All articles
48 articles
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Gastro Retentive Drug Target System: Its Needs, Advantages, Limitation and Approaches
Abstract: Background: Gastro retentive drug delivery systems (GRDDS) address limitations of oral therapy for drugs with poor solubility, instability at intestinal pH, or narrow absorption windows by prolonging gastric residence and increasing contact with the gastric mucosa. Objectives: To review GRDDS approaches—floating systems, mucoadhesive systems, and super porous hydrogels—with emphasis on formulation strategies and polymer–excipient selection to enhance gastric retention, modulate buoyancy/swelling/adhesion, and ultimately improve oral bioavailability and therapeutic outcomes for …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 Read article
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Child Friendly Innovation: A New Era in Pediatrics Drug Delivery Systems
Abstract: Pediatric formulations are becoming more and more popular as a result of advancements in pharmaceutical delivery technology. For young patients, there isn't a safe and effective drug delivery system in place. Since children's pharmacokinetics and pathophysiologic profiles differ from those of adults, it is imperative to design and develop an innovative and appropriate delivery system to provide accurate and dependable medicine administration to pediatric patients. Discussions will be held under …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 Read article
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pH-Triggered In-Situ Nasal Gel Systems for Migraine Therapy: A Review
Abstract: Intranasal drug delivery has gained considerable attention as a non-invasive route for delivering drugs to both systemic circulation and the central nervous system, particularly for the treatment of migraine. Traditional nasal formulations such as sprays and drops often show poor therapeutic performance due to rapid mucociliary clearance and limited retention within the nasal cavity. To overcome these challenges, in-situ gel systems have been designed, which transform from a liquid to …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 Read article
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Smart Drug Delivery Using Nanorobots
Abstract: In recent years, the field of micro/nanorobot research has gained popularity. Because it can be used in targeted medication distribution, surgical procedures, disease detection, etc., it has enormous promise in medical therapy. Different from conventional medication delivery, which depends on blood flow to drug delivery to difficult-to-reach locations is made possible by the planned micro/nanorobots' ability to move independently. Micro/nanorobots were powered by either endogenous power (chemical reaction energy) or …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 Read article
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Advances in Stimuli-Responsive Smart Drug Delivery Systems: A Systematic Review
Abstract: Imagine a world where medicines work smarter, not harder. Stimuli-responsive drug delivery systems (SRDDS) are transforming healthcare by releasing therapeutic agents in response to specific triggers. These triggers can be internal, like changes in pH or temperature, or external, like light or magnetic fields. By leveraging these triggers, SRDDS can optimize treatment and minimize side effects. The potential applications of SRDDS are vast, from cancer treatment to gene delivery and …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 Read article
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AI-Powered Drug Delivery: Revolutionizing Formulation Science
Abstract: Artificial Intelligence (AI) is emerging as a groundbreaking tool in revolutionizing Drug Delivery Systems (DDS), offering promising advancements in precision, efficiency, and personalized treatment strategies. The integration of AI technologies into pharmaceutical research and development is transforming how drugs are formulated, delivered, and monitored in real time. By leveraging machine learning algorithms and data analytics, researchers can design drug delivery models that are not only more effective but also tailored …
Published in Trends in Drug Delivery · Vol. 13, Issue 1, 2026 · pp. 48–61 Read article
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Space Pharmacy for Human Space Exploration: Overcoming Drug Stability, Packaging Challenges, Pharmacokinetic Variations, and Developing Innovative On-Demand Therapeutic Solutions for Long- Duration Missions Beyond Earth
Abstract: As humankind prepares for prolonged space exploration and the establishment of lunar and Martian habitats, ensuring reliable access to safe and effective medicines has emerged as a critical challenge. The evolving discipline of space pharmacy addresses the unique pharmaceutical needs of astronauts in microgravity and radiation-rich environments, where drug stability, packaging, and pharmacokinetics are markedly different from conditions on Earth. Traditional dosage forms often undergo accelerated degradation, while altered fluid …
Published in Trends in Drug Delivery · Vol. 13, Issue 1, 2026 · pp. 32–47 Read article
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AI in Healthcare: Drug Delivery in Tuberculosis
Abstract: Tuberculosis (TB) , mainly caused by Mycobacterium tuberculosis, remains a major global health burden, accounting for millions of new infections and deaths each year. Although progress has been made in diagnosis and treatment, the growing threat of multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB makes disease control increasingly difficult. Conventional diagnostic approaches such as chest X-rays, sputum smear microscopy, and culture methods continue to play an important role, but they …
Published in Trends in Drug Delivery · Vol. 13, Issue 1, 2026 · pp. 9–17 Read article
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Rapid-On-Tongue Delivery: A Review of ODT Technologies, Taste Masking and Compliance
Abstract: Orodispersible Tablets (ODTs), another name for Fast Dissolving Drug Delivery Systems (FDDS), are innovative drugs that dissolve in the mouth rapidly without requiring water. These will be especially helpful for kids, the elderly, and others who have difficulty swallowing ordinary tablets or capsules. Superdisintegrants are used in these pills to break down quickly in the mouth, while flavorings or sweeteners are used to cover up any harsh or unpleasant taste. …
Published in Trends in Drug Delivery · Vol. 13, Issue 1, 2026 · pp. 01–08 Read article
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Comprehensive Review on Pulsatile Drug Delivery System: Hybrid Approaches
Abstract: Pulsatile drug delivery systems (PDDS) represent a groundbreaking approach in pharmaceutical technology, allowing for controlled, targeted, and programmable drug release that aligns with circadian rhythms or caters to time-sensitive therapeutic requirements. Although traditional pulsatile systems have shown considerable clinical promise, their effectiveness is frequently compromised by physiological variations such as gastrointestinal transit times, changes in pH, and enzymatic activity. To tackle these obstacles, hybrid PDDS have been developed by combining …
Published in Trends in Drug Delivery · Vol. 13, Issue 1, 2026 · pp. 18–31 Read article
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Microneedles: A Modern Breakthrough in Drug Delivery Systems
Abstract: Microneedles (MNs) represent a revolutionary and transformative advancement in the realm of transdermal drug delivery systems, which are designed to facilitate the administration of therapeutic agents through the skin. These exceptionally small, micron-scale needles penetrate the stratum corneum, thereby enabling the direct delivery of pharmacological agents into the underlying dermis or the upper epidermis, consequently enhancing bioavailability while simultaneously circumventing the detrimental effects of first-pass metabolism and the degradation that …
Published in Trends in Drug Delivery · Vol. 12, Issue 3, 2025 · pp. 01–07 Read article
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Reinventing Drug Delivery Through Cutting-Edge Nanotechnology
Abstract: Nanotechnology has emerged as a revolutionary platform in the field of drug delivery, offering novel strategies for the precise, efficient, and controlled delivery of therapeutic agents. The integration of nanocarriers, such as liposomes, polymeric nanoparticles, dendrimers, micelles, and inorganic nanoparticles, has significantly enhanced drug solubility, stability, bioavailability, and targeted delivery to specific tissues or cells. Targeted drug delivery systems based on nanotechnology minimize off-target effects, reduce systemic toxicity, and improve …
Published in Trends in Drug Delivery · Vol. 12, Issue 3, 2025 · pp. 44–61 Read article
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Hydrogels: Innovations, Applications, and Future Directions in Biomedical Research
Abstract: iomedical applications, drug delivery, hydrogels, smart hydrogels, tissue engineering
Published in Trends in Drug Delivery · Vol. 12, Issue 3, 2025 · pp. 17–27 Read article
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Controlled Release Drug Delivery Using 3D Printing Techniques: A Current Scenario In Personalized Medicine
Abstract: Three-dimensional (3D) printing is particularly influencing the pharmaceutical manufacturing sector in the creation of controlled release drug delivery systems. This technology enables the precise fabrication of personalized medicines with tailored drug release profiles, dosages, and geometries, marking a significant advancement over traditional mass production methods. An array of 3D printing techniques, including extrusion-based, powder-based, and others, can be used to build complex dosage forms that regulate drug release through processes …
Published in Trends in Drug Delivery · Vol. 12, Issue 3, 2025 · pp. 28–43 Read article
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4D Printing in Drug Delivery: Application of Shape- Morphing Materials in Controlled Drug Release
Abstract: Four-dimensional printing technology has transformed the pharmaceutical landscape, offering unprecedented opportunities for innovation in drug development and delivery. This emerging technology enables the creation of complex geometries and customized structures, facilitating the design of personalized medications tailored to individual patient needs. Personalized dosing and drug release profiles, customized pill shapes and sizes for improved swallowability. Enhanced drug solubility and bioavailability, rapid prototyping and testing of pharmaceutical products. Development of complex …
Published in Trends in Drug Delivery · Vol. 12, Issue 3, 2025 · pp. 08–16 Read article
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Pharmaceutical Bead Formulations: A Comprehensive Overview into Advanced Drug Delivery
Abstract: Pharmaceutical beads are a unique and flexible drug delivery vehicle that provides numerous possibilities to control the release of drugs, protect them, and increase their therapeutic performance. These beads make it possible to design several types of therapeutic regimens by incorporating active pharmaceutical ingredients in a polymeric or lipid matrix. This review discusses the bead technology in drug delivery from its inception to its present application, focusing on the most …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 78–100 Read article
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Formulation and Evaluation of Transdermal Patch to Enhance Treatment of Alopecia
Abstract: The improvement of novel topical sedate conveyance frameworks has picked up noteworthy consideration due to their potential in upgrading the helpful viability and persistent compliance whereas minimizing systemic side impacts. This thinks about centers on the definition and assessment of transdermal patches planned to discharge allicin, the essential naturally dynamic compound determined from garlic (Allium sativum) extricate. Allicin is eminent for its wide range of pharmacological properties, counting antimicrobial, anti-inflammatory, …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 20–33 Read article
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Nano-Therapeutics in Diabetes Mellitus: Revolutionizing Diagnosis, Treatment, and Drug Delivery
Abstract: Diabetes mellitus is a chronic metabolic disorder in which blood glucose concentration remains high over an extended duration, resulting in significant lethal complications, including neuropathy, nephropathy and cardiovascular diseases. However, conventional diabetes management strategies, including insulin therapy and oral hypoglycemic agents, rarely exhibit poor bioavailability, high doses, off target delivery, etc. Nanotechnology has brought the rise of diabetes treatment revolution, by overcoming the challenges present in standard treatment, owing to …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 08–19 Read article
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Innovative Approaches in Excipient Co-Processing: A Comprehensive Review
Abstract: Co-processing of existing excipients is an innovative strategy in pharmaceutical formulation that offers a cost-effective, efficient alternative to the development of entirely new excipients. This process involves combining two or more well-established excipients to create new material with enhanced properties, thereby improving the functionality, performance, and manufacturability of pharmaceutical products. By leveraging the unique characteristics of each excipient, co-processing can significantly enhance attributes, such as flowability, compressibility, solubility, stability, and …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 34–51 Read article
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Advances in Nanoformulations for Targeted Drug Delivery Systems
Abstract: The work examines modern nanoformulations used for enhancing targeted drug delivery systems that simultaneously produce better therapeutic effects with reduced adverse effects. The pharmaceutical industry achieved deliverable drug development progress through diverse nanocarrier innovation which encompasses liposomes and nanoparticles and dendrimers and micelles. Tissue and cell-based directed delivery becomes possible via this technology to enhance the management of neurological disorders and cancer diseases. The investigation analyzes different nanoformulations by reviewing …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 01–07 Read article