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1953 articles for “phosphoinositol-3-kinase pathway” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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Advances in Polymer-Based Orthodontic Materials for Enhanced Treatment Efficiency
Abstract: Polymers, particularly shape-memory polymers, fiber-reinforced composites, and elastomeric materials, provide enhanced mechanical properties such as flexibility, durability, and controlled force application, leading to improved treatment outcomes. These materials offer superior biocompatibility, reducing irritation and discomfort for patients while ensuring efficient and predictable tooth movement. It is important to note one of the key advancements in orthodontics is the use of shape-memory polymers, which can respond to temperature or external stimuli, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 1016–1024 Read article
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Polymeric Materials in Assistive Devices for Cerebral Palsy: Advances and Applications
Abstract: The neurological condition known as cerebral palsy (CP) impairs muscle coordination and movement often necessitating assistive devices for mobility, support, and rehabilitation. These devices are crucial for enhancing CP patients' quality of life by boosting their independence, comfort, and overall functionality. Recent advancements in polymer chemistry have revolutionized the development of assistive devices, offering enhanced flexibility, durability, and biocompatibility. The integration of polymeric materials in orthotic supports, adaptive braces, and …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 316–322 Read article
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Innovations in Targeted Drug Discovery for Personalized Medicine
Abstract: Personalized medicine is revolutionizing modern healthcare by custoizing treatment plans to match an individual’s genetic makeup, protein expression, and metabomlic characteristics. Also referred to as precision medicine, this approach seeks to improve therapeutic outcomes, reduce adverse effects, and make efficient use of healthcare resources. The incorporation of various omics technologies—including genomics, proteomics, transcriptomics, metabolomics, and epigenomics—has greatly advanced our ability to understand disease biology and molecular variations specific to each …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 3, 2025 · pp. 19–41 Read article
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Revolutionizing Artificial Organs: Next-Generation Membrane Technologies for Precision Medicine and Global Health
Abstract: Membrane technology has emerged as a cornerstone in the advancement of artificial organ systems, offering critical functionalities in selective molecular filtration, tissue scaffolding, and controlled therapeutic delivery. Recent innovations have propelled the field beyond traditional polymeric membranes to include nanostructured, biomimetic, and stimuli-responsive materials, significantly enhancing biocompatibility, selectivity, and durability. The integration of smart technologies, such as AI-driven membrane design, bioelectronic sensors, and personalized fabrication via 3D printing, is ushering …
Published in International Journal of Membranes · Vol. 2, Issue 2, 2025 · pp. 29–39 Read article
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Association of Metabolic Syndrome with Cholelithiasis in Female Patients and Its Impact on Clinical Management and Surgical Outcome
Abstract: Background: Metabolic syndrome (MetS) is associated with obesity, insulin resistance, dyslipidemia, and hypertension, which may predispose to gallstone formation. This study aimed to evaluate the association between MetS and cholelithiasis in female patients and to assess its impact on clinical presentation, surgical difficulty, and postoperative outcomes. Methods: A prospective observational study was conducted on 88 female patients with ultrasonography-confirmed cholelithiasis. Patients were divided into two groups: MetS (n=44) and non-MetS …
Published in Research and Reviews : Journal of Surgery · Vol. 14, Issue 3, 2025 · pp. 1–7 Read article
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Development of River Flood Management plan “Case of Patna City”
Abstract: This Research Paper develops an Integrated River Flood Management plan for Patna city, which includes Policy Framework and Implementation Strategy by increasing resilience and reducing river flood through various Interventions like Land use planning, Low Impact Development, Embankments, leaves, Dykes and ecosystem-based adaptation, resilient infrastructure, and community engagement identified from various Literature studies. It ensures Development of framework for River Flood in the region. It also talks about the Parameters …
Published in Journal of Water Resource Engineering and Management · Vol. 12, Issue 3, 2025 · pp. 38–79 Read article
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In Silico Screening of Terminalia chebula Phytocompounds as Potential Inhibitors of NTCP and DDB1 in Hepatitis B Virus Infection
Abstract: Hepatitis B virus (HBV) infection is a major global health concern, and chronic carriers are at risk of developing cirrhosis, hepatocellular carcinoma (HCC), and even death. Existing treatments can effectively inhibit viral replication, but they achieve little eradication of the virus because of covalently closed circular DNA (cccDNA) retention. In this investigation, bioactive compounds of Terminalia chebula, a plant known for its hepatoprotective and antiviral properties in traditional medicine, were …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 1, 2026 · pp. 33–44 Read article
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Nanomedicine in the Tumor Microenvironment: Physiological Modulation Through Tissue Engineering Approaches
Abstract: The integration of nanomedicine and tissue engineering offers transformative strategies for cancer therapy by directly modulating the physiological processes within the tumor microenvironment (TME). This review emphasizes recent advances in nanomedicine that enable precise drug delivery, controlled release, and real-time monitoring of key physiological parameters influencing tumor progression, angiogenesis, and immune evasion. Tissue-engineered 3D tumor models provide physiologically relevant platforms that better mimic in vivo conditions than traditional 2D cultures, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 1, 2026 · pp. 19–31 Read article
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Comparative Analysis of Tensile Properties of Virgin and Rice Husk-Reinforced PLA and ABS Filaments
Abstract: This study focuses on evaluating the tensile behavior of polylactic acid (PLA) and acrylonitrile butadiene styrene (ABS) filaments reinforced with rice husk ash (RHA) particles, in comparison with their respective virgin counterparts. The incorporation of RHA, an abundant agricultural waste by-product, was considered with the objective of developing eco-friendly composites suitable for additive manufacturing applications. Tensile testing was carried out to assess the influence of the reinforcement on the mechanical …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 224–229 Read article
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Electroactive Graphene–Polymer Nanocomposites for Self-Sustaining and Multifunctional Flexible Devices
Abstract: Graphene–reinforced polymer–composites were developed and systematically investigated to explore their multifunctionality in flexible electronic applications. The study specifically aims to correlate graphene-induced structure–property–function relationships with electroactive performance and self-sustaining behaviour in flexible devices. The hybridization of electroactive polymers—polyaniline (PANI), poly(3,4-ethylenedioxythiophene): polystyrene sulphonate (PEDOT:PSS), and polyvinylidene fluoride (PVDF)—with graphene nanoplatelets enabled simultaneous enhancement of electroactivity, energy-harvesting, and sensing functionalities. Morphological studies confirmed uniform graphene dispersion at 5 wt.% loading, forming continuous …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 260–271 Read article
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Comparative Analysis of Disc Brake Using Eco-Friendly Material
Abstract: Brakes are crucial components for slowing or stopping the vehicle. Almost all vehicles use disc brakes. The working of a disc brake is simple; when the brake pedal is pressed, braking pads are forced mechanically against the rotor or disc on both surfaces. The friction generated between the rotor and brake pads slows down the vehicle. The design and materials of disc brakes play a significant role in their performance. …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 532–544 Read article
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A Correlational Study to Assess the Effect of Social Media Engagement on Body Image Among Adolescents in Selected School, Haryana, India
Abstract: Social media has become an undeniable force in shaping modern social interactions, particularly among adolescents. Social media platforms are often criticized for perpetuating unattainable beauty ideals. These platforms frequently showcase images highlighting slimness, youth, and flawless skin, often manipulated by filters, photo editing tools, or even cosmetic surgery. These portrayals of "ideal" beauty can distort adolescents' sense of themselves, leading to increased body dissatisfaction. Objectives of the study were: (i) …
Published in International Journal of Community Health Nursing And Practices · Vol. 3, Issue 2, 2025 · pp. 46–64 Read article
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A Quasi-Experimental Study to Assess the Effectiveness of Yog-Nidra on Improving Quality of Life Among Cancer Patients Undergoing Radiotherapy in Selected Cancer Hospitals at Raipur (Chhattisgarh)
Abstract: The present study aimed to evaluate the effectiveness of Yog-Nidra on improving the quality of life among cancer patients undergoing radiotherapy. The specific objectives were to assess pre-test and post-test scores before and after the Yog-Nidra intervention in both experimental and control groups, determine its effectiveness in enhancing quality of life, and identify any associations between pre-test scores and selected demographic variables. A pre-experimental one-group pre-test and post-test design was …
Published in International Journal of Oncological Nursing and Practices · Vol. 3, Issue 2, 2025 · pp. 29–55 Read article
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Nano Shield-EV: Graphene and CNT-Infused Polymer Composites for Advanced EMI Shielding in Electric Vehicles
Abstract: The rapid growth of electric vehicles (EVs) has intensified the need for lightweight, thermally stable, and mechanically robust electromagnetic interference (EMI) shielding materials to ensure the reliable performance of advanced electronic systems. Traditional metallic shields, though highly effective, increase vehicle weight and restrict design flexibility, thereby motivating the search for multifunctional polymer-based alternatives. In this study, NanoShield-EV introduces novel polymer nanocomposites fabricated via melt blending and compression molding, combining engineering-grade …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1036–1047 Read article
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Alcohol, Circadian Glymphatic Dysfunction, and Neurodegenerative Protein Accumulation: An Emerging Concern in the Indian Context
Abstract: Alcohol consumption has long been identified as a major public health issue, yet its deeper and more subtle effects on the human brain are only now coming into sharper focus. Traditional explanations often emphasize direct neuronal damage, but emerging research in neuroscience suggests a more intricate story. Recent findings indicate that alcohol not only harms brain cells but also disrupts the body’s internal biological clock—the circadian rhythm—which plays a critical …
Published in International Journal of Brain Sciences · Vol. 3, Issue 1, 2026 · pp. 1–4 Read article
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Caries-Preventive Effects of Self-Applied Subacidic 0.5% NaF-HF Gel via Toothbrushing in 7–8-Year-Old Schoolchildren: A Randomized Controlled Clinical Trial
Abstract: To assess the caries-preventive effectiveness of self-applied subacidic 0.5% sodium fluoride–hydrofluoric acid (NaF-HF) gel used during toothbrushing in children aged 7–8 years Objective: To assess the caries-preventive effectiveness of self-applied subacidic 0.5% sodium fluoride–hydrofluoric acid (NaF-HF) gel used during toothbrushing in children aged 7–8 years. Methods: This 1-year, multi-arm, double-blind, placebo-controlled, parallel-group randomized study evaluated the caries-preventive efficacy of self-applied 0.5% NaF-HF gel among primary schoolchildren. A total of 1200 …
Published in Research and Reviews: A Journal of Dentistry · Vol. 17, Issue 1, 2026 · pp. 14–19 Read article
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Fabrication of Polydimethylsiloxane Composites with Nickel Nanoparticles: Unification and Current–Voltage Relationship
Abstract: Polydimethylsiloxane (PDMS)–nickel nanoparticle (NiNPs) nanocomposite films were fabricated and systematically investigated to understand their electrical transport behavior through current–voltage (I–V) characterization. Nanocomposite films with varying Ni nanoparticle filler concentrations (14.88 wt%, 15.77 wt%, and 16.65 wt%) were prepared using a solution-mixing and spin-coating technique, followed by controlled thermal curing. The electrical properties of both pristine PDMS and PDMS– NiNPs nanocomposites were examined over a wide voltage range (up to 800 …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 16, Issue 1, 2026 · pp. 22–29 Read article
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Stem Cell Therapy: Advancements, Applications, and Future Prospects in Regenerative Medicine
Abstract: Stem cell therapy has come up as a revolutionary technique in regenerative medicine living up to the promise in treating numerous diseases and injuries. The latest discoveries made in the field of stem cell research such as the introduction of gene editing technology like CRISPR and the creation of the 3D bioprinting process have increased the accuracy and efficacy of stem cell-based therapies. Examples include cardiac regeneration and repair of …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 4, Issue 1, 2026 Read article
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Histoplasma capsulatum (Dimorphic Fungus) in India: Biological Features, Virulence Mechanisms, and Clinical Implications of Histoplasmosis.
Abstract: Histoplasmosis is a systemic mycosis caused by the thermally dimorphic fungus Histoplasma capsulatum. Infection is acquired primarily by inhalation of infectious microconidia and may range from asymptomatic infection to severe disseminated disease. Although histoplasmosis has classically been associated with the river valleys of the Americas, it is being increasingly recognized in Asia, including India, where it frequently mimics tuberculosis, leishmaniasis, lymphoma, and leprosy, resulting in delayed diagnosis and treatment. Cutaneous …
Published in International Journal of Fungi · Vol. 3, Issue 1, 2026 · pp. 38–48 Read article
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Sudarshan Kriya Intervention and Rise of Protective Prostaglandins in Advanced-Stage Breast Cancer: Double-Blind, Randomized, Controlled Trial
Abstract: Background: Breast cancer patients in advanced stages of cancer are managed by palliative care. This study reports important prostaglandin changes observed with added intervention of Sudarshan Kriya in their ongoing palliative care. Level of Prostaglandin A₂ (PGA₂) indicates tumor growth suppression; its level rises if person’s general condition is good, physically fit and active while PGE₂ and D₂ are considered pro-inflammatory. Quantitative assessment of Prostaglandins was done pre and post …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 15, Issue 1, 2026 · pp. 62–68 Read article