Search
382 articles for “F protein”
-
In Silico Identification of Therapeutic Agents for Dengue Virus by Molecular Docking
Abstract: The dengue virus causes serious health issues and a loss of quality of life. Dengue poses a yearly threat to half of the world’s population. The drugs that are based on allopathy are expensive and also exhibit toxic effects on tissues and biological activities. It is also generally accepted that most pharmacologically active drugs, including those derived from medicinal plants, are isolated from natural sources. The present study is directed …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 · pp. 01–14 Read article
-
Green Pastures, Healthy Herd: The Intricate Interplay of Nutrition, Milk Yield, Reproduction, and Welfare in Dairy Cows
Abstract: The study explores the intricate interplay between green pastures, nutrition, milk yield, reproduction, and welfare in dairy cows, emphasizing the multifaceted benefits of pasture-based systems. Green grass serves as a natural, nutrient-rich feed source that supports optimal dairy cow performance by providing essential nutrients such as energy, proteins, vitamins, and minerals, which are crucial for high milk production. The natural grazing behavior associated with green pastures enhances rumen function, facilitating …
Published in Research & Reviews : Journal of Botany · Vol. 14, Issue 2, 2025 · pp. 51–66 Read article
-
In Silico Analysis and Molecular Docking Studies of COX-2 Inhibitors for Anti-Inflammatory Activity
Abstract: Although nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used to treat pain, lower fevers, and control inflammation, they frequently cause gastrointestinal side effects because they inhibit the COX-1 and COX-2 enzymes. Despite their effectiveness and lack of gastrointestinal side effects, selective COX-2 inhibitors have been linked to cardiovascular risks. To find new COX-2 inhibitors that are safer and more effective, this study uses in silico techniques, such as molecular docking and …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 38–55 Read article
-
Integrating Network Pharmacology and Molecular Docking to Assess Rutin’s Pharmacological Properties
Abstract: Objectives: In the present research, the network pharmacology process was applied to determine the underlying mechanism of the pharmacological properties of Rutin. Network pharmacology was utilized to reveal the interactions between medications and the targets of illnesses, and it is capable of completely articulating the complexity between diseases and medications. The identification of diverse drug-target interactions using network pharmacology may be utilized to discover novel medications for difficult conditions like …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 20–33 Read article
-
Screening of Newer Phytoconstituents on Novel Enzymes for their Biological Activity
Abstract: Background: Hyperlipidemia and gout are prevalent metabolic disorders significantly impacting global health. The xanthine oxidase and HMG-CoA reductase pathways play pivotal roles in the pathophysiology of these conditions. This study explores the potential of natural phytoconstituents—daidzein, resveratrol, and genistein—as dual inhibitors for these enzymatic targets, offering insights into innovative therapeutic strategies. Aim: To evaluate the potential of natural phytoconstituents—daidzein, resveratrol, and genistein—as dual inhibitors of xanthine oxidase and HMG-CoA reductase …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 1, 2025 · pp. 81–86 Read article
-
Advanced Computational Models for Predicting Molecular Interactions
Abstract: Understanding molecular interactions is essential for a number of disciplines, including biochemistry, materials science, and medication development. Traditional experimental methods, while accurate, are often time-consuming and expensive. Advanced computational models have emerged as powerful tools to predict molecular interactions efficiently. In order to predict the behavior and interactions of molecules at the atomic and subatomic levels, this paper reviews the most recent developments in computational techniques, such as machine learning …
Published in International Journal of Advance in Molecular Engineering · Vol. 2, Issue 1, 2024 · pp. 8–13 Read article
-
Deciphering the Roles of Estrogen Receptors and 27-Hydroxycholesterol in BC Progression
Abstract: Breast cancer (BC) ranks among the top causes of cancer-related deaths in women worldwide. Many risk factors of BC are linked to estrogen. Experiments of Beatson in 1896 show the role of steroid hormones as major determinant in BC. Action of steroid hormones is mediated by their receptors including Estrogen receptors (ERs). ERs are part of a subfamily of ligand-regulated transcription factors. Their primary role is to translate hormone signals …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 2, 2024 · pp. 18–26 Read article
-
Using Multitarget Molecular Docking to Examine the Antiviral Potential of Clerodendrum Phlomidis against Measles
Abstract: Objective: Measles, a viral disease caused by a member of the Paramyxoviridae virus family, is highly contagious and characterized by a respiratory illness and a maculopapular rash on the skin. Children are the main victims of the illness. In the context of drug development, this study investigates the efficacy of phytocompounds derived from Clerodendrum phlomidis against the target protein of the measles virus. Methods: The 7SKS protein was retrieved from …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 2, 2023 · pp. 32–42 Read article
-
Structure and Origin Insight of Recent Coronavirus with Ongoing Therapeutic Approach
Abstract: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is highly transmissible zoonotic virus that was initially reported in late 2019 in Wuhan, China. Presently, it has infected approximately 1.5 million person and responsible for more than 0.1 million death across the world. It is likely evolved from bats and pangolin and genetically different from SARS-CoV-1, responsible for SARS disease. In present review, we have discussed the recent finding of its origin from …
Published in Research and Reviews : A Journal of Life Sciences Read article
-
Surajmukhi (Helianthus annuus L.): Medicinal Importance in Unani Literature and Modern Evidence
Abstract: Helianthus annuus L. (Sunflower), belonging to the family Asteraceae, is a well-recognized plant in both traditional and modern systems of medicine. In Unani medicine, it is described under the name “Shams-ul-Nahar,” attributed with specific Mizaj (temperament) and pharmacological actions. The plant is considered to possess a hot and moist temperament (Har Ratab), and different parts, including its seeds, oil, and leaves, have been employed in classical formulations. Sunflower seeds are …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 14, Issue 3, 2025 · pp. 52–65 Read article
-
Bioinspired Nanocomposite Bone Pins: Fabrication, Evaluation, and Suitability for Orthopedic Implant Applications
Abstract: Bone tissue engineering (BTE) requires scaffolds that mimic bone’s mineral–organic composition, offering mechanical strength, bioactivity, and degradation rates compatible with regeneration. Conventional metallic implants face corrosion and toxic ion release risks, while ceramics like hydroxyapatite (HAp) are bioactive but brittle. This study reports a multifunctional hybrid scaffold combining HAp for osteoconductivity; polycaprolactone (PCL) and collagen for flexibility and biocompatibility with sodium citrate for nanoparticle dispersion, ferrocene (Fc) for catalytic bioactivity; …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 526–540 Read article
-
Stretching Boundaries: A Comprehensive Review of Ehlers-Danlos Syndrome and its Subtypes
Abstract: The Ehlers-Danlos syndromes (EDS) encompass 13 inheritable disorders affecting connective tissue. These conditions arise from genetic alterations impacting the structure of connective tissue. Every variant of Ehlers-Danlos syndrome (EDS) exhibits distinct features and has specific diagnostic criteria. While certain traits such as joint hypermobility, skin hyperextensibility, and tissue fragility are common across all types of EDS. The range of clinical presentations spans from minor skin and joint looseness to severe …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 44–57 Read article
-
Exploration of 5-Hydroxybowdichione Flavonoids As Inhibitors of Dengue Virus Ns5 RNA-Dependent RNA Polymerase Using Molecular Docking Approach
Abstract: Objectives: Human lives are now seriously threatened by dengue fever, which is brought on by the dengue virus (DENV). Aedes aegypti mosquitoes, which reproduce in still water, are the primary vectors of the arboviral virus known as dengue. It is well-recognized that phytochemicals have a high potential to eliminate bacterial, viral, and fungal infections in people. Thus, it demonstrates its inhibitory effects on the dengue virus. This study identifies some …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 1, 2023 · pp. 1–16 Read article
-
Exploring Azadirachta indica’s Potential to Combat Visceral Leishmaniasis Through GP63 Inhibition
Abstract: Objectives: Millions of people worldwide suffer from the parasite disease visceral leishmaniasis. Determine the naturally occurring active ingredients in Azadirachta indica, which are employed as a disease-prevention agent and have several uses in medicine. To choose the best ligand to use as a medication, absorption, distribution, metabolism, and excretion (ADME) studies and molecular docking are employed. Methods: To obtain the GP63 protein, the Protein Data Bank (PDB) database was accessed. …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 2, 2024 · pp. 1–12 Read article
-
Optimizing Grazing Systems for Promoting Early Puberty in Dairy Heifers: An Integrated Nutritional Perspective
Abstract: The onset of puberty in dairy heifers is a critical milestone in ensuring optimal reproductive performance and overall herd productivity. Grazing systems, when strategically managed, may play a significant role in accelerating puberty through their influence on nutritional intake and heifer management practices. This review explores the impact of different grazing systems on the nutritional status of dairy heifers, emphasizing the balance between nutrient supply and demand during critical growth …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 4, Issue 1, 2026 Read article
-
Biopolymer-Based Nanocomposites for Oral Drug Delivery
Abstract: Because they are biocompatible, biodegradable, and can hold a lot of different healing agents, biopolymer-based nanocomposites are looking like a good way to give drugs orally. These materials are made up of natural polymers mixed with nanoparticles. They have many benefits for drug delivery systems, such as making drugs more soluble, controlling when they are released, and making enclosed drugs more stable. Drug release rates may be altered by mixing …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 400–412 Read article
-
In-Silico Screening of Phytochemicals for Identification of Alternative Therapy for Thyroid Cancer
Abstract: Thyroid cancer remains a significant health concern globally, necessitating the exploration of novel therapeutic alternatives to improve treatment outcomes. This study targets COT kinase (Cancer Osaka Thyroid Kinase), a protein implicated in the progression of thyroid cancer, using molecular docking methods with various phytochemicals to identify potential therapeutic compounds. PyRx and Discovery Studio were employed to evaluate the interactions and binding affinities of a diverse set of natural compounds with …
Published in International Journal of Toxins and Toxics · Vol. 2, Issue 2, 2025 · pp. 31–55 Read article
-
Cell Membranes as Therapeutic Targets: Implications in Infectious and Metabolic Disorders
Abstract: This is a review of the crucial role played by cell membranes in health and disease with respect to their contribution to infectious and metabolic diseases. Dysfunction of membranes, such as membrane transporter changes and changes in lipid content, has been associated with a variety of diseases, including diabetes, cardiovascular disease, and cancer. The present therapeutic approaches are focused on attacking membrane constituents by disrupting the entry of pathogens or …
Published in International Journal of Membranes · Vol. 3, Issue 1, 2026 · pp. 47–53 Read article
-
Space Pharmacy for Human Space Exploration: Overcoming Drug Stability, Packaging Challenges, Pharmacokinetic Variations, and Developing Innovative On-Demand Therapeutic Solutions for Long- Duration Missions Beyond Earth
Abstract: As humankind prepares for prolonged space exploration and the establishment of lunar and Martian habitats, ensuring reliable access to safe and effective medicines has emerged as a critical challenge. The evolving discipline of space pharmacy addresses the unique pharmaceutical needs of astronauts in microgravity and radiation-rich environments, where drug stability, packaging, and pharmacokinetics are markedly different from conditions on Earth. Traditional dosage forms often undergo accelerated degradation, while altered fluid …
Published in Trends in Drug Delivery · Vol. 13, Issue 1, 2026 · pp. 32–47 Read article
-
Characterization Of Senna Occidentalis (Link.) Seed Extract
Abstract: Senna occidentalis (L.) Link commonly known as "coffee senna" or majamfari/rai dore in Hausa is a plant with a long history of traditional and medicinal uses against diseases such as inflammation, pains, and diabetes. This study presents characterization of the bioactive compounds of the seed extracts. Physicochemical analysis of seed powder was carried out following standard procedures. Qualitative phyto-chemical contents were determined for the presence and absence of major metabolites. …
Published in Research & Reviews : Journal of Botany · Vol. 13, Issue 3, 2024 · pp. 13–22 Read article