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Research & Reviews: A Journal of Drug Design & Discovery

Design, Synthesis and Anticancer Evaluation of Chalcone-thiazolidinone Hybrids

  1. Ruchika Goyal
  2. A. Kumar
  3. S. Kumar

Abstract

A small series of chalcone-thiazolidinone hybrids has been designed, synthesized in good yield and evaluated for anticancer activity on the three cell lines A-549, U-87 and COLO-205. All the compounds showed significant cytotoxic effect in micromolar range on the three cell lines. Compounds CT8 and CT6 were found to be the most potent on A-549 and COLO-205 (IC50 = 38.89 µM and 52.23 µM), respectively. Keywords: Chalcone-thiazolidinone, cytotoxic, anticancer activityCite this ArticleKumar A, Goyal R, Kumar S. Design, Synthesis and Anticancer Evaluation of Chalcone-thiazolidinone Hybrids. Research & Reviews: A Journal of Drug Design & Discovery. 2016; 3(2):        23–30p.
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