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31 articles for “layer by layer. Drugs”
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Biodegradable and Natural Fiber-Reinforced Polymer Composites for Co-Delivery of Multiple Therapeutic Agents
Abstract: The co-delivery of multiple drugs using advanced nanocarriers has revolutionized targeted therapy in various diseases, particularly in cancer, infectious diseases, and neurological disorders. Multi-layered polymeric nanocarriers (MLPNs) offer a sophisticated platform to encapsulate multiple therapeutic agents with precise control over drug release, bioavailability, and synergistic effects. These nanocarriers are designed with distinct polymer layers that enable sequential or simultaneous drug release based on stimuli-responsive mechanisms such as pH, temperature, and …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 406–419 Read article
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Novel Nano Polymeric Lipid-Based Carriers for Emerging Pain Management of Rheumatoid Arthritis
Abstract: An inflammatory condition known as rheumatoid arthritis (RA) results in chronic joint inflammation, severe disability, and early death. RA is 3–5 times more common in women than in men, with a global frequency of roughly 0.3 percent–1%. The ultimate goal of RA treatment is to give symptomatic alleviation; there is no recognized cure for RA. NSAIDs are frequently used to treat RA, including indomethacin, diclofenac, ibuprofen, celecoxib, and specifies the …
Published in Research and Reviews : A Journal of Immunology · Vol. 12, Issue 2, 2022 · pp. 30–38 Read article
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Microneedles: An Innovative Drug Delivery System
Abstract: Microneedles represent a groundbreaking innovation in drug delivery systems, offering a transformative alternative to conventional hypodermic needles and transdermal patches. This advanced technology combines the precision and efficacy of needle-based delivery with the convenience and pain-free nature of patches, creating a minimally invasive platform that addresses many limitations of traditional drug administration. Microneedles are designed to penetrate the stratum corneum – the skin’s outermost layer – without reaching pain-sensitive nerves …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 60–67 Read article
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Review On: Liquid Crystal Cream for Topical Drug Delivery
Abstract: A Liquid crystal creams represent a novel approach in skincare formulations, leveraging the unique properties of liquid crystal technology to improve skin hydration and barrier function. An overview of current developments in liquid crystal cream formulations is given in this article, with an emphasis on the benefits they offer for skincare and their composition and structure. Liquid crystal creams mimic the lipid bilayers of the skin, offering enhanced compatibility and …
Published in Trends in Drug Delivery · Vol. 11, Issue 1, 2024 · pp. 1–8 Read article
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Revolutionizing Gastro-retentive Drug Delivery: Exploring Innovative Formulation Strategies and Mechanisms in Floating in Situ Gel Raft Forming System
Abstract: An in-depth exploration of the transformative shift underway in gastro-retentive drug delivery, spotlighting the utilization of Floating Drug Delivery Systems (FDDS) and specifically honing in on the innovative formulation strategies and mechanisms inherent in Floating In Situ Gel Raft Forming Systems. FDDS present a promising avenue for revolutionizing drug delivery efficacy by capitalizing on buoyancy to float atop the gastric fluid surface, thereby extending gastric residence time and improving drug …
Published in Trends in Drug Delivery · Vol. 11, Issue 1, 2024 · pp. 9–21 Read article
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Using Artificial Intelligence for The Design of Polymeric Drug Delivery Systems
Abstract: AI is cost effective and time efficient process. Artificial intelligence is a method which uses high speed calculation, the improvement regarding algorithm along with collection about biological and chemical features in pharmaceutical exploration and development .Present day because continuous progress towards machine learning (ML),Artificial intelligence an effective statistics analysing technology might have been broadly utilized in drug design .In pharmaceutical exploration and research employ of AI in target identification, compound …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 1018–1027 Read article
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The Inappropriate Application of Medication in the Context of Surgical Procedures: A Review
Abstract: The initiation of substance abuse frequently commences during adolescence, a critical developmental period. Extensive research has consistently revealed a pronounced connection between drug use and the consumption of cigarettes and alcohol. Understanding the prevalence of substance abuse, with a specific focus on the use of cigarettes and alcohol, is paramount in formulating effective strategies for prevention and control of drug consumption. Therefore, embarking on an initial exploration of the prevalence …
Published in Research and Reviews : Journal of Surgery · Vol. 12, Issue 3, 2023 · pp. 27–32 Read article
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Chitosan-Based Polymer Coatings for Antimicrobial Catheter Surfaces
Abstract: Catheter-associated infections (CAIs) remain a major clinical challenge. Microbial adhesion and subsequent biofilm formation on catheter surfaces significantly reduce the effectiveness of antimicrobial therapy, resulting in prolonged hospitalization, increased healthcare costs, and higher patient morbidity. Consequently, the development of antimicrobial polymer coatings has emerged as an effective strategy for minimizing catheter-associated infections while improving device performance. Among the various biomaterials investigated, chitosan has attracted considerable attention owing to its intrinsic …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 Read article
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A Literature Review on Extrusion/Spheronisation-A Pelletization Technology
Abstract: Extrusion-spheronization is a leading pelletization technology, widely favored for its economic and commercial viability. It is a cost-effective method suitable for large-scale production, making it the most efficient approach for oral drug delivery. This process provides multiple benefits, such as improved flow characteristics, lower friability, a narrow particle size range, easier coating, consistent packing, reduced likelihood of dose dumping, and more predictable gastric emptying. Pellets usually measure between 0.5 and …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 1, 2025 · pp. 61–71 Read article
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Standardization of Barg-e-neem (Azadirachta indica)
Abstract: The leaves of Azadirachta indica are commonly used medicinally in number of herbal products and herbal medicines The objective of the current study is to standardise Azadirachta indica leaves through qualitative and quantitative evaluation of various extracts. Physio-chemical analysis like determination of the pH value, determination of loss on drying, total ash value, acid insoluble ash value, different extractive values and presence of heavy metal was done on powdered leaves …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 12, Issue 1, 2023 · pp. 19–24 Read article
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Design and Assessment of Fixed Dose Combination Containing Fenofibrate and Pravastatin Sodium in Tablet Formulation: A Bioinformatics Approach
Abstract: The aim of this is study is to formulate and evaluate fixed dose combination of Fenofibrate and Pravastatin sodium in tablet dosage for the treatment of Dyslipidemia. For the formulation and optimization of fenofibrate layer, two factor three level factorial design was used as experimental design for optimization with a minimum of nine run. All the nine trial (F1–F9) has been formulated according to the experimental design by wet granulation …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 11, Issue 1, 2024 · pp. 1–20 Read article
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Advancements in Buccal Patch Drug Delivery Systems: A Comprehensive Review of Evaluation Parameters
Abstract: The most dependable delivery method is buccal patches because it offers many improvements over alternative methods.This delivery method circumvents the hepatic first pass metabolism to deliver the medication into the systemic circulation. Buccal patches are inserted between the cheek and gums, where they dissolve and absorb through the buccal cavity's mucosal membrane. Polymers can be used to control the drug's delivery, and intelligent polymeric systems are a good option for …
Published in OmniScience: A Multi-disciplinary Journal · Vol. 15, Issue 2, 2025 Read article
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Advanced Techniques in Filler Layering for the Malar Region: Implications for Cellular Integrity and Long-Term Outcomes
Abstract: Objective: This review investigates advanced filler layering techniques for the malar region, focusing on cellular integration, collagen remodeling, hydration dynamics via aquaporin channels, genetic responses, and filler performance over time. Emphasis is placed on high-density HA fillers (Lyft, Voluma, Volift, and Volux), examining cellular-level mechanisms, genetic interactions, and the role of key pathways (TGF-β, ERK/MAPK, AQP3) in long-term outcomes. Methods: A systematic review was conducted, focusing on genetic, cellular, and …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 1, 2025 · pp. 10–19 Read article
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Biodegradable and Natural Fiber-Reinforced Polymer Composites for Advanced Controlled Drug Delivery Systems
Abstract: Polymer-gel forms have gained popularity in medicine as means of medication delivery over the skin. This is so since they enable medications pass the skin more readily. These products allow medicine to be administered without surgery and provide continuous active ingredient supply. They are excellent for long-term therapy for managing conditions that keep resurfacing. From tiny synthetic ones to huge biological ones, polymer gels can store a wide spectrum of …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 271–284 Read article
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A Classical Drug Review, Pharmacognostical and Physicochemical Analysis on Madhupipplyadi Yoga
Abstract: The drugs of Madhupipplyadi Yoga are Tridosha Shamaka properties with Vranashodhana, Vranaropana, as well as anti-inflammatory, antioxidant, cleaning and wound healing properties. The goal of the current study was to examine the pharmacognostical, physiochemical, and detailed drug review of Madhupipplyadi Yoga as well as to verify the authenticity of the drugs used in the preparation. All Ayurvedic texts, data from web-based search engines, and journal articles were used in the …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 12, Issue 2, 2023 · pp. 14–22 Read article
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An Experimental Pathological Study on the Prophylactic Effect of N-acetylcysteine on Alopecia from Anti-cancer Drugs
Abstract: Prevention of alopecia from anti-cancer drug, Cyclophosphamide, is important for improving quality of life in patients with cancer. Empirically, when Cyclophosphamide (150 mg/kg) infused to rats subcutaneously and intraperitoneally, severe alopecia developed in rats infused intraperitoneally. Moreover, rats infused both of N-acetylcysteine and Cyclophosphamide showed less skin vasculature and scaring of hair follicle, larger caliber of hair follicle and hair, thicker medullary and cortical layers and epimysium, and denser hair …
Published in Research and Reviews: A Journal of Medicine · Vol. 13, Issue 1, 2023 · pp. 21–27 Read article
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AQUASOMES: A Vesicular, Self-assembled Ceramic Nanoparticulate Drug Carrier
Abstract: Nano-biopharmaceutics involves delivery of biopharmaceutical product through different biomaterials like multi-functional nanoparticles, quantum dots, aquasomes, super-paramagnetic iron oxide crystals, and liposomes dendrimers. Aquasomes are considered as one of the most recently developed delivery systems for bioactive molecules like peptides, proteins, hormones, antigens and genes to specific sites. Aquasomes have a spherical shape and a particle size of 60–300 nm. These are three layered self-assembled nano-particulate carrier system. This three-layered structure …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 12, Issue 3, 2025 · pp. 1–14 Read article
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Novel Strategic Framework for AI-Driven Discovery and Development of Smart and Sustainable Polymers in Healthcare
Abstract: The development of new smart and sustainable polymers is emerging as a priority of new health care innovative development, but event before it may be actualized, the usual culprit is the delay and unproductive execution of the old-fashioned R&D efforts. The current paper proposes a strategic plan which will solve all these shortcomings and speed up the material discovery process by using Artificial Intelligence (AI) and Machine Learning (ML). The …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1535–1550 Read article
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Stomach Mimicry of A-Forte for Pharmacokinetic Insight
Abstract: Drug absorption from solid dosage forms after oral administration depends on the release of the drug substance from the drug product, the dissolution or solubilization of the drug under physiological conditions, and the permeability across the gastrointestinal tract. In vitro dissolution may be relevant to the prediction of in vivo performance. To evaluate the in vitro dissolution of A-forte, a siddha proprietary medicine and the influencing factors, a study of …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 2, Issue 2, 2015 · pp. 8–12 Read article
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Engineering Novel Blue Emissive Thiazolidinedione (TD) Poly Lactic Acid (PLA) Composite Thin Films for Bioplastic Scintillation
Abstract: In this article, we demonstrate luminescent properties of PLA blended with new 3-[2-(4-methylphenyl)-2-oxoethyl]-5-(thiophen-2-ylmethylidene)-1, 3-thiazolidine-2, 4-dione and 3-[2-(4-chlorophenyl)-2-oxoethyl]-5-(thiophen-2-ylmethylidene)-1, 3-thiazolidine-2, 4-dione (TD). This paper mainly aims at the preparation of intercalated thin films of PLA and TD. The formation of matrix-dopant composite films was confirmed by FTIR, SEM, TGA, DSC and XRD characterizations. This work really stands out from our previous work as TD has been better recognized as drug material in …
Published in Journal of Polymer & Composites · Vol. 8, Issue 3, 2020 · pp. 10–23 Read article