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1909 articles for “result” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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Computational Molecular Docking Studies to Design Novel 2, 3-Substituted-1-(4-(Piperidin-1-yl) butyl)-1H- indol-5-ol Derivatives for Estrogen Receptor Alfa in AF-2 Domain
Abstract: The present manuscript describes the designing of novel 2, 3-Substituted-1-(4-(Piperidin-1-yl) butyl)- 1H-indol-5-ol derivatives as specific estrogen receptor alfa modulators and their screening by docking studies to determine the binding interaction for the best-fit conformations in the binding site of the ERα receptor. Based on the results of docking studies, the selected ligands reveal the all- important functional groups of the ligands that interact with active amino acid residues in the …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 12, Issue 3, 2025 · pp. 15–49 Read article
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Assessment of Groundwater Quality in Rumuodara, Rivers State, Nigeria
Abstract: The assessment of groundwater quality from selected borehole in Rumuodara, Rivers State, Nigeria was evaluated. The results of the physicochemical parameters revealed that pH ranged from 6.57-6.60, temperature: 26.10-28.54oC, turbidity: 1.57-2.96NTU, conductivity: 41.24-68.44 μS/cm, salinity: 26.10-50.37mg/l, total dissolved solid: 18.9-63.14mg/l, total hardness: 38.21-48.30mg/l, alkalinity: 55.30-70.17mg/l, chloride: 28.40-75.14mg/l, sulphate: 21.50-30.60mg/l, nitrate: 1.50-3.04mg/l, phosphate: 59.24-65.40mg/l, calcium: 37.81-45.27mg/l, Iron: 0.133-0.190mg/l, sodium: 16.70- 21.13mg/l, copper: 0.22–0.50mg/l, total suspended solid: 2.94-3.60mg/l, Lead: < 0.01mg/l-2.27mg/l, zinc: …
Published in Research & Reviews : Journal of Ecology Read article
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Prevalence and Associated Risk Factors of Major Gastrointestinal Nematodes of Cattle in Hawassa City.
Abstract: Gastrointestinal nematodiasis is a major constraint of livestock production causing huge economic loss to livestock sector of a country. A cross-sectional study aimed to assess prevalence of major gastrointestinal nematodes and associated risk factors was conducted from February 2021 to November 2021 in Hawassa city. In the study, fecal samples were collected from randomly selected 384 cattle and coprological examination was employed by using floatation method. The study result revealed …
Published in Research and Reviews : Journal of Veterinary Science and Technology Read article
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Modeling the Novel Coronavirus Disease (COVID-19) as Hidden Markov Chains
Abstract: The Hidden Markov Model has over the years been an appropriate method for modeling diseases such as HIV AIDS, heart failure, and so on. With the ongoing pandemic affecting Nigeria by being responsible for 2,745 death cases out of 207,616 confirmed cases as of October 10, 2021, the need to study an important parameter of COVID-19, the case fatality rate by building a model and estimating the case fatality rate …
Published in Research & Reviews : Journal of Statistics Read article
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Yield Loss Assessment in Common Bean (Phaseolus vulgaris L.) due to Ascochyta Blight (Phoma exigua var. diversispora (Bubak) Boerema) Disease
Abstract: Ascochyta blight (Phoma exigua var. diversispora (Bubak) Boerema) causes a severe, rapidly developing disease on common beans (Phaseolus vulgaris L.) that can bring about complete plant defoliation and extensive yield loss. Studies were conducted in Rwanda to quantify the yield loss attributed to bean ascochyta blight on 64 common bean genotypes including bush and climbing. Using a split plot design, trials were conducted at three locations, where ascochyta disease is …
Published in Research & Reviews : Journal of Agricultural Science and Technology Read article
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Numerical Studies on Deep Drawability of the Aluminium Alloy, AA6082 and Parameters Affecting It
Abstract: Deep drawing is a metal forming operation used for manufacturing sheet-metal components for application in the automobile, aerospace, and packaging industries. The objective of the present work was to study the various parameters influencing the drawability of AA6082. The deep-drawing process was modeled and simulated in Ls-Dyna Pre-Post(R) V4.6.17 software. The tensile test was performed according to the ASTM-E8M standard on AA6082-T6 material and subsequently annealed to attain higher ductility. …
Published in Journal of Polymer & Composites Read article
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Experimental Analysis of Cutting Forces Under Different Machining Parameters and Carbide Inserts During Turning of Hardened AISI 4340 Steel
Abstract: Turning of hardened materials with an advanced coated carbide insert has numerous advantages over the grinding process, e.g., reduced process cost, high material removal rate, and less environmental concern due to the elimination of the cutting fluid. Process parameters in conventional machining operations like cutting speed, feed, and depth of cut play the most crucial role behind the generation of heat which also leads to microstructural changes, improved tool life, …
Published in Journal of Polymer & Composites Read article
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A Review on Structural Design Analysis and Environmental Auditing of Railways
Abstract: In the present time, Indian railway is the major transport medium. It is so efficient, economic, and services are moderate eco-friendly technology. Changes are on the basis of engineering, logistics, time and luxury. The new structure has faced lots of challenges and every day demands led to some changes day to day. In so many years of Indian railway the tracks are challenging and quite tough which carries lots of …
Published in Journal of Energy, Environment & Carbon Credits Read article
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Experimental Study on Heart Disease Prediction Using Different Machine Learning Algorithms
Abstract: Heart disease which can also be referred to as the cardiovascular disease is one of the raising concerns in today’s world. It is one of the major health problems causing death among humans irrespective of the age group and therefore has made it necessary to look into different medical factors that are required to predict the same in advance using the collected historical datasets of various patients. Thus we have …
Published in Journal of Artificial Intelligence Research & Advances Read article
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Proof-of-Minimum Privacy Leak Consensus Strategy in Blockchain
Abstract: In this study, we propose a novel consensus algorithm to preserve the security and privacy of a transaction. We propose a Proof-of-Minimum Privacy Leak consensus strategy. This means that the competing nodes which participate in the competition to mine the next block should give a proof of minimum privacy leak during its transaction. Only this proof will give highest votes to that node, and it will be elected as the …
Published in E-Commerce for Future & Trends Read article
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A Study on Remote Online Notarization and E-signatures
Abstract: The e-signatures and remote online notarization application allows notary attorneys and anyone else who needs to certify electronic documents to use secure electronic notarization. E-notary software provides first-rate security and convenience method for both businesses and consumers who deal with notarizations on a regular basis. The software also allows for transparent access to documents that are waiting to be countersigned, as well as to those who have been granted access …
Published in Journal of Multimedia Technology & Recent Advancements Read article
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In Silico Molecular Docking of Indigofera tinctoria Phytocompounds to Target EGFR/ERK and FGFR/FGF Pathway Proteins Involved in Prostate Cancer
Abstract: Objective: Prostate cancer being the second major cause of cancer-related deaths in males, affects the small walnut-shaped gland below the bladder called the prostate gland. The epidermal growth factor protein (EGFR), cascade protein (ERK), and fibroblast growth factor proteins (FGFR and FGF) are involved in the different signaling pathways that lead to the formation of different products, that are responsible for the progression of cancer and thus can be considered …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 34–56 Read article
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Network Pharmacology and Molecular Docking Approach to Reveal the Underlying Mechanisms of Isorhamnetin in the Treatment of Lymphangitis Carcinomatosis
Abstract: Objective: Lymphangitic carcinomatosis (LC) is a tumor that spreads through lung lymphatics and is most commonly seen secondary to adenocarcinoma. In the majority of cases, LC is a result of tumor cells spreading through the lymphatic system. However, approximately 20% of LC cases can be attributed to lymphangitis caused by tumors obstructing lymphatic drainage. This blockage commonly occurs near the lung hilum, where a centrally located mass can cause inflammation …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 1, 2023 · pp. 28–45 Read article
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Pharmacoinformatic Based Screening Of Phytocompound Epigallocatechin Gallate To Identify As A Potential Bcl-2 Inhibitor
Abstract: Objectives: The B-cell lymphoma-2 (Bcl-2) is a protein that is particularly though to be involved in preventing apoptosis. Bcl-2 family members also essential for cancer survival, and its over expression has been linked to tumor genesis, development and resistance to anticancer treatments. The Bcl-2 family of members that inhibit apoptosis is a promising target for the creation of anticancer drugs. Methods: The study was based on computational approach using different …
Published in International Journal of Bioinformatics and Computational Biology Read article
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Enhancing the Strength of Black Cotton Soil with Enzyme and Industrial Waste
Abstract: Expansive soils are troublesome and prone to ground movements, which can cause substantial damage to underlying buildings as well as a loss in bearing capacity. Moisture fluctuation activates the expansive character of soils, causing it to swell and shrink. This has long been known in geotechnical engineering. To treat expansive soils, a variety of stabilizing additives such as lime, cement, and fly ash have been employed. In recent years the …
Published in International Journal of Environmental Planning and Development Architecture · Vol. 1, Issue 1, 2023 · pp. 1–11 Read article
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A Study to Assess Prevalence of Tobacco Use Among Adolescents and Assess the Effectiveness of Structured Teaching Program Regarding Ill Effects of Tobacco Use and Its Prevention Among Adolescents in Selected Community of New Delhi
Abstract: Tobacco use among adolescents has become a global challenge and it is reaching pandemic levels. The objectives of the study were (a) to assess the prevalence of tobacco use among adolescents in a selected community of New Delhi, (b) To provide an organised education programme on the negative effects of tobacco smoking and how to prevent it for teenagers in a chosen New Delhi community, (c) to determine whether the …
Published in International Journal of Community Health Nursing And Practices · Vol. 1, Issue 1, 2023 · pp. 23–38 Read article
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Optimization of Window Sizes based on Different Climatic Conditions
Abstract: Different climatic conditions have an impact on a building's performance. Climate-related factors will also affect how energy-efficient a structure is. As a result, making comparisons between buildings in various climate zones will produce inappropriate results. It is crucial to understand how much a building's energy performance can vary depending on the climate. By running energy simulation on the typical building, the climatic condition ratio is established for various climate zones …
Published in International Journal of Environmental Planning and Development Architecture · Vol. 1, Issue 1, 2023 · pp. 33–43 Read article
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Assessing Workspaces of Office Buildings; A Case of Lagos Office Spatial Characteristics
Abstract: The spatial characteristics of an office space play a fundamental role in contributing to the performance of the employees who use the office space. An efficient and functional workspace should be designed to cater to the needs of employees as this is critical to their performance as well. Studies from various authors have shown that better results and outcomes are gotten from employees who are satisfied with their workspaces. Although …
Published in International Journal of Environmental Planning and Development Architecture · Vol. 1, Issue 2, 2023 · pp. 17–30 Read article
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Flow Structures Around Proposed Bridge Piers
Abstract: The current study investigated the flow hydrodynamics around proposed bridge pier and made comparison with existing bridge pier. To quantify the flow structures around the piers, the flow and turbulence parameters are analysed to understand the interference of one bridge pier over another. The experiments were performed on recirculating channel of 15 m length, 0.89 m width and 0.65 m height. Instantaneous three-dimensional velocity data was recorded by acoustic Doppler …
Published in Journal of Polymer & Composites · Vol. 11, Issue 1, 2023 · pp. 14–21 Read article
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Artificial Neural Network Modelling to Optimize Micro-Drilling Parameters of ECDM of Developed Novel Zn/(Ag+Fe)-MMC
Abstract: Several engineering fields have increased their use of metal matrix composites (MMCs) in the past few years. Due to the increase in composites, the demand for accurate machining has also become important. Specifically, pertaining to biomaterial applications, accuracy factor with desired surface finish is critical. While the near-net shape manufacturing process has advanced, MMCs frequently require post-mould machining to achieve surface quality, and dimensional tolerances. In the present study, a …
Published in Journal of Polymer & Composites · Vol. 11, Issue 1, 2023 · pp. 01–13 Read article