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508 articles for “Anti – infective”
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Metagenome-Informed Engineering of Monoclonal Antibodies: Mining Microbial Immunoglobulin-Like Domains for Ultra-Stable Therapeutics
Abstract: Metagenome-informed engineering represents an emerging strategy for improving the stability and functionality of monoclonal antibodies (mAbs) by leveraging the vast diversity of microbial immunoglobulin-like (Ig-like) domains (10,24). These domains, derived from uncultured bacteria and bacteriophages, exhibit exceptional thermostability, protease resistance, and structural resilience due to adaptation to extreme environments (29,30). This review highlights advances in metagenomic mining, structural characterization, and protein engineering that enable the integration of microbial Ig-like scaffolds …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 1, 2026 · pp. 70–83 Read article
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An Approach to Treat Corvid-19: An Opinion to Use Angiotensin Converting and 4-Dipeptidyl Peptidase Enzymes Inhibitors
Abstract: Abstract Coronavirus (CoV) attach the cell surface and enter the host cell via interaction with angiotensin converting enzyme receptor. Viral replication induces dysregulation of the autophagy process and interferes with the natural function of the lysosomes. Antimalarial drugs, including chloroquine and hydroxychloroquine through their lysosomotropic and autophagy inhibiting effects may be useful in the management of CoV infections. Among the people who at risk of developing CoV infections are hypertensive …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 7, Issue 2, 2020 · pp. 8–12 Read article
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Molecular Identification of Common Bacterial Infection in Chronic Otitis Media in an Outpatient Department of Tertiary Care Hospital
Abstract: Chronic otitis media (COM) is a chronic inflammation of the mucoperiosteum of the middle ear left which leads to profuse discharge from the ear and hearing impairment that may have a serious long-term effect on language, auditory and cognitive development and on educational progress. In the present study, the prevalence of culture-positive cases of an active mucosal variety of COM was 92.65%. Pseudomonas aeruginosa (41.2%) was the predominant aerobic bacterial …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 8, Issue 1, 2019 · pp. 18–24 Read article
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Evaluation of Chale Neem (Azadirachta Indica) As an Immunomodulator in Elderly Persons: A Single Blind Randomized Placebo Controlled Study
Abstract: Elderly subjects have loss of functionality and dysregulation of immune system. Immunosenescence is associated with deleterious changes, primarily in adaptive immunity and particularly in T cell subset. It includes reduced production of T cells in bone marrow and thymus and diminished function of mature lymphoid tissues. As a result, elderly individuals do not respond to immune challenge and are at increased risk of infection and related complications. Chale Neem (Azadirachta …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 6, Issue 3, 2016 · pp. 48–52 Read article
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Evaluation of Different Essential Oils for Antifungal Activity on Postharvest Decay of Avocado (Persea Americana Mill.) of Sikkim, India
Abstract: Commercially available essential oils of Basil oil, Clove oil, Citronella oil, Ginger oil and methanol extracted fern oil, Artemisia oil, and Stinging nettle oil were tested for growth inhibitions of two fungi isolated from infected avocado fruit from Sikkim, India which were identified as Fusarium sp. and Penicillium digitatum on the basis of colony morphology and microscopic examination. Inhibitory effect of essential oils was investigated by well diffusion method by …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 9, Issue 2, 2019 · pp. 44–51 Read article
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In vitro Antibacterial Activity of Averrhoa carambola Leaf Extracts
Abstract: The aim of the present study was to determine the phytochemical constituents and antimicrobial potential of Averrhoa carambola leaf extracts against three gram-positive bacteria (Bacillus subtilis, Staphylococcus aureus and Streptococcus mutans) and three gram-negative bacteria (Klebsiella pneumoniae, Proteus vulgaris and Pseudomonas aeruginosa) which are some of the infectious bacteria. The A.carambola leaves were extracted in three different solvents of increasing polarities (hexane, ethyl acetate, and acetone). The phytochemical analysis showed …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 8, Issue 2, 2018 · pp. 27–32 Read article
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A Review on Diagnosis and Management of Conjunctivitis
Abstract: Conjunctivitis, typically recounted as crimson eye, is a super ocular circumstance affecting men and ladies of all ages. This abstract aims to summarize the findings of a comprehensive study that delves into the pathogenesis, clinical manifestations, and management strategies for conjunctivitis. A multifaceted approach was employed, including a systematic literature review of conjunctivitis-related studies, clinical observations, and interviews with leading ophthalmologists. The various cases were analysed to assess demographic patterns, …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 2, 2024 · pp. 35–46 Read article
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The Review on Efficacy of Ozone Therapy in the Treatment of COVID 19
Abstract: The Corona Virus Disease 2019 (COVID 19) has created a global pandemic with a significant mortality and morbidity rate. Presently, with no vaccine or standard therapy available, the healthcare system has turned to correlate the existing therapies with the disease pathology and viral structure of corona virus. So thereby revisiting the existing therapies, here one of the highly efficient, safe and inexpensive ozone therapies. A multitude of ozone therapies have …
Published in Research and Reviews: A Journal of Medicine · Vol. 10, Issue 3, 2020 · pp. 7–11 Read article
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Next-Generation mRNA Vaccines: Applications Beyond COVID-19
Abstract: Messenger RNA (mRNA) vaccine technology has become a paradigm shift in contemporary medicine and, with remarkable success in the COVID-19 pandemic, has opened the door to a new wave of vaccines development. In contrast to the traditional vaccine methods, mRNA vaccines are based on the synthetic genetic code that allows host cells to express target antigens, thus eliciting strong humoral and cellular immunity. The speed of development, efficacy, scalability of …
Published in International Journal of Vaccines · Vol. 3, Issue 2, 2026 · pp. 15–26 Read article
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Helicobacter pylori Sialic Acid-Specific Surface Lectin Associated with Pathogenecity Island cag PAI
Abstract: Normal 0 false false false MicrosoftInternetExplorer4 Helicobacter pylori bacterium causing gastritis, duodenitis, non-ulcer dyspepsia, adenocarcinoma, MALT lymphoma and now-a-days causing hepatocellular carcinoma and cholengiocarcinoma has been studied for its surface antigens. There are many virulence factors which have been studied since many years. Cag-PAI is the site for virulence and causes mixed infections. Sialic acid is a type of glycan which is a surface lectin associated with adherence to cell …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 5, Issue 3, 2015 · pp. 10–17 Read article
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Effect of Toxoplasma gondii on some Neurotransmitter Levels in Patients with Toxoplasmosis Infection
Abstract: Background: The study of Toxoplasma gondii on some neurotransmitter levels in patients with toxoplasmosis infection is one of the challenges of sustainable development. Toxoplasma gondii is a parasite that can alter host behavior by affecting neurotransmitters of the host. Aim: To diagnose if there are differences in neurotransmitter levels in infected people by toxoplasmosis and healthy people to predict the psychological and neurological diseases. Methods: The study included collecting 60 …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 16, Issue 1, 2026 · pp. 1–8 Read article
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Biomedical Applications of Green-Synthesized Cobalt Oxide Nanoparticles
Abstract: The biomedical potential of cobalt oxide nanoparticles (Co3O4 NPs) synthesized via green methods is gaining recognition due to their biocompatibility and multifunctionality. This article reviews the antibacterial and anticancer properties of Co3O4 NPs synthesized using Delonix regia leaf extract. Characterization techniques confirmed their nanoscale size and uniform morphology. The antibacterial assay against Escherichia coli revealed significant activity, attributed to enhanced permeability and interaction with bacterial membranes. These findings highlight the …
Published in Emerging Trends in Chemical Engineering · Vol. 12, Issue 1, 2025 · pp. 20–29 Read article
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Advances in Polymer-Based Materials for Dental Applications: A Case Study on PVC and Ceramic Coatings in Digital Mouth Mirrors
Abstract: Polymeric materials play a crucial role in modern dentistry, providing improved mechanical properties, biocompatibility, and enhanced functionality in dental instruments. These materials contribute significantly to the advancement of dental tools, ensuring durability, safety, and efficiency. This study explores the application of polyvinyl chloride (PVC), ceramic coatings, and anti-fog polymer layers in the development of a digital mouth mirror. The integration of these materials results in enhanced durability, corrosion resistance, and …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 244–252 Read article
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Blood Cell Saver Machine
Abstract: Intraoperative Cell Salvage (ICS) is a crucial technique in modern surgical practice aimed at minimizing the need for allogeneic blood transfusions. By collecting, filtering, washing, and re-infusing a patient’s own blood lost during surgery, ICS provides a safer and cost-effective alternative to donor transfusion, reducing the risk of transfusion-related infections and immunologic reactions. Initially conceptualized in the early 19th century, ICS technology evolved significantly with the introduction of the Cell …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 15, Issue 2, 2025 · pp. 51–59 Read article
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Prevalence and Distribution of Staphylococcus Aureus in Clinical Samples Across Age Groups
Abstract: The bacteria that cause everything from ordinary skin infections to serious illnesses is called Staphylococcus aureus. It is now known that Staphylococcus aureus may develop resistance to a variety of drugs. Staphylococcus aureus has been displaying an unusual kind of resistance to antibiotics, especially to those based on β-lactum. As a result, Methicillin Resistant Staphylococcus Aureus (MRSA) is the new name for the resistant strain of Staphylococcus aureus. The prevalence …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 2, 2024 · pp. 15–19 Read article
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Application of Drug Delivery using Nano- technology to Cure Mental Disorders (Schizophrenia)
Abstract: Nanotechnology involves the manipulation of the count at an atomic scale to create novel systems, materials, and devices. This groundbreaking era holds substantial potential for scientific development across various domain names, which includes manufacturing, patron items, electricity, substances, and remedies. In current times, the sphere of prescribed drugs has witnessed a brilliant surge in the usage of nanotechnology for the improvement of revolutionary medications. Schizophrenia, a neuropsychiatric disorder affecting the …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 1, 2024 · pp. 51–65 Read article
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Effect of Local Application of Phenytoin on Wound Healing in Surgical Wounds: A Scientific Review
Abstract: Surgical wound healing is a dynamic biological process influenced by local tissue response, vascularity, infection control, and systemic patient factors. Delayed wound healing contributes significantly to postoperative morbidity and healthcare costs. Phenytoin, a hydantoin derivative traditionally used as an antiepileptic agent, has demonstrated unexpected wound-healing properties when applied topically. This review critically evaluates experimental and clinical evidence regarding the role of locally applied phenytoin in enhancing wound healing in surgical …
Published in Research and Reviews : Journal of Surgery · Vol. 15, Issue 1, 2026 · pp. 15–19 Read article
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A Novel Method for the Preparation of Eco-enzymes
Abstract: A novel method for the production of an eco-enzyme has been developed. The eco-enzyme prepared is a complex solution produced by fermentation of fresh kitchen waste (fruit and vegetable dregs), sugar (brown sugar, jaggery or molasses sugar) and water. It is dark brown and has a strong sweet sour fermented scent. Eco enzyme is a multipurpose liquid and its applications cover household, agriculture, animal husbandry etc.The enzyme prepared can be …
Published in Journal of Catalyst & Catalysis · Vol. 7, Issue 1, 2020 · pp. 6–12 Read article
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Management of Renal Calculi by Three Powerful Herbs—Overview
Abstract: Renal calculi also called as kidney stones, is found in every one of twenty individuals during their life time. Decreased urine volume or increased excretion of stone forming components such as calcium, oxalate, urate, cystine, xanthine and phosphate is the main cause for development of stones. There are many herbal formulations available for renal calculi but this review article is focussed on Varuna, Kulattha and Gokshura. Kulattha have diuretic, antilithiac …
Published in Research and Reviews: A Journal of Health Professions · Vol. 8, Issue 2, 2018 · pp. 27–30 Read article
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Emerging Trends in Horticultural Crops: Role of Date Fruit in Promoting Urinary and Kidney Health
Abstract: Dates, or Phoenix dactylifera L., have been widely consumed in different cultures, both as a food source and for their health benefits. Whereas dates have been reported extensively to improve cardiovascular, gastrointestinal, and metabolic function, their role in urinary tract and renal health has received lesser attention in mainstream nutritional sciences. This review systematically evaluates and synthesizes the current literature on the potential effects of dates to promote urinary health …
Published in International Journal of Trends in Horticulture · Vol. 3, Issue 1, 2026 · pp. 24–32 Read article