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669 articles for “modulation”
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Exploring the Therapeutic Potential of Phytochemicals in Aloe Barbadensis Miller Through Molecular Docking for Ulcerative Colitis Management
Abstract: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by mucosal inflammation of the colon, often associated with immune dysregulation and oxidative stress. Natural compounds have gained significant attention as alternative therapeutic agents due to their efficacy and minimal side effects. Quercetin, a flavonoid abundantly found in Allium cepa (onion), has demonstrated potent anti-inflammatory and antioxidant properties. This study employs an in silico approach to evaluate the therapeutic potential …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 13, Issue 1, 2026 · pp. 06–12 Read article
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Smart Solar Garage with PSO-Based Optimization for Energy and Vehicle Performance
Abstract: The swift growth of electric mobility, coupled with a rising global focus on sustainable energy, has propelled the advancement of smart garages that incorporate renewable energy, the Internet of Things (IoT), and sophisticated optimization methods. These systems aim to reduce energy waste, boost operational efficiency, and aid in the development of smart, eco-friendly urban infrastructure. This paper outlines the design and execution of a Smart Solar Garage that utilizes Particle …
Published in International Journal of Energy and Thermal Applications · Vol. 3, Issue 2, 2025 · pp. 6–18 Read article
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Thermodynamic Optimization and Exergy-Based Performance Analysis of Hybrid Thermal Management Systems for Electric Vehicles
Abstract: The transition toward sustainable transportation has brought electric vehicles (EVs) to the forefront of modern engineering innovation. Despite their environmental benefits and improved energy efficiency, EVs face major thermal challenges that affect performance, safety, and durability. Efficient thermal management of batteries, power electronics, and electric drive systems is vital to ensure reliability under diverse operating conditions. This study presents a detailed thermodynamic optimization and exergy-based performance analysis of hybrid thermal …
Published in International Journal of Energy and Thermal Applications · Vol. 3, Issue 2, 2025 · pp. 19–23 Read article
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Edutrade Web Portal: A Comprehensive Educational Trading Platform for Students
Abstract: EduTrade is a comprehensive online portal developed to address the challenges faced by students in accessing academic resources and fostering collaboration in a digital learning environment. The platform integrates key features such as a peer-to-peer book exchange module, where students can buy and sell textbooks with real-time condition assessments; a repository for faculty and student notes to promote knowledge sharing; and a dedicated section for accessing previous years' question papers …
Published in Journal of Computer Technology & Applications · Vol. 16, Issue 3, 2025 · pp. 95–102 Read article
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Marine Algal Microfiber and Agro-Waste Reinforced Crosslinked Polymer Composites for Sustainable Coastal Materials
Abstract: Crosslinked bio-polymer composites reinforced with marine algal microfibers and agro-waste fillers were fabricated and systematically characterized for sustainable coastal applications. Mechanical testing revealed that tensile strength increased from 18.5 MPa for neat polymer to 25.1 MPa at 20 wt.% reinforcement (~35% improvement), while the flexural modulus improved from 0.72 GPa to 1.02 GPa (~42% increase). Impact strength, however, decreased from 3.8 kJ/m² for neat polymer to 2.9 kJ/m² at 30 …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 210–223 Read article
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Solar-Responsive Photo-Thermal Polymer Composites with Carbon Nanostructures for On-Demand Water Purification
Abstract: The development of solar-responsive polymer nanocomposites offers a sustainable pathway for water purification. In this work, polyvinyl alcohol (PVA) films reinforced with graphene nanoplatelets (GNPs) and multi-walled carbon nanotubes (MWCNTs) were fabricated and systematically investigated for their mechanical, thermal, viscoelastic, and thermal transport properties. Neat PVA displayed moderate tensile strength (~38 MPa) and high elongation (~165%), whereas 1.0 wt% nanofiller loading enhanced tensile strength to ~52 MPa and modulus to …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 199–209 Read article
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Immune Dysregulation and Cytokine Circuitry in Genital Endometriosis: Mechanistic Insights and Next-Generation Immunotherapeutic Strategies
Abstract: Genital endometriosis is increasingly recognized as an immune-mediated inflammatory disorder driven by complex interactions between dysregulated immune cells, cytokine hubs, and microbiome-derived modulators. This review introduces a novel “immune–cytokine circuitry” framework that unifies innate and adaptive immune abnormalities with key cytokine loops sustaining chronic inflammation, angiogenesis, neuroinflammation, and immune tolerance. Within this circuitry, macrophage polarization, dendritic cell immaturity, NK-cell anergy, Treg expansion, Th17 amplification, and B-cell–mediated autoimmunity converge to establish …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 06–16 Read article
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Flexural Vibration of Non-Uniform Beam on Bi-Parametric Foundation Under Harmonic Moving Load with Non-Classical Boundary Conditions
Abstract: The dynamic response to harmonically varying moving loads of non-uniform elastic beam resting on bi-parametric foundation with non-classical boundary condition, time dependent in particular is examined in this paper. Here, the beam is considered non-uniform, with the moment of inertia and the distributed mass varying continuously along the span L as functions of the position 𝑥. In order to guarantee a more stable structure and a reduce risk of resonance, …
Published in International Journal of Mechanical Dynamics and Systems Analysis · Vol. 3, Issue 2, 2025 · pp. 28–42 Read article
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Finite Element Modelling of Contact Stresses in Helical Gear Systems
Abstract: Helical gears are widely used in modern power‐transmission systems because of their high load‐carrying capacity, smooth meshing action, and increased overlapping of gear teeth. However, the design of helical gear pairs is constrained by contact stresses generated at the mating tooth surfaces, which can lead to surface fatigue (pitting), micro-cracking, and ultimately gear failure. Traditional analytical methods, such as those of the American Gear Manufacturers Association (AGMA) or International Organization …
Published in Trends in Machine design · Vol. 12, Issue 3, 2025 · pp. 35–39 Read article
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Mood Mate: A Solid-State Edge-AI System for Real-Time Facial Emotion Recognition
Abstract: Recent progress in solid-state electronics and embedded vision systems has enabled real-time emotion-aware applications at the edge. This paper presents MoodMate, a solid-state edge-AI framework for real-time facial emotion recognition using camera-based sensing and embedded processing. The proposed system integrates a solid-state image sensor with an AI- driven emotion classification pipeline optimized for low-latency and resource-constrained environments. Intelligent, emotion-aware apps can now be deployed right at the network edge thanks …
Published in International Journal of Solid State Innovations & Research · Vol. 3, Issue 2, 2025 · pp. 24–30 Read article
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Structure–Property Relationships in Poly (N isopropylacrylamide) Hydrogels: Toward Thermoresponsive Polymer Composites
Abstract: Poly(N-isopropylacrylamide) (PNIPAAm) hydrogels can shift from solid to gel and back again at body temperature. Due to their lack structural integrity, thermal stability, and mechanical strength, they are difficult to use. This study mixed PNIPAAm with biocompatible fillers like chitosan and silicon nanoparticles to create hydrogels with superior structure-property correlations. Free radical polymerization with ammonium persulfate/TEMED initiator and N,N′-methylenebisacrylamide crosslinker produced the composites. Scanning electron microscopy showed a denser, interconnected …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 884–895 Read article
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Polymer-Based Acousto-Optic Ultrasonic Sensor for Non-Destructive Evaluation of Dielectric Insulation
Abstract: A dual-polymer fiber-optic sensor for monitoring partial discharge (PD) activity in high-voltage polymeric insulation is presented in this work for non-destructive evaluation and dielectric testing applications. Dielectric weakness within polymeric insulation leads to partial discharge activity, generating ultrasonic acoustic waves that propagate through the medium. The developed sensing assembly comprises a conical polymer-based horn that gathers and concentrates the ultrasonic acoustic emission energy generated by dielectric weakness, and a single-mode …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 11–24 Read article
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Interaction of Mosquito’s hppd Enzyme with Lansoprazole Sulfide A New Hope to Tackle the Mosquito Menace – an in-Silico Study
Abstract: Tyrosine detoxification is an important physiological process that helps blood-feeding insects, such as mosquitoes that transmit Plasmodium parasites causing malaria, digest their blood meals. An enzyme known as 4-hydroxyphenylpyruvate dioxygenase (HPPD), which is part of the tyrosine detoxification pathway, helps in removing excess tyrosine in a high-protein blood meal. Excess tyrosine can be lethal to the insects, and hence, the role of HPPD enzyme is very critical. Inhibitors of HPPD …
Published in International Journal of Insects · Vol. 3, Issue 1, 2026 · pp. 1–11 Read article
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Structure-Property-Process Relationships in BNNS-Modified PEEK Nanocomposites for High-Performance Applications
Abstract: This study reports the design and performance evaluation of boron nitride nanosheet (BNNS)-reinforced polyetheretherketone (PEEK) nanocomposites fabricated using melt compounding and high-temperature Fused Filament Fabrication (FFF). PEEK, a high-performance thermoplastic, was reinforced with BNNS at 0.5–5wt.% to enhance mechanical, thermal, and tribological functionalities for advanced engineering use. Composite filaments were extruded and printed using a modified Bambu Lab FFF printer. Mechanical testing revealed a peak tensile strength of 108 MPa …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 867–888 Read article
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Diet-Gene Interactions in Farm Animals: Molecular Dynamics, Gene Expressions, Signalling Pathways and Precision Nutrition for Sustainable Productivity
Abstract: Diet-gene interactions represent a central mechanism through which nutrition influences growth, health, and productivity in farm animals. Recent advances in molecular biology and genetics have revealed that nutrients act not only as metabolic substrates but also as signalling molecules capable of modulating gene expression, cellular pathways, and epigenetic regulation. This review synthesizes current knowledge on the molecular dynamics of nutrient utilization in farm animals, with emphasis on nutrigenomic responses, nutrient …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 4, Issue 1, 2026 Read article
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Immunological Biomarkers and Epidemiological Evaluation of Lymphatic Filariasis Elimination Efforts in Osun State, Nigeria
Abstract: Lymphatic filariasis (LF) remains a neglected tropical disease affecting millions globally, despite extensive elimination efforts. While the interruption of transmission is a key goal, the long-term immunological effects on individuals with existing complications like elephantiasis remain poorly understood. This study assessed the current transmission status of LF and the haematological profiles of infected individuals across selected Local Government Areas (LGAs) in Osun State, Nigeria. A total of 7,388 individuals from …
Published in International Journal of Tropical Medicines · Vol. 3, Issue 1, 2026 · pp. 22–30 Read article
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Experimental Evaluation of Carbon Fiber Reinforced Epoxy Composites for Structural Applications
Abstract: Composites made of carbon fibre reinforced polymer (CFRP) are currently one of the most widely used material classes in advanced engineering applications because of their remarkable environmental resistance, dimensional stability, and strength-to-weight ratio. The vacuum bag moulding method was used in this study to create CFRP laminates with different fiber-to-resin weight ratios: 50:50, 55:45, 60:40, 65:35, and 70:30. The reinforcement phase was made of unidirectional carbon fibre fabric and the …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 401–415 Read article
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Investigation on Mechanical Properties of Bamboo Fibre Reinforced Composites
Abstract: This study investigates the mechanical performance of bamboo fibre-reinforced polymer composites (BFRPCs), emphasizing tensile, flexural, and impact properties. The composites were fabricated using an epoxy resin matrix combined with untreated bamboo fibres in varying fibre contents ranging from 25% to 45%, utilizing the hand lay-up method. Among the tested compositions, the composite with 35% bamboo fibre content exhibited the most favorable mechanical characteristics. It achieved the highest tensile strength of …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 325–338 Read article
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Mechanical and Thermal Performance of PETG Composites Reinforced with Short Carbon Fibers via Fused Filament Fabrication
Abstract: The study investigates the fabrication and characterization of polyethylene terephthalate glycol (PETG) composites reinforced with short carbon fibers (CF) using the fused filament fabrication (FFF) technique. Composite filaments with varying CF weight fractions (0, 5, 10, 15, and 20 wt%) were produced and evaluated for their mechanical, thermal, and morphological performance. The influence of CF reinforcement on tensile, flexural, and impact behavior was systematically examined, alongside thermal stability metrics including …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1219–1238 Read article
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Investigation on The Effect of Carbon Fiber Reinforcement on The Mechanical and Physical Properties of FDM 3d Printed PLA
Abstract: In this work, the effects of annealing on the physical properties and mechanical behavior of short-carbon-fiber-reinforced polylactic acid (CF/PLA) composites made using fused deposition modeling (FDM) are systematically investigated. Pristine PLA and CF/PLA composites with 10% fibers have been made and evaluated in accordance with ASTM standards. Tensile, bending, and hardness tests were used to evaluate the performance of as-received and annealed composites. The tensile and hardness properties of PLA …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 284–298 Read article