Chronic Kidney Disease
Abstract: Background: In this work, we provide strong evidence for the safety and efficacy of finerenone in people with type 2 diabetes and chronic kidney disease. Our goal is to improve patients' quality of life and general well-being through our research. Aim: Finerenone exhibited a significant decrease in the likelihood of renal and cardiovascular (CV) events in individuals with both type 2 diabetes and chronic kidney disease. This exploratory subgroup analysis …
Published in International Journal of Antibiotics · Vol. 1, Issue 2, 2024 · pp. 06–09 Read article
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In Silico Screening and Evaluation of Some Metabolites from Momordica charantia in the Treatment of Peptic Ulcers
Abstract: Peptic ulcers are also called as or duodenal ulcers or gastric ulcers that are open sores generally develop in the lining of the stomach due to food and climatic factors. H. pylori infections are potentially the most dangerous and are linked to several diseases like diabetes, cancer, cardiovascular diseases, etc. In the present study, in silico screening and evaluation of some metabolites from Momordica charantia like Momorcharin, Momordicin, Metformin, Pioglitazone, …
Published in Research and Reviews : Journal of Computational Biology Read article
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Advances in Biological Systems Modeling for Predicting Drug Effects in Chronic Disease
Abstract: Biological systems modeling has emerged as a promising tool for understanding and predicting the effects of drugs in the treatment of chronic diseases. Chronic diseases, such as diabetes, cardiovascular diseases, and neurodegenerative disorders pose significant challenges to traditional drug development due to their complex, multifactorial nature. Systems biology approaches, which integrate computational modeling with experimental data, provide a holistic view of disease mechanisms and treatment responses. This review explores recent …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 1, 2025 · pp. 17–22 Read article
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RNA- Based Drug Delivery, Current Advances, Pharmaceutical Applications, and Future Perspectives
Abstract: RNA-based therapeutics have emerged as a transformative approach in modern medicine due to their ability to regulate gene expression with high specificity and precision. Advances in molecular biology, RNA chemistry, and nanotechnology have accelerated the development of diverse RNA modalities, including messenger RNA (mRNA), small interfering RNA (siRNA), microRNA (miRNA), antisense oligonucleotides (ASOs), and RNA aptamers. These therapeutics offer promising strategies for the treatment of cancer, genetic disorders, infectious diseases, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 Read article
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Reinventing Drug Delivery Through Cutting-Edge Nanotechnology
Abstract: Nanotechnology has emerged as a revolutionary platform in the field of drug delivery, offering novel strategies for the precise, efficient, and controlled delivery of therapeutic agents. The integration of nanocarriers, such as liposomes, polymeric nanoparticles, dendrimers, micelles, and inorganic nanoparticles, has significantly enhanced drug solubility, stability, bioavailability, and targeted delivery to specific tissues or cells. Targeted drug delivery systems based on nanotechnology minimize off-target effects, reduce systemic toxicity, and improve …
Published in Trends in Drug Delivery · Vol. 12, Issue 3, 2025 · pp. 44–61 Read article
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Comparative Proteomics: From Cell Lines to Clinical Samples
Abstract: Comparative proteomics is a powerful tool for understanding the molecular differences between various biological samples. It entails identifying and measuring proteins in complex biological samples to assess their abundance, modifications, and interactions under various conditions. This approach plays a crucial role in advancing biomedical research, especially in disease understanding, biomarker discovery, and therapeutic development. While cell lines are widely used for proteomic studies due to their controlled environments and reproducibility, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 3, 2024 · pp. 30–34 Read article
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Long Non-Coding RNAs: Key Regulators of Gene Expression in Development and Disease
Abstract: Long non-coding RNAs (lncRNAs) are RNA molecules that do not make proteins but are essential for controlling how genes are turned on or off in the body. These molecules help with various biological functions, such as guiding cell growth, shaping development, and influencing the progression of diseases. Recent advancements in genomics and transcriptomics have revealed the vast and complex roles of lncRNAs, with an increasing recognition of their involvement in …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 1, 2025 · pp. 11–15 Read article
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Prevention of Primary Hypertension Through Asbab-e-Sitta Zaruriya: A Therapeutic Paradigm
Abstract: Hypertension, defined as blood pressure elevation to a level that increases the risk of organ damage, Recent guidelines classify hypertension as systolic blood pressure ≥130 mmHg or diastolic blood pressure ≥80 mmHg, distinguishing between primary (essential) and secondary forms. It affects over one billion individuals globally and contributes to approximately 9.4 million deaths annually. Nearly 63% of total deaths in India are due to non-communicable diseases, of which 27% are …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 11, Issue 3, 2024 · pp. 13–20 Read article