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239 articles for “methodological frameworks”
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Prime Editing and Base Editing in Human Hematopoietic Stem Cells Toward Scarless Correction of Monogenic Blood Disorders
Abstract: Monogenic hematological disorders – such as sickle cell disease (SCD), β-thalassemia, and X-linked chronic granulomatous disease (X-CGD) – affect >400, 000 newborns worldwide each year, with a considerable burden in low-resource settings . Although donor-derived allogeneic hematopoietic stem-cell transplantation (HSCT) is widely regarded as curative, its application is limited due to issues of donor availability and graft-versus-host disease (GVHD) and conditioning-related toxicity. DSB-based conventional CRISPR-Cas9 strategies are limited by inefficient …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 4, Issue 1, 2026 · pp. 15–22 Read article
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Historical Antecedents of Boko Haram Insurgency and Its Implications on Educational Development in Northeast Nigeria
Abstract: The Boko Haram insurgency has greatly affected the socio-economic and educational systems of Northeast Nigeria. This paper examines the historical antecedents of the insurgency, analyzing how socio-political, economic, and ideological factors have contributed to its emergence and persistence. The study highlights the enduring impact of colonial legacies, socio-economic marginalization, and governance failures, which have collectively created fertile ground for the radicalization of disenfranchised populations. The insurgency’s deliberate targeting of educational …
Published in OmniScience: A Multi-disciplinary Journal · Vol. 14, Issue 3, 2024 · pp. 54–63 Read article
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CIPHER Intelligence: AI-Powered Global Military Expenditure Analysis and Predictive Modeling
Abstract: Military expenditure analysis has emerged as a critical component of economic and geopolitical intelligence in the modern era. This paper presents CIPHER Intelligence, a comprehensive AI-powered platform for analyzing and predicting global military spending patterns across 211 countries spanning54 years (1970-2024). We employ advanced machine learning techniques, particularly Random Forest regression models, to achieve 99.5% prediction accuracy for military expenditure forecasting based on economic indicators. The platform integrates data from …
Published in Research & Reviews : Journal of Statistics · Vol. 15, Issue 1, 2026 · pp. 1–8 Read article
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Hybrid Machine Learning and Finite Element Framework for Predicting Damage Behavior in Fiber-Reinforced Polymer Composites
Abstract: Fiber Reinforced Polymer (FRP) composites have broad spread use in aerospace, automotive, marine and structural applications due to its high specific strength, stiffness and corrosion resistance. The various damage mechanisms such as matrix cracking, fiber breakage, delamination and interfacial failure, however, make the forecasting of damage particularly complex. In this work, a hybrid machine learning (ML) and finite element (FE) system is proposed for predicting the damage behavior of FRP …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 Read article
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A study in Leveraging Deep Learning and IoT Arrays for Dynamic, Hyper-Local Atmospheric Intelligence
Abstract: The critical demand for high-resolution, actionable atmospheric data is challenged by the high cost and sparse coverage of traditional regulatory monitoring stations. This paper explores the synergistic paradigm shift enabled by integrating low-cost, dense Internet of Things (IoT) sensor arrays with advanced Artificial Intelligence (AI) methodologies, specifically Deep Learning (DL) models. We address the primary limitations of low-cost sensors—inherent bias, sensitivity to environmental drift (temperature/humidity), and calibration inconsistency—by utilizing AI …
Published in International Journal of Atmosphere · Vol. 2, Issue 2, 2025 · pp. 50–62 Read article
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Image-Based Evaluation of Implant Tissue Interface Integrity in Polymer Orthopaedic Devices
Abstract: Polymer orthopedic implants offer radiolucency and mechanical compatibility with bone, but long-term success depends on maintaining a stable implant–tissue interface. Routine imaging is widely available for follow-up, yet interface integrity is commonly judged qualitatively, limiting early detection of fixation compromise and reducing comparability across devices and time points. This work presents an image-based methodology to quantify interface integrity by extracting interpretable interface descriptors from a standardized interface belt around the …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 170–179 Read article
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Multicriteria Decision Making using SR-Fuzzy Sets
Abstract: In this study, we introduce and explore square-root fuzzy sets (SR-Fuzzy sets), a novel extension within the realm of fuzzy set theory. We begin by establishing a comparative analysis between SR-Fuzzy sets and two well-known fuzzy set models: Intuitionistic Fuzzy Sets (IFS) and Pythagorean Fuzzy Sets (PFS). This comparison highlights the unique characteristics and mathematical structure of SR-Fuzzy sets. A particular focus is placed on the complement operator, which plays …
Published in Recent Trends in Mathematics · Vol. 1, Issue 2, 2024 · pp. 12–20 Read article
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Software Development Using Component Based Testing
Abstract: Segment Testing is utilized in Software advancement. Right now, part will be tried. Principle Reason for utilizing Component testing is reuse. In Component Testing less assets utilized for growing new programming. Various sorts of Component gathered and incorporated for programming improvement. It is decreased advancement time and improved programming quality and make moves toward interactional. Testing is performed not exclusively to submit the basic programming mistake free in any case …
Published in Journal of Microcontroller Engineering and Applications · Vol. 8, Issue 3, 2021 · pp. 22–26 Read article
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Importance of Network Architecture: An Overview
Abstract: Network architecture is the design of a communications network. It includes the physical and logical layout of the network, the framework of accepted standards and specifications of elements, equipment, services, protocols and functions, growth and change assumptions, and high-level operational principles and procedures. Modern networks encompass a variety of architectural and design principles, which must be understood and articulated by a network organization in order to maintain best practices. Standardized …
Published in Journal of Open Source Developments · Vol. 9, Issue 2, 2022 · pp. 34–38 Read article
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AI-Driven Psychological Profiling on Social Media: Mechanisms, Ethical Breaches, and Regulatory Challenges in Data Inference
Abstract: This literature review examines AI-driven psychological profiling on social media, analyzing 21 academic studies that focus on machine learning techniques such as supervised learning, deep neural networks, sentiment analysis, and natural language processing. These methodologies infer mental health indicators—such as depression, anxiety, and stress—from users' digital footprints, encompassing linguistic patterns, engagement metrics, and temporal behaviors. While these tools offer potential for early detection of psychological distress, they also raise significant …
Published in Recent Trends in Social Studies · Vol. 2, Issue 1, 2025 · pp. 1–7 Read article
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Beach Profile Analysis of Moheshkhali Island to Develop Marine Spatial Planning: Planning for Blue Economy
Abstract: This research discusses the work on beach or coastal profiling done to develop marine spatial planning (MSP) methodology at Moheshkhali Island that will use the systems approach to use the beach area for economic development. Survey transects following shore normal from the dune to the low water line are commonly used to monitor beach profile. Coastal and beach monitoring studies and management processes benefit from the information provided by beach …
Published in Journal of Offshore Structure and Technology · Vol. 10, Issue 2, 2023 · pp. 11–23 Read article
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Recent Advances in Quality Control and Quality Assurance: Enhancing Pharmaceutical Product Integrity and Compliance
Abstract: The pharmaceutical industry is undergoing a paradigm shift driven by stringent regulatory expectations and the demand for high-quality, safe, and efficacious drug products. Quality Control (QC) and Quality Assurance (QA) serve as the two foundational pillars that ensure pharmaceutical integrity from raw material acquisition through to product release. Traditional QC and QA practices, while effective, have been challenged by complex formulations, biologics, and personalized medicine, requiring innovative methodologies and technologies. …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 2, 2025 · pp. 54–62 Read article
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A Review of Blocking Side-Channel Threats in Parallel Cloud Systems
Abstract: Side-channel attacks (SCAs) pose a critical security threat to parallel computing systems, particularly in shared cloud environments where multi-tenancy and resource contention create exploitable vulnerabilities. This study presents a comprehensive review of SCAs in parallel architectures, analyzing attack vectors such as cache-based exploits (e.g., Prime + Probe, Flush + Reload), timing attacks, power analysis, and network-based covert channels. We examine real-world cases including Spectre and Meltdown vulnerabilities that exposed fundamental …
Published in Recent Trends in Parallel Computing · Vol. 12, Issue 2, 2025 · pp. 15–25 Read article
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Maintain Attendance Using Image Processing Technique
Abstract: Attendance tracking stands as a pivotal pillar in organizational management, bearing significant implications for operational efficiency, resource allocation, and fostering accountability. Traditional methodologies for attendance maintenance frequently exhibit deficiencies in terms of precision, security, and scalability, thus necessitating the exploration of avant-garde solutions. This research endeavors to introduce a pioneering approach to attendance upkeep, harnessing the prowess of image processing techniques synergized with artificial intelligence (AI) algorithms to surmount prevailing …
Published in Journal of Image Processing & Pattern Recognition Progress · Vol. 11, Issue 2, 2024 · pp. 29–34 Read article
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Symmetry Principles in Digital Twin Systems: Modeling, Integration, and Applications
Abstract: This systematic review comprehensively examines the burgeoning field of Digital Twin (DT) technology, analyzing its current state, diverse applications, and future trajectory. Through a rigorous methodology involving a systematic search of academic databases and relevant industry literature, this review synthesizes findings across a spectrum of disciplines. We identify the core components and underlying principles of DTs, distinguishing them from traditional simulation models by their dynamic, realtime data integration and bi-directional …
Published in Emerging Trends in Symmetry · Vol. 1, Issue 2, 2025 · pp. 06–24 Read article
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A Critical Review of the Limitations of the Arithmetic Mean and the Robustness of the Median in Statistical Analysis
Abstract: Arithmetic mean is an extremely popular measure of central tendency used in statistical analyses, primarily because it is so easy to calculate and has many positive mathematical characteristics. However, when there are outliers, skewed distributions or heterogeneous spread of data, the reliability of the arithmetic mean diminishes greatly. This paper includes a critical review of the limitations of the arithmetic mean and an assessment of the robustness of the median …
Published in OmniScience: A Multi-disciplinary Journal · Vol. 16, Issue 2, 2026 · pp. 21–29 Read article
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Artificial Intelligence in Healthcare for Implants and Tissue Regeneration: Advances, Challenges, and Future Directions
Abstract: Artificial intelligence (AI) has been a revolutionary influence in contemporary healthcare, especially in implant design, biomaterials research, and tissue regeneration. In regenerative medicine, AI facilitates predictive modeling, optimization, and decision-making via the analysis of intricate biological, material, and clinical information. This study analyzes current research on AI applications in implant technologies and tissue regeneration, specifically addressing scaffold engineering, biomaterial characterisation, stem cell and gene treatments, smart biomaterials, and implant planning. …
Published in Journal of Artificial Intelligence Research & Advances · Vol. 13, Issue 3, 2025 Read article
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Productivity Improvement Using Kaizen-Muda Elimination
Abstract: In today's fiercely competitive business environment, achieving operational excellence and sustainable growth is paramount for organizations across diverse industries. The Kaizen philosophy, rooted in Japanese principles, offers a powerful framework for driving continuous improvement by systematically identifying and eliminating waste, or "muda." This paper explores the concept of Kaizen and its application in eradicating muda, paving the way for enhanced productivity, cost reduction, and a competitive advantage. Kaizen, which translates …
Published in International Journal of Industrial and Product Design Engineering · Vol. 2, Issue 1, 2024 · pp. 1–6 Read article
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Implementing Quality by Design (QbD): Strategies, Challenges, and Best Practices across Industries
Abstract: The present comprehensive review investigated the dynamic landscape of quality standards within the pharmaceutical sector, with a primary focus on the implementation and impact of Quality by Design principles. It illuminated the multifaceted challenges encountered by pharmaceutical companies in upholding stringent quality standards amidst evolving regulatory requirements and complex manufacturing processes. By embracing Quality by Design principles, the industry aims to foster a proactive and systematic approach to product development …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 28–36 Read article
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Wear and Tribological Characteristics of Novel Metal Matrix Composites
Abstract: The development of advanced metal matrix composites (MMCs) with enhanced tribological performance has become increasingly important due to the premature failure of critical engineering components operating under severe wear conditions in automotive, aerospace, marine, defense, and power generation systems. Conventional composites such as Copper–Alumina and Aluminium–Silicon Carbide have demonstrated improved mechanical and wear characteristics; however, their widespread application is often limited by issues including particle agglomeration, non-uniform reinforcement distribution, porosity …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1326–1346 Read article