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30 articles for “Immunomodulatory”
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Experimental Study on the Effect of Membranous Milkvetch and Ledebouriella divaricate Immunomodulatory Tablets on cytokine production in allergic rhinitis model mice
Abstract: We have established allergic rhinitis models for use in the treatment of allergic rhinitis with the help of the traditionall Koryo medicine administration, lade-screen Powder-extracted Membranous Milkvetch and Ledebouriella divaricate immunomodulatory tablet and the effect of lade-screen Powder on cytokine production in allergic rhinitis model mice. In the allergic rhinitis model, the administration of Membranous Milkvetch and Ledebouriella divaricate immunomodulatory tablets, along with Lade-screen Powder, demonstrated significant therapeutic effects. These …
Published in Research and Reviews : A Journal of Immunology · Vol. 15, Issue 3, 2025 Read article
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Repurposing Approved Immunomodulatory Drugs for Target Proteins in the Pancreas of European eel: A Molecular Docking Approach
Abstract: Leishmaniasis is a disease caused by tiny parasites called Leishmania, which spread to humans through the bite of an infected female sand fly. The disease manifests in three different forms, and the protein calcitonin promotes the disease’s spread. By reducing blood calcium levels, inhibiting osteoclast activity, increasing calcium excretion, and possibly playing a role in neurotransmitter modulation, calcitonin, a hormone released by vertebrates, promotes the progression of pathogenesis and lessens …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 12–19 Read article
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Expression Profiling of Immunomodulatory Genes in Canine Adipose Tissue–Derived Mesenchymal Stem Cells
Abstract: Adipose tissue–derived mesenchymal stem cells (AT-MSC) represent a heterogeneous population of self-renewing, multipotent progenitor cells residing in the stromal compartment of adipose tissue. Canine adipose tissue-derived mesenchymal stem cells have attracted significant interest in regenerative medicine due to their therapeutic potential in naturally occurring canine diseases and their translational relevance to human medicine. In the present study, canine adipose tissue–derived MSCs (cAT-MSCs) were isolated and differentiated into osteogenic, chondrogenic and …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 15, Issue 1, 2026 Read article
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Exploring Phytochemicals from Ricinus Communis for Potential Therapeutic Applications in Rheumatoid Arthritis: An in-Silico Approach
Abstract: Aim: Rheumatoid arthritis (RA) is a long-term autoimmune condition characterized by the immune system mistakenly attacking the joints, leading to swelling, discomfort, and joint deformities. Current management strategies include anti-rheumatic drugs and biologics, which have limitations. This study aims to explore the therapeutic potential of Ricinus communis (castor bean plant) phytochemicals as plant-based therapies for autoimmune conditions, like RA. Methods: Phytochemicals from Ricinus communis were retrieved using the IMPPAT database, …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 1, 2025 · pp. 32–41 Read article
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The Study On Sphaeranthus Indicus
Abstract: The increasing usage of plant-based medications is mostly due to their lower costs, greater efficacy, and little or nonexistent adverse effects as compared to contemporary medications. To support the claims made about medicinal plants in traditional medicine systems, a great deal of research is being done on them. The Asteraceae family includes the aromatic herb Sphaeranthus indicus. It thrives as a weed in paddy fields and is found throughout India's …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 11, Issue 1, 2024 · pp. 37–43 Read article
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A Concentrated Review of Current Developments in the Diagnosis and Treatment of Viral Mumps
Abstract: Viral mumps, caused by the mumps virus, continues to pose public health challenges globally despite the availability of vaccines. Considerable advancements have been achieved in the last few years about the pathophysiology, diagnosis, and management of viral mumps. This focused review aims to highlight the latest advances in the diagnosis and treatment of viral mumps, with a particular emphasis on innovative strategies and emerging therapies. Key topics covered include the …
Published in International Journal of Tropical Medicines · Vol. 1, Issue 1, 2024 · pp. 01–07 Read article
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Assessing the Efficacy of Carica Papaya Leaf Extract in Preventing Thrombocytopenia: A Review
Abstract: A clinical condition known as thrombocytopenia is characterized by a low platelet count (less than 150 × 103/μL) in the blood, which leads to an imbalance in hemostasis and can result in multiple deadly consequences. Although the exact causes are not always known, they always lead to death by interfering with the formation of platelets and encouraging their destruction. Research demonstrates that Carica papaya leaf has special medicinal and therapeutic …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 11, Issue 2, 2024 · pp. 25–33 Read article
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Stiff Person Syndrome: Advances in Understanding, Diagnosis, and Treatment of a Rare Autoimmune Disorder
Abstract: Stiff Person Syndrome (SPS) is a rare and complex autoimmune neurological disorder characterized by progressive muscle stiffness, rigidity, and painful spasms. This chapter provides a comprehensive overview of SPS, exploring its pathophysiology, clinical presentation, diagnostic challenges, and current treatment approaches. We discuss the latest research findings, including the role of autoantibodies, genetic factors, and environmental triggers in the development of SPS. The chapter examines various diagnostic methods, emphasizing the importance …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 35–43 Read article
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Understanding the Impact: Adult BCG Vaccination in the Fight Against Tuberculosis
Abstract: Tuberculosis (TB) remains a big global health challenge, with significant mortality rates, especially in developing nations. India holds most TB cases throughout the globe. As HIV rates, multidrug-resistant tuberculosis (MDR-TB), and extensively drug-resistant tuberculosis (XDR-TB) continue to increase, the situation is deteriorating. These all come in the way of the End TB epidemic campaign by the World Health Organization (WHO) by 2030. Immunology and vaccinology represent critical fronts in TB …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 3, 2024 · pp. 1–6 Read article
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Integrative Therapeutics for Antimicrobial Resistance and Autoimmune Disease: Evidence and Pathways
Abstract: Background: Antimicrobial resistance (AMR) is accelerating globally, while autoimmune diseases and adverse drug reactions (ADRs) continue to rise. Ayurveda offers immunomodulatory, antimicrobial, and detoxification‑oriented interventions that may complement biomedical strategies. Objective: To propose a hypothesis‑driven integrative model combining Ayurvedic phytotherapy, panchakarma detoxification, and personalized dosha‑based care with evidence‑based medical management to mitigate AMR emergence, modulate autoimmunity, and reduce ADR incidence. Methods: A synthesis of mechanistic literature on Ayurvedic herbs with …
Published in Research and Reviews : A Journal of Immunology · Vol. 16, Issue 2, 2026 · pp. 25–30 Read article
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Development of Zinc Gluconate Vitamin C Effervescent Tablet for Immunity Improvement and Management of Corona Virus Disease (COVID-19)
Abstract: The global pandemic of coronavirus disease- 2019 (COVID-19) continues to pose a threat to people, societies, and economic and healthcare systems. COVID-19s progression and lethality are determine by the host immune system, as is the case with many other diseases. revolutionary idea that has been used to treat other diseases is the control of inflammatory response and cytokine production based on immunonutrition. Some COVID-19 clinical trials are now using zinc, …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 1, 2024 Read article
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Formulation And Evaluation of Vyadhikshamatva Vardhak Giloy Ghanvatis
Abstract: The product of Kalka Kalpana, one of the five essential ayurvedic medicinal preparations, is vati Kalpana. Because of its many advantages, such as its tasty nature, ease of administration, ease of dispensing, and ease of transportation, vati kalpana is a vital part of the ayurvedic formulation. A pharmaceutical technique called vati kalpana uses powder of unprocessed medications (herbal or herbo minerals) and is triturated using juice, honey, or kassayam, and …
Published in Research & Reviews : Journal of Herbal Science · Vol. 13, Issue 2, 2024 · pp. 7–13 Read article
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Aquatic Ecosystems: A Review on Prospecting of Anticancer Molecules from Fungi & Other Microbes
Abstract: Marine biota; namely, actinomycetes, bacteria, fungi, microalgae, green algae, oceanic weeds, mangroves, and other extremophiles constitute about 90% of the oceanic biomass. The organisms are taxonomically diverse, biologically productive/active, and biochemically unique. These unique biochemiques may act as a great source for the discovery of new bioactive molecules, including anticancer drugs. The marines produce medicinally potent biochemicals; namely, sulfated saccharides, polyphenols, and, sterols. Only a few of these alkaloids have …
Published in International Journal of Fungi · Vol. 1, Issue 2, 2024 · pp. 1–22 Read article
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A Traditional Indian Unani Dynamic Drug Amla (Emblica Officinalis) And Its Unani Pharmacological Activities In The Light of Recent Experimental Studies: A Comprehensive Review
Abstract: Since ancient times, plants have been essential to human development, serving as a primary source of natural remedies. The challenges associated with producing synthetic medications, along with their potential side effects and high costs, have driven researchers around the world to focus on the study of medicinal plants. In recent years, numerous publications have highlighted the role of plant-derived bioactive compounds in treating a wide range of human ailments, underscoring …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 11, Issue 3, 2024 · pp. 21–29 Read article
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Exploring The Therapeutical Potential Of Pongamia Pinnata For Herpes Simplex Virus Type 1 (HSV-1)
Abstract: Objective: Pongamia pinnata (L.), commonly known as Indian beech or pongam tree, is a tropical plant renowned for its medicinal properties in traditional medicine systems. Extracts derived from various parts of Pongamia pinnata have demonstrated antimicrobial, anti-inflammatory, and immunomodulatory activities. Such attributes make it a compelling candidate for exploring its therapeutic potential against HSV infections. Thymidine kinase is the target protein mostly used in the treatment of HSV1 infections. In …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 1, 2025 · pp. 1–9 Read article
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Unlocking Microbial Potential: Innovations in Natural Product Biosynthesis and Therapeutic Applications
Abstract: MNPs play a pivotal role in diverse fields, spanning medicine, agriculture, and industry. This review paper synthesizes insights from various discussions on microbial natural products, encompassing their sources, bioactive properties, and applications. We explore microbial diversity contributing to natural product synthesis, emphasizing bacteria and fungi as prolific producers. The methods for isolating and characterizing these compounds underscore the interdisciplinary nature of microbial natural product research utilizing various analytical techniques contributing …
Published in International Journal of Fungi · Vol. 2, Issue 1, 2025 · pp. 18–38 Read article
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Carica papaya Linn.: A review on Nutritional and Medicinal Value of Papaya
Abstract: Papaya (Carica papaya Linn.) is a popular fruit tree in the tropical part of the world. It is a delicious, sweet fruit with a pleasant aroma. The papaya is consumed worldwide as a fresh fruit and vegetable. which is healthy for humans because all parts of the plant, including fruit, stem, bark, peel, fruit, seeds, and pulp, have medicinal properties. Papaya also has nutritional value and is also used as …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 1, 2025 · pp. 67–75 Read article
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Quinine: Past, Present, and Future Perspective in Malaria and Autoimmune Disorder
Abstract: Quinine, a natural alkaloid extracted from the bark of the cinchona tree, has traditionally played a key role in treating malaria, a disease caused by parasites of the Plasmodium genus. Since its discovery in the 17th century, quinine has evolved from a rudimentary treatment to an essential component of modern antimalarial therapies. This article explores the historical use of quinine in the fight against malaria, its role in current treatment …
Published in International Journal of Pathogens · Vol. 2, Issue 1, 2025 · pp. 24–33 Read article
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The Impact of Plastic Pollution on Terrestrial Ecosystems: Microplastics, Heavy Metals, and Quorum Sensing in Soil Health
Abstract: Plastic pollution is one of the most significant environmental challenges today, particularly in the context of terrestrial ecosystems. The widespread accumulation of plastic waste, including microplastics, has led to pervasive contamination of soil, disrupting ecosystems and human health. This article explores the interactions between plastic pollutants and the terrestrial environment, with a focus on soil pollution, microplastic behavior, and the implications for ecosystems. Microplastics, which are tiny plastic particles with …
Published in International Journal of Environmental Noise and Pollution Control · Vol. 2, Issue 2, 2024 · pp. 10–13 Read article
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Fungal-derived Nutraceuticals & Bioactive Compounds with Physiotherapeutic and Health- promoting Properties: A Comprehensive Review
Abstract: Fungal-derived nutraceuticals represent a rapidly expanding field in biomedical research, offering a rich source of bioactive compounds with diverse therapeutic applications. This comprehensive review examines the physiotherapeutic and health-promoting properties of fungal metabolites, including polysaccharides, terpenes, proteins, peptides, alkaloids, fatty acids, vitamins, and minerals. Fungi produce over 9,000 bioactive compounds from approximately 22,500 microbial metabolites, with less than 5% of the fungal kingdom explored [1] . The major bioactive constituents …
Published in International Journal of Fungi · Vol. 2, Issue 2, 2025 Read article