Search
25 articles for “Insulin Resistance”
-
Correlation of Serum Vitamin D Levels with Insulin Resistance in Young Adults
Abstract: Among young adults, both insulin resistance (IR)and vitamin D deficiency are common and pose the risk of complications, such as type 2 diabetes mellitus (T2DM). A few studies demonstrated that vitamin D deficiency might negatively influence insulin sensitivity, but the results of these studies have been inconsistent and/or inconclusive. This review focuses on young adults and aims to summarize and critique studies that assess the relationship between IR and serum …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 15, Issue 1, 2026 Read article
-
The Interplay Between Hyperglycemia, Endothelial Dysfunction, and Cardiovascular Risk in the Context of COVID-19: Implications for Long-term Health
Abstract: The COVID-19 pandemic has highlighted the potential impact of hyperglycemia, especially its link to cardiovascular disease (CVD) and endothelial dysfunction. COVID-19 can cause systemic inflammation and endothelial damage, worsening complications related to hyperglycemia. Persistent inflammation and endothelial dysfunction are crucial elements in the progression of atherosclerosis and other cardiovascular diseases. The long-term health effects of COVID-19, known as “Long COVID” or post-acute sequelae of SARS-CoV-2 infection (PASC), have raised concerns …
Published in Research and Reviews: A Journal of Medicine · Vol. 14, Issue 2, 2024 · pp. 27–31 Read article
-
Understanding Metabolic Syndrome and its Nutritional Management
Abstract: Metabolic syndrome (MetS) is a collection of risk factors, especially when at least three occur together, including abdominal obesity, dyslipidemia, low high-density lipoprotein cholesterol (HDL-c) levels, hypertension, and insulin resistance. MetS is linked to an increased risk of diabetes and cardiovascular diseases (CVDs) if treatment is not received.The causes of MetS include both genetic and acquired factors that contribute to issues such as insulin resistance, chronic low-grade inflammation, and obesity. …
Published in International Journal of Sustainability · Vol. 2, Issue 1, 2025 · pp. 26–37 Read article
-
Postbiotics Unveiled: Mechanistic Insights and Therapeutic Implications in Obesity.
Abstract: The burgeoning global obesity epidemic necessitates innovative therapeutic approaches, and postbiotics, bioactive compounds arising from microbial fermentation, have emerged as promising contenders in reshaping obesity management. This comprehensive review explores the multifaceted mechanisms by which postbiotics impact obesity, from modulating gut microbiota composition to influencing metabolic pathways and enhancing energy expenditure. The exploration of postbiotics is rooted in a deeper understanding of the gut–brain axis and bidirectional communication between gut …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 1, 2026 · pp. 11–28 Read article
-
Metabolic Syndrome in Psoriatic Patients: A Cross-Sectional Study
Abstract: Background: Psoriasis is a chronic immuno-inflammatory disease affecting the skin and joints. Studies have demonstrated an increased prevalence of conventional cardiovascular risk factors such as diabetes mellitus, hypertension, and metabolic syndrome in these patients. The aim of this study was to determine the association between psoriasis and metabolic syndrome. Material and Method: An observational cross-sectional study was carried out between November 2023 and October 2024, including participants with and without …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 15, Issue 1, 2026 · pp. 17–23 Read article
-
Vitamin D Mitigates Inflammation and Downregulates Importin α3 in Non-Alcoholic Fatty Liver Disease (NAFLD)
Abstract: Non-alcoholic fatty liver disease (NAFLD) affects about one-third of the population in the United States and Western countries, reaching up to 90% among obese individuals and those undergoing bariatric surgery. Characterized by hepatic fat accumulation, NAFLD progresses from simple steatosis to non-alcoholic steatohepatitis (NASH), fibrosis, and, in rare cases, hepatocellular carcinoma. Linked intricately with metabolic syndrome, including diabetes and obesity, NAFLD development involves insulin resistance and hyperinsulinemia. Experimental evidence consistently …
Published in International Journal of Cheminformatics · Vol. 4, Issue 1, 2026 Read article
-
Vitamin D Mitigates Inflammation and Downregulates Importin α3 in Non-Alcoholic Fatty Liver Disease (NAFLD)
Abstract: Background: Pro-inflammatory cytokines, such as TNF-α, IL-1β, IL-6, and IL-8, seem to play a crucial role in the progression of NAFLD as they activate the transcription factor NF-кB. The activated NF-кBp50/RelA subunits are translocated to the nucleus by Importin α3 and Importin α4. Numerous studies have indicated a negative association between NAFLD and vitamin D levels. Low vitamin D levels have been correlated with histological severity, necro-inflammation, and fibrosis in …
Published in International Journal of Cheminformatics · Vol. 4, Issue 1, 2026 · pp. 1–16 Read article
-
Diabetes Prediction Using ML Techniques
Abstract: Diabetes mellitus, commonly referred to as diabetes, denotes a cluster of prevalent endocrine disorders characterized by persistent elevated levels of blood sugar. Diabetes is classified into two main types: type 1 and type 2. Type 1 diabetes arises when the body is unable to produce insulin, while type 2 diabetes involves either insulin resistance or insufficient insulin production. Early detection and intervention are essential to reduce its harmful impacts. The …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 11, Issue 3, 2024 · pp. 1–9 Read article
-
History, Processing, Types and Health Benefits of Indian Yogurt
Abstract: Yogurt is a food which is nutrient rich and it is produced after the milk bacterial fermentation. Yogurt should have 3.25% milk fat and 8.25% milk solids non fat and the titrable acidity of at least 0.9%, which is expressed as lactic acid. Before adding bulky flavoring additives, the USDA yogurt criteria specify that the yogurt must satisfy the composition requirements of milk fat and MSNF. The data used in …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 13, Issue 1, 2024 · pp. 1–6 Read article
-
Gut Microbiome Dysbiosis During Metabolic Disorders: Diabetes
Abstract: Understanding the intricate interplay between gut microbiome dysbiosis and diabetes is crucial due to the escalating prevalence and impact of diabetes mellitus globally. This comprehensive review examines the current understanding of this relationship, elucidating how alterations in the gut microbiome composition contribute to diabetes pathogenesis by influencing metabolic homeostasis, immune regulation, and insulin resistance. Dysregulation of gut microbial communities leads to shifts in diversity and abundance, exacerbating chronic low-grade inflammation …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 2, 2024 · pp. 56–75 Read article
-
A Review on The effect of Polycystic Ovary Syndrome on some Hormonal and Metabolic Disturbances in Women
Abstract: Polycystic ovary syndrome (PCOS) is a common hormonal condition that affects women of reproductive age. It usually begins to appear during adolescence. The ovaries produce an abnormal amount of "androgens", which are male sex hormones that are usually found in women in small quantities. Ovarian syndrome causes hormonal imbalances, irregular menstrual cycles, increased cysts in the ovaries, in addition to hair growth all over the body, acne, and pain in …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 1, 2025 · pp. 21–28 Read article
-
Role of PI3K/AKT/mTOR Signaling Pathways in Breast Cancer
Abstract: Abstract: Breast cancer is among the most commonly diagnosed cancers and remains a leading cause of mortality among women globally. Although early detection and interventions aimed at curtailing tumor progression have significantly improved breast cancer survival rates, there is an ongoing demand for more potent systemic therapies to effectively prevent metastasis. A central pathway frequently associated with the growth, survival, and motility of breast cancer cells is the PI3K/AKT/mTOR signaling …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 1, 2025 · pp. 23–34 Read article
-
Edible Mushrooms: Management of Diabetes Mellitus and Phytochemical Screening of Agaricus Bisporus
Abstract: A metabolic disease characterized by elevated blood glucose levels; diabetes mellitus affects millions of people. If not treated on time, it causes problems, damage organs, and even life-threatening. Studies have shown that diabetes can be avoided and controlled with a healthy lifestyle that incorporates exercise and a balanced diet. While there are several synthetic medications available to treat this illness using them over an extended period of time is linked …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 1, 2025 · pp. 1–13 Read article
-
Nutritional Management of Polycystic Ovarian Disease: Integrating Unani and Contemporary Approaches
Abstract: In Unani medicine, dietary management, known as Ilaj bil Ghiza, plays a vital role in restoring humoral balance and maintaining a healthy temperament (mizaj). This principle aligns with modern medical understanding, particularly in conditions, like polycystic ovarian syndrome (PCOS), which is often associated with insulin resistance and obesity. Modifying dietary habits has shown promise in improving both metabolic and reproductive functions in PCOS patients. Unani scholars attribute PCOS to a …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 12, Issue 2, 2025 · pp. 1–6 Read article
-
Tackling Water Hardness: Understanding the Issue for Sustainable Development
Abstract: Hard water poses a serious threat to human health and industrial operations. The pervasiveness of water hardness, characterized by elevated concentrations of calcium and magnesium ions, originates from seepage and runoff from soils, as well as polyvalent metallic ions from sedimentary rocks. These minerals, while essential in moderate amounts, can become problematic when consumed in excess. Epidemiological studies have established correlations between excessive consumption of calcium and magnesium and increased …
Published in Journal of Water Pollution & Purification Research · Vol. 12, Issue 2, 2025 · pp. 73–79 Read article
-
Role of Inflammatory Markers and Lipid Abnormalities in Glycemic Dysregulation Among Type 2 Diabetics
Abstract: Background: Diabetes mellitus (DM) is a chronic metabolic disorder characterized by systemic inflammation and associated with various complications in multiple organs. Type 2 diabetes mellitus (T2DM) specifically involves insulin resistance, hyperglycemia, and inflammatory responses. This study investigates the levels of various inflammatory markers and their correlation with glycaemic control in T2DM patients. Objective: To evaluate the levels of inflammatory markers (including NLR, PLR, SII, SIRI, CRP, IL-6, TNF-α, TGF-β, MCP-1, …
Published in Emerging Trends in Metabolites · Vol. 2, Issue 2, 2025 Read article
-
Association of Metabolic Syndrome with Cholelithiasis in Female Patients and Its Impact on Clinical Management and Surgical Outcome
Abstract: Background: Metabolic syndrome (MetS) is associated with obesity, insulin resistance, dyslipidemia, and hypertension, which may predispose to gallstone formation. This study aimed to evaluate the association between MetS and cholelithiasis in female patients and to assess its impact on clinical presentation, surgical difficulty, and postoperative outcomes. Methods: A prospective observational study was conducted on 88 female patients with ultrasonography-confirmed cholelithiasis. Patients were divided into two groups: MetS (n=44) and non-MetS …
Published in Research and Reviews : Journal of Surgery · Vol. 14, Issue 3, 2025 · pp. 1–7 Read article
-
Impact of Spinal Cord Injury on Body Composition and Weight
Abstract: Weight gain is a common consequence of spinal cord injury (SCI), often resulting from decreased physical activity, metabolic alterations, and changes in body composition. This study aimed to assess post-injury weight changes among individuals with SCI. Data was obtained using a multistage random sampling method, utilizing a patient questionnaire administered to 28 individuals diagnosed with SCI. Participants’ baseline weights were compared with their recorded weights at follow-up. The mean initial …
Published in Research and Reviews : Journal of Surgery · Vol. 15, Issue 1, 2026 · pp. 19–34 Read article
-
Gut Microbial Metabolites in Inflammatory, Metabolic, and Neurologic Disorders.
Abstract: The human gut microbiota transforms dietary and hostderived substrates into a diverse array of metabolites—including shortchain fatty acids (SCFAs), hydrogen sulfide (H₂S), bile acid derivatives, indoles, trimethylamine Noxide (TMAO), branchedchain amino acid (BCAA) derivatives, and lipopolysaccharide (LPS)—that act as key signaling mediators along epithelial, immune, endocrine, and neural axes. These metabolites regulate barrier integrity, energy homeostasis, inflammation, and gut–brain communication and are increasingly implicated in the pathogenesis of inflammatory bowel …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 1, 2026 · pp. 58–64 Read article
-
Childhood Obesity: From Determinants to Clinical Management strategies
Abstract: Childhood obesity is one of the major global health problems in whole world, with a dramatic increase in prevalence over the recent few decades. Obesity associated with very serious long term health complications and sometimes very serious complications, such as metabolic disorders, cardiovascular, neurological, renal and psychological disorders. There are various factors such as genetic, environmental, behavioural, and socio-economic factors are some key player in the pathogenesis of obesity. In …
Published in Research and Reviews: A Journal of Health Professions · Vol. 16, Issue 1, 2026 · pp. 45–53 Read article