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478 articles for “ADME”
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Computational Investigation of Phytochemicals Targeting AKT1 for Major Depressive Disorder: A Molecular Docking and ADMET Study
Abstract: Major depressive disorder (MDD) is a prevalent neuropsychiatric condition affecting approximately 280 million individuals worldwide, with women exhibiting a 50% higher likelihood of diagnosis than men. Despite significant advancements in treatment, MDD remains a chronic and relapsing disorder, necessitating the exploration of novel therapeutic interventions. This study focuses on the AKT1 gene, a key player in neuropsychiatric disorders, and investigates its interactions with natural phytochemicals as potential alternatives to conventional …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 2, 2025 Read article
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Prescription Opioid Use, Misuse and Motivation for Misuse among patients admitted in a drug treatment center
Abstract: Background: Opioid misuse remains a significant public health concern in Nigeria and globally. The risk of misuse complicates opioid prescriptions, potentially leading to overdose and fatal outcomes if not promptly addressed. Objectives: To determine the prevalence of prescription opioid use, misuse, and the underlying motivations for misuse. Method: This study utilized a retrospective cross-sectional design to examine the prevalence and patterns of prescription opioid use and misuse. Data were collected …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 2, 2025 Read article
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Analysis of a New Approach to Admission Call Control
Abstract: This study presents a new method of managing call admission in wireless networks using a resource reservation technique. The system under study comprises a defined number of operating devices, standby units, and technicians assigned to repair failed devices. In this method, the failure and repair of devices are assumed to follow an exponential distribution. Whenever a device fails, a standby unit replaces it to maintain seamless functionality, and the failed …
Published in International Journal of Mobile Computing Technology · Vol. 3, Issue 2, 2025 · pp. 01–06 Read article
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A Retrospective Study to Assess the Incidence of Anaemia Among Pregnant Women Admitted in a Tertiary Care Centre, Jalandhar, Punjab
Abstract: Background: Anemia during pregnancy is a common and preventable condition that contributes significantly to adverse maternal and neonatal outcomes, including preterm delivery, low birth weight, and increased maternal morbidity. Despite the implementation of various national health programs in India, the burden of anemia among pregnant women remains high, particularly in rural regions. Objective: To assess the incidence and severity of anemia among pregnant women admitted to a tertiary care center …
Published in International Journal of Women's Health Nursing And Practices · Vol. 3, Issue 2, 2025 · pp. 38–42 Read article
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Possible Histological Changes in the pancreas of Female Albino Rats for Prolonged Administration of Aspartame
Abstract: Aspartame sweetener was noted to be inducing histopathological changes on the pancreatic tissue of female albino rats so this study defined the aims and objectives properly. Biometry did use materials from the animal facility of the Department of Biology College of Science, University of Kufa. The study was carried out over the duration of two months where thirty male rats aged between 15 to 20 weeks with body weight of …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 1, 2025 · pp. 15–21 Read article
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In Silico Analysis and Docking Study of the Active Phyto Compounds of Ginkgo Biloba Against Alzheimer's Amyloid-Beta Protein
Abstract: Objective: Alzheimer's disease, an age-related progressive neurological condition, arises due to the accumulation of amyloid-beta protein within the brain. In this study, an attempt was made to explore the potential of natural compounds derived from Ginkgo, known for their diverse medicinal properties, in the prevention of the disorder by employing molecular docking techniques, conducting drug-likeness prediction assessments, and performing ADME analysis. Methods: Amyloid beta protein was retrieved from the PDB …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 Read article
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Task and Resources Administration Methodology
Abstract: The field of app development has evolved into a dynamic and transformative industry, significantly shaping our interaction with technology in daily life. In today's fast-paced and ever-changing world, mobile application development has emerged as a key driver of innovation, convenience, and connectivity. This multifaceted discipline brings together a diverse range of skills and technologies, converging to transform ideas into intuitive and functional applications. At its essence, app development involves the …
Published in Journal of Computer Technology & Applications · Vol. 15, Issue 2, 2024 · pp. 50–54 Read article
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Bringing Serverless Edge Computing to School Administration: Challenges and Opportunities
Abstract: Serverless edge computing is revolutionizing app development by creativity in infrastructure management. However, traditional cloud-based serverless architectures can suffer from latency and reliability issues when serving users at the edge of the network. While edge computing brings storage and computing closer to data sources, upgrading performance and reducing network issues. This paper explores the convergence of serverless edge computing, examining the opportunities and challenges that arise from this integration. Delving …
Published in Recent Trends in Parallel Computing · Vol. 12, Issue 1, 2025 · pp. 1–12 Read article
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Regulations for Toothbrushes: A Comparative Study Between India, the US, Europe, and Australia
Abstract: Toothbrushes are essential tools for maintaining oral hygiene, making their regulation vital for consumer safety and health efficacy. This article presents a comparative analysis of toothbrush regulations in India, the United States, Europe, and Australia, highlighting the unique frameworks each region has developed to address manufacturing, distribution, and marketing challenges. In India, the Bureau of Indian Standards (BIS) and the Food Safety and Standards Authority of India (FSSAI) set safety …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 2, 2025 · pp. 1–6 Read article
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Strength Enhancement of Concrete with Nano-Based Admixtures
Abstract: The integration of advanced nanomaterials such as nano-silica and nano-clay has emerged as a highly promising and innovative technique to significantly enhance the mechanical characteristics and long-term durability of conventional concrete. In this comprehensive study, the effects of nano-modification on various concrete properties, including workability, compressive strength, split tensile strength, and flexural behavior, were thoroughly evaluated through a systematic experimental program. A series of concrete mix designs incorporating varying proportions …
Published in Journal of Structural Engineering and Management · Vol. 12, Issue 3, 2025 Read article
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A Study to Assess the Effectiveness of Mint Leaf Chutney Administration on Improving Iron Deficiency Anemia Among Adolescent Girls in Selected Pre-University Colleges at Kolar
Abstract: Iron deficiency anemia remains a prevalent nutritional disorder among adolescent girls, particularly in developing regions. This study aimed to assess the effectiveness of mint leaves chutney in improving iron deficiency anemia among adolescent girls in selected pre-university colleges at Kolar. A quasi-experimental research design was adopted, involving 60 adolescent girls aged 15–18 years who were screened and found to be anemic based on their hemoglobin levels. Participants were selected using …
Published in Journal of Nursing Science & Practice · Vol. 15, Issue 3, 2025 Read article
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A Structure-based Design Approach to Catharanthus roseus Phytoconstituents as Potential Inhibitors of B-Cell Lymphoma 6 Protein
Abstract: Objectives: Lymphoma is a cancerous disease. It develops into millions of people worldwide. Identify the naturally active compounds from Catharanthus roseus, they have multiple values in the medicinal field of Siddha, and Indian Ayurveda are used as a disease-preventing agent. Drug illness prediction, toxicity prediction, statistical information, molecular docking, as well as absorption, distribution, metabolism, and excretion (ADME) analysis are used to predict the fit ligand as a drug. Methods: …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 14–34 Read article
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In Silico Docking Analysis to Identify Therapeutic Benzoic Acid Derivatives for Acute Myeloid Leukaemia
Abstract: Background: The study is anchored to initiate subjugation against modern cancer therapy for Acute Myeloid Leukaemia (AML) which involves natural therapeutics as an alternative therapy that would degrade the prospect of adverse side effects along with anti-cancer properties. Objectives: Collate the various characteristics of Giltertinib with natural benzoic acid derivative phytochemicals for a disquisition regarding their similarities and differences in the context of providing adverse side effects. Methods: ADME toxicity …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 · pp. 50–63 Read article
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Computational Screening of Vitex negundo Compounds for Potential Arthritis Therapies in India
Abstract: Objective: Arthritis is a pervasive medical condition that manifests as inflammation and discomfort within the joints. As of September 2021, arthritis has affected an estimated 180 million people in India, making it a substantial public health concern with a considerable impact on individuals' quality of life and healthcare systems. Therefore, using molecular docking, drug-likeness prediction, and ADME analysis, an effort was made to identify natural compounds from Vitex negundo, which …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 01–18 Read article
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Targeting Vasopressin 2 Receptor (V2R) in Renal Cystogenesis by Exploring the Nephroprotective Potential of “Terminalia arjuna”
Abstract: Objectives: Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disorder, leading to the formation of multiple cysts in the kidneys. It is a major cause of end-stage renal disease (ESRD), which often requires dialysis or a kidney transplant for survival. This research focuses on identifying potential bioactive compounds derived from natural sources that show promise for drug development targeting the V2R gene. Methods: The naturally occurred …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 2, 2024 · pp. 14–24 Read article
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QSAR Modeling of a Novel Series of Methoxylated Chalcones as Antioxidant Agents Against Gram-Positive Bacteria Staphylococcus aureus
Abstract: Background: Chalcones are aromatic ketones belonging to the flavonoid family. They are plant-based compounds and are widely found in nature. For centuries, these bioactive molecules have been utilized in various traditional medicines for the treatment of several ailments. Chalcones have antibacterial, antiviral, antimalarial, antifungal, antioxidant, and antileishmanial properties. They are also used to treat inflammation and cancer. Chalcones act as angiogenesis inhibitors, an important factor in cancer progression and metastasis. …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 1, 2025 · pp. 28–34 Read article
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Care Sched: Doctor and Patient Appointment Management
Abstract: The medical appointment system is a web application that uses PHP, JavaScript, and CSS to improve the efficiency of booking medical appointments. It features two interfaces: an admin side where patients and doctors manage their appointments and a user side where they may handle an appointment and to view records, and manage their medicines. The web platform that the system makes available provides a convenient online experience from any internet-enabled …
Published in International Journal of Computer Science Languages · Vol. 3, Issue 1, 2025 · pp. 1–12 Read article
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Performance Evaluation of High-Performance Fiber Reinforced Concrete Incorporating Fly Ash, Coir Husk Ash, and Hybrid Fibers
Abstract: High-Performance Fiber-Reinforced Concrete (HPFRC) is an advanced composite material designed to improve the mechanical properties and durability of conventional concrete. This study investigates the effects of fly ash (FA), coir pith ash (CPA), and various fiber reinforcements (polypropylene, coir, and kenaf) on the compressive strength of HPFRC. The research evaluates the influence of natural admixtures, single fiber additions, and hybrid fiber combinations to optimize mix proportions for enhanced structural performance. …
Published in Journal of Structural Engineering and Management · Vol. 12, Issue 2, 2025 · pp. 10–15 Read article
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Exploration of 5-Hydroxybowdichione Flavonoids As Inhibitors of Dengue Virus Ns5 RNA-Dependent RNA Polymerase Using Molecular Docking Approach
Abstract: Objectives: Human lives are now seriously threatened by dengue fever, which is brought on by the dengue virus (DENV). Aedes aegypti mosquitoes, which reproduce in still water, are the primary vectors of the arboviral virus known as dengue. It is well-recognized that phytochemicals have a high potential to eliminate bacterial, viral, and fungal infections in people. Thus, it demonstrates its inhibitory effects on the dengue virus. This study identifies some …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 1, 2023 · pp. 1–16 Read article
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An Automated System for Training and Placement Activities
Abstract: The training and placement cell constitutes a vital component of any institution, playing a pivotal role in molding the career trajectories of students. This system allows students, companies, and admins to log in for campus recruitment purposes. The primary aim of this project is to create a platform for the college’s placement cell, benefiting students, visiting companies, and the placement officer. The admin has access to student information, allowing for …
Published in International Journal of Mobile Computing Technology · Vol. 1, Issue 2, 2023 · pp. 31–37 Read article