All articles
290 articles
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Evolution and Impact of Forensic DNA Typing in Modern Investigation
Abstract: Forensic DNA typing is sometimes called DNA fingerprinting. Immigration, paternity, and criminal investigations use forensic DNA typing. Forensic genetics today includes bodily fluid identification, fast DNA analysis, forensic microbiology, and phenotypic profiling. Human cells contain DNA, a molecular code. Human DNA sequences are 99.9% the same in everyone. Every person has almost 0.1% unique DNA. Forensic experts also worry about this 0.1 percent of DNA that is unique. There are …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 1, 2024 · pp. 62–66 Read article
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Deciphering the Pathophysiology of Migraine: Understanding Trigeminovascular System Activity and the Importance of the Gut-Brain Axis
Abstract: Migraine, a prevalent and disabling neurological condition, manifests in distinct phases: premonitory, aura, headache, postdrome, and interictal. Being a primary contributor to adult disability, it presents a substantial economic challenge on a global scale. Even with extensive research spanning centuries, the complete grasp of its root causes continues to evade us. This intricate neurovascular disorder primarily involves local vasodilation of intracranial and extracerebral blood vessels, coupled with simultaneous stimulation of …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 1, 2024 · pp. 50–61 Read article
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Unraveling the Nexus: Parkinson's Disease, Alpha-synuclein, Desulfovibrio, and the Gut Microbiome
Abstract: Parkinson's disease (PD) is now recognized as a chronic condition which is once considered a highly intricate disorder involving the central, autonomic, and enteric nervous systems. The prevailing perspective attributes the disease by the formation of Lewy bodies, primarily triggered by the misfolding of α-Synuclein, leading to the demise of dopaminergic neurons in the substantia nigra. Constipation, one of the most common non-motor symptoms in PD patients, is believed to …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 1, 2024 · pp. 18–28 Read article
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Exploring the Pathophysiology of Henoch-Schönlein Purpura (HSP): A Comprehensive Review
Abstract: Blood from tiny veins can leak into nearby tissues, causing purpura, a disorder marked by red spots or patches on the skin that may have an impact on the kidneys. Henoch-Schönlein purpura (HSP) is associated with vasculitis and inflammation of blood vessels. The range of renal conditions associated with purpura includes severe glomerulonephritis and mild proteinuria. For instance, immunological complex accumulation in the renal glomeruli of HSP patients might result …
Published in International Journal of Cell Biology and Cellular Functions Read article
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Effectiveness of Temporins for the Treatment of HPV Infections
Abstract: Objectives: Human papillomavirus (HPV), especially high-risk variants like type-16 have been linked to the formation of malignant tumors. HPV-16 has been implicated in most cases of cervical cancer in women. This study aims to assess the effectiveness of three types of temporin molecules, i.e., antiviral peptides secreted by certain frog species, for the inhibition of the viral L1 protein. Methods: In the present study, various computational tools were used to …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 1, 2024 · pp. 41–53 Read article
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Influence of Agitation and Static Cultivation on Physicochemical Characteristics of Bacterial Cellulose Produced by Gluconacetobacter liquefaciens MTCC 3135
Abstract: Bacterial cellulose (BC) a with applications spanning biomedical, food, paper, electronics, and diverse industrial processes. Its unique properties include high purity, biocompatibility, and flexibility. BC is a versatile natural biopolymeric material, secreted by certain acetic acid bacteria. BC has numerous benefits over plant cellulose due to distinctive features, e.g., higher polymerization degree and purity, superior crystalline structure, water retention, biocompatibility, and biodegradability, which make BC a valuable material in creating …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 2, 2024 · pp. 1–11 Read article
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Hidradenocarcinoma: A Rare Skin Disease
Abstract: Hidradenocarcinoma (HAC) also known as ‘‘sweat gland tumor” is an aggressive, uncommon, highly malignant, adnexal tumor derived from the intradermal duct of eccrine sweat glands. It is said to be aggressive as it has a high risk of local recurrence (50%–75%) and a high potential to metastasize to nearby lymph nodes or to other distant sites. Hidradenocarcinoma has other recognized variants which are known by different names such as Malignant …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 1, 2024 · pp. 1–12 Read article
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Application of Medicinal Plants to Cure Mental Disorders
Abstract: Mental fitness is a state of well-being in which individuals apprehend their talents, manage existing pressures, remain efficient, and contribute to their groups. Mental contamination regularly used interchangeably with intellectual illness, is vital to apprehending and addressing man or woman desires and challenges. Schizophrenia, a psychological disorder characterized by hallucinations and delusions, is a complex situation with two important classes: bad symptoms (withdrawal from social interactions, loss of force, and …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 1, 2024 · pp. 69–78 Read article
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Computational Screening of Vitex negundo Compounds for Potential Arthritis Therapies in India
Abstract: Objective: Arthritis is a pervasive medical condition that manifests as inflammation and discomfort within the joints. As of September 2021, arthritis has affected an estimated 180 million people in India, making it a substantial public health concern with a considerable impact on individuals' quality of life and healthcare systems. Therefore, using molecular docking, drug-likeness prediction, and ADME analysis, an effort was made to identify natural compounds from Vitex negundo, which …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 01–18 Read article
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Zinc Oxide Nanoparticles from Murayya koenigii: Antibacterial Potential Review
Abstract: Nanoparticles (NPs) display unique characteristics in contrast to conventional physico-chemical synthesis methods, and they are utilized in various life science fields including surface coating, catalysis, food packaging, corrosion prevention, environmental cleanup, electronics, biomedical applications, and antimicrobial purposes. Metal NPs synthesized through green methods, particularly from plant origins, have garnered significant interest because of their inherent traits such as environmental friendliness, quick production, and cost efficiency. Over the past few years, …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 1, 2024 · pp. 54–67 Read article
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Optimizing Microbial Consortia for Enhanced Biofuel Production: A Metabolic Engineering Approach
Abstract: Biofuels, derived from renewable biomass sources, offer a promising avenue for reducing greenhouse gas emissions and mitigating environmental impact. Among the various approaches to biofuel production, microbial fermentation using microbial consortia has gained significant attention due to its potential for enhancing efficiency and sustainability. Microbial consortia, consisting of diverse populations of microorganisms, exhibit synergistic interactions between different types of microbes that can improve substrate utilization and metabolic robustness compared to …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 1, 2024 · pp. 46–53 Read article
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Characterization of Cellulose Producing Bacterial Isolates from Rotten Fruits
Abstract: Cellulose, the most abundant natural polymer, is predominantly sourced from plant wood but can also be synthesized by certain bacteria in the form of bio-cellulose. The potential applications of bio-cellulose are extensive, particularly in the biomedical field for tissue engineering, drug delivery, and more. The distinct properties and purity of bacterial cellulose, in contrast to plant-derived cellulose, underscore its importance and drive further research in the area. This study focuses …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 1, 2024 · pp. 38–45 Read article
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In Situ Investigation of Hemidesmus indicus Phytocompound Extracts as a Therapeutic Target for Acute Myeloid Leukemia
Abstract: Objective: Acute myeloid leukemia (AML) is an apoptotic condition in the hematopoietic system induced by the differentiation and maturation of stem cells into erythrocytes, and leukemic cell proliferation is suppressed as the PI3K-Akt-mTOR pathway is pharmacologically targeted with certain inhibitors. As a result, in silico molecular docking of compounds against AML receptors, CTMP, was used in computational research on Hemidesmus indicus to uncover therapeutic phytochemicals for AML. Thus, this study …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 38–53 Read article
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Green Synthesis of Copper Nanoparticle for the Treatment of Neurodegenerative Disease
Abstract: The study of ecologically friendly CuNP synthesis is a growing area with potential applications in biomedical research and environmental remediation, as well as sustainable nanotechnology. Generally, reducing, and stabilizing agents such as microbes, plant extracts, or other natural sources are used. The green synthesis methodology guarantees the production of nanoparticles with desired characteristics for biomedical applications while simultaneously mitigating the environmental effect that comes with conventional chemical processes. CuNPs possess …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 1, 2024 · pp. 13–24 Read article
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In Silico Investigation of 2,3-Dihydrobenzofuran from Centella asiatica: A Possible Pioneer in the Management of Tetanus
Abstract: Objective: Tetanus toxin (TeNT) is a neuroprotein toxin, the most toxic known. They have three functional domains and are structurally similar. They possess an N-terminal catalytic section (light chain), an internal domain for heavy-chain translocation (HN domain), and a C-terminal receptor binding domain for the heavy chain (Hc domain or RBD). Tetanus, an acute nerve-affecting disease, is provoked by a toxin-producing bacterium called Clostridium tetani. This bacterium is environmental, Gram-positive, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 19–30 Read article
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Computational Exploration of Bhrijraj-derived Phytochemicals as Potential Anti-inflammatory Agents: A Molecular Docking Study with Cyclooxygenase-II Complex
Abstract: The molecular docking analysis was meticulously conducted using state-of-the-art computational tools, notably Chimera and Python. These tools were employed to unravel the complex interactions between the identified phytochemicals from Bhrijraj and the target protein, COX-II. The 3D structures of the phytochemicals were prepared with precision using ChemSketch, ensuring accuracy in the subsequent molecular docking simulations. This rigorous approach enhances the reliability and validity of the findings. This research aims to …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 31–37 Read article
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Hemoglobin is the Breath of Life within Our Cells: An Update
Abstract: Hemoglobin is a fascinating protein found in human red blood cells. This specialist protein carries oxygen from your lungs to every cell in your body, functioning as a little delivery system. While hemoglobin’s stronghold on oxygen is necessary, releasing it at the right time is a delicate challenge. This adaptable protein masterfully balances holding on to its oxygen cargo or releasing it swiftly. This article explores how hemoglobin achieves this …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 1, 2024 · pp. 25–31 Read article
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A Comprehensive Review on Impact of Natural Selection Leading to Convergence
Abstract: This tale explores the complex relationship between genetic creativity, adaptation and common ecological problems that is arranged by the master sculptor, natural selection. Convergence reveals the adaptive genius that runs throughout the structure of evolution and is an acknowledgment to the continued power of natural selection. This journey aims to solve the enigma of convergent evolution. Natural selection has been influencing every link in the complex web of life on …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 1, 2024 · pp. 1–7 Read article
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Stretching Boundaries: A Comprehensive Review of Ehlers-Danlos Syndrome and its Subtypes
Abstract: The Ehlers-Danlos syndromes (EDS) encompass 13 inheritable disorders affecting connective tissue. These conditions arise from genetic alterations impacting the structure of connective tissue. Every variant of Ehlers-Danlos syndrome (EDS) exhibits distinct features and has specific diagnostic criteria. While certain traits such as joint hypermobility, skin hyperextensibility, and tissue fragility are common across all types of EDS. The range of clinical presentations spans from minor skin and joint looseness to severe …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 44–57 Read article
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Recombinant Insulin
Abstract: Recombinant insulin, a revolutionary product of biotechnology, has transformed the landscape of diabetes treatment. Developed through genetic engineering techniques, recombinant insulin offers a safer, more consistent alternative to traditional animal-derived insulin. Its production involves the insertion of the human insulin gene into host organisms such as Escherichia coli or Saccharomyces cerevisiae, which serve as efficient factories for insulin synthesis. Recombinant insulin is used to treat diabetic patients who are allergic …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 39–43 Read article