All articles
41 articles
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Toxicological Profiling and Safety Assessment of NASAT 2.0: A Conceptual Framework for Adaptive Nanoparticle Therapy in Rabies
Abstract: Rabies, caused by the highly neurotropic Rabies lyssavirus, remains one of the most enigmatic and universally lethal infectious diseases known to modern medicine. Once clinical symptoms manifest following successful neuroinvasion, the fatality rate approaches absolute certainty (approximately 99.9%), a staggering statistic that has remained largely unchallenged despite massive, concurrent advances in modern virology, critical care medicine, and cellular immunology. Current late-stage therapeutic protocols, most notably the widely debated Milwaukee Protocol, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 2, 2026 · pp. 1–19 Read article
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Nanoparticle and Lipid-Based Vaccine Delivery Systems: A Systematic Review of Platforms, Stability, Pharmacokinetics, and Immune Modulation
Abstract: The rapid evolution of vaccine technologies over the past decade has highlighted the transformative role of nanoparticle (NP) and lipid-based delivery systems in modern immunization practices. These platforms – including polymeric nanoparticles, lipid nanoparticles (LNPs), liposomes, nanoemulsions, and solid lipid nanoparticles (SLNs) – enable enhanced antigen stability, improved cellular uptake, targeted antigen delivery, and potent immune activation. This systematic review critically examines the physicochemical foundations, manufacturing approaches, stability challenges, pharmacokinetic …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 1, 2026 · pp. 18–36 Read article
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The Effects of Steroids on One’s Health
Abstract: The widespread use of steroids for both medicinal and non-medical purposes is a significant issue in contemporary culture. This article examines the considerable impact of steroids on human health, focusing on the therapeutic benefits and the adverse side effects associated with their consumption. In the treatment of conditions, such as inflammation, autoimmune disorders, and hormone imbalances, steroids, are frequently prescribed, providing significant relief from symptoms. However, the abuse of these …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 1, 2026 · pp. 47–63 Read article
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Prospective Evaluation of the Optimal Concentration and Effect of Epinephrine as an Adjuvant to Local Anesthetics for Prolonging Block Duration and Reducing Systemic Toxicity in Outpatient Surgery
Abstract: Purpose: To evaluate the optimal concentration and effect of epinephrine as an adjuvant to local anesthetics for prolonging block duration and reducing systemic toxicity in outpatient surgery. Methods: The study involved a randomized double-blind clinical trial on 80 adult patients awaiting day-care extremity surgery. The patients were randomly assigned to two groups of equal size. One group, Group E, was given the local anesthetic agent along with epinephrine as an …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 1, 2026 · pp. 64–69 Read article
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Drug-Induced Liver Injury: Hepatotoxicity and Treatment - A Literature Review
Abstract: Drug-induced liver injury (DILI) is a major clinical and regulatory challenge, posing risks to patient safety and drug development worldwide. As the primary organ responsible for xenobiotic metabolism, the liver is particularly susceptible to toxic injury from prescription drugs, over-the-counter medications, herbal products, and dietary supplements. Drug-induced liver injury (DILI) accounts for a substantial proportion of acute liver failure cases and remains a leading cause of post-marketing drug withdrawal. Its …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 1, 2026 · pp. 1–17 Read article
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Mycotoxins in Grains: Toxicological Impact, Detection Strategies, and Public Health Implications
Abstract: Many types of fungi create mycotoxins, which contaminate cereal grains like wheat, maize, rice, and barley. Even at low doses, aflatoxins, ochratoxins, fumonisins, and deoxynivalenol are harmful to humans and animals. This study covers mycotoxin occurrence, detection, toxicological consequences, and public health concerns in grain-based food systems. Advanced analytical methods, like LC–MS, ELISA, and biosensors, are discussed for their sensitivity and routine monitoring applications. Experimental and epidemiological studies analyze chronic …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 3, 2025 · pp. 8–18 Read article
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Zebrafish in Drug Research: Decoding Biological Mechanisms and Finding Novel Therapeutic Targets
Abstract: The zebrafish, scientifically known as Danio rerio, is a powerful model organism in biological research because of its favorable traits, which include rapid development, genetic tractability, and transparent embryos. Zebrafish were first identified for their use in studies of vertebrate development, but they have since spread to a variety of disciplines, such as pharmacology, clinical research as a disease model, and most notably, drug development. Zebrafish have emerged as a …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 3, 2025 · pp. 1–8 Read article
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Issue of E-Waste Management on Environment and Society
Abstract: Electronic waste, or e-waste, is becoming an increasingly significant and urgent challenge for industries worldwide. E-waste includes discarded electronic items, such as computers, smartphones, televisions, refrigerators, generators, and various other household and office appliances, that are no longer functional. It poses significant environmental and health hazards because these devices contain toxic substances like lead, mercury, cadmium, and other harmful chemicals. Improper disposal or recycling of e-waste can lead to contamination …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 3, 2025 · pp. 1–7 Read article
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Heavy Metal Exposure in Industrial Workers of Punjab
Abstract: Background: Particularly for those in sectors such textiles, metallurgy, and electronics, heavy metal exposure in industrial environments is a major health issue. A range of negative health effects can result from metal exposure including lead (Pb), cadmium (Cd), chromium (Cr), arsenic (As), and nickel (Ni), including neurological, pulmonary, and renal ones. There is little information available on the degree of heavy metal exposure industrial workers in Punjab, India experience. Objective: …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 3, 2025 · pp. 1–7 Read article
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A Study on AI-Enhanced Environmental Toxicology: Sensor-Driven Predictive Framework
Abstract: Traditional environmental toxicology relies heavily on labor-intensive, often retrospective, sampling and analysis, limiting our understanding of dynamic pollutant behaviors and their real-time impact on ecosystems and human health. This study presents a novel, integrated framework leveraging advanced sensor networks and artificial intelligence (AI) to revolutionize the monitoring, assessment, and predictive modeling of environmental contaminants. We deployed a sophisticated array of multi-parameter sensors (e.g., electrochemical, optical, biosensors for heavy metals, organic …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 3, 2025 Read article
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E-Waste Toxicity and Its Environmental Impact, Challenges, and Solutions for Sustainable Waste Management in India
Abstract: Introduction: E-waste describes any electronic component that is obsolete or no longer functional. The ever-increasing public concern of e-waste in India stems predominantly from the aggressive expansion of the electronics industry along with insufficient recycling and disposal practices. Lead, mercury, and cadmium in e-waste pose serious risks to human health and the environment by polluting air, soil, and water. Informal recycling methods further exacerbate these hazards through unsafe practices. This …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 2, 2025 · pp. 1–11 Read article
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Prescription Opioid Use, Misuse and Motivation for Misuse among patients admitted in a drug treatment center
Abstract: Background: Opioid misuse remains a significant public health concern in Nigeria and globally. The risk of misuse complicates opioid prescriptions, potentially leading to overdose and fatal outcomes if not promptly addressed. Objectives: To determine the prevalence of prescription opioid use, misuse, and the underlying motivations for misuse. Method: This study utilized a retrospective cross-sectional design to examine the prevalence and patterns of prescription opioid use and misuse. Data were collected …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 2, 2025 Read article
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Exploring Psychotropic Trends of Medication Use in Psychiatric Outpatients: An Observational Study at a Tertiary Care Hospital
Abstract: Background: Psychotropic medications are essential in managing a wide range of psychiatric disorders, including depression, anxiety, bipolar disorder, and schizophrenia. Prescribing habits in outpatient clinics can differ a lot depending on things like the patient’s age, background, and medical conditions. Aim: This study aims to explore the trends in psychotropic medication use among psychiatric outpatients at a tertiary care hospital, with a focus on understanding prescribing patterns, demographic factors, and …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 2, 2025 · pp. 15–23 Read article
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Protective Effects of Phyllanthus amarus and Sida acuta Extracts Against DoxorubicinInduced Toxicity in Chick Embryo Models
Abstract: Chemotherapy remains a cornerstone of cancer treatment, yet severe side effects, including cardiotoxicity often limit its clinical application. Doxorubicin, a widely used anticancer drug, is particularly associated with dose-dependent toxicities that impact the heart, liver, and kidneys. In search of complementary approaches to mitigate these adverse effects, this study evaluates the protective potential of hydro-alcoholic extracts from Phyllanthus amarus and Sida acuta, two medicinal plants with known antioxidant and anti-inflammatory …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 2, 2025 Read article
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Study Review: Molecular Mechanisms of Nanoparticle-Cell Interaction – Implications for Drug Delivery and Toxicity
Abstract: The application of nanoparticles in drug delivery and biomedical therapies holds great promise, yet their interaction with cells and the underlying molecular mechanisms remains areas of active research. This study explores the molecular mechanisms of nanoparticle-cell interactions, focusing on the effects of gold nanoparticles (AuNPs) and silica nanoparticles (SiNPs) in human cancer cell lines (HeLa and MCF-7). The study examines how nanoparticles are internalized by cells, their impact on cellular …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 2, 2025 · pp. 31–40 Read article
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Comprehensive Insights into Toxicology: Mechanisms, Applications, and Modern Developments
Abstract: Toxicology, the study of the harmful effects of substances on living organisms, has become increasingly vital in today's world due to industrial growth, agricultural advancements, and heightened exposure to environmental and chemical toxins. This article examines the foundations of toxicology, exploring its definitions, core principles, and mechanisms of action. It also delves into specialized branches such as forensic, environmental, and medical toxicology, highlighting the differences between toxicants, toxins, and poisons, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 1, 2025 · pp. 31–37 Read article
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Health Hazards of Nanoparticles and Environmental Pollutants
Abstract: The exponential growth in the use of nanoparticles and the prevalence of environmental pollutants have raised significant concerns regarding their health hazards. Nanoparticles, owing to their unique physicochemical properties—such as small size, high surface areatovolume ratio, and chemical reactivity—can penetrate biological barriers, including the bloodbrain barrier, and interact at the cellular and molecular levels. This can lead to oxidative stress, inflammation, and cellular dysfunction, ultimately resulting in potential toxicity. Similarly, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 1, 2025 · pp. 1–9 Read article
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Harnessing Honeybee Venom For Cancer Treatment: A Natural Remedy In Oncology
Abstract: Honeybee venom (HBV) has harvested significant attention as a promising natural compound with therapeutic potential in cancer treatment. This review investigates deeply into the current scientific understanding of honeybee venom, focusing on its anticancer mechanisms, molecular interactions, and potential clinical applications. Honeybee venom comprises various bioactive components, including melittin, apamin, phospholipase A2, and other peptides, which exhibit a wide range of biological activities. Recent research has demonstrated its ability to …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 1, 2025 · pp. 10–14 Read article
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Evaluating the therapeutic effects of Asystasia gangetica (Chinese violet) on the chronic respiratory condition- Asthma
Abstract: Asthma is a chronic condition affecting the respiratory system. Its symptoms affect the immune pathways via helper T-cells. The plant Asystasia gangetica is prevalent throughout tropical regions around the world. It has been used in some herbal remedies to relieve symptoms of asthma. This study used computational techniques to assess the effectiveness of several phytocompounds present in A. gangetica in relieving symptoms of Asthma. Three proteins associated with asthma, namely …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 1, 2025 · pp. 15–21 Read article
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Possible Histological Changes in the pancreas of Female Albino Rats for Prolonged Administration of Aspartame
Abstract: Aspartame sweetener was noted to be inducing histopathological changes on the pancreatic tissue of female albino rats so this study defined the aims and objectives properly. Biometry did use materials from the animal facility of the Department of Biology College of Science, University of Kufa. The study was carried out over the duration of two months where thirty male rats aged between 15 to 20 weeks with body weight of …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 1, 2025 · pp. 15–21 Read article