STM Journals Peer-reviewed research from Consortium e-Learning Network

Trends in Drug Delivery Review Article

Hydrogels: Innovations, Applications, and Future Directions in Biomedical Research

  1. Rahul Sharma Department of Pharmaceutics, Ganpat University – Institute of Pharmacy, Ganpat Vidyanagar, Mehsana
  2. Sunil Shastri Department of Pharmaceutics, Ganpat University – Institute of Pharmacy, Ganpat Vidyanagar, Mehsana
  3. Sanjeev Acharya Department of Pharmaceutics, Ganpat University – Institute of Pharmacy, Ganpat Vidyanagar, Mehsana

Abstract

iomedical applications, drug delivery, hydrogels, smart hydrogels, tissue engineering

Keywords

References (31)

  1. Bahram M, Mohseni N, Moghtader M. An introduction to hydrogels and some recent applications. In: Emerging Concepts in Analysis and Applications of Hydrogels. In: TechOpen; 2016. p. 9–38.
  2. Bordbar-Khiabani A, Gasik M. Smart hydrogels for advanced drug delivery systems. Int J Mol Sci. 2022;23(7):3665.
  3. Talebian S, Mehrali M, Taebnia N, Pennisi CP, Kadumudi FB, Foroughi J, et al. Self-healing hydrogels: The next paradigm shift in tissue engineering? Adv Sci. 2019;6(16):1801664.
  4. Sirousazar M, Forough M, Farhadi K, Shaabani Y, Molaei R. Hydrogels: Properties, preparation, characterization and biomedical applications in tissue engineering, drug delivery and wound care. In: Tiwari A, editor. Advanced Healthcare Materials. Scrivener Publishing; 2014. p. 295–358.
  5. Zhao Y, Wang X, Qi R, Yuan H. Recent advances of natural-polymer-based hydrogels for wound antibacterial therapeutics. Polymers. 2023;15(15):3305.
  6. Garg S, Garg A. Hydrogel: classification, properties, preparation and technical features. Asian J Biomater Res. 2016;2(6):163–70.
  7. Gulrez SKH, Al-Assaf S, Phillips GO. Hydrogels: Methods of preparation, characterisation and applications. In: Carpi A, editor. Progress in Molecular and Environmental Bioengineering – From Analysis and Modeling to Technology Applications. Rijeka (Croatia): InTech; 2011. p. 117–62.
  8. Choi JR, Yong KW, Choi JY, Cowie AC. Recent advances in photo-crosslinkable hydrogels for biomedical applications. BioTechniques. 2019;66(1):40–53.
  9. Nikolić LB, Zdravković AS, Nikolić VD, Ilić-Stojanović SS. Synthetic hydrogels and their impact on health and environment. In: Mondal MIH, editor. Cellulose-Based Superabsorbent Hydrogels. Cham (Switzerland): Springer; 2018. p. 1–22.
  10. Summonte S, Racaniello GF, Lopedota A, Denora N, Bernkop-Schnürch A. Thiolated polymeric hydrogels for biomedical application: cross-linking mechanisms. J Control Release. 2021;330:470–82.
  11. Jeong B, Kim SW, Bae YH. Thermosensitive sol–gel reversible hydrogels. Adv Drug Deliv Rev. 2002;54(1):37–51.
  12. Kharkar PM, Kiick KL, Kloxin AM. Designing degradable hydrogels for orthogonal control of cell microenvironments. Chem Soc Rev. 2013;42(3):733–55.
  13. Karchoubi F, Ghotli RA, Pahlevani H, Salehi MB. New insights into nanocomposite hydrogels; a review on recent advances in characteristics and applications. Adv Ind Eng Polym Res. 2024;7:54–78.
  14. Hoare TR, Kohane DS. Hydrogels in drug delivery: progress and challenges. Polymer (Guildf). 2008;49(8):1993–2007.
  15. Athanassiadis AG, Ma MZ, Moreno-Gomez N, Melde K, Choi E, Goyal R, et al. Ultrasound-responsive systems as components for smart materials. Chem Rev. 2022;122(5):5165–208.
  16. Kharkar PM, Kiick KL, Kloxin AM. Designing degradable hydrogels for orthogonal control of cell microenvironments. Chem Soc Rev. 2013;42(3):733–55.
  17. Luo Z, Wang M, Wang H, Han Y, Shen Y, Yuan W, et al. Injectable porous microchips with oxygen reservoirs and an immune-niche enhance the efficacy of CAR T cell therapy in solid tumors. ACS Appl Mater Interfaces. 2021;13(3):4781–96.
  18. Annabi N, Zhang YN, Assmann A, Sani ES, Cheng G, Lassaletta AD, et al. Engineering a highly elastic human protein–based sealant for surgical applications. Sci Transl Med. 2017;9(410):eaai7466.
  19. Smith TT, Stephan SB, Moffett HF, McKnight LE, Ji W, Reiman D, et al. Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors. J Clin Invest. 2017;127(6):2176–91.
  20. Grosskopf AK, Roth GA, Smith AA, Gale EC, Hernandez HL, Hubka KM, et al. Delivery of CAR-T cells in a transient injectable stimulatory hydrogel niche improves treatment of solid tumors. Sci Adv. 2022;8(14):eabn8264.
  21. Gounden V, Singh M. Hydrogels and wound healing: current and future prospects. Gels. 2024;10(1):43.
  22. Drury JL, Mooney DJ. Hydrogels for tissue engineering: scaffold design variables and applications. Biomaterials. 2003;24(24):4337–51.
  23. Sulley A, Dumbleton K. Silicone hydrogel daily disposable benefits: the evidence. Cont Lens Anterior Eye. 2020;43(4):298–307.
  24. Patra SK, Majumdar R, Acharya A, Paul PK, Basu S. Prospects of hydrogels in agriculture for enhancing crop and water productivity under water deficit condition. Int J Polym Sci. 2022;2022:4914836.
  25. Tavakoli J, Tang Y. Hydrogel based sensors for biomedical applications: an updated review. Polymers. 2017;9(8):364.
  26. Soto-Bustamante F, Bassu G, Fratini E, Laurati M. Effect of composition and freeze-thaw on the network structure, porosity and mechanical properties of polyvinyl-alcohol/chitosan hydrogels. Gels. 2023;9(5):396.
  27. Rahmanian-Devin P, Rahimi VB, Askari VR. Thermosensitive chitosan-β-glycerophosphate hydrogels as targeted drug delivery systems: an overview on preparation and their applications. Adv Pharmacol Pharm Sci. 2021;2021:6640893.
  28. Di J, Price J, Gu Z, Zhao X. Stretch-triggered drug delivery from wearable elastomer films containing therapeutic depots. ACS Nano. 2015;9(9):9407–15.
  29. Crompton KE, Goud JD, Bellamkonda RV, Gengenbach TR, Finkelstein DI, Horne MK, et al. Polylysine-functionalised thermoresponsive chitosan hydrogel for neural tissue engineering. Biomaterials. 2007;28(3):441–9.
  30. Shukla SK, Mishra AK, Arotiba OA, Mamba BB. Chitosan-based nanomaterials: a state-of-the-art review. Int J Biol Macromol. 2013;59:46–58.
  31. Mamidi N, De Silva FF, Vacas AB, Gómez JAG, Goo NYM, Mendoza DR, et al. Multifaceted hydrogel scaffolds: Bridging the gap between biomedical needs and environmental sustainability. Adv Healthc Mater. 2024;13(14):2401195.
Support