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220 articles for “Multi-targeted”
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In Silico Drug Designing of Breast Cancer in Homo sapiens
Abstract: Breast cancer is a severe health concern in India, with the highest mortality rate among women. It is brought on by uncontrolled cell division and has the potential to spread to other body regions. As a transcription factor, interactions with estrogen receptor (ER) alpha are primarily responsible for malignant tumors through regulating the transcription of numerous genes. Because most of the medications now used to treat breast cancer have significant …
Published in Research and Reviews : Journal of Computational Biology · Vol. 11, Issue 2, 2022 · pp. 12–27 Read article
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Analysis and A.I. Modelling of Parameters of Symmetrical Multistory Building using Non-linear Static Analysis
Abstract: Non-linear static analysis (Push over Analysis) is the emerging field in seismic design of structures.The major drawback of elastic analysis is that the response beyond the linear state is neither linearnor simple extrapolation. Although elastic analysis gives a good indication of the elastic capacity ofstructures, but it cannot account for redistribution of forces during progressive yielding of a structurethat follows and to predict its failure mechanism or detect possible location …
Published in Journal of Construction Engineering, Technology & Management · Vol. 11, Issue 1, 2021 · pp. 1–15 Read article
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An Overview of Heavy-ion Collisions
Abstract: AbstractA large number of experiments have been performed to explore the heavy-ion collisions dynamics using accelerator facilities available in India. The experimental results have revealed that in reactions induced by nucleons or light particles at energies of the order of a few tens MeV, the great majority of the processes one observes are of statistical nature though they cannot be interpreted as a consequence of the decay of a fully …
Published in Journal of Nuclear Engineering & Technology · Vol. 9, Issue 2, 2019 · pp. 8–23 Read article
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Finite Element Modelling of Rollcrete Concrete Pavement
Abstract: The present study carried out to find the characteristic compressive Strength of Rollcrete (RCC) by using accelerated curing method so as to satisfy the required target mean strength in one day and comparing the same results with the normal curing strength at 28 days.Further, the study is undertaken to design of rollcrete pavements using finite element approach and evaluated the benefit of rollcrete pavement. Considering rutting as a failure criteria, …
Published in Journal of Construction Engineering, Technology & Management · Vol. 6, Issue 2, 2016 · pp. 62–66 Read article
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Advanced 4-Element UWB-MIMO Antenna Design: Achieving High Isolation and Multi-Band Rejection for Advanced Wireless Applications
Abstract: In this study, we present the design, fabrication, and analysis of a step-by-step Ultra-Wideband (UWB) Multi-Input Multi-Output (MIMO) antenna operating from 3 to 14 GHz. The antenna consists of four elements, each characterized by high isolation and equipped with four band-rejection features. These elements are implemented on a Rogers substrate with εr=3. Each antenna element is a modified rectangular patch, incorporating partial ground etching to achieve wider bandwidth. Two sets …
Published in Journal of Communication Engineering & Systems · Vol. 15, Issue 1, 2025 · pp. 40–62 Read article
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The Emerging Roles of the School Librarian in the Tech Era: A Transformative Synergy with NEP 2020 and KVS Initiatives
Abstract: The implementation of the National Education Policy (NEP) 2020 in India mandates a radical paradigm shift in the school education ecosystem, moving from rote-based learning toward a 5+3+3+4 pedagogical structure centered on critical thinking and multidisciplinary exploration. This paper employs a Qualitative Policy-to-Practice Synthesis (QPPS) design to analyze the evolving role of the school librarian as a strategic catalyst within this framework, with a specific focus on the Kendriya Vidyalaya …
Published in International Journal of Trends in Humanities · Vol. 3, Issue 2, 2026 · pp. 15–21 Read article
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FUNGI IN THE GLOBAL BIOECONOMY: HARNESSING THE R POTENTIAL ACROSS AGRICULTURE, MEDICINE, INDUSTRY, AND ENVIRONMENTAL SUSTAINABILITY
Abstract: One of the most diverse and functionally versatile groups of living organisms, fungi has played a significant role in maintaining ecological balance, human well-being, agricultural production, and industrial processes. Despite their vast potential, the use of fungi systems in solving some of the most serious challenges facing the world today, such as climate change, food security, and AMR, is still in its infancy. New developments in genomics, biotechnology, and systems …
Published in International Journal of Fungi · Vol. 3, Issue 1, 2026 · pp. 20–27 Read article
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Anticancer, Bioactive, & Therapeutic Applications of Cannabinoids
Abstract: Cannabinoids, a complex class of lipophilic compounds found in Cannabis sativa L., are attracting significant clinical interest for their multifaceted therapeutic potential, particularly within oncology. This review provides a comprehensive synthesis of contemporary knowledge detailing the distinct anti-cancer properties of phytocannabinoids (such as δ-tetrahydrocannabinol and cannabidiol), endogenous endocannabinoids, and synthetic analogues. Accumulating evidence from robust in vitro and in vivo oncological models demonstrates that these compounds aggressively suppress tumor progression …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 15, Issue 2, 2026 · pp. 17–30 Read article
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Melanoma Skin Cancer Detection Using Deep Learning
Abstract: Cancer as one of the major diseases rank in the World is still very challenging to diagnose and treat hence need for the technological advancements. Chemotherapy, radiation, as well as surgery therapies have several drawbacks including non-selective action, damage to healthy tissues, and multi-drug resistance. Smart nano-theranostics, an advanced integration of nanotechnology with diagnostic and therapeutic modalities, offers a next-generation approach for precision oncology. Thus, the development of multifunctional nanoparticles …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 2, 2025 Read article
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AI in Healthcare: Drug Delivery in Tuberculosis
Abstract: Tuberculosis (TB) , mainly caused by Mycobacterium tuberculosis, remains a major global health burden, accounting for millions of new infections and deaths each year. Although progress has been made in diagnosis and treatment, the growing threat of multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB makes disease control increasingly difficult. Conventional diagnostic approaches such as chest X-rays, sputum smear microscopy, and culture methods continue to play an important role, but they …
Published in Trends in Drug Delivery · Vol. 13, Issue 1, 2026 · pp. 9–17 Read article
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Cardiovascular Modeling with Computational and Mathematical Methods
Abstract: The cardiovascular system, a complex network responsible for delivering life-sustaining oxygen and nutrients throughout the body, is a prime target for advanced understanding and improved therapies. Due to the inherent difficulties in directly observing internal physiological processes and the complexities of interactions within the system, computational and mathematical modeling have emerged as powerful tools in cardiovascular research. This article explores the significance of these methods in unveiling the heart's secrets …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 12, Issue 2, 2025 · pp. 11–21 Read article
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Nutrition Induced Remodeling Dynamics of Cell Membranes: Implications for Performance, Health, and Welfare Issues in Food Animals
Abstract: Cell membranes represent dynamic structural and functional platforms that integrate nutritional signals with cellular metabolism, immune competence, and physiological adaptation in food animals. Beyond their classical role as selective barriers, membranes actively regulate nutrient transport, signal transduction, and bioenergetics through highly responsive lipid and protein networks. Dietary components, particularly fatty acids, vitamins, minerals, amino acids, and bioactive compounds, critically influence membrane composition, fluidity, and stability, thereby shaping cellular function and …
Published in International Journal of Membranes · Vol. 3, Issue 1, 2026 · pp. 25–37 Read article
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Emerging Therapies in Respiratory Tract Infections: Current Advances and Future Perspectives
Abstract: The impact of respiratory tract infections (RTI) as a global public health problem continues to be high morbidity and mortality rates. The development of novel therapeutic approaches stemmed from the fact that conventional treatment strategies, antibiotics, antivirals, antifungals etc. have become increasingly ineffective because of rise of antimicrobial resistance (AMR). Next generation therapies, such as novel antimicrobial agents, host directed therapies and novel drug delivery systems have come on the …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 2, 2025 · pp. 17–25 Read article
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Exploring Recent Advancements in Nanomedicine for Tumor Microenvironmental Tissue Engineering
Abstract: The combination of tissue engineering and nanomedicine is transforming cancer treatment by offering creative ways to get around problems with conventional therapies. Recent developments in nanomedicine are examined in this review, with an emphasis on how they might be used to comprehend and control the tumor microenvironment (TME), a dynamic and complex environment that has a major impact on the course of cancer and the effectiveness of treatment. Targeted interactions …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 122–136 Read article
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Comprehensive Review on Pulsatile Drug Delivery System: Hybrid Approaches
Abstract: Pulsatile drug delivery systems (PDDS) represent a groundbreaking approach in pharmaceutical technology, allowing for controlled, targeted, and programmable drug release that aligns with circadian rhythms or caters to time-sensitive therapeutic requirements. Although traditional pulsatile systems have shown considerable clinical promise, their effectiveness is frequently compromised by physiological variations such as gastrointestinal transit times, changes in pH, and enzymatic activity. To tackle these obstacles, hybrid PDDS have been developed by combining …
Published in Trends in Drug Delivery · Vol. 13, Issue 1, 2026 · pp. 18–31 Read article
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Prospects and Growth Opportunities of Female-Owned Rural Farm Businesses in Plateau State, Nigeria
Abstract: The potential and growth chances of female-owned rural agricultural companies in Nigeria's Plateau State were investigated in this study. The objectives were to assess the prospects and opportunities available to female-owned rural farm businesses and to determine their effect on business growth and development across the state. The study covered female farm business owners engaged in crop production, livestock farming, mixed farming, and agro- processing across all 17 Local Government …
Published in Journal of Energy, Environment & Carbon Credits · Vol. 16, Issue 2, 2026 Read article
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AI-Based Machine Learning Web Application Firewall (ML-WAF)
Abstract: This research investigates the use of deep learning techniques for the real-time detection of malicious activities in web traffic and proposes an intelligent, AI-driven Web Application Firewall (WAF) designed to provide automated and adaptive security. The system analyzes diverse components of HTTP requests, including request methods, URLs, headers, cookies, and payload content, to accurately identify and classify malicious behavior. The proposed model targets a wide range of common and critical …
Published in Journal of Computer Technology & Applications · Vol. 17, Issue 1, 2026 Read article
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Autonomous Utility Bot with Self Balancing and Obstacle Avoidance
Abstract: Over the last decade, there has been a surge in global interest in two-wheeled self-balancing robot research. The kinematics model of a two-wheeled self-balancing autonomous mobile robot is described in this paper. After the mechatronics system design for the robot is completed, the analysis of the entire kinematics model can be divided into two wheels and a body. The velocity decompositions of the robot wheel and body are then examined. …
Published in Recent Trends in Sensor Research & Technology · Vol. 9, Issue 2, 2022 · pp. 18–24 Read article
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Time Multiplexed Binary Offset Carrier (TMBOC) Transmitter with Polarimetric Interferometric Synthetic Aperture Radar (Pol-InSAR)
Abstract: This paper provides insights into Time Multiplexed Binary Offset Carrier (TMBOC), a modulation technique employed in satellite navigation systems, specifically designed for GPS L1C. TMBOC improves signal correlation properties by time-multiplexing Binary Offset Carrier (BOC) (1, 1) and (6, 1). The text discusses various TMBOC models, including spectral representations and power distributions. Performance analysis reveals the potential of TMBOC signals in achieving superior tracking accuracy and interference resistance compared to …
Published in International Journal of Satellite Remote Sensing · Vol. 4, Issue 1, 2026 · pp. 34–49 Read article
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Recent Advances in Diabetes Management: A Gendered Approach in North India
Abstract: Background: Diabetes Mellitus remains a major public health issue in India, with disproportionate burdens observed in North India and among women. Objectives: To examine gender and residence-based disparities in glycemic control, medication adherence, and healthcare access among adults with Type 2 Diabetes Mellitus (T2DM) in North India. Page 2 of 7 Methods: A cross-sectional study was conducted among 800 adults with T2DM across five North Indian states. Data on clinical …
Published in Research and Reviews: A Journal of Health Professions · Vol. 16, Issue 2, 2026 Read article