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412 articles for “Gene targeting”
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Application of Drug Delivery using Nano- technology to Cure Mental Disorders (Schizophrenia)
Abstract: Nanotechnology involves the manipulation of the count at an atomic scale to create novel systems, materials, and devices. This groundbreaking era holds substantial potential for scientific development across various domain names, which includes manufacturing, patron items, electricity, substances, and remedies. In current times, the sphere of prescribed drugs has witnessed a brilliant surge in the usage of nanotechnology for the improvement of revolutionary medications. Schizophrenia, a neuropsychiatric disorder affecting the …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 1, 2024 · pp. 51–65 Read article
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Agrobot: IoT Enabled Crop-care
Abstract: Agriculture serves as the foundation of global civilization, particularly in nations like India, where it accounts for roughly 70% of the GDP, underscoring its pivotal role in economic stability. Despite its significance, traditional agricultural practices have often overlooked critical elements such as disease identification and precise pesticide application, focusing primarily on conventional methods like harvesting and seedling techniques. To address these gaps and usher in a new era of efficiency …
Published in Journal of Experimental & Applied Mechanics · Vol. 15, Issue 1, 2024 · pp. 38–45 Read article
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Innovative strategies in capsule formulation from concept to market
Abstract: Innovative strategies in capsule formulation have revolutionized drug delivery and nutraceutical development, offering advanced solutions from initial concept to market release. This report explores the transformative techniques at each stage of capsule formulation, detailing novel approaches in ingredient selection, encapsulation technology, and manufacturing processes. By leveraging advancements in artificial intelligence, encapsulation methods, such as liposomal and nanoparticle technologies, and materials science, formulators can optimize the bioavailability, stability, and targeted delivery …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 1, 2025 · pp. 1–8 Read article
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A multi-index remote sensing analysis for Characterizing water stress, and environmental indicators in Girnar Wildlife Sanctuary, Gujarat, India
Abstract: Water scarcity is a critical concern in arid and semi-arid regions, with implications for ecological stability, public health, and sustainable resource management. The Girnar Wildlife Sanctuary, Gujarat, presents a case where ecological fragility intersects with cultural and religious pressures. This study employs satellite remote sensing and GIS-based approach to characterize water stress parameters within the sanctuary. Key spectral indices along with Land Use and Land Cover (LULC) were integrated through …
Published in Journal of Remote Sensing & GIS · Vol. 17, Issue 1, 2026 · pp. 1–11 Read article
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Erythrodermic Psoriasis: A Case Report Highlighting Clinical Features and Management
Abstract: Background: Erythrodermic psoriasis (EP) is a rare and severe variant of psoriasis that presents as widespread erythema, scaling, and systemic complications such as fever, dehydration, and electrolyte imbalances. It requires urgent medical attention due to the risk of life-threatening complications, including sepsis and multi-organ failure. The condition can arise de novo or as an exacerbation of pre-existing psoriasis, often triggered by medication withdrawal, infections, or systemic inflammation. Case Presentation: We …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 2, 2025 · pp. 01–05 Read article
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Pathophysiology Reimagined: Integrating Systems Biology and AI for Disease Understanding
Abstract: Pathophysiology, the study of disease mechanisms at molecular, cellular, and systemic levels, has traditionally relied on reductionist approaches that often fail to capture the complex, dynamic, and interconnected nature of biological systems. Diseases such as cancer, neurodegenerative disorders, and infectious diseases arise from intricate interactions among genetic, epigenetic, metabolic, and environmental factors, necessitating integrative, data-driven methodologies for a deeper understanding. Systems biology has emerged as a powerful approach by leveraging …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 2, 2025 · pp. 63–71 Read article
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Looking Forward to the Promising Anti-filarial Plant Resources and Futuristic Drug Discovery Approaches
Abstract: In tropical and subtropical nations, lymphatic filariasis (LF) is considered a significant public health issue. Adult worms may survive in an infected person for many years, generating microfilariae (mf) and aiding disease transmission via vector mosquitoes. Elephantiasis, river blindness, and tropical pulmonary eosinophilia are among the illnesses caused by filarial worms. The medication of choice for treating filariasis has a slew of negative side effects. Current filariasis control methods aren't …
Published in Research & Reviews : Journal of Botany · Vol. 10, Issue 3, 2021 · pp. 9–23 Read article
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Structural, Optical, Surface, and Gas-Sensing Properties of rGO/Sn1–xZnxO₂ Nanocomposites
Abstract: rGO/Sn₁–ₓZnₓO₂ nanocomposites with x = 0.00–0.75 were synthesized by sol–gel auto-combustion followed by wet impregnation with reduced graphene oxide. The adopted synthesis route enabled homogeneous Zn incorporation into the SnO₂ matrix and uniform distribution of rGO, leading to improved structural integrity and interfacial contact between the two components. XRD confirmed a dominant tetragonal cassiterite SnO₂ structure, while FTIR, FESEM, EDS, UV–visible, and BET analyses verified oxide–rGO coupling, Zn-dependent structural modification, …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 429–452 Read article
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AI-Based Machine Learning Web Application Firewall (ML-WAF)
Abstract: This research investigates the use of deep learning techniques for the real-time detection of malicious activities in web traffic and proposes an intelligent, AI-driven Web Application Firewall (WAF) designed to provide automated and adaptive security. The system analyzes diverse components of HTTP requests, including request methods, URLs, headers, cookies, and payload content, to accurately identify and classify malicious behavior. The proposed model targets a wide range of common and critical …
Published in Journal of Computer Technology & Applications · Vol. 17, Issue 1, 2026 Read article
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Herbal Frontiers: The Role of Alternative Remedies in Combating Typhoid Fevers
Abstract: Typhoid fever, caused by Salmonella typhi, remains a major health challenge, particularly in developing regions where sanitation and healthcare resources are limited. With an estimated global incidence of 17 million cases annually, the disease poses a significant public health burden. The growing resistance to conventional antibiotics, such as fluoroquinolones and third-generation cephalosporins, exacerbates treatment challenges. This has spurred interest in alternative remedies, including herbal and homeopathic treatments.Herbal medicine offers a …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 1, 2025 Read article
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Quantification and Forecasting of Plastic waste in Gorakhpur city, India
Abstract: Plastic pollution is one of the biggest environmental threats faced by human society, especially in cities like Gorakhpur, which have minimal resources for waste management but a very high amount of waste that keeps on increasing day by day. The purpose of this research is to determine the total amount of plastic waste (PW) generated in Gorakhpur city and forecast plastic waste generation. The snowball sampling method was used for …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 946–962 Read article
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Eco-Efficient Skies: Life Cycle Assessment and Carbon Footprint Minimization of Fiber-Reinforced Polymer Composites in Aerospace Application
Abstract: The increasing integration of fiber-reinforced polymer (FRP) composites in aerospace structures necessitates a rigorous evaluation of their environmental sustainability throughout their entire life cycle. This study presents a comprehensive life cycle assessment (LCA) and carbon footprint analysis of carbon fiber-reinforced polymer (CFRP) and glass fiber-reinforced polymer (GFRP) composites applied to structural and semi-structural components in commercial aerospace applications. Following ISO 14040/14044 standards and employing the ReCiPe 2016 Midpoint (H) impact …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 147–160 Read article
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Harnessing the Bioactive Potential of Calotropis gigantea and Calotropis procera
Abstract: The medicinal plants of the Apocynaceae family Calotropis gigantea and Calotropis procera have gained more and more interest as source of bioactive molecules for biomedical applications like cancer therapy. They have various pharmacological activities, which are believed to be linked to various phytochemical constituents such as cardenolides, cardiac glycosides, flavonoids, triterpenoids, steroids, phenolic compounds, alkaloids, and proteins in their latex. The recent molecular and cellular studies show that extracts and …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 2, 2026 Read article
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A Review on the Clinical and Pathological Significance of Prorenin Receptor [(P)RR]
Abstract: The (pro)renin receptor (P)RR discovery, which is a novel constituent of Renin Angiotensin-Aldosteron System (RAS) has brought renin and (pro)renin back into spotlight. The (P)RR binds both renin and its inactive precursor (pro)renin, this binding triggers a cascade of intracellular signalling that eventually leads to upregulation of the expression of profibrotic genes, potentially leading to pathogenesis of cardiac and renal fibrosis, growth and remodelling. Clinically, it is also seen that …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 5, Issue 2, 2015 · pp. 11–17 Read article
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A Study of the Masticatory Efficiency in Patients with Telescopic Crown Dentures
Abstract: The authors’ aim was to investigate the masticatory process in patients with telescopic crown dentures using an artificial test bite. The targets of the study were 65 patients, divided into two groups: a Control group and a Clinical group. The test bite sample used was Protab®, suitable for prosthetic dentitions. A sieve analysis was applied in determining the particles’ size after chewing and the particle-size distribution using a set of …
Published in Research and Reviews: A Journal of Dentistry · Vol. 9, Issue 1, 2018 · pp. 18–22 Read article
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Prevalence of Dysmenorrhea in Different Age Groups
Abstract: Dysmenorrhea (painful menstruation) is one of the major gynecological problems, encountered in women of reproductive age. It accounts for more than 1/4th gynaec patients’ visits to the gynecologist. The pain may be spasmodic or congestive type and occurs in lower abdomen, low back or in the thighs. It starts one or two days before onset of menstruation and continues for two days with same intensity or sometimes the pain decreases …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 1, Issue 1, 2014 · pp. 23–28 Read article
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Design and Analysis of Dispersion Flattened Low Loss Photonic Crystal Fiber
Abstract: AbstractThis paper demonstrates the study of triangular lattice hexagonal photonic crystal fiber with GeO2 doped core. The photonic crystal fiber (PCF) studied in this research work has a core doped with 97% molar concentrated GeO2 with seven layers of air-capillaries around the core. The design and analysis of optical characteristics, i.e., dispersion, confinement loss, and effective area have been studied extensively for optimizing the structure for a certain range of …
Published in Trends in Opto-electro & Optical Communication · Vol. 7, Issue 2, 2017 · pp. 41–50 Read article
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Analysis for Respiratory Transmittable Diseases via Mass Spectrometry
Abstract: Microbial identification in clinical diagnostic laboratories has mainly relied on conventional phenotypic and gene sequencing identification techniques. The development of matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) devices has revolutionized the repetitive identification of microorganisms in clinical microbiology laboratories by introducing an easy, rapid, high throughput, low-cost, and effective identification technique. This technology has been modified to the restraint of clinical diagnostic laboratories and has likely to replace …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 7, Issue 1, 2017 · pp. 26–30 Read article
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Current Prospective of NLCs in Parkinson’s Disease: An Outlook
Abstract: Parkinson's disease (PD) is 2nd most a neuro-degenerative disorder of the central nervous system affecting 7–10 million people of worldwide as the report of WHO 2014. It occurs due to the death of dopamine-generating cells in the substantia nigra, a region of the midbrain. It is characterized by tremor, rigidity, bradykinesia, dementia, depression and falls or emerges with the progression of the disease. Ropinirole Hydrochloride is a drug of choice …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 2, 2018 · pp. 18–29 Read article
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In Silico Drug Designing of Breast Cancer in Homo sapiens
Abstract: Breast cancer is a severe health concern in India, with the highest mortality rate among women. It is brought on by uncontrolled cell division and has the potential to spread to other body regions. As a transcription factor, interactions with estrogen receptor (ER) alpha are primarily responsible for malignant tumors through regulating the transcription of numerous genes. Because most of the medications now used to treat breast cancer have significant …
Published in Research and Reviews : Journal of Computational Biology · Vol. 11, Issue 2, 2022 · pp. 12–27 Read article