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2602 articles
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Exploring the Role of MAPK3 in Major Depressive Disorder: Molecular Docking, Dynamics, and Binding Free Energy Analysis of Natural Compounds as Alternatives to Conventional Drugs
Abstract: Major Depressive Disorder (MDD) is a prevalent neuropsychiatric disorder with limited treatment efficacy and significant side effects associated with conventional antidepressants. Recent studies have highlighted the role of mitogen-activated protein kinase 3 (MAPK3) in the mechanisms underlying MDD, positioning it as a potential target for the development of novel therapeutic drugs. In this study, we employed various computational approaches to explore natural compounds as viable alternatives to synthetic antidepressants. Researchers …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 53–68 Read article
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Investigating The Alkalizing Potential of Chandanasava For Restoring Acid-Base Homeostasis in Renal Tubular Acidosis: A Computational and In Silico Pharmacological Study
Abstract: Chandanasava, a traditional Ayurvedic formulation, is recognized for its potential alkalizing properties, which may help restore acid-base homeostasis in conditions such as renal tubular acidosis (RTA). This study aims to investigate the active components of Chandanasava and their interactions with key renal target proteins, Pendrin and Carbonic Anhydrase II, which are essential for maintaining acid-base balance. An in silico approach was utilized to explore the pharmacological potential of the phytochemicals …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 28–52 Read article
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Eye Disease Classification Using K-means Clustering Algorithm and Ensemble Classification Approach
Abstract: In this study, we present a comprehensive approach for the classification of eye diseases, specifically targeting normal, cataract, glaucoma, and diabetic retinopathy conditions. This research uses a dataset from Kaggle, which provides a wide and varied collection of retinal images to ensure good representation. The methodology encompasses advanced image processing and machine learning techniques to ensure accurate diagnosis and prediction. The preprocessing phase involves a series of image enhancement techniques …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 15–27 Read article
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Hybrid Material Systems for Flexible Electronics Electro-Mechanical Performance and Future Prospects
Abstract: Flexible electronics are transforming the landscape of modern electronic systems, enabling devices that are lightweight, stretchable, and adaptable to complex surfaces. These technologies are particularly impactful in applications such as wearable health monitors, soft robotics, energy harvesting systems, and implantable biomedical devices. At the heart of this evolution are hybrid material systems—engineered composites that combine organic polymers and inorganic nanomaterials to achieve synergistic electro-mechanical properties. These materials address the limitations …
Published in International Journal of Electro-Mechanics and Material Behaviour · Vol. 3, Issue 1, 2025 · pp. 7–12 Read article
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Antidiabetic Potential of Bryophyllum pinnatum: A Study on its Pharmacological Effects and Synergistic Action with Glibenclamide
Abstract: Diabetes is a long-term metabolic disorder that profoundly impacts an individual’s overall health, social interactions, and quality of life. While significant progress has been made in diabetes management with the use of medications such as insulin and oral hypoglycemic agents, the limitations of these existing treatments highlight the need for new therapeutic alternatives. Moreover, the high cost of current diabetes medications makes them inaccessible to many, particularly in rural areas …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 2, 2025 · pp. 18–30 Read article
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Smart Wireless Charging Infrastructure for Electric Vehicles
Abstract: Wireless Power Transfer (WPT) of Electric Vehicles (EVs) is a potential technology with large scale potential to change how EVs may be charged, eliminate range anxiety, and simplify charging infrastructure. As opposed to the existing conductive charging systems that necessitate physical contact between two charging points, WPT makes power transfer possible regardless of an air gap between charging and the receptive points, making it possible to recharge EVs practically automatically, …
Published in International Journal of Energy and Thermal Applications · Vol. 3, Issue 1, 2025 · pp. 30–42 Read article
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Microorganisms used in aquaculture
Abstract: Microorganisms play a vital role in the health and sustainability of aquaculture systems, contributing to water quality management, disease control, and the overall productivity of aquatic farms. Beneficial microorganisms, including bacteria, fungi, algae, and probiotics, are increasingly recognized for their positive impact on aquaculture operations. These microorganisms can enhance nutrient cycling, promote the breakdown of organic waste, and reduce the need for harmful chemicals, thus improving the environmental footprint of …
Published in International Journal of Marine Life · Vol. 2, Issue 2, 2025 Read article
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In-Silico Docking of Rubia cordifolia Phytocompounds as Potential MMP-2 Inhibitors for Varicose Vein Management
Abstract: Varicose veins are one of the most common disorders, affecting the vein structure and function of lower limbs, yet there has been no absolute cure found yet. One of the underlying causes for worsening of the condition is the proteolytic activity of MMPs which are a group of enzymes that affect the extracellular matrix (ECM) surrounding the affected veins. Phytocompounds of Rubia cordifolia (Manjishta) were docked against the MMP-2 protein …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 2, 2025 · pp. 31–42 Read article
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Functional Role of Feed Enzymes in Broiler Diets: A Pathway to Enhanced Nutrient Utilization, Performance, Health and Welfare
Abstract: The inclusion of feed enzymes in broiler diets has emerged as a pivotal strategy for improving nutrient utilization, enhancing growth performance, and promoting overall health and welfare in modern poultry production. Feed enzymes, such as phytase, xylanase, and protease, facilitate the breakdown of complex molecules in feed ingredients, leading to increased bioavailability of essential nutrients and improved digestion efficiency. This review explores the underlying mechanisms by which feed enzymes contribute …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 2, 2025 · pp. 9–17 Read article
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Preparation and Evaluation of Herbal Gel Containing Multiple Plant Extracts for Acne Treatment
Abstract: A persistent inflammatory condition affecting the pilosebaceous unit, acne is caused by an increase in sebum production by sebaceous glands and an incorrect desquamation of hair follicles in response to rising testosterone levels throughout teenage years. Follicular obstruction results in follicular distention, which frequently triggers an inflammatory reaction and the growth of the Propionibacterium acnes bacteria. This project mainly focused on the formulation of a herbal gels for acne. These …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 2, 2025 · pp. 18–30 Read article
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Pharmacokinetic Profiling and Molecular Docking of Carvacrol and Structural Analogs: Targeting Quorum Sensing Proteins to Disrupt Biofilm-Mediated Antimicrobial Resistance in Multidrug-Resistant Bacterial Pathogen
Abstract: Antibiotic resistance, particularly in Pseudomonas aeruginosa, has become a major global health threat, exacerbated by the organism's ability to form biofilms and regulate virulence through quorum sensing (QS). The LuxR and LasR receptors are key regulators in this process, influencing both pathogenicity and antibiotic resistance. This study investigates potential QS inhibitors targeting these receptors as a strategy to mitigate antibiotic resistance. The primary objective was to identify novel ligands that …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 2, 2025 · pp. 43–61 Read article
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The Role of Adaptive Physical Education in Improving Quality of Life for Disabled Individuals
Abstract: The purpose of this paper is to analyze the effectiveness of Adaptive Physical Education (APE) in enhancing the quality of life of disabled students at Punjabi University, Patiala. APE refers to an interface that is mainly aimed at the person with disabilities’ physical and psychological characteristics, which enable the original physical activities to be adapted to the disabled person's nature and rounded by conductive physical health examinations, fitness tests, and …
Published in Recent Trends in Sports · Vol. 2, Issue 2, 2025 · pp. 1–9 Read article
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Energy-Efficient Thermal Management: Advanced Cooling Techniques for Electronics, Automotive, and Aerospace Applications
Abstract: The growing demand for energy-efficient systems across diverse industrial sectors, including electronics, automotive, aerospace, and renewable energy, has elevated the importance of advanced thermal management techniques. Effective heat dissipation is critical not only for maintaining optimal operating conditions in electronic devices but also for enhancing the performance and reliability of broader energy and mechanical systems. Inadequate thermal management can compromise energy efficiency, reduce component lifespan, and increase environmental impact. This …
Published in International Journal of Energy and Thermal Applications · Vol. 3, Issue 1, 2025 · pp. 18–23 Read article
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Climate-Induced Infertility in Dairy Cows: Pathways, Challenges, and Solutions for Sustainable Dairy Development
Abstract: Climate change has emerged as a significant challenge to dairy production, with profound implications for reproductive performance in dairy cows. The interplay of rising temperatures, fluctuating rainfall patterns, and increased frequency of extreme weather events disrupts key physiological, nutritional, and behavioral processes essential for fertility. Heat stress alters hormonal balance, impairs oocyte and embryo quality, reduces estrus expression, and affects pregnancy outcomes. Concurrently, climate-induced nutritional deficits, immune suppression, and increased …
Published in International Journal of Climate Conditions · Vol. 2, Issue 2, 2025 Read article
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The Effect of Attachment Styles on Emotional Regulation Impacting Relationship Satisfaction: An Exploratory Case Study Design
Abstract: This study explores the impact of early attachment experiences, emotional regulation, and relationship dynamics among six participants through a qualitative case study approach. Using thematic and narrative analyses, the research identifies key patterns in emotional suppression, fear of abandonment, trust issues, and self-awareness. Participants' narratives reveal how childhood experiences with caregivers influenced their emotional regulation strategies and attachment styles in adulthood. Findings indicate that those with secure emotional upbringings exhibited …
Published in International Journal of Behavioral Sciences · Vol. 2, Issue 2, 2025 · pp. 1–17 Read article
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Low-Grade Heat Recovery: Emerging Materials and Systems for Efficient Utilization
Abstract: Low-grade heat (LGH), generally characterized by temperatures below 200°C, constitutes a significant portion of wasted thermal energy in industrial, commercial, and even residential processes. Despite its vast availability, the efficient recovery and utilization of LGH remains underdeveloped due to its inherently low exergy content and the limitations of traditional heat recovery technologies. The creation of cutting-edge materials and creative system-level approaches for LGH recovery has accelerated significantly as companies continue …
Published in International Journal of Energy and Thermal Applications · Vol. 3, Issue 1, 2025 · pp. 24–29 Read article
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Understanding the Intersectional Challenges of LGBTQ community in the Indian Society: A Systematic Review Paper
Abstract: This study examines the intersectional issues that the LGBTQ population faces in Indian society, examining how their lived experiences are shaped by caste, class, religion, and regional differences. The purpose of this study is to investigate how the experiences of LGBTQ people in India are impacted by several axes of identification, including caste-based discrimination, economic position, geographical inequities, and religious biases. 43 research papers have been reviewed from which 30 …
Published in Recent Trends in Social Studies · Vol. 2, Issue 2, 2025 · pp. 22–30 Read article
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Bridging the digital divide for school students with Specific Learning Disability in India: A Systematic Literature Review
Abstract: This systematic literature review aims to investigate the educational materials now utilized in inclusive classrooms in India to close the digital divide for children with specific learning disabilities (SLD). With an emphasis on policy, assistive technology, and teacher preparedness, the goal is to assess how well these resources work to create inclusive learning environments and look at how they might be tailored to help different learners. The review followed PRISMA …
Published in International Journal of Education Sciences · Vol. 2, Issue 2, 2025 · pp. 17–25 Read article
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Exploring Spirituality and Cognitive Styles as a Predictor of Suicidal Ideation in Urban Population
Abstract: Suicidal ideation, or the thought of suicide, is a complicated and multi-dimensional issue of public health that effects individuals globally at a individual level, in families and in society at large. It is one of the main causes of death in the world. Beliefs, practices and experiences pertaining to the transcendence, sacred or divine, are all included in the broad category of spirituality. In cognitive psychology, the term "cognitive style" …
Published in International Journal of Behavioral Sciences · Vol. 2, Issue 2, 2025 Read article
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The Impact of Geographical Indications on Sustainable Rural Development: Comprehensive Economic and Cultural Insights from Wayanad, Kerala
Abstract: Geographical Indications (GIs) play a vital role in fostering sustainable rural development by linking unique local products to their geographic origins. This study explores the impact of GIs on economic growth, cultural preservation, and environmental sustainability in Wayanad, Kerala. Drawing from extensive secondary data and detailed case studies including Wayanad Coffee, Jeerakasala Rice, and traditional handicrafts, the research highlights how GI certification enhances market value, improves income levels, and preserves …
Published in International Journal of Rural and Regional Development · Vol. 3, Issue 2, 2025 · pp. 18–29 Read article