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1260 articles for “CTLA-4”
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5-Methyl-2-phenyl-2,4-dihydro-3H-pyrazol-4-one: Synthesis and Reactions
Abstract: The presence of the five-member pyrazole nucleus in different structures leads to a large diversity in its applications. In almost every research study, the pyrazole derivatives biological importance faces a competitive challenge in areas of technology, medicine and agriculture. This reflects the description of these derivatives as antibacterial, antifungal, anticancer, antidepressant, anti-inflammatory, anti-tuberculosis, antioxidant as well as antiviral agents. In our review, we will discuss and show the highlights of …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 16, Issue 3, 2025 Read article
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Influence of Carbonyl Iron Particle Loading on the Dimensional and Rheological Properties of 4D-Printed TPU-Based Magnetorheological Elastomers
Abstract: The advancement of 4D printing technologies has created new opportunities for fabricating smart materials with tunable properties, including magnetorheological elastomers (MREs). This study investigates the fabrication and characterization of thermoplastic polyurethane (TPU)-based MREs with varying carbonyl iron particle (CIP) loadings (10–50 wt.%) using the fused filament fabrication (FFF) method. MRE filaments were produced through a solvent-assisted mixing and extrusion process, ensuring consistent diameters within 1.75 ± 0.10 mm. Test specimens …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 127–138 Read article
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Current Developments In 4D Printing Technology
Abstract: The perception of four-dimensional (4D) printing expertise was prompted through the time dimension inclusion in three-dimensional (3D) printing. Many other industries, including engineering, health, and the arts, have revealed a great deal of attention it. Recently, innovations in bioscience have been established that can be implemented using 4D printing. The ability to integrate time with situational variations has many benefits, but perceptibility and adaptability are merely two. Smart material, stimulus, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 108–120 Read article
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Industry 4.0 and Smart Manufacturing: A Review
Abstract: This review looks at Industry 4.0 and smart manufacturing's idea, enabling technologies, implementation issues, and future prospects. Drawing on recent literature, the paper synthesizes key pillars such as the Industrial Internet of Things (IIoT), cyber-physical systems (CPS), artificial intelligence, digital twins, and additive manufacturing. It highlights integration requirements across supply chains, cyber security concerns, workforce implications, and standards activities that influence adoption. The literature survey focuses on empirical studies and …
Published in International Journal of Manufacturing and Production Engineering · Vol. 3, Issue 2, 2025 · pp. 14–17 Read article
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A Computational Study of Lift and Drag Characteristics for NACA 4415 and NACA 2412 Aerofoils
Abstract: The performance of an aerofoil is crucial in designing wind turbine blades, aircraft wings, and other aerodynamic surfaces. This project presents a comparative analysis of two widely used aerofoil profiles, NACA 4415 and NACA 2412, to study their lift and drag characteristics under different flow regimes. The aerofoil geometries were developed using the NACA four-digit notation and modeled in ANSYS Design Modeler. Numerical simulations were conducted in ANSYS Fluent for …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1298–1315 Read article
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Revolutionizing Material Flow and Handling: Industry 4.0 Integration in Logistics Management
Abstract: The integration of Industry 4.0 technologies has become pivotal in reshaping material flow and handling paradigms within logistics management. This paper presents an in-depth analysis of this transformative phenomenon. Industry 4.0's emergence has heralded an era of unprecedented automation, seamless data exchange, and cutting-edge technologies, fundamentally altering conventional logistics practices. Through an extensive review of recent literature, this study meticulously examines the profound impact of Industry 4.0 on material flow …
Published in International Journal of Advanced Robotics and Automation Technology · Vol. 2, Issue 1, 2024 · pp. 24–34 Read article
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Design and Implementation of a 4-Bit Breadboard CPU Using Digital Integrated Circuits
Abstract: This paper presents the design and hardware realization of a simple 4-bit CPU built using discrete TTL integrated circuits on a breadboard. The CPU employs a 4-bit common data bus with tri-state buffers for device arbitration, three 4-bit registers (Register A, Register B, and an Output Register) implemented with 74LS175 quad D flip-flops, and a 4-bit ALU for addition/subtraction using a 74LS83 adder and XOR gates. Manual control signals (load, …
Published in Journal of Electronic Design Technology · Vol. 17, Issue 2, 2026 Read article
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Revolutionizing Form and Function: Exploring 4D Printing as a Novel Manufacturing Approach for Complex Generative Structures and Customized Formworks
Abstract: This research delves into the transformative potential of 4D printing manufacturing technology, focusing on its innovative application in fabricating intricate generative and computational structures for adaptable formwork in both individualized and mass-customized scenarios. Spanning the interdisciplinary realms of digital design, digital fabrication, and material science, the study comprehensively explores the integration of these diverse fields. Utilizing generative algorithms and parametric design tools, the research employs simulations to realize complex patterns …
Published in International Journal of Manufacturing and Production Engineering · Vol. 1, Issue 2, 2023 · pp. 41–50 Read article
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Synthesis, Characterization, and Reactivity of Bivalent Tin(II) with 4-Tert-butylphenol
Abstract: Bivalent tin(II)-4-tert. butylphenoxide of composition Sn(OC6H4X-4)2(I), where X = But, has been synthesized by the reaction of stannous chloride (SnCl2) with bimolar amounts of 4-tert. butyl phenol (HOC6H4But-4) in the presence of the base, diethyl amine, in tetrahydrofuran (THF) solvent. The resulting complex was characterized by elemental analysis, molecular weight determination, molar conductance measurement, IR, and 1H NMR spectral studies. The reactivity of the newly synthesized complex (I) with HgCl2 …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 2, Issue 1, 2024 · pp. 14–19 Read article
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Industry 4.0 and Smart Supply Chains: Transforming Supply Chain Processes for Enhanced Efficiency and Sustainability
Abstract: The fourth industrial revolution, or Industry 4.0, is an important transformation in how industries function via the use of cutting-edge digital technology. Supply chain management is being substantially altered by integrating technologies like blockchain, big data, automated processes, artificial intelligence, and the internet of things into typical operations of the supply chain. With the help of these technologies, corporations can design intelligent supply chains that are more effective, flexible, and …
Published in International Journal of Industrial and Product Design Engineering · Vol. 3, Issue 1, 2025 · pp. 36–41 Read article
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Smart Manufacturing with Advanced Polymer Composites: Enabling Industry 4.0 Readiness in Indian MSMEs
Abstract: Thanks to Industry 4.0, manufacturing is now undergoing major changes that highlight using technology, machines, and sustainable solutions. Yet, very few Indian MSMEs can use these technologies due to obstacles like a lack of resources and outdated systems. This research looks at how combining Smart Manufacturing with Advanced Polymer Composites can improve Indian MSMEs’ preparations for Industry 4.0. When APCs are combined with cyber-physical systems, IoT, machine learning, and additive …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 194–216 Read article
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Novel Poly (Methyl Cellulose-G-Acrylamide)/Sodium Alginate Based Zeolite 4A Filled Mixed Matrix Membranes for The Separation of Water-Isopropyl Alcohol Mixtures by Pervaporation
Abstract: The Filled blend matrix membranes of (Methyl Cellulose-g-Acryl amide)/Sodium Alginate {(MC-g-AAm)/NaAlg} prepared via solution casting method by in situ incorporation with 4A zeolite particles in 5, 10 and 15 mass % with respect to the weight of (MC-g-AAm)/NaAlg membrane. Several analytical tools such as scanning electron microscope (SEM), atomic force microscope (AFM), Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and thermo-gravimetric analysis (TGA) were …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 131–152 Read article
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Mechanical Characterization of Kevlar 49 and Pina Fiber Hybrid Composites
Abstract: The pursuit of sustainable yet high-performance materials has accelerated research into hybrid composites that combine synthetic and natural fibers. This study investigates the fabrication and characterization of a Kevlar 49/Pina fiber hybrid composite using epoxy resin as the matrix. Kevlar 49, known for its exceptional tensile strength and energy absorption, was employed as the face sheet material, while Pina fiber, a biodegradable reinforcement extracted from pineapple leaves, was incorporated as …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 301–316 Read article
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Novel 1,3,4-Thiadiazole Derivatives: Design, Synthesis, Characterization and Anticancer Evaluation – A Review
Abstract: Cancer remains one of the leading causes of mortality worldwide despite significant advances in diagnosis and treatment. The clinical usefulness of many anticancer drugs is often restricted by toxicity, poor selectivity, and the emergence of drug resistance. These limitations have encouraged the search for novel heterocyclic compounds with improved therapeutic efficacy and safety. Among these, the 1,3,4-thiadiazole scaffold has gained considerable attention because of its favorable physicochemical characteristics, metabolic stability, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 Read article
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Experimental Analysis of Cutting Forces Under Different Machining Parameters and Carbide Inserts During Turning of Hardened AISI 4340 Steel
Abstract: Turning of hardened materials with an advanced coated carbide insert has numerous advantages over the grinding process, e.g., reduced process cost, high material removal rate, and less environmental concern due to the elimination of the cutting fluid. Process parameters in conventional machining operations like cutting speed, feed, and depth of cut play the most crucial role behind the generation of heat which also leads to microstructural changes, improved tool life, …
Published in Journal of Polymer & Composites Read article
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Opportunities and Challenges in the Operations Management for Industry 4.0
Abstract: This study investigates the opportunities and challenges in the operations of composite manufacturing industry for the adoption of Industry 4.0. As known from the literature that industry-4.0 is referred as the fourth industrial revolution which majorly focuses on cyber-physical systems. It is suggested that the instantaneous integration of digital and physical systems, in conjunction with new transformative technologies that facilitate work, will revolutionise the ways of work and, as a …
Published in International Journal of Advanced Robotics and Automation Technology · Vol. 3, Issue 1, 2025 · pp. 7–17 Read article
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Integrating Digital Twins, Smart Materials, and Human Machine Collaboration for Sustainable Smart Manufacturing: Smart CNC & Industry 4.0 Applications
Abstract: The rapid evolution of Industry 4.0 and the emerging transition toward Industry 5.0 have been catalyzed by the convergence of intelligent digital technologies such as digital twins, cyber–physical systems (CPS), artificial intelligence (AI), the Internet of Things (IoT), and human-in-the-loop (HITL) frameworks. These technologies have transformed traditional manufacturing into adaptive, data-centric ecosystems capable of real-time optimization and predictive decision-making. In recent years, the fusion of computer numerical control (CNC) machines, …
Published in International Journal of Manufacturing and Production Engineering · Vol. 3, Issue 2, 2025 · pp. 1–8 Read article
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Synthesis and Spectral Characterization of Complexes Tin(II) With 4-Nitrophenol
Abstract: Tin(II)4-nitrophenoxide complexes with the formulas SnCl(OC₆H₄NO₂-4) and Sn(OC₆H₄NO₂-4)₂ were prepared through the reaction of stannous chloride (SnCl₂) with 4-nitrophenol (HOC₆H₄NO₂-4) in 1:1 and 1:2 molar ratios, respectively. The reaction was performed in tetrahydrofuran (THF) with diethylamine serving as the base. The resulting compounds were characterized through elemental analysis, determination of molecular weight, molar conductance measurements, and spectroscopic methods including IR and ¹H NMR spectroscopy. Current investigations are directed toward assessing …
Published in International Journal of Advance in Molecular Engineering · Vol. 4, Issue 1, 2026 · pp. 22–26 Read article
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Selection of Maintenance Strategy Using Hybrid AHP-VIKOR Approach for a Smart Manufacturing Application in Industry 4.0
Abstract: In Industry 4.0, choosing the right maintenance strategy is important for improving machine performance, reducing downtime, and ensuring smooth operation in smart manufacturing systems. This study aims to find the most suitable maintenance strategy for a customized machine-making company by using a combination of AHP and VIKOR methods. In this study, four types of maintenance strategies are considered: breakdown maintenance, time-based maintenance, condition-based maintenance, and predictive maintenance. First, the AHP …
Published in Journal of Production Research & Management · Vol. 16, Issue 2, 2026 Read article
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Phase Behaviour Study of a Mesogen in a Solvent Role of Molecular Rigidity and Configurational Entropy
Abstract: The phase behaviour of a nematogen 4’-n-pentyloxy-4-biphenylcarbonitrile (POBPCB) has been studied with respect to the translational and orientational motions. The charges of atoms and their dipole moments have been estimated by implementing the complete neglect differential overlap (CNDO/2) method. The long-range interactions have been analyzed using modified Rayleigh- Schrodinger Perturbation theory together with the multicentred-multipole expansion scheme. The “6- exp” potential function has been considered to study the short-range interactions. …
Published in Research & Reviews : Journal of Physics Read article