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404 articles for “anal disease”
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Extrapolations of Periwinkle Secondary Metabolites as Multitarget Inhibitor of Breast Cancer Proteins
Abstract: Objective: Breast cancer is considered one of the most common and dangerous forms of cancer. It is a significant public health issue on a global scale. The study estimates that 10.0 million people will die from cancer this year, and 19.3 million people will develop the disease overall (BC). In this computation approach, nowadays emphasizes new drug discovery, the target protein epidermal growth factor receptor (EGFR) (5UGB), estrogen receptor (ER) …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 1, 2023 · pp. 36–49 Read article
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Challenges in Diabetes Management Barriers and Support Systems in North India
Abstract: Background: The prevalence of Diabetes mellitus is ever growing in India and management of the disease is hindered by socio-economic, healthcare, and psychosocial barriers. Insofar as economic and social barriers pose challenges ranging from limited access to medical care, social stigma, specialist support leading to improper glycemic control, which is a strong predictor for diabetes complications, morbidity and mortality. Moreover, developing an understanding of systemic challenges and available supports is …
Published in Emerging Trends in Metabolites · Vol. 2, Issue 2, 2025 Read article
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Cutting-edge Deep Learning Methods for Predicting and Detecting Cardiovascular Diseases
Abstract: Cardiovascular diseases (CVDs) remain a major global health issue, highlighting the need for improved early detection and risk assessment methods. This research investigates the efficacy of both deep learning and traditional machine learning methods in forecasting cardiovascular diseases (CVDs). We evaluate a variety of models, including Convolutional Neural Networks (CNNs), Recurrent Neural Networks (RNNs), Multilayer Perceptrons (MLPs), Long Short-Term Memory (LSTM) networks, as well as Logistic Regression (LR), Decision Trees …
Published in Recent Trends in Parallel Computing · Vol. 11, Issue 2, 2024 · pp. 36–42 Read article
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Complex Tuberculous Meningitis: A Case Series Highlighting Rare Co-infections and Severe Complications
Abstract: This case series presents two complex cases of tuberculous meningitis (TBM) with different complications, illustrating the diverse clinical presentations and management challenges of this disease. Case 1 involves an 18-year-old female with TBM complicated by cryptococcal co-infection, while Case 2 describes a 64-year-old female with TBM complicated by obstructive hydrocephalus and secondary bacterial infections. Both patients had been on anti-tubercular therapy before presentation. Diagnostic approaches included cerebrospinal fluid analysis, cultures, …
Published in International Journal of Pathogens · Vol. 1, Issue 2, 2024 · pp. 1–7 Read article
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An Insight to Diagnosis and Management of Druginduced Hepatotoxicity: An Overview
Abstract: (ADRs) Adverse Drug Reactions are constitute and mutual chief health problem. Throughout the last period liver toxicity has remained one of the most recurrent reasons for pharmacovigilance protection intelligences and the withdrawal from the marketplace of an accepted medicinal product. Liver is a main organ elaborate in the systemic deposition and decontamination of exogenous and endogenous ingredients. Liver disfunction challenges not only health care specialists but also the pharmaceutical manufacturing …
Published in Trends in Drug Delivery · Vol. 8, Issue 2, 2023 · pp. 39–54 Read article
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Identification of Secondary Metabolites from Zingiber officinale as Inhibitors for Keap 1-Nrf2 small Molecules through Molecular Docking Techniques
Abstract: Objective: Therapeutic plants aid in treating cancer-based cell signaling pathways and preventing certain risk factors. Zingiber officinale has a variety of anti-inflammatory characteristics also contributing to enhanced immunity, reducing cancer risk and used to target the KEAP NRF2. When overexpressed in response to oxidative stress and DNA damage, elevates the risk of developing multiple cancers. NRF2 cellular sensors, which also control and coordinate their expression aid in defending healthy cells …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 35–48 Read article
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Transfer Learning in Deep Learning Models for Medical Imaging: Utilizing Pretrained Models to Improve Performance in Medical Image Analysis
Abstract: Transfer learning is now a trending technique in deep learning, especially in medical imaging. This technique solves landmark problems by utilizing the pre-trained models, including the limited availability of the annotated medical data and the time-consuming computational costs of training deep learning models from scratch. The generalizability of deep models could increase diagnostic precision for specific medical tasks, require fewer samples to train, and take less time to train due …
Published in Journal of Image Processing & Pattern Recognition Progress · Vol. 12, Issue 1, 2025 · pp. 67–85 Read article
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Role of Pharmaceutical Software in Vaccine Development and Manufacturing Process Optimization
Abstract: Vaccine development and manufacturing have become increasingly complex due to the emergence of diverse vaccine platforms, stringent regulatory expectations, and global demand for safe and effective immunization. Across the vaccine lifecycle – from antigen design and preclinical evaluation to large‑scale manufacturing and post‑marketing surveillance – pharmaceutical software now plays a central role in handling data, optimizing processes, and ensuring regulatory compliance. Software tools support in silico antigen and epitope design, …
Published in International Journal of Vaccines · Vol. 3, Issue 1, 2026 · pp. 1–8 Read article
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The Clinical Landscape of Wogonin: Advancing Targeted Treatments for Chronic Diseases
Abstract: The traditional Chinese medicinal herb Scutellaria baicalensis Georgi, commonly known as Chinese skullcap or Huang-Qin, has long been used to treat a variety of conditions, including cancer, viral infections, and seizures. Its pharmacological effects are largely attributed to the high concentration of flavones, particularly wogonoside, and its aglycone derivative, wogonin. Among the bioactive compounds found in S. baicalensis, wogonin has garnered the most scientific attention due to its potent therapeutic …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 1, 2025 · pp. 46–52 Read article
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Environmental and Sanitation Challenges and Their Role in Malaria Transmission: A Case Study of Duport Road Community, Paynesville City, Liberia
Abstract: Introduction: Environmental sanitation plays a crucial role in controlling malaria transmission, yet several factors continue to impede its effectiveness, particularly in communities with poor waste management and drainage systems. This study explores the factors that hinder proper environmental sanitation and their association with the spread of malaria among residents of Duport Road Community, Paynesville City, Liberia. Methods: A descriptive cross-sectional study was conducted, gathering data from 400 participants—both men and …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 2, 2025 · pp. 24–29 Read article
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Alzheimer disorders diagnosis system design using machine learning for EEG signal
Abstract: The diagnosis of Alzheimer's disorders (AD), a prevalent neurological disorder, can created by utilising a range of therapeutic methods, including the electroencephalogram (EEG), which has been especially successful in the past. The objective for this study is to develop a computer-aided diagnosis tool which may recognize AD from EEG data. The EEG information was cleaned up with a band-pass elliptic digital filter to remove any interference or disruptions. The filtered …
Published in Journal of Control & Instrumentation Read article
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Exploring Malaria Fever (Vishama Jwara) Through an Ayurvedic Lens: A Comprehensive Review
Abstract: Malaria fever, known as Vishama Jwara in Ayurveda, is a significant global health challenge caused by the Plasmodium species transmitted via Anopheles mosquitoes. While conventional medicine has advanced in diagnosing and treating malaria, exploring it through the Ayurvedic perspective offers valuable insights into its holistic understanding and management. Ayurveda describes Vishama Jwara as a fever with irregular patterns, aligning with the cyclical febrile episodes seen in malaria. This review delves …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 13, Issue 3, 2024 · pp. 47–53 Read article
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Post Covid-Sequela: Novel-Inception of DM: A Review
Abstract: As patients recovers from COVID 19 pandemic, a subset of the covid patients experienced a post covid condition with long term symptoms, few weeks after their discharge or recovery from the (SARS-CoV-2) infection. Hence, we tried to prove the hypothesis whether diabetes mellites is an afresh possible sequala of covid infection by systematically evaluating the consistently changing glucose level of the post covid patients. The databases PubMed and Google Scholar …
Published in Research and Reviews : A Journal of Immunology · Vol. 16, Issue 2, 2026 Read article
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Pregnancy Outcomes on Chronically Hemodialyzed Women in Arab World: A Systematic Review
Abstract: Pregnancy carries a major risk of difficulties, as highlighted by the present systemic study on pregnancy outcomes in persistently hemodialyzed women in the Arab world. The objective of this systematic review was to describe the pregnancy outcomes among chronically hemodialyzed pregnant women in Arab countries in terms of the incidence of pregnancy among women on maintenance hemodialysis and the incidence of maternal and fetal complications of pregnant women on hemodialysis. …
Published in International Journal of Midwifery Nursing And Practices · Vol. 2, Issue 1, 2024 · pp. 25–36 Read article
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Fabrics and medical devices (catheters) coated with Zn doped CuO nanoparticles kills micro-oganisms and provide healthy environment
Abstract: These days, drug resistance by microorganisms is a major challenge in the field of medicinal chemistry. Most of the familiar antibiotics turnout to be of no impact in curbing the proliferation of microorganism (bacteria, virus and fungus). To address the issue of multi-drug resistance (MDR) and extremely drug resistance (EDR) in microorganisms that cause various health complications, like the dental decay, biofilm formation, foul smell, delayed wound healing, aggravation of …
Published in Journal of Catalyst & Catalysis · Vol. 12, Issue 1, 2025 · pp. 1–9 Read article
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A Comprehensive Review of Metabolite
Abstract: Metabolites, tiny chemicals, are essential to physiology, signalling, and biological function. This extensive review classifies metabolites into primary and secondary categories by biological relevance. Alkaloids, flavonoids, and terpenoids contribute to ecological interactions and defence systems, while amino acids, nucleotides, and carbohydrates directly affect development and cellular function. The article examines metabolic pathways, mass spectrometry, NMR, and metabolomics, a growing field. Metabolites play a crucial role in various scientific and practical …
Published in Emerging Trends in Metabolites · Vol. 2, Issue 2, 2025 Read article
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A Study to Evaluate the Impact of Health Education on Awareness of Long-term Complications of Hypertension Among Hypertensive Patients in A Selected Hospital, Bengaluru
Abstract: The rising burden of non-communicable diseases, particularly hypertension, poses significant public health challenges, especially in developing nations. This study aimed to assess the effectiveness of a health education program focused on lifestyle modifications to prevent hypertension-related complications among patients at selected hospitals in Bengaluru. Employing a quasi-experimental design, we recruited 60 hypertensive patients through purposive sampling. Initial knowledge was evaluated using a structured questionnaire, followed by an educational intervention provided …
Published in International Journal of Evidence Based Nursing And Practices · Vol. 2, Issue 2, 2024 · pp. 31–63 Read article
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Targeting Dystrophin Restoration and Neuroprotection in Duchenne Muscular Dystrophy: Insights from Withania somnifera
Abstract: Duchenne muscular dystrophy is a genetic disorder. This disease affects men more common than women. Main objective of the present study was to identify the naturally active phytocompounds from Withania somnifera (Ashwagandha). Ashwagandha has a great value in the field of Ayurveda and Indian medicine and is used for treating muscular and neurological disorders. Toxicity prediction, molecular docking, statistical information, drug illness prediction, and Absorption, distribution, metabolism, excretion, and toxicity …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 64–84 Read article
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Revolutionizing Vaccine Development:The Transformative Role of Bioinformatics in Designing Next-Generation Immunotherapies
Abstract: Vaccines have long been central to the prevention and control of infectious diseases, dramatically reducing morbidity and mortality worldwide. In the modern era, the integration of bioinformatics has revolutionized vaccine development by enabling rapid, precise, and cost-effective identification of potential vaccine targets. This seminar explores the multifaceted applications of bioinformatics in vaccinology, including antigen discovery, epitope prediction, structural modeling, molecular docking, and immunoinformatics-driven vaccine design. Special emphasis is placed on …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 12, Issue 3, 2025 · pp. 19–33 Read article
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Expression Profiling of Immunomodulatory Genes in Canine Adipose Tissue–Derived Mesenchymal Stem Cells
Abstract: Adipose tissue–derived mesenchymal stem cells (AT-MSC) represent a heterogeneous population of self-renewing, multipotent progenitor cells residing in the stromal compartment of adipose tissue. Canine adipose tissue-derived mesenchymal stem cells have attracted significant interest in regenerative medicine due to their therapeutic potential in naturally occurring canine diseases and their translational relevance to human medicine. In the present study, canine adipose tissue–derived MSCs (cAT-MSCs) were isolated and differentiated into osteogenic, chondrogenic and …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 15, Issue 1, 2026 Read article