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1363 articles for “Pre-clinical”
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Computational Investigation of Phytochemicals Targeting AKT1 for Major Depressive Disorder: A Molecular Docking and ADMET Study
Abstract: Major depressive disorder (MDD) is a prevalent neuropsychiatric condition affecting approximately 280 million individuals worldwide, with women exhibiting a 50% higher likelihood of diagnosis than men. Despite significant advancements in treatment, MDD remains a chronic and relapsing disorder, necessitating the exploration of novel therapeutic interventions. This study focuses on the AKT1 gene, a key player in neuropsychiatric disorders, and investigates its interactions with natural phytochemicals as potential alternatives to conventional …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 2, 2025 Read article
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Cosmeceuticals Unveiled Innovation and Efficacy in Skincare Science
Abstract: By combining the terms "Cosmeceuticals" and "pharmaceuticals," the phrase refers to goods that combine the medicinal benefits of pharmaceuticals with the aesthetic benefits of cosmetics. These innovative products do not strictly fall into the categories of either cosmetics or pharmaceuticals but serve as a bridge between the two, offering a unique combination of beauty enhancement and health improvement. Similar to pharmaceuticals, Cosmeceuticals contain active ingredients and compounds that are scientifically …
Published in Recent Trends in Cosmetics · Vol. 1, Issue 2, 2024 · pp. 1–7 Read article
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Therapeutic Potential of Terminalia arjuna Bark in the Management of Hemorrhoids: A Comprehensive Review
Abstract: Background: Hemorrhoids appear frequently among anorectal disorders since they create vascular swelling together with pain symptoms, while leading to bleeding and mucosal tissue tending to slide out. Though effective therapy exists, traditional treatments produce various adverse effects and lead to recurrence and inconsistent patient following of medical recommendations over the long term. Plantbased therapeutic medicines have gained rising demand, which leads experts to investigate medicinal plants with established pharmacological effects. …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 2, 2025 · pp. 22–32 Read article
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Accelerating Drug Discovery with AI: Transforming the Pharmaceutical Pipeline
Abstract: The revolutionary potential of artificial intelligence (AI) is examined in this essay the pharmaceutical industry, highlighting its application across the drug development lifecycle. Artificial Intelligence, specifically via deep learning models and machine learning (ML) such as GANs, RNNs, and transformers, enhances drug discovery, formulation, toxicity prediction, and clinical trials. It streamlines processes like identification of targets, virtual screening, modelling of structure-activity relationships, and medication repurposing. AI is also employed in …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 77–84 Read article
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Gene Therapy 2.0: Harnessing Cutting-Edge Technologies for Precision Medicine
Abstract: Somatic gene therapy has become the standard form of gene therapy; this creates the Gene Therapy 2.0 era. This new and distinct time consists in the new-generation genome-editing tools and markers, more efficient systems for gene delivery, and personalized medicine approaches that raise the efficacy and safety of the treatment. Base and prime editing are two types of CRISPR-based gene editing tools have provided high precision and reduced off-target effects …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 2, 2025 Read article
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Review on Formulation and Evaluation of Herbal Gel of Moringa oleifera and Aloe vera for management of acne
Abstract: Acne vulgaris is a prevalent chronic inflammatory disorder of the pilosebaceous units, characterized by excessive sebum production, follicular hyperkeratinization, bacterial colonization, and inflammation. Conventional therapies often result in side effects and the development of drug resistance, prompting the exploration of natural alternatives. This review highlights the potential of Moringa oleifera and Aloe vera in acne management via topical drug delivery systems (TDDS). Moringa oleifera is rich in bioactive compounds such …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 1, 2026 · pp. 10–16 Read article
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Integrative Therapeutics for Antimicrobial Resistance and Autoimmune Disease: Evidence and Pathways
Abstract: Background: Antimicrobial resistance (AMR) is accelerating globally, while autoimmune diseases and adverse drug reactions (ADRs) continue to rise. Ayurveda offers immunomodulatory, antimicrobial, and detoxification‑oriented interventions that may complement biomedical strategies. Objective: To propose a hypothesis‑driven integrative model combining Ayurvedic phytotherapy, panchakarma detoxification, and personalized dosha‑based care with evidence‑based medical management to mitigate AMR emergence, modulate autoimmunity, and reduce ADR incidence. Methods: A synthesis of mechanistic literature on Ayurvedic herbs with …
Published in Research and Reviews : A Journal of Immunology · Vol. 16, Issue 2, 2026 · pp. 25–30 Read article
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Cancer Treatment by Radionuclide Therapy
Abstract: Recently, pretargeted nuclear imaging and radiotherapy have gained tremendous attention for diagnosis and treatment of cancer with nanomedicines. Radionuclide therapy (RNT) is one of the rapidly growing fields of nuclear medicine which works on the mechanism of delivery of cytotoxic levels of radiation to the disease sites, sparing the normal cells. RNT targets diseases at the cellular level rather than on a topographic anatomical level when compared to conventional external …
Published in Journal of Nuclear Engineering & Technology · Vol. 8, Issue 2, 2018 · pp. 4–7 Read article
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Approach to Ziabetes Sukari (Diabetes Mellitus) in Ancient Ages and Its Management with Unani Herbal Drugs: A Review
Abstract: AbstractIn Unani System of Medicine, Diabetes has been mentioned as Ziabetus Sukari. It is estimated that around 2−4% of the world population is suffering from this disease. In India, the prevalence is about 40.9 million and it is expected to be 69.6 million by 2025. It is due to weakness of kidneys, dilatation of orifices of vessels of the kidneys, Sue Mizaj Haar Kuliya (Ill temperament of kidney), Burudat Kuliya …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 3, Issue 3, 2014 · pp. 1–6 Read article
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Mechanism of Odontogenic Pain: Clinical Considerations
Abstract: Management of Dental Pain, especially, in Endodontics requires a clear understanding and comprehensive knowledge of underlying various kinds of nerve fibers, their type, composition, structure, conduction speed and pain associated. Just by attentive audition of Dental History of patient, clinician can predict and comprehend the basic mechanism of the Odontogenic pain which assists him culminating upon a provisional diagnosis. An attempt herein is made to elaborate the different types of …
Published in Research and Reviews: A Journal of Dentistry · Vol. 12, Issue 1, 2021 · pp. 19–22 Read article
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A Review on T POXX (TECOVIRIMAT)—A New Bioweapon Against Small Pox
Abstract: As an author in the present review, I have provided all the available information regarding T POXX (TECOVIRIMAT)—a new bioweapon against small pox—like its synonym, history of discovery and approval, chemical structure, pharmacology, adverse drug reactions, drug interactions, safety concerns, contraindications, warnings/cautions, preclinical and clinical trial information and all other information after thoroughly searching in all the available resources. I hope this can be helpful to all the healthcare professionals …
Published in Research and Reviews: A Journal of Medicine · Vol. 8, Issue 2, 2018 · pp. 9–11 Read article
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Respiratory Tract Infection: A Focus on Upper Respiratory Tract Infection
Abstract: Respiratory tract infection (RTI) is considered as one of the most important public health problems in developing countries. Respiratory infections that occur in upper respiratory tract are seen with great frequency in both children and adults. RTIs are common cold, sore throat, sinusitis, laryngitis, pharyngitis, earache, and otitis media. Upper respiratory tract infections (URTIs) are general illnesses that are often treated with antibiotics even though bacteria cause only 25% of …
Published in Research and Reviews: A Journal of Medicine · Vol. 4, Issue 1, 2014 · pp. 30–35 Read article
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Novel plasma therapy for covid-19: A Perspective
Abstract: Coronavirus disease (COVID-19) is an induced disease caused by the coronavirus-19 that causes acute respiratory syndrome (SARS COVID-19). In the month of December 2019, the first case was recorded in Wuhan, China. No specific medications have yet been approved for their treatment; convalescent plasma therapy is projected to boost the survival rate. Early in the twentieth century, convalescent plasma therapy was developed. Convalescent plasma therapy is widely utilized around the …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 10, Issue 3, 2021 · pp. 30–34 Read article
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Literature review on Kalarchi - Caesalpinia bonduc (L.) Roxb
Abstract: AbstractKalarchi is one of the Siddha drug traditionally being in use since ancient times to treat Poly Cystic Ovarian Syndrome (PCOS). The botanical name of Kalarchi is Caesalpinia bonduc (L.) Roxb is belonging to the family Caesalpiniaceae. It is a climber up to 15 m long, throughout India, near sea-coast, especially all over Bengal, Bombay and whole of Southern India. Poly Cystic Ovarian Syndrome is the highly prevalence disease among …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 7, Issue 1, 2020 · pp. 1–6 Read article
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Nanocrystalline Silver–Carbon
Abstract: This study is on the properties of nanocrystalline silver products and examines on the internal relation between silver and carbon particles. Nanocrystalline utilizes nanotechnology to release nanocrystalline silver crystals. Nanocrystalline releases 60 times fewer silver cations than silver–carbon interaction in between strongly. Silver impregnated fast releases dressings release minute concentrations of silver which are quickly bounds up by the chloride in the wound exudates. The silver and carbon ions are …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 9, Issue 2, 2018 · pp. 27–29 Read article
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Role of Unani Herbal Medicine in the Management of Acute Hepatitis (Warm Kabid Haad)
Abstract: In unani system of medicine acute hepatitis is known as Warm Kabid Haad. Almost all unani physicians described about hepatitis; its etiology, sign and symptoms, prevention and treatment in their classical texts. In conventional system viral infections of the liver are classified as hepatitis A, B, C, D and E viruses. Hepatitis A is a milder version of the disease, whereas hepatitis D is more severe. Hepatitis is of two …
Published in Research & Reviews : Journal of Herbal Science · Vol. 4, Issue 2, 2015 · pp. 9–15 Read article
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Role of Unani Herbal Medicines in the Management of Diabetes Mellitus and Its Complications – A Review
Abstract: AbstractDiabetes mellitus is a common and chronic metabolic disorder characterized by increased blood glucose level. In Unani system of medicine, diabetes mellitus is known as Ziabetus Sukkari. The prevalence of diabetes in India is 40.9 million and it is expected to be 69.6 million by 2025 if imperative preventive measurements are not taken. In this condition, the patient will suffer from chronic hyperglycemia which leads to irreversible damage to vital …
Published in Research & Reviews : Journal of Herbal Science · Vol. 3, Issue 1, 2014 · pp. 20–27 Read article
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Diagnosis and Surgical Management of Dog Bite Induced Cystorrhexis in a Dog
Abstract: AbstractA two years male Pomeranian dog was presented to clinics with a history of dog bite wounds on the ventral abdomen, anuria and anorexia since last two days. It was tentatively diagnosed as lower urinary tract trauma with uroperitoneum based on physical examination, abdominocentesis, radiography and ultrasonography. Emergency laparotomy under general anaesthesia was performed and cystorrhaphy was done after retrograde catheterization of the urethra and an indwelling catheter was placed …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 5, Issue 1, 2016 · pp. 20–22 Read article
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Cystic Endometrial Hyperplasia-Pyometra Complex in a Bitch: A Case Report
Abstract: AbstractAn eight-year-old nulliparous Spitz bitch was presented to clinics with a complaint of persistent vomiting and anorexia since fifteen days. It had a history of purulent discharges from vulva one year back. Based on findings of clinical examination, radiography, ultrasonography and laboratory reports, the condition was diagnosed as cystic endometrial hyperplasia. The clinical symptomology, surgical outcome of the case along with histopathological and immunohistochemical studies of the affected uterus were …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 5, Issue 2, 2016 · pp. 1–4 Read article
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Learning, Frame of Mind and Recognition towards “Hypothyroidism” in the Tertiary Consideration Emergency Clinics
Abstract: The thyroid gland is an endocrine gland which secretes its hormone directly into the bloodstream. It is a largest gland in the body. It plays an important role in calcium metabolism. The common causes of hypothyroidism in adults are Hashimoto’s thyroiditis, Lymphocytic thyroiditis, Thyroid destruction, Pituitary gland, Medications and Severe iodine deficiency. The study aims to learn, frame of mind and recognition towards “hypothyroidism” in the tertiary consideration emergency clinics. …
Published in Research and Reviews: A Journal of Health Professions · Vol. 10, Issue 1, 2020 · pp. 8–13 Read article