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412 articles for “PKA/CREB pathway”
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Effect of Microbial Species and Inoculum Dosage on Anaerobic Digestion
Abstract: This work aims at studying the effect of microbial species and inoculum dosage on anaerobic digestion of food waste using cattle rumen content as inoculum. Four different batch runs were carried out with different percentage inoculations which were (control sample), 25% dosage, 50% dosage and 75% dosage. To have both logical and scientific explanation why the inoculated samples had better performance than the control sample, microbial identification was carried out …
Published in Emerging Trends in Chemical Engineering · Vol. 13, Issue 1, 2026 · pp. 12–23 Read article
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Thin Film Technology in Sensor Manufacturing – A Technical Discussion
Abstract: Thin‑film technology has become the cornerstone of modern sensor manufacturing, enabling the convergence of miniaturisation, multifunctionality, and cost‑effective mass production. This paper surveys the latest advances in deposition techniques—ranging from magnetron sputtering and chemical vapour deposition to atomic‑layer deposition (ALD) and ink‑jet‑printed sol‑gel processes—and examines how their unique material‑control capabilities translate into performance gains across the sensor spectrum (chemical, physical, and bio‑sensing). By integrating nanoscale thickness control (≤ 10 nm) …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 13, Issue 1, 2026 · pp. 48–58 Read article
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A Knowledge Graph Approach for Breast Cancer Diagnosis and Data Sharing Platform Implementation in the Context of Human Papillomavirus Infection
Abstract: Background: Breast cancer remains among the most prevalent malignancies in women worldwide, and effective diagnosis and data integration continue to challenge clinical practice. Diagnostic reports from mammography and ultrasound contain rich clinical information that is often under-utilised due to heterogeneous formats and limited data-sharing infrastructure. In the context of human papillomavirus (HPV) infection, which may influence oncogenic pathways and data complexity, advanced computational methods offer new solutions to this problem. …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 15, Issue 1, 2026 Read article
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Correlation of Serum Vitamin D Levels with Insulin Resistance in Young Adults
Abstract: Among young adults, both insulin resistance (IR)and vitamin D deficiency are common and pose the risk of complications, such as type 2 diabetes mellitus (T2DM). A few studies demonstrated that vitamin D deficiency might negatively influence insulin sensitivity, but the results of these studies have been inconsistent and/or inconclusive. This review focuses on young adults and aims to summarize and critique studies that assess the relationship between IR and serum …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 15, Issue 1, 2026 Read article
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A study on Bridging Chemical Transformation and Climate Feedbacks in the Earth System
Abstract: The atmosphere operates as a vast and complex chemical reactor, where minute-scale transformations exert profound influence on planetary-scale climate stability. This research investigates the multi-scale coupling between reactive tropospheric chemistry and large-scale climate feedbacks, challenging traditional modeling approaches that often divorce chemical kinetics from dynamic processes. By integrating high-resolution chemical transport models (CTMs) with comprehensive Earth System Models (ESMs), we map the flow of energy and matter from the molecular …
Published in International Journal of Climate Conditions · Vol. 2, Issue 2, 2025 · pp. 1–8 Read article
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Comprehensive Evaluation of Quercetin from Bauhinia purpurea for Its Anti-Acne and Anti-Inflammatory Potential, Including Advances in Quercetin-Loaded Nanogel Formulation
Abstract: Acne vulgaris is among the most prevalent chronic inflammatory dermatoses in clinical dermatology, afflicting a substantial proportion of the global adolescent and adult population. Conventional pharmacotherapies — including topical retinoids, benzoyl peroxide, and systemic antibiotics — remain the therapeutic mainstay; however, their long-term utility is progressively undermined by adverse cutaneous reactions, systemic toxicity, and the rising prevalence of antibiotic-resistant Cutibacterium acnes strains. These limitations have intensified scientific interest in plant-derived …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 2, 2026 Read article
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Machine Learning Optimization for VARTM Carbon Polymer Laminates
Abstract: Vacuum-assisted resin transfer moulding (VARTM) is a key low-cost, out-of-autoclave process for manufacturing large-scale carbon-fibre reinforced polymer (CFRP) laminates crucial to aerospace wings, wind-turbine blades, marine hulls, and automotive structures. Unpredictable resin flow often leads to voids, dry spots, and race-tracking defects, resulting in 27.9% scrap rates and lengthy, costly trial-and-error design cycles. Although surrogate models provide rapid impregnation predictions for simple flat-plate geometries, vision-based monitoring is limited to idealized …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 229–245 Read article
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The Renaissance and Resilience of CB1 Reverse Agonists: From Central Liabilities to Peripheral Promise
Abstract: Building upon these foundational insights, current research has increasingly focused on refining the pharmacological profile of CB1 reverse agonists to maximize therapeutic benefit while minimizing central adverse effects. The adverse neuropsychiatric outcomes associated with first-generation agents such as Rimonabant including anxiety, depression, and suicidal ideation highlighted the critical role of central CB1 receptors in mood regulation. Consequently, drug development strategies have shifted toward peripherally restricted CB1 reverse agonists that exhibit …
Published in International Journal of Cheminformatics · Vol. 4, Issue 1, 2026 · pp. 30–35 Read article
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Molecular Dynamics and Therapeutic Architectures of Cannabinoid Receptors: A Comprehensive Review
Abstract: Expanding on these foundations, recent structural biology studies using cryo-electron microscopy have provided high-resolution insights into the conformational dynamics of CB₁ and CB₂ receptors. These findings have enabled a more precise understanding of ligand–receptor interactions, particularly how agonists, antagonists, and reverse agonists stabilize distinct receptor states. Such knowledge is critical for rational drug design, allowing researchers to selectively modulate downstream signaling pathways. For instance, CB₁ receptors primarily couple to Gi/o …
Published in International Journal of Cheminformatics · Vol. 4, Issue 1, 2026 · pp. 36–40 Read article
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Thermo-Hydraulic Enhancement of Annular Finned Shell-and-Tube Heat Exchangers Using Epoxy-Based Polymer Composites: A Material–Geometry Coupled CFD Investigation
Abstract: Shell-and-tube heat exchangers remain a backbone of industrial thermal systems, yet their performance is often limited by relatively low shell-side heat transfer and the weight and cost associated with conventional metallic components. In this context, the integration of polymer composite materials offers a promising pathway toward lightweight, corrosion-resistant, and performance-tunable heat exchanger designs. The present study investigates the thermo-hydraulic performance of a straight-tube shell-and-tube heat exchanger equipped with annular fins, …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 669–684 Read article
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Image-Based Evaluation of Implant Tissue Interface Integrity in Polymer Orthopaedic Devices
Abstract: Polymer orthopedic implants offer radiolucency and mechanical compatibility with bone, but long-term success depends on maintaining a stable implant–tissue interface. Routine imaging is widely available for follow-up, yet interface integrity is commonly judged qualitatively, limiting early detection of fixation compromise and reducing comparability across devices and time points. This work presents an image-based methodology to quantify interface integrity by extracting interpretable interface descriptors from a standardized interface belt around the …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 170–179 Read article
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AI-Integrated Graphene-Modified Polymer Interfaces for Real-Time Crack Detection and Autonomous Healing in Smart Concrete Structures
Abstract: This study presents the design and development of a graphene-reinforced multifunctional polymer composite interface engineered for structural reinforcement, self-sensing, and autonomous healing applications in cementitious systems. A thermosetting polymer matrix embedded with graphene nanoplatelets (0.25–1.5 wt.%) was developed to establish a conductive polymer nano-composite network. Electrical characterization confirmed a distinct percolation threshold at ~0.6–0.8 wt.%, beyond which a sharp increase in conductivity was observed due to the formation of interconnected …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 30–42 Read article
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Structure–Property Modeling of Cement-Based Multi-Component Composites Using Ensemble Machine Learning and Explainable Feature Attribution
Abstract: Accurate prediction of compressive strength is central to structure–property optimization, quality control, and sustainability-driven design in cement-based composite materials. Cementitious systems represent heterogeneous multi-phase composites composed of reactive binder matrices and dispersed aggregate phases, whose macroscopic mechanical performance emerges from complex nonlinear interactions among constituents and curing-dependent microstructural evolution. This study develops a data-driven structure–property modeling framework to quantify the nonlinear dependence of compressive strength on multi-component composite composition and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 112–131 Read article
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IoT-Enabled Polymer–Gel PCM Composites for Intelligent Thermal Management in Solar Facade Applications
Abstract: The present study investigates the development of a multifunctional polymer–gel phase change composite designed for solar façade applications with integrated real-time thermal monitoring capability. A crosslinked polyvinyl alcohol–borax matrix was employed as a three-dimensional polymer scaffold to encapsulate paraffin-based phase change material, ensuring leakage-free operation and structural integrity under repeated thermal cycling. Graphite nanoplatelets were incorporated as thermally conductive nano-fillers to enhance heat transfer through the polymer composite via percolation-driven …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 99–111 Read article
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Smart Bio-Polymer Composite Systems for Sustainable Bio-Polymer Composite Media for Enhanced Pollutant Removal in Constructed Wetland Systems Using Machine Learning
Abstract: Constructed wetlands are widely used for wastewater treatment due to their low cost and ecological compatibility; however, their efficiency in removing emerging contaminants remains limited. This study presents the development of biodegradable polymer-based composite materials integrated into wetland filtration systems to enhance pollutant removal efficiency. Bio-polymers combined with natural fillers such as biochar and clay were synthesized and evaluated under simulated wetland conditions. The results demonstrate improved adsorption capacity, increased …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 190–200 Read article
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Upgrading Nutritive Value of Rice Straw: Processing, Supplementation, and Agronomic Innovations for Improved Utilization
Abstract: Rice straw, a major byproduct of rice production, holds significant potential as a livestock feed but is constrained by its high lignocellulosic content, low crude protein, and poor digestibility. Enhancing its nutritive value is imperative for sustainable livestock production. This study explores a range of innovative strategies aimed at improving rice straw’s digestibility and overall nutritional quality. Physical processing techniques, including chopping, grinding, soaking, and steam treatment, enhance its surface …
Published in Research & Reviews : Journal of Botany · Vol. 15, Issue 1, 2026 · pp. 42–58 Read article
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Structure Property Correlation of Polymer Dielectrics Using Electrical Response Data
Abstract: Polymer dielectrics are foundational to insulation, capacitors, embedded passives, and flexible electronics, where performance is governed by the frequency-dependent electrical response rather than a single dielectric constant. This study presents a spectroscopy-aware structure–property correlation framework that transforms dielectric response data into physically interpretable spectral fingerprints and learns mappings from polymer descriptors to these fingerprints for prediction and interpretation. Broadband spectra are standardized on a log-frequency grid and parameterized using relaxation-informed …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 315–324 Read article
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Myco-Engineering Systems: Harnessing Fungal Networks for Carbon Sequestration and Sustainable Ecosystem Restoration
Abstract: Fungal organisms play a foundational role in global ecosystem stability, particularly through their contributions to nutrient cycling, soil regeneration, and carbon sequestration. Recent scientific advances have highlighted the potential of fungal mycelial networks as natural bioengineered systems capable of supporting sustainable environmental restoration. This paper introduces the concept of Myco-Engineering Systems, an interdisciplinary framework that integrates fungal biology, environmental science, and artificial intelligence (AI) to enhance carbon capture and ecosystem …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 16, Issue 2, 2026 Read article
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Ilaj bil-Ma’ (Hydrotherapy) as a Regimenal Modality in Pain Management: Conceptual Foundations in Unani Medicine and Modern Correlation
Abstract: Waja‘ (pain) is one of the most common clinical complaints encountered worldwide and remains a leading cause of disability, impaired functional capacity, and diminished quality of life. In the Unani system of medicine, pain is not considered merely a symptom but a significant manifestation of disturbed physiological balance. Classical Unani scholars describe pain as arising from derangement in Mizāj (temperament), imbalance of Akhlāṭ (humours), Sudad (obstruction within bodily channels), Waram …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 13, Issue 2, 2026 · pp. 12–19 Read article
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Polymer-Mediated Electron Transfer in Eco-Friendly P3HT–rGO Nanocomposites for Optoelectronic Applications
Abstract: Conducting polymer–graphene hybrid nanocomposites have emerged as promising materials for next-generation optoelectronic applications owing to their solution processability, tunable interfacial properties, and mechanical flexibility. Recent studies have highlighted the importance of graphene–polymer hybrid systems in enhancing charge transport pathways, exciton dissociation efficiency, and interfacial stability in organic optoelectronic devices. Despite these advantages, a key challenge remains the efficient production of individual graphene sheets through the reduction of graphene oxide using …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 413–423 Read article