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138 articles for “computational analysis”
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Computational Analysis of Tinospora Cordifolia Phytochemicals as Potential Inhibitors of BRCA1-BRCT Domain Interaction in Breast Cancer
Abstract: Breast cancer is a leading cause of cancer-related deaths worldwide, accounting for a significant proportion of mortality rates among women. Despite current therapeutic approaches, the disease remains characterized by molecular heterogeneity, making it challenging to develop effective treatments. This study explores the potential of Tinospora cordifolia, a medicinal plant, in breast cancer therapy. Guduchi, scientifically known as Tinospora cordifolia, boasts a centuries-long history of use in traditional medicine, with a …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 27–37 Read article
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An Extensive Analysis of Computer-Aided Drug Design for Novel Psychotropic and Neurological Substances
Abstract: A comprehensive review of the use of computer-aided drug design (CADD) in the creation of innovative neurologic and neuropsychiatric medications is given in this article. It discusses the challenges in traditional drug discovery approaches and highlights the role of computational methods in accelerating the identification and optimization of drug candidates targeting psychiatric and neurological disorders. The method of finding new drugs has been completely transformed by Computer-Aided Drug Design (CADD), …
Published in International Journal of Brain Sciences · Vol. 1, Issue 2, 2024 · pp. 19–27 Read article
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Effects of Cluster Computing on Big Data Analysis and Network Topology
Abstract: The rapid expansion of big data has posed substantial difficulties for conventional computing systems. As a result, cluster computing has grown to be a potent method for effective large data processing. Cluster computing involves multiple interconnected nodes functioning as a unified system, pooling together their processing, storage, and memory resources. These nodes are typically connected through high-speed networks such as ethernet or InfiniBand, facilitating efficient data sharing and communication among …
Published in International Journal of Algorithms Design and Analysis Review · Vol. 1, Issue 1, 2023 · pp. 31–39 Read article
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Productivity Estimation of any Manufacturing Industry Using Fuzzy Logic in MATLAB Software
Abstract: In every industry/organization Labor Productivity plays a major part in the overall growth and production. Many time it is observed that industries do not attain their desired goals due to poor labor productivity. Labor Productivity is dependent on many different factors like Delay in Payment, management supervision over workers, proper work planning and scheduling, poor site safety program, lack of financial motivation system, etc. In this study, we estimated labor …
Published in International Journal of Manufacturing and Production Engineering · Vol. 2, Issue 2, 2024 · pp. 1–14 Read article
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Computation of the Necking in Bars Without Geometrical Imperfection
Abstract: This paper presents a finite element analysis to compute the neck profiles of smooth, circular cylindrical bars in shear-free grip under uniaxial tensile load. The analysis uses 4-node quadrilateral element with linear displacement variation, as well as 8-node Serendipity quadrilateral element with curved sides and a quadratic variation of the displacement field, for power law hardening materials that follow von Mises plasticity. All the elements are based on isoparametric formulation. …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 2, Issue 2, 2024 · pp. 10–19 Read article
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Computational Approaches to Understanding Cellular Signaling Pathways
Abstract: Cellular signaling pathways are fundamental in regulating vital processes, such as cell growth, differentiation, and apoptosis. The intricate and interconnected nature of these signaling networks requires sophisticated methods for their analysis. Computational approaches, including mathematical modeling, network analysis, and machine learning, have revolutionized the way researchers analyze and simulate cellular signaling. This article provides a comprehensive overview of computational strategies employed to model signaling pathways, with a focus on integrating …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 2, 2024 · pp. 8–13 Read article
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Topology and Geometry in Data Science: Persistent Homology and Beyond
Abstract: In recent years, the interplay between topology, geometry, and data science has gained substantial momentum, offering powerful frameworks to analyze and interpret complex datasets. Traditional statistical and machine learning methods often rely on linear or metric- based assumptions, which may fail to capture the intrinsic structure of high-dimensional or nonlinear data. In contrast, topological and geometric methods provide shape-oriented, scale- invariant tools that focus on the continuity, connectivity, and global …
Published in Recent Trends in Mathematics · Vol. 1, Issue 2, 2024 · pp. 21–27 Read article
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Molecular Docking Analysis of Phytocompounds from Ficus hispida Aagainst Epidermal Growth Factor Receptor Kinase Domain
Abstract: The Epidermal Growth Factor Receptor (EGFR) kinase domain plays a key role in cancer, as it promotes tumour growth and helps cancer cells survive, making it an important focus for developing treatments. Through comprehensive computational analysis, this study investigates the anticancer potential of phytocompounds from Ficus hispida, a medicinal plant renowned for its diverse bioactive compounds, as novel EGFR inhibitors. Molecular docking techniques using Py Rx software were employed to …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 Read article
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Molecular Docking Analysis of Phytocompounds from Ficus hispida Against Epidermal Growth Factor Receptor Kinase Domain
Abstract: The Epidermal Growth Factor Receptor (EGFR) kinase domain plays a key role in cancer, as it promotes tumour growth and helps cancer cells survive, making it an important focus for developing treatments. Through comprehensive computational analysis, this study investigates the anticancer potential of phytocompounds from Ficus hispida, a medicinal plant renowned for its diverse bioactive compounds, as novel EGFR inhibitors. Molecular docking techniques using Py Rx software were employed to …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 48–62 Read article
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AI-Based Sentiment Analysis of Public Perception Under Bangabandhu Sheikh Mujibur Rahman
Abstract: Sheikh Mujibur Rahman, known as Bangabandhu, played a pivotal role in Bangladesh’s post-liberation period (1971–1975). Understanding public sentiment during his leadership is crucial for historical analysis. This study employs Artificial Intelligence (AI)-based Sentiment Analysis to examine public perception through archived newspapers, parliamentary speeches, and historical records. Using Natural Language Processing (NLP) techniques, including sentiment classification and opinion mining, we analyze textual data to assess the prevailing public mood during his …
Published in International Journal of Algorithms Design and Analysis Review · Vol. 3, Issue 2, 2025 · pp. 21–29 Read article
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Exploring the Therapeutic Potential of Grapeseed Phytoconstituent Through Molecular Docking Analysis for Multiple System Atrophy Treatment
Abstract: Objective: Alpha-synuclein (α-Syn) aggregates are a common neurodegenerative disorder associated with Parkinson’s disease and multiple system atrophy (MSA). As a fruit that is extensively grown, grapes have several pharmacological advantages when it comes to reducing oxidative stress. Research has indicated that grape seed phytoconstituents have a major effect on α-Syn. The objective of this study is to inquire into the pharmacological characteristics and potential therapeutic applications of grape seed derivatives …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 14–26 Read article
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Analyzing and Predicting Academic Behavior from Peer Pressure Indicators Using Machine Learning
Abstract: The academic achievement of a student is determined by their capability, but also by the companions with whom they associate. Friends can have a positive impact on students' motivation for school, and at times friends are distractions leading to a lack of attention on their school assignments. This particular study focuses on the number and quality of companions students associate with and to what extent that could be used as …
Published in International Journal of Education Sciences · Vol. 3, Issue 2, 2026 Read article
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Anti Covid-19 Drugs Suggested by Computational Methods: A Review
Abstract: Background and aims: Long COVID refers to the persistence of illness in individuals who have survived from COVID-19 infection. This article reviews long covid and the use of in silico techniques in drug development for COVID-19. Results: Many COVID-19 survivors have long COVID, which has become a burden in daily life. Various attempts have been undertaken to relieve symptoms and manage it, but there is no cure as of yet. …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 1, 2023 · pp. 16–34 Read article
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Inhibition of PI3K/Akt/mTOR Signaling Pathway by Vitis Vinifera Phytocompounds: A Promising Strategy for Supressing Colorectal Cancer Growth and Metastasis
Abstract: Objectives: Colorectal cancer was not typically identified a few decades ago. Today, with almost 900 000 fatalities each year, it is the fourth most dangerous cancer in the world. Colorectal cancer is responsible for about 10% of all cancer diagnoses annually and cancer-related deaths worldwide. It is the second most common type of cancer in women and the third most common type in men. Incidence and death are roughly 25% …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 · pp. 64–75 Read article
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The Importance of DNA Profiling Today
Abstract: DNA profiling has changed a lot of sectors, from health and criminal justice to ancestry research and animal conservation. It is one of the most important scientific instruments of our time. This technique makes it possible to identify people, analyse family relationships, and learn more about biology by looking at unique genetic markers in a person's DNA. DNA profiling has changed the way forensic science works by making it easier …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 4, Issue 1, 2026 Read article
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Atmospheric Modeling: A Comprehensive Review of Numerical Approaches and Applications
Abstract: Atmospheric modeling plays a crucial role in understanding and predicting atmospheric processes, weather patterns, and climate variability. This review synthesizes current methodologies and applications across several types of atmospheric models, including numerical weather prediction (NWP), climate models, air quality models, and chemical transport models. We explore the intricacies of data assimilation, model evaluation, parameterization, and the importance of high-performance computing in advancing model accuracy and efficiency. Special emphasis is placed …
Published in International Journal of Atmosphere · Vol. 1, Issue 2, 2024 · pp. 16–21 Read article
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Virtual Machine Cost & Computing comparison between cloud service
Abstract: Cloud computing has revolutionized enterprise IT infrastructure with virtual machines forming the cornerstone of Infrastructure as a Service deployment. This study provides a detailed comparative evaluation of virtual machine pricing and computational performance among three leading cloud computing platforms: Amazon Web Services (AWS), Microsoft Azure, and Google Cloud Platform (GCP). Through quantitative analysis of current pricing data from September 2025, independent performance benchmarks from Cockroach Labs 2021 Report, and market …
Published in International Journal of Mobile Computing Technology · Vol. 4, Issue 2, 2026 Read article
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Implementing and Analyzing Network Commands in Cloud and Edge Computing Environments with Cisco Simulators
Abstract: The present review examines edge and cloud topologies and compares them according to latency. Instead of using distant data centers like cloud computing platforms, edge computing designs process data physically close to the source. Increased demand for Internet of Things (IoT) devices, which are growing more concerned with real-time data processing and analysis, has fueled the expansion of edge computing and cloud computing. In essence, each of these designs offers …
Published in International Journal of Satellite Remote Sensing · Vol. 2, Issue 2, 2024 · pp. 62–69 Read article
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Molecular Docking Studies of Nyctanthes arbor-tristis Phytochemicals for Targeting TNF Receptor in Arthritis
Abstract: Rheumatoid Arthritis is an autoimmune disorder which results in inflammation. Tumor necrosis factor-alpha (TNF-α) is responsible for the progression of inflammatory arthritis by promoting immune cell activation and cytokine release. The present study explores the potential of bioactive compounds derived from Nyctanthes arbor-tristis (Parijat) in modulating TNF receptor activity through molecular docking. Computational methods were employed to evaluate the binding affinity of selected phytocompounds from N. arbor-tristis against the extracellular …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 11–21 Read article
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Exploring Potential Phytochemicals for Myasthenia Gravis Treatment: A Molecular Docking and ADME Analysis Approach
Abstract: Objective: Muscle feebleness and exhaustion derived from a disruption in neuromuscular transference are hallmarks of the crippling autoimmune disease myasthenia gravis (MG). The drawbacks of the current MG therapy options are frequently partial efficacy and adverse effects. To investigate the potential of phytochemicals in MG control, in this work we integrated molecular docking with ADME (absorption, distribution, metabolism, and excretion) analysis using a computer method. We identified molecules exhibiting favorable …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 1–13 Read article